{"id":"https://openalex.org/W4379340482","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e23528","title":"Diverse genomic characterization of Chinese patients with osteosarcoma and soft tissue sarcoma.","display_name":"Diverse genomic characterization of Chinese patients with osteosarcoma and soft tissue sarcoma.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379340482","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e23528"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.e23528","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e23528","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e23528","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2023.41.16_suppl.e23528","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2023.41.16_suppl.e23528","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102894611","display_name":"Mengxiong Sun","orcid":"https://orcid.org/0000-0002-5514-7160","observed_orcids":["https://orcid.org/0000-0002-5514-7160"]},"institutions":[{"id":"https://openalex.org/I4210135742","display_name":"Shanghai First People's Hospital","ror":"https://ror.org/04a46mh28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135742"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengxiong Sun","raw_affiliation_strings":["The Orthopaedic Oncology Department, Shanghai General Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Orthopaedic Oncology Department, Shanghai General Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210135742"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Quan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Quan","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huan Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Yi","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086148906","display_name":"Zhongyu Lu","orcid":"https://orcid.org/0009-0000-6813-7650","observed_orcids":["https://orcid.org/0009-0000-6813-7650"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongyu Lu","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086163460","display_name":"Yangyang Yu","orcid":"https://orcid.org/0000-0002-2754-5954","observed_orcids":["https://orcid.org/0000-0002-2754-5954"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Yu","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460981","display_name":"Siqi Chen","orcid":"https://orcid.org/0000-0002-9498-3823","observed_orcids":["https://orcid.org/0000-0002-9498-3823","https://orcid.org/0009-0002-2779-8326","https://orcid.org/0009-0002-6239-9240","https://orcid.org/0009-0003-5956-3123","https://orcid.org/0009-0008-6124-286X","https://orcid.org/0009-0009-0829-1897"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Chen","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101917640","display_name":"Ran Ding","orcid":"https://orcid.org/0000-0002-7453-8968","observed_orcids":["https://orcid.org/0000-0002-7453-8968"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran Ding","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110985727","display_name":"Wanglong Deng","orcid":"https://orcid.org/0000-0003-4242-9166","observed_orcids":["https://orcid.org/0000-0003-4242-9166"]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanglong Deng","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089674189","display_name":"Fanfeng Bu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096870","display_name":"Simcere Pharmaceutical (China)","ror":"https://ror.org/00t01w369","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210096870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanfeng Bu","raw_affiliation_strings":["The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Medical Department, Nanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, China","institution_ids":["https://openalex.org/I4210096870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"e23528","last_page":"e23528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":1.0},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.5730000138282776},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8069999814033508},{"id":"https://openalex.org/keywords/gene-fusion","display_name":"gene fusion","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.6919999718666077},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.871999979019165},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ca125","display_name":"CA125","score":0.8320000171661377},{"id":"https://openalex.org/keywords/lrp1b","display_name":"LRP1B","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fat2","display_name":"FAT2","score":0.414000004529953},{"id":"https://openalex.org/keywords/med12","display_name":"MED12","score":0.6359999775886536},{"id":"https://openalex.org/keywords/stag2","display_name":"STAG2","score":0.8410000205039978},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cell-cycle-pathway","display_name":"cell cycle pathway","score":0.4729999899864197},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.6610000133514404},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.41600000858306885},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.8758160471916199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6490037441253662},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6281423568725586},{"id":"https://openalex.org/C2776300330","wikidata":"https://www.wikidata.org/wiki/Q17860505","display_name":"CDKN2B","level":4,"score":0.6208099722862244},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.575425386428833},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.5441688895225525},{"id":"https://openalex.org/C74231797","wikidata":"https://www.wikidata.org/wiki/Q14905160","display_name":"GNAS complex locus","level":3,"score":0.5290433764457703},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5120533108711243},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.473898321390152},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.4640082120895386},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.46393588185310364},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40514901280403137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3586792051792145},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31614553928375244},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2809973359107971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2779640555381775},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26645252108573914},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26511597633361816},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.23809108138084412},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.16019082069396973},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.e23528","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e23528","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e23528","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2023.41.16_suppl.e23528","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.e23528","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e23528","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e23528","pdf_url":"https://ascopubs.org/doi/pdf/10.1200/JCO.2023.41.16_suppl.e23528","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379340482.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3180709870","https://openalex.org/W4280560944","https://openalex.org/W4200084487","https://openalex.org/W3180724562","https://openalex.org/W4384944311","https://openalex.org/W4386877826","https://openalex.org/W7162512175","https://openalex.org/W4393073781","https://openalex.org/W7167791947","https://openalex.org/W3166358590"],"abstract_inverted_index":{"e23528":[0],"Background:":[1],"Osteosarcoma(OST)":[2],"differs":[3],"from":[4,87,254,266],"soft":[5],"tissue":[6],"sarcoma(STS)":[7],"in":[8,19,28,35,119,152,160,179,198,212,221,231,237,244,260,299,312,335,350,365,376],"terms":[9],"of":[10,31,68,251,263,303,315],"pathology":[11],"and":[12,33,61,82,91,127,154,169,188,214,233,279,284,319,328,344,382,394],"chemotherapy,":[13],"but":[14],"there":[15,372],"is":[16],"partial":[17],"overlap":[18],"targeted":[20,66,392],"therapy.":[21],"Few":[22],"articles":[23],"have":[24],"described":[25],"the":[26,47,96,132,300,336,351],"differences":[27,359,375],"genetic":[29,377],"profiles":[30,378],"OST":[32,161,286,321,381],"STS":[34,213,283,318],"Chinese":[36,380],"patients":[37,109,270],"based":[38,116],"on":[39,77,117],"extensive":[40],"sample":[41],"data,":[42],"at":[43],"this":[44],"point,":[45],"identifying":[46],"difference":[48],"genomic":[49],"characterization":[50],"between":[51,379],"them":[52],"may":[53,385],"provide":[54],"new":[55],"drug":[56],"targets":[57],"for":[58,390],"clinical":[59],"diagnosis":[60],"treatment.":[62],"Methods:":[63],"A":[64],"551-gene":[65],"panel":[67],"DNA-based":[69],"Next":[70],"Generation":[71],"Sequencing":[72],"(NGS)":[73],"assay":[74],"was":[75,105,136,307],"performed":[76],"tumor":[78,120],"tissue(n":[79],"=":[80,84,89,93,100,167,174,186,193,331,342,346],"613)":[81],"plasma(n":[83],"136)":[85],"obtained":[86],"STS(n":[88],"586)":[90],"OST(n":[92],"163)":[94],"patients,":[95],"majority":[97],"were":[98,129,146,176,195,205,227,242,253,265,271,322,355],"male(n":[99],"430,":[101],"57.4%),":[102],"median":[103],"age":[104],"49(range":[106],"1-87),":[107],"101":[108],"also":[110],"measured":[111],"additional":[112],"67":[113],"gene":[114],"fusions":[115,241,257],"RNA-seq":[118],"samples.":[121],"All":[122],"variants":[123],"(SNV,":[124],"INDEL,":[125],"CNV":[126],"fusion)":[128],"entered":[130],"into":[131],"result":[133],"analysis.":[134],"PD-L1expression":[135],"tested":[137],"by":[138],"IHC(SP263).":[139],"Results:":[140],"The":[141,200,368],"top":[142],"5":[143],"mutant":[144],"genes":[145,226],"TP53(28%),":[147],"CDK4(20%),":[148],"MDM2(18%),":[149],"CDKN2A(15%),":[150],"CDKN2B(15%)":[151],"STS,":[153,180,232,261,304,325,383],"TP53(26%),":[155],"MYC(19%),":[156],"CDK4(18%),":[157],"MUC16(13%),":[158],"CDKN2B(13%)":[159],"respectively.":[162],"MDM2(18%":[163],"vs":[164,171,183,190],"10%,":[165],"p":[166,173,185,192],"0.030)":[168],"PTEN(11%":[170],"4%,":[172],"0.007)":[175],"significantly":[177,224],"higher":[178],"while":[181,305,339],"GNAS(7%":[182],"3%,":[184],"0.045)":[187],"IDH1(5%":[189],"1%,":[191],"0.002)":[194],"more":[196,295,308,333,348,387],"common":[197,334,349],"OST.":[199,222,238,316,366],"most":[201],"frequently":[202],"affected":[203],"pathways":[204],"Cell":[206,215],"cycle(42%),":[207],"Genome":[208,217],"integrity(34%),":[209],"RTK":[210],"signaling(27%)":[211],"cycle(36%),":[216],"integrity(33%),":[218],"transcription":[219],"factor(28%)":[220],"Additional":[223],"co-altered":[225],"RB1/PTEN,":[228],"LRP1B/FAT3,":[229],"FAT2/SPTA1":[230],"MUC16/LRP1B,":[234],"LRP1B/POLE,":[235],"MED12/STAG2":[236],"More":[239],"rare":[240],"identified":[243],"STS.":[245,255],"Wefound":[246],"15":[247],"PTPRB":[248],"fusions,":[249],"14":[250],"which":[252,264,384],"MDM2":[256],"only":[258,276],"detected":[259],"8":[262],"liposarcoma.":[267],"Almost":[268],"all":[269],"defined":[272],"as":[273,288],"MSS(625/629),":[274],"with":[275],"4":[277],"MSI-L":[278],"no":[280,356],"MSI-H.":[281],"2.9%(17/589)":[282],"3.1%(5/163)":[285],"scored":[287],"TMB-H(\u226510.00":[289],"Muts/Mb).":[290],"TP53(p\uff1c0.001),":[291],"MUC16(p\uff1c0.001),":[292],"LRP1B(p\uff1c0.001),":[293],"FAT3(p\uff1c0.001)were":[294],"likely":[296,309],"to":[297,310,361],"appear":[298,311],"TMB-H":[301,313],"group":[302,314],"MUC16(p\uff1c0.001)":[306],"32.3%(83/257)":[317],"29.6%(8/27)":[320],"PD-L1-positive(PD-L1\u22651%).":[323],"In":[324],"PDCD1LG2(p\uff1c0.001),":[326],"CD274(p\uff1c0.001)":[327],"JAK2":[329],"(p":[330,341],"0.001)were":[332],"PD-L1-positive":[337],"group,":[338],"MDM4":[340],"0.018)":[343],"PARP1(p":[345],"0.003)were":[347],"PD-L1-negtive":[352],"group.":[353],"There":[354],"statistically":[357],"significant":[358],"due":[360],"limited":[362],"PD-L1":[363],"data":[364],"Conclusions:":[367],"analysis":[369],"revealed":[370],"that":[371],"are":[373],"some":[374],"provid":[386],"precise":[388],"basis":[389],"personalized":[391],"therapy":[393],"immunotherapy.":[395]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2023-06-05T00:00:00"}