{"id":"https://openalex.org/W4379470206","doi":"https://doi.org/10.1038/s41598-023-30322-7","title":"A spike in circulating cytokines TNF-\u03b1 and TGF-\u03b2 alters barrier function between vascular and musculoskeletal tissues","display_name":"A spike in circulating cytokines TNF-\u03b1 and TGF-\u03b2 alters barrier function between vascular and musculoskeletal tissues","publication_year":2023,"publication_date":"2023-06-05","ids":{"openalex":"https://openalex.org/W4379470206","doi":"https://doi.org/10.1038/s41598-023-30322-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/37277369","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10241787"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-30322-7","doi":"https://doi.org/10.1038/s41598-023-30322-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-30322-7","pdf_url":"https://www.nature.com/articles/s41598-023-30322-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-30322-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069830059","display_name":"Lucy Ngo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lucy Ngo","raw_affiliation_strings":["MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MechBio Team, Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004319969","display_name":"Melissa L. Knothe Tate","orcid":"https://orcid.org/0000-0002-3552-2525","observed_orcids":["https://orcid.org/0000-0002-3552-2525"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Melissa L. Knothe Tate","raw_affiliation_strings":["Blue Mountains World Interdisciplinary Innovation Institute, New South Wales, Australia. proftate.bmwi3@gmail.com","Blue Mountains World Interdisciplinary Innovation Institute, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blue Mountains World Interdisciplinary Innovation Institute, New South Wales, Australia. proftate.bmwi3@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Blue Mountains World Interdisciplinary Innovation Institute, New South Wales, Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004319969"],"corresponding_institution_ids":[],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":2.9272,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.9159557,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"9119","last_page":"9119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.05130000039935112,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":1.0},{"id":"https://openalex.org/keywords/tight-junction-barrier-function","display_name":"tight junction barrier function","score":0.8939999938011169},{"id":"https://openalex.org/keywords/molecular-transport","display_name":"molecular transport","score":0.6380000114440918},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.5099999904632568},{"id":"https://openalex.org/keywords/guinea-pig-model","display_name":"guinea pig model","score":0.5},{"id":"https://openalex.org/keywords/knee-joint","display_name":"knee joint","score":0.5830000042915344},{"id":"https://openalex.org/keywords/albumin-transport","display_name":"albumin transport","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.653389573097229},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6515167951583862},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6061262488365173},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5403973460197449},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.51747727394104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5077932476997375},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.47256535291671753},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47186416387557983},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3715643286705017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32100191712379456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25661563873291016},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-30322-7","doi":"https://doi.org/10.1038/s41598-023-30322-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-30322-7","pdf_url":"https://www.nature.com/articles/s41598-023-30322-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10241787","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10241787","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10241787/pdf/41598_2023_Article_30322.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37277369","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37277369","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ad312fec235b4d11a2605b5b45b30fc9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ad312fec235b4d11a2605b5b45b30fc9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-30322-7","doi":"https://doi.org/10.1038/s41598-023-30322-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-30322-7","pdf_url":"https://www.nature.com/articles/s41598-023-30322-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337544","display_name":"Office of Extramural Research, National Institutes of Health","ror":"https://ror.org/05aq6yn88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379470206.pdf","grobid_xml":"https://content.openalex.org/works/W4379470206.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W284783631","https://openalex.org/W1483393222","https://openalex.org/W1571406711","https://openalex.org/W1572626374","https://openalex.org/W1670675606","https://openalex.org/W1710973382","https://openalex.org/W1922310012","https://openalex.org/W1971322232","https://openalex.org/W1989919731","https://openalex.org/W1999173314","https://openalex.org/W2004158860","https://openalex.org/W2004633453","https://openalex.org/W2033765991","https://openalex.org/W2044052935","https://openalex.org/W2050022968","https://openalex.org/W2082954333","https://openalex.org/W2092282157","https://openalex.org/W2092887367","https://openalex.org/W2097492875","https://openalex.org/W2101802039","https://openalex.org/W2102957754","https://openalex.org/W2111601530","https://openalex.org/W2135213015","https://openalex.org/W2136761840","https://openalex.org/W2143026615","https://openalex.org/W2153753664","https://openalex.org/W2157929110","https://openalex.org/W2164175676","https://openalex.org/W2168579380","https://openalex.org/W2279009708","https://openalex.org/W2395338705","https://openalex.org/W2478769891","https://openalex.org/W2478854880","https://openalex.org/W2584503597","https://openalex.org/W2587406388","https://openalex.org/W2766310128","https://openalex.org/W2782987256","https://openalex.org/W2790056846","https://openalex.org/W2791975532","https://openalex.org/W2800728832","https://openalex.org/W2803209358","https://openalex.org/W2811092976","https://openalex.org/W2988119267","https://openalex.org/W2989935861","https://openalex.org/W3093928288","https://openalex.org/W4210338655","https://openalex.org/W4214568842","https://openalex.org/W4378808064"],"related_works":["https://openalex.org/W4414672133","https://openalex.org/W4382362935","https://openalex.org/W7223153085","https://openalex.org/W2811092976","https://openalex.org/W7221153973","https://openalex.org/W2939767724","https://openalex.org/W2156585562","https://openalex.org/W7125505119","https://openalex.org/W3060305244","https://openalex.org/W3193501355"],"abstract_inverted_index":{"Molecular":[0],"transport":[1,45,148],"between":[2,264,320],"the":[3,39,84,105,115,127,138,156,177,182,229,265,276,280,284,291,300,306,333,337],"circulatory":[4,157,266],"and":[5,14,26,42,151,158,210,235,267,290,302,319,326,335],"musculoskeletal":[6,159,268],"systems":[7],"regulates":[8],"articular":[9],"joint":[10,21,66,132,285,341],"physiology":[11],"in":[12,89,95,114,124,225,254,275,299],"health":[13],"disease.":[15],"Osteoarthritis":[16],"(OA)":[17],"is":[18,223],"a":[19,58,80,96,195,242,250],"degenerative":[20,340],"disease":[22],"linked":[23],"to":[24,50,70,83,186,190,227,305,331],"systemic":[25],"local":[27],"inflammation.":[28],"Inflammatory":[29],"events":[30],"involve":[31],"cytokines,":[32,110],"which":[33],"are":[34],"secreted":[35],"by":[36],"cells":[37],"of":[38,74,100,117,131,140,155,164,237,244,283,323,339],"immune":[40,122],"system":[41],"modulate":[43,126],"molecular":[44,147,316],"across":[46,152],"tissue":[47,133,153,288,321],"interfaces":[48,154],"(referred":[49],"as":[51,79,119,121,313,344],"tight":[52],"junction":[53],"[TJ]":[54],"barrier":[55,128,262,271],"function).":[56],"In":[57,279],"previous":[59],"study":[60,99],"from":[61],"our":[62,324],"group,":[63],"OA":[64,197],"knee":[65,205],"tissues":[67,150],"were":[68,207],"shown":[69],"exhibit":[71],"size":[72,226],"separation":[73],"different":[75],"sized":[76],"molecules":[77],"delivered":[78,170],"single":[81,162],"bolus":[82,163],"heart":[85],"(Ngo":[86],"et":[87],"al.":[88],"Sci.":[90],"Rep.":[91],"8:10254,":[92],"2018).":[93],"Here,":[94],"follow":[97],"up":[98],"parallel":[101],"design,":[102],"we":[103,136],"test":[104],"hypothesis":[106],"that":[107],"two":[108],"common":[109],"with":[111,175,270],"multifaceted":[112],"roles":[113],"etiology":[116],"osteoarthritis":[118],"well":[120],"state":[123],"general,":[125],"function":[129,263,272],"properties":[130],"interfaces.":[134],"Specifically,":[135],"probe":[137],"effect":[139],"an":[141],"acute":[142],"cytokine":[143,179,184],"increase":[144],"(spike)":[145],"on":[146],"within":[149,318],"systems.":[160],"A":[161],"fluorescent-tagged":[165,221],"70":[166,219],"kDa":[167,220],"dextran,":[168],"was":[169,296],"intracardially,":[171],"either":[172,176],"alone,":[173],"or":[174,181,258],"pro-inflammatory":[178],"TNF-\u03b1":[180,257,277],"anti-inflammatory":[183],"TGF-\u03b2,":[185],"skeletally":[187],"mature":[188],"(11":[189],"13-month-old)":[191],"guinea":[192],"pigs":[193],"(Dunkin-Hartley,":[194],"spontaneous":[196],"animal":[198],"model).":[199],"After":[200],"five":[201,248],"minutes'":[202],"circulation,":[203],"whole":[204],"joints":[206,325],"serial":[208],"sectioned":[209],"fluorescent":[211],"block":[212],"face":[213],"cryo-imaged":[214],"at":[215],"near-single-cell":[216],"resolution.":[217],"The":[218],"tracer":[222,238,245,294],"analogous":[224],"albumin,":[228],"most":[230],"prevalent":[231],"blood":[232],"transporter":[233],"protein,":[234],"quantification":[236],"fluorescence":[239],"intensity":[240],"gave":[241],"measure":[243],"concentration.":[246],"Within":[247],"minutes,":[249],"spike":[251],"(acute":[252],"doubling)":[253],"circulating":[255],"cytokines":[256,312],"TGF-\u03b2":[259],"significantly":[260,297],"disrupted":[261],"systems,":[269],"essentially":[273],"abrogated":[274],"group.":[278],"entire":[281],"volume":[282],"(including":[286],"all":[287],"compartments":[289,322],"bounding":[292],"musculature),":[293],"concentration":[295],"decreased":[298],"TGF-\u03b2-":[301],"TNF-\u03b1-":[303],"compared":[304],"control-group.":[307],"These":[308],"studies":[309],"implicate":[310],"inflammatory":[311],"gatekeepers":[314],"for":[315],"passage":[317],"may":[327],"open":[328],"new":[329],"means":[330],"delay":[332],"onset":[334],"mitigate":[336],"progression":[338],"diseases":[342],"such":[343],"OA,":[345],"using":[346],"pharmaceutical":[347],"and/or":[348],"physical":[349],"measures.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-06-07T00:00:00"}
