{"id":"https://openalex.org/W4379328514","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.1036","title":"Metastatic breast cancer (MBC) with ultra-high tumor mutational burden (UHTMB): A comprehensive genomic profiling (CGP) study.","display_name":"Metastatic breast cancer (MBC) with ultra-high tumor mutational burden (UHTMB): A comprehensive genomic profiling (CGP) study.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379328514","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.1036"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.1036","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.1036","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.1036","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058970015","display_name":"Kristina A. Fanucci","orcid":"https://orcid.org/0000-0003-3400-7211","observed_orcids":["https://orcid.org/0000-0003-3400-7211"]},"institutions":[{"id":"https://openalex.org/I4210151747","display_name":"Lifespan","ror":"https://ror.org/04yt1rh21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristina Fanucci","raw_affiliation_strings":["Lifespan Health System, Providence, RI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lifespan Health System, Providence, RI","institution_ids":["https://openalex.org/I4210151747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086903918","display_name":"Maryam B. Lustberg","orcid":"https://orcid.org/0000-0001-8559-5645","observed_orcids":["https://orcid.org/0000-0001-8559-5645"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam B. Lustberg","raw_affiliation_strings":["Ohio State University Comprehensive Cancer Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ohio State University Comprehensive Cancer Center, Columbus, OH","institution_ids":["https://openalex.org/I2799885155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114043678","display_name":"Neal A. Fischbach","orcid":"https://orcid.org/0000-0002-5416-9114","observed_orcids":["https://orcid.org/0000-0002-5416-9114"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal A. Fischbach","raw_affiliation_strings":["Yale Cancer Center, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, New Haven, CT","institution_ids":["https://openalex.org/I2802730090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091324080","display_name":"Maureen Pelletier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maureen Pelletier","raw_affiliation_strings":["Foundation Medicine, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063392256","display_name":"Abirami Sivapiragasam","orcid":"https://orcid.org/0009-0003-5362-591X","observed_orcids":["https://orcid.org/0009-0003-5362-591X"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abirami Sivapiragasam","raw_affiliation_strings":["SUNY Upstate Medical University, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Upstate Medical University, Syracuse, NY","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066825903","display_name":"Prashanth Ashok Kumar","orcid":"https://orcid.org/0000-0001-6236-2822","observed_orcids":["https://orcid.org/0000-0001-6236-2822"]},"institutions":[{"id":"https://openalex.org/I4210106223","display_name":"Upstate University Hospital","ror":"https://ror.org/019zp2770","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prashanth Ashok Kumar","raw_affiliation_strings":["Upstate University Hospital, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Upstate University Hospital, Syracuse, NY","institution_ids":["https://openalex.org/I4210106223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069307164","display_name":"Mansi Kallem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mansi Kallem","raw_affiliation_strings":["SUNY UPSTATE, Syracuse, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY UPSTATE, Syracuse, NY","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007596753","display_name":"Natalie A. Danziger","orcid":"https://orcid.org/0000-0003-2642-7160","observed_orcids":["https://orcid.org/0000-0003-2642-7160"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Danziger","raw_affiliation_strings":["Foundation Medicine, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067701996","display_name":"Ethan S. Sokol","orcid":"https://orcid.org/0000-0002-5480-8473","observed_orcids":["https://orcid.org/0000-0002-5480-8473","https://orcid.org/0000-0002-2988-0537"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Sokol","raw_affiliation_strings":["Foundation Medicine, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020119624","display_name":"Smruthy Sivakumar","orcid":"https://orcid.org/0000-0001-7790-5615","observed_orcids":["https://orcid.org/0000-0001-7790-5615"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smruthy Sivakumar","raw_affiliation_strings":["Foundation Medicine, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032268177","display_name":"Dean C. Pavlick","orcid":"https://orcid.org/0000-0001-6075-6246","observed_orcids":["https://orcid.org/0000-0001-6075-6246"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean C. Pavlick","raw_affiliation_strings":["Foundation Medicine, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088559019","display_name":"Jeffrey S. Ross","orcid":"https://orcid.org/0000-0001-8494-2596","observed_orcids":["https://orcid.org/0000-0001-8494-2596"]},"institutions":[{"id":"https://openalex.org/I4392738181","display_name":"Foundation Medicine (United States)","ror":"https://ror.org/02ackr434","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4392738181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Ross","raw_affiliation_strings":["Foundation Medicine, Inc., Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation Medicine, Inc., Cambridge, MA","institution_ids":["https://openalex.org/I4392738181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021113979","display_name":"Lajos Pusztai","orcid":"https://orcid.org/0000-0001-9632-6686","observed_orcids":["https://orcid.org/0000-0001-9632-6686"]},"institutions":[{"id":"https://openalex.org/I2802730090","display_name":"Yale Cancer Center","ror":"https://ror.org/03j7sze86","country_code":"US","type":"facility","lineage":["https://openalex.org/I2802730090","https://openalex.org/I4210117499","https://openalex.org/I4210165192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lajos Pusztai","raw_affiliation_strings":["Yale Cancer Center, Yale School of Medicine, New Haven, CT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale Cancer Center, Yale School of Medicine, New Haven, CT","institution_ids":["https://openalex.org/I2802730090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"1036","last_page":"1036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.38280001282691956,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/comprehensive-genomic-profiling","display_name":"comprehensive genomic profiling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.8259999752044678},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.8970000147819519},{"id":"https://openalex.org/keywords/her2-status","display_name":"HER2 status","score":0.8569999933242798},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.4339999854564667},{"id":"https://openalex.org/keywords/tumor-suppressor-mutations","display_name":"tumor suppressor mutations","score":0.33799999952316284},{"id":"https://openalex.org/keywords/lobular-breast-carcinoma","display_name":"lobular breast cancer","score":0.4259999990463257},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.6309999823570251},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7800277471542358},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.6922755837440491},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6347606778144836},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.629917323589325},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.535503625869751},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4802534878253937},{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.473640114068985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4595524072647095},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.43650147318840027},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4205652177333832},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4026104807853699},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.396864116191864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12784335017204285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12064597010612488},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0961240828037262},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07549619674682617},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.1036","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.1036","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.1036","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334461","display_name":"Foundation Medicine","ror":"https://ror.org/02ackr434"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322774265","https://openalex.org/W7161779646","https://openalex.org/W3168113744","https://openalex.org/W2806557019","https://openalex.org/W4415899156","https://openalex.org/W4376613784","https://openalex.org/W3112928625","https://openalex.org/W2886861139","https://openalex.org/W7162089692","https://openalex.org/W4324136169"],"abstract_inverted_index":{"1036":[0],"Background:":[1],"Pts":[2],"with":[3,31,136,140,175,380,406],"MBC":[4,30,42,87,124,363,404],"whose":[5],"tumors":[6],"feature":[7],"high":[8,253,276,284,381,408],"TMB":[9],"(\u2265":[10],"10":[11],"mutations/Mb)":[12],"are":[13],"eligible":[14],"for":[15,119,219,418],"on":[16,75,224],"label":[17],"immune":[18],"checkpoint":[19],"inhibitor":[20],"(ICI)":[21],"treatment.":[22],"This":[23],"study":[24],"evaluated":[25],"the":[26,110,171,348],"genomic":[27,52],"landscape":[28],"of":[29,51,71,86,112,213,273,371,383,410],"\u201cUltra":[32],"high\u201d":[33],"TMB,":[34,55],"defined":[35],"at":[36,109],">":[37],"20":[38],"mutations/Mb.":[39],"Methods:":[40],"2049":[41],"underwent":[43],"hybrid":[44],"capture-based":[45],"CGP":[46,120],"to":[47,251,396],"evaluate":[48],"all":[49,214],"classes":[50],"alterations":[53,389],"(GA),":[54],"microsatellite":[56],"instability":[57],"(MSI)":[58],"and":[59,103,125,164,194,198,210,239,328,387,392],"trinucleotide":[60],"mutational":[61],"signatures.":[62],"HER2":[63,176,183,202,207,220],"IHC":[64,80,177,184,203],"results":[65],"were":[66,88,142,182,189,201,217,240,355],"available":[67],"in":[68,121,131,262,271,282,296,390],"a":[69,365,407],"subset":[70,370],"pts.":[72],"PD-L1":[73,336],"expression":[74,346],"immunocytes":[76],"was":[77,117,129,260,268,278],"determined":[78],"by":[79,347,377],"(Ventana":[81],"SP142).":[82],"Results:":[83],"45/2049":[84],"(2.2%)":[85],"UHTMB.":[89],"45":[90],"(100%)":[91],"pts":[92,139],"had":[93,98,155,228],"metastatic":[94,126],"disease.":[95,421],"38":[96],"(84%)":[97],"documented":[99,105],"Stage":[100],"IV":[101],"disease":[102,166],"7":[104],"axillary":[106],"LN":[107],"metastases":[108],"time":[111],"sequencing.":[113],"Local":[114],"breast":[115,374],"tumor":[116],"used":[118,130],"19":[122],"(42.2%)":[123],"site":[127],"biopsy":[128],"26":[132],"(57.8%).":[133],"When":[134],"compared":[135,250],"2004":[137],"non-UHTMB":[138,252],"UHTMB":[141,173,215,226,263,283,297,362,403],"older":[143],"(mean":[144,232],"64.6":[145],"yrs":[146,149],"vs":[147,159,168,234,245,287,302,309,316,323,331,342,353],"58.2":[148],"p":[150,161,236,247,289,304,311,318,325,333],"<":[151,162,237,290,305,312,326],".0001),":[152,306,313],"more":[153,229,280,293],"often":[154,242],"lobular":[156,385],"histology":[157,386],"(40.0%":[158],"14.5%":[160],".0001)":[163,238,327],"ER+":[165,384],"(86.6%":[167],"70.0%).":[169],"Of":[170],"35":[172],"cases":[174,209,216,227,285,298],"data":[178],"available,":[179],"11":[180],"(31.4%%)":[181],"negative":[185],"(0+),":[186],"21":[187],"(60.0%)":[188],"HER2-low":[190,411],"status":[191,277,412],"(9":[192],"1+":[193],"12":[195],"2+/ISH":[196],"negative)":[197],"3":[199],"(8.6%)":[200],"positive":[204,218],"(3+).":[205],"1/3":[206],"IHC2+":[208],"2/45":[211],"(4.4%)":[212],"copy":[221],"number":[222],"gain":[223],"CGP.":[225],"driver":[230],"GA/tumor":[231],"9.8":[233],"5.7":[235],"less":[241],"TNBC":[243],"(13.3%":[244],"27.0%":[246],"=":[248,319,334],".041)":[249],"cancers.":[254],"Mutation":[255],"signature":[256,267],"analysis":[257],"revealed":[258],"APOBEC":[259,378],"predominant":[261],"samples":[264],"(82.5%);":[265],"MMR":[266],"also":[269],"observed":[270],"10%":[272],"cases.":[274],"MSI":[275],"significantly":[279,357],"frequent":[281,388],"(11.6%":[286],"0.4%":[288],".0001).":[291],"GA":[292],"frequently":[294],"identified":[295],"included":[299],"CDH1":[300,391],"(45.5%":[301],"14.3%":[303],"PIK3CA":[307],"(81.8%":[308],"37.9%":[310],"CDKN2A":[314],"(11.4%":[315],"3.2%":[317],".017),":[320],"ARID1A":[321],"(25.0%":[322],"5.0%":[324],"NF1":[329],"(20.5%":[330],"5.9%":[332],".0014).":[335],"(":[337],"CD274)":[338],"gene":[339],"amplification":[340],"(2.3%":[341],"1.3%)":[343],"or":[344],"protein":[345],"Ventana":[349],"SP142":[350],"assay":[351],"(57.14%":[352],"51.10%)":[354],"not":[356],"different":[358],"among":[359],"groups.":[360],"Conclusions:":[361],"is":[364],"rare,":[366],"yet":[367],"clinically":[368,372],"important":[369],"advanced":[373],"cancer":[375],"driven":[376],"mutagenesis,":[379],"incidence":[382],"PIK3CA.":[393],"In":[394],"addition":[395],"potential":[397],"benefit":[398],"from":[399],"ICI":[400],"based":[401],"treatment,":[402],"present":[405],"frequency":[409],"which":[413],"may":[414],"impact":[415],"therapy":[416],"decisions":[417],"this":[419],"rare":[420],"[Table:":[422],"see":[423],"text]":[424]},"counts_by_year":[],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2023-06-05T00:00:00"}