{"id":"https://openalex.org/W4379330249","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e14548","title":"Correlation of micronuclei formation in circulating stromal cells with their PD-L1 expression and predicts for poorer clinical outcomes in metastatic breast cancer.","display_name":"Correlation of micronuclei formation in circulating stromal cells with their PD-L1 expression and predicts for poorer clinical outcomes in metastatic breast cancer.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379330249","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e14548"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.e14548","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e14548","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e14548","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066513117","display_name":"Dimpal M. Kasabwala","orcid":"https://orcid.org/0000-0001-6986-6820","observed_orcids":["https://orcid.org/0000-0001-6986-6820"]},"institutions":[{"id":"https://openalex.org/I4210118300","display_name":"Creatv MicroTech (United States)","ror":"https://ror.org/02htbg024","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimpal M. Kasabwala","raw_affiliation_strings":["Creatv MicroTech, Inc., Monmouth Junction, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creatv MicroTech, Inc., Monmouth Junction, NJ","institution_ids":["https://openalex.org/I4210118300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032987754","display_name":"Massimo Cristofanilli","orcid":"https://orcid.org/0000-0002-4194-7175","observed_orcids":["https://orcid.org/0000-0002-4194-7175"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massimo Cristofanilli","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049901305","display_name":"R. Katherine Alpaugh","orcid":"https://orcid.org/0000-0002-6775-5323","observed_orcids":["https://orcid.org/0000-0002-6775-5323"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Katherine Alpaugh","raw_affiliation_strings":["Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052187738","display_name":"Saranya Chumsri","orcid":"https://orcid.org/0000-0001-7117-1446","observed_orcids":["https://orcid.org/0000-0001-7117-1446"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saranya Chumsri","raw_affiliation_strings":["Mayo Clinic, Jacksonville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Jacksonville, FL","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021852926","display_name":"Cha\u2010Mei Tang","orcid":"https://orcid.org/0000-0003-3017-0732","observed_orcids":["https://orcid.org/0000-0003-3017-0732"]},"institutions":[{"id":"https://openalex.org/I4210118300","display_name":"Creatv MicroTech (United States)","ror":"https://ror.org/02htbg024","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cha-Mei Tang","raw_affiliation_strings":["Creatv MicroTech, Inc, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creatv MicroTech, Inc, Rockville, MD","institution_ids":["https://openalex.org/I4210118300"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062792789","display_name":"Rena G. Lapidus","orcid":"https://orcid.org/0000-0002-4422-743X","observed_orcids":["https://orcid.org/0000-0002-4422-743X"]},"institutions":[{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rena G. Lapidus","raw_affiliation_strings":["Greenebaum Comprehensive Cancer Center, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Comprehensive Cancer Center, Baltimore, MD","institution_ids":["https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110085328","display_name":"Giuseppe Del Priore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe Del Priore","raw_affiliation_strings":["BriaCell Therapeutics Corp., Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BriaCell Therapeutics Corp., Philadelphia, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064693797","display_name":"Mingjin Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingjin Chang","raw_affiliation_strings":["BriaCell Therapeutics Corp., Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BriaCell Therapeutics Corp., Philadelphia, PA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018426062","display_name":"Toshiaki Iwase","orcid":"https://orcid.org/0000-0002-5302-2292","observed_orcids":["https://orcid.org/0000-0002-5302-2292"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshiaki Iwase","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088814426","display_name":"Naoto Tada Ueno","orcid":"https://orcid.org/0000-0002-0166-7275","observed_orcids":["https://orcid.org/0000-0002-0166-7275"]},"institutions":[{"id":"https://openalex.org/I4390039246","display_name":"University of Hawaii Cancer Center","ror":"https://ror.org/00kt3nk56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039246"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoto T. Ueno","raw_affiliation_strings":["University of Hawai\u2019i Cancer Center (UHCC), Honolulu, HI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hawai\u2019i Cancer Center (UHCC), Honolulu, HI","institution_ids":["https://openalex.org/I4390039246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005317276","display_name":"Daniel L. Adams","orcid":"https://orcid.org/0000-0002-1916-9637","observed_orcids":["https://orcid.org/0000-0002-1916-9637"]},"institutions":[{"id":"https://openalex.org/I4210118300","display_name":"Creatv MicroTech (United States)","ror":"https://ror.org/02htbg024","country_code":"US","type":"company","lineage":["https://openalex.org/I4210118300"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L Adams","raw_affiliation_strings":["Creatv MicroTech, Inc, Monmouth Junction, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creatv MicroTech, Inc, Monmouth Junction, NJ","institution_ids":["https://openalex.org/I4210118300"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"e14548","last_page":"e14548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3747999966144562,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3747999966144562,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.288100004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9440000057220459},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.875},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.7429999709129333},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5690000057220459},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.5569999814033508},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6600000262260437},{"id":"https://openalex.org/keywords/circulating-tumor-cells","display_name":"circulating tumor cells","score":0.5220000147819519},{"id":"https://openalex.org/keywords/clinical-outcome-prediction","display_name":"clinical outcome prediction","score":0.5139999985694885},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.6110000014305115},{"id":"https://openalex.org/keywords/chemotherapy-induced-genotoxicity","display_name":"chemotherapy-induced genotoxicity","score":0.47600001096725464},{"id":"https://openalex.org/keywords/radiation-induced-genotoxicity","display_name":"radiation genotoxicity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.7868796586990356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7360001802444458},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5576025247573853},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5555310845375061},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5538755059242249},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5459988117218018},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5199012160301208},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5049963593482971},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4900166094303131},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.46031519770622253},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4533396065235138},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4225753843784332},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40110257267951965},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.15061119198799133},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.12586358189582825},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.07973372936248779}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.e14548","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e14548","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e14548","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362543567","https://openalex.org/W4322771029","https://openalex.org/W4378173457","https://openalex.org/W2886604923","https://openalex.org/W3097618836","https://openalex.org/W7162656147","https://openalex.org/W6958455759","https://openalex.org/W3209378804","https://openalex.org/W2605181848","https://openalex.org/W4409377485"],"abstract_inverted_index":{"e14548":[0],"Background:":[1],"Micronuclei":[2],"(MN)":[3],"are":[4,59,68,380,421],"small,":[5],"excised":[6],"DNA":[7,12],"fragments":[8],"resulting":[9],"from":[10,131,152,184],"biological":[11],"repair":[13],"mechanisms":[14],"in":[15,35,39,72,92,150,251,348,360,382,403,436],"response":[16,82],"to":[17,83,136,169,198,211,406,423],"internal":[18],"chromosomal":[19],"instability,":[20],"such":[21],"as":[22],"those":[23],"caused":[24],"by":[25,173,204,234],"genotoxic":[26],"events":[27,52],"(i.e.":[28],"chemotherapy":[29],"and":[30,32,109,164,200,225,237,256,287,302,358,370,387,394,418],"radiation),":[31],"whose":[33],"formation":[34,56,148],"tumor":[36],"stromal":[37,101],"cells":[38,102,190],"blood":[40,155],"circulation":[41],"is":[42],"prognostic":[43,261],"for":[44,106,142,158,162,262],"worse":[45,263,395],"clinical":[46,107,214,416],"outcomes":[47,108],"(Fenech":[48],"2020).":[49],"Further,":[50,344,398],"mutagenic":[51],"occurring":[53],"during":[54],"the":[55,62,73,181,399,427],"of":[57,64,127,140,218,254,280,295,325,336,346,401,426,429],"MN":[58,88,147,203,207,248,283,289,298,304,309,319,326,337,356,364,379,402,430],"associated":[60],"with":[61,112,193,195,282,297,323,362,384,391,408],"development":[63],"cancer":[65,95],"neoantigens,":[66],"which":[67],"a":[69,119,124,313,351],"major":[70],"element":[71],"programmed":[74],"cell":[75,114],"death":[76],"ligand":[77],"(PD-L1)":[78],"pathway":[79],"that":[80,87,104,378],"influences":[81],"immunotherapies.":[84],"We":[85,117,145],"hypothesized":[86],"can":[89],"be":[90],"detected":[91,381],"metastatic":[93],"breast":[94],"(mBC)":[96],"patients":[97],"(pts)":[98],"within":[99,180,412],"circulating":[100],"(CStCs)":[103],"prognosticates":[105],"may":[110,388],"associate":[111],"PD-L1":[113,163,194,219,316,332,347,359,410,434],"expression.":[115],"Methods:":[116],"initiated":[118],"prospective":[120],"pilot":[121],"study":[122],"using":[123],"compiled":[125],"set":[126],"n=124":[128],"mBC":[129,386],"samples,":[130],"multiple":[132],"institutions,":[133],"enrolled":[134],"prior":[135],"starting":[137],"new":[138],"lines":[139],"treatment":[141],"progressive":[143],"mBC.":[144],"enumerated":[146],"found":[149],"CStCs":[151,255,311,321,349,404,432],"whole":[153],"peripheral":[154],"(7.5mL),":[156],"filtered":[157],"CStCs,":[159],"then":[160],"stained":[161,192],"DAPI.":[165],"DAPI":[166],"was":[167,209,259,284,290,299,305],"used":[168],"identify":[170,389],"MN,":[171],"defined":[172],"small":[174],"(<3":[175],"\u00b5m)":[176],"DAPI+":[177],"circular":[178],"formations":[179],"cytoplasm,":[182],"separate":[183],"primary":[185],"nuclei.":[186],"In":[187],"conjunction,":[188],"all":[189,212],"were":[191,232,249],"expression":[196,317,333,411],"normalized":[197],"background":[199],"evaluated":[201],"against":[202],"T-test":[205],"analysis.":[206],"presence":[208,258],"compared":[210],"available":[213],"variables,":[215],"including":[216],"induction":[217],"immunotherapy.":[220],"Pts\u2019":[221],"progression-free":[222],"survival":[223,227,396],"(PFS)":[224],"overall":[226],"(OS)":[228],"hazard":[229],"ratios":[230],"(HRs)":[231],"analyzed":[233],"censored":[235],"univariate":[236],"multivariate":[238],"analyses":[239],"based":[240],"on":[241,433],"RECIST":[242],"v1.1":[243],"over":[244,275],"24":[245,276],"months.":[246,277,292,307],"Results:":[247],"identified":[250],"56%":[252],"(n=70/124)":[253],"their":[257],"significantly":[260,314],"PFS":[264],"(HR=2.4,":[265],"CI=":[266],"1.53-3.76,":[267],"p<0.001)":[268],"&":[269],"OS":[270],"(HR=":[271],"1.89":[272],"CI=1.07-3.34,":[273],"p=0.039)":[274],"Overall,":[278],"mPFS":[279],"pts":[281,296,328,339,383,390],"2.8":[285],"months":[286,301],"without":[288,303],"12.1":[291],"The":[293],"mOS":[294],"12.7":[300],"20.8":[306],"Additionally,":[308],"positive":[310,327,338,431],"had":[312],"higher":[315,409],"than":[318],"negative":[320],"(p<0.001),":[322],"67%":[324],"(n=46/66)":[329],"having":[330,341],"high":[331],"while":[334],"30%":[335],"(n=20/66)":[340],"low":[342],"PD-L1.":[343],"evaluation":[345],"showed":[350],"linear":[352],"relationship":[353],"(R=0.9806)":[354],"between":[355],"number":[357,400],"cells,":[361],"0":[363],"average=0.016,":[365],"1":[366],"MN=0.200,":[367],"2":[368],"MN=0.318,":[369],"\u22653":[371],"MN=0.400.":[372],"Conclusions:":[373],"These":[374],"initial":[375],"findings":[376],"suggest":[377],"advanced":[385],"faster":[392],"progression":[393],"outcomes.":[397],"appears":[405],"correlate":[407],"cells.":[413],"Follow":[414],"up":[415],"information":[417],"subtyping":[419],"studies":[420],"ongoing":[422],"also":[424],"evaluate":[425],"effect":[428],"immunotherapies":[435],"these":[437],"pts.":[438]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-06-05T00:00:00"}
