{"id":"https://openalex.org/W4379329478","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e12588","title":"Association of circulating tumor DNA with survival in neoadjuvant-treated triple negative breast cancer independent of pathological complete response.","display_name":"Association of circulating tumor DNA with survival in neoadjuvant-treated triple negative breast cancer independent of pathological complete response.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379329478","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e12588"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.e12588","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e12588","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e12588","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100653025","display_name":"Li Yan","orcid":"https://orcid.org/0000-0002-4792-9998","observed_orcids":["https://orcid.org/0000-0002-4792-9998"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Fujian Medical University Union Hospital, Fuzhou, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101445406","display_name":"Xiaobin Chen","orcid":"https://orcid.org/0000-0002-5664-3721","observed_orcids":["https://orcid.org/0000-0002-5664-3721"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobin Chen","raw_affiliation_strings":["Fujian Medical University Union Hospital, Fuzhou, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048223283","display_name":"Yuxiang Lin","orcid":"https://orcid.org/0000-0002-3963-3468","observed_orcids":["https://orcid.org/0000-0002-3963-3468"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxiang Lin","raw_affiliation_strings":["Fujian Medical University Union Hospital, Fuzhou, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068838849","display_name":"Fangmeng Fu","orcid":"https://orcid.org/0000-0002-3065-5708","observed_orcids":["https://orcid.org/0000-0002-3065-5708"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangmeng Fu","raw_affiliation_strings":["Fujian Medical University Union Hospital, Fuzhou, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fujian Medical University Union Hospital, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100443610","display_name":"Chuan Wang","orcid":"https://orcid.org/0000-0002-9742-9756","observed_orcids":["https://orcid.org/0000-0002-9742-9756","https://orcid.org/0000-0002-4451-0788"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuan Wang","raw_affiliation_strings":["Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China","institution_ids":["https://openalex.org/I4210163933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210163933"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"e12588","last_page":"e12588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.6797000169754028,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.28780001401901245,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8650000095367432},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/pathological-complete-response","display_name":"pathological complete response","score":0.8349999785423279},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.8429999947547913},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.640999972820282},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8266263604164124},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7002830505371094},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6995373368263245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6340546607971191},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.623076319694519},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5696775317192078},{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.5609198212623596},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.538325309753418},{"id":"https://openalex.org/C66339696","wikidata":"https://www.wikidata.org/wiki/Q6089397","display_name":"Log-rank test","level":3,"score":0.4221653938293457},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.42101171612739563},{"id":"https://openalex.org/C191093355","wikidata":"https://www.wikidata.org/wiki/Q9250577","display_name":"Exact test","level":2,"score":0.41953855752944946},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41738301515579224},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.15827444195747375},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.15271806716918945}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.e12588","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e12588","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e12588","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3083427612","https://openalex.org/W4401627214","https://openalex.org/W4410810235","https://openalex.org/W2570341714","https://openalex.org/W4322771698","https://openalex.org/W4390607200","https://openalex.org/W2947171618","https://openalex.org/W4376614006","https://openalex.org/W4411985140","https://openalex.org/W3138631797"],"abstract_inverted_index":{"e12588":[0],"Background:":[1],"Many":[2],"patients":[3,66,147,237],"with":[4,68,102,171,189],"triple":[5],"negative":[6],"breast":[7],"cancer":[8],"(TNBC)":[9],"still":[10],"succumb":[11],"to":[12,21,37,44,57,201],"their":[13],"disease":[14],"after":[15],"systematic":[16],"treatment.":[17],"It":[18],"is":[19,186,245],"crucial":[20],"identify":[22],"those":[23],"at":[24],"high":[25],"risk.":[26],"Circulating":[27],"tumor":[28,39,60],"DNA":[29,74],"(ctDNA)":[30],"has":[31],"recently":[32],"become":[33],"a":[34,103,127,190],"promising":[35],"marker":[36],"monitor":[38],"burden.":[40],"Our":[41],"study":[42],"aimed":[43],"evaluate":[45],"the":[46,50,59,107,116,137,175,202,210],"clinical":[47,184,205,211],"value":[48],"of":[49,55,144,174,193,209],"presence":[51],"and":[52,62,82,106,118,134,160,222],"dynamic":[53],"change":[54],"ctDNA":[56,153,218],"predict":[58],"response":[61,178],"prognosis":[63],"in":[64,163,225,235],"TNBC":[65,146,236],"treated":[67],"neoadjuvant":[69],"chemotherapy":[70],"(NAC).":[71],"Methods:":[72],"Cell-free":[73],"(cfDNA)":[75],"was":[76,124],"isolated":[77],"from":[78],"pre-NAC":[79],"plasma":[80],"samples":[81],"then":[83],"analyzed":[84],"by":[85],"duplex":[86],"sequencing.":[87],"A":[88,142,180,240],"Chi-square":[89],"test":[90,94,105],"or":[91],"Fisher":[92],"exact":[93],"were":[95,113,150,168],"used":[96,114],"for":[97,115,195],"categorical":[98],"variables.":[99],"Kaplan\u2010Meier":[100],"analysis":[101],"Log\u2010rank":[104],"Cox":[108],"proportional":[109],"hazard":[110],"regression":[111],"model":[112,185,203,244],"univariate":[117],"multivariable":[119],"survival":[120,172,198],"analysis.":[121],"Survival":[122],"prediction":[123],"assessed":[125],"using":[126],"time-dependent":[128,191],"receiver":[129],"operating":[130],"characteristic":[131],"(ROC)":[132],"curve":[133,139],"area":[135],"under":[136],"ROC":[138,192],"(AUC).":[140],"Results:":[141],"total":[143],"82":[145],"receiving":[148,238],"NAC":[149],"enrolled.":[151],"Baseline":[152,217],"detection":[154,182,242],"indicated":[155],"significantly":[156,169],"worse":[157],"survival.":[158],"TP53":[159,181,220,241],"genes":[161,223],"involved":[162,224],"PI3K-Akt":[164,226],"signaling":[165,227],"pathway":[166,228],"mutations":[167],"associated":[170],"independent":[173,232],"pathological":[176],"complete":[177],"(pCR).":[179],"combined":[183],"highly":[187,246],"predictive,":[188],"0.936":[194],"3-year":[196],"overall":[197],"(OS),":[199],"compared":[200],"including":[204],"variables":[206],"only":[207],"(AUC":[208],"predictor:":[212],"0.751,":[213],"P=":[214],"0.028).":[215],"Conclusions:":[216],"detection,":[219],"mutations,":[221],"mutation":[229],"are":[230],"all":[231],"prognostic":[233],"factors":[234],"NAC.":[239],"combining":[243],"predictive.":[247]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-06-05T00:00:00"}