{"id":"https://openalex.org/W4379283319","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.2588","title":"Patient-derived skin MicroOrganoSpheres and clinical response to immunotherapy.","display_name":"Patient-derived skin MicroOrganoSpheres and clinical response to immunotherapy.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379283319","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.2588"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.2588","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.2588","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2588","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006453605","display_name":"Rikhia Chakraborty","orcid":"https://orcid.org/0000-0002-6661-8079","observed_orcids":["https://orcid.org/0000-0002-6661-8079"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rikhia Chakraborty","raw_affiliation_strings":["Xilis, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xilis, Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060739449","display_name":"Katerina D. Fagan\u2010Solis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katerina Fagan-Solis","raw_affiliation_strings":["Xilis Inc, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xilis Inc, Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061575800","display_name":"Jessica DeVilla","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica DeVilla","raw_affiliation_strings":["Xilis, Inc, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xilis, Inc, Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087108665","display_name":"Timothy Recaldin","orcid":"https://orcid.org/0009-0005-6333-4053","observed_orcids":["https://orcid.org/0009-0005-6333-4053"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Timothy Recaldin","raw_affiliation_strings":["Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066163473","display_name":"Michael Bscheider","orcid":"https://orcid.org/0000-0001-7808-3270","observed_orcids":["https://orcid.org/0000-0001-7808-3270"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Bscheider","raw_affiliation_strings":["Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044529811","display_name":"Nikolche Gjorevski","orcid":"https://orcid.org/0000-0001-8320-0443","observed_orcids":["https://orcid.org/0000-0001-8320-0443"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikolche Gjorevski","raw_affiliation_strings":["Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061601409","display_name":"Aaron M. Fullerton","orcid":"https://orcid.org/0009-0005-9380-9419","observed_orcids":["https://orcid.org/0009-0005-9380-9419","https://orcid.org/0000-0001-9240-4819"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron Fullerton","raw_affiliation_strings":["Genentech, San Fransisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, San Fransisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081183519","display_name":"Rodney A. Prell","orcid":"https://orcid.org/0000-0002-4762-2937","observed_orcids":["https://orcid.org/0000-0002-4762-2937"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney Prell","raw_affiliation_strings":["Genentech, San Fransisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, San Fransisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089152025","display_name":"Zia Khan","orcid":"https://orcid.org/0000-0002-7859-3489","observed_orcids":["https://orcid.org/0000-0002-7859-3489"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Zia Khan","raw_affiliation_strings":["Genentech, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358060","display_name":"Zhaohui Wang","orcid":"https://orcid.org/0000-0003-4357-9780","observed_orcids":["https://orcid.org/0000-0003-4357-9780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaohui Wang","raw_affiliation_strings":["Xilis, Inc., Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xilis, Inc., Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089906166","display_name":"Shengli Ding","orcid":"https://orcid.org/0000-0003-4657-1506","observed_orcids":["https://orcid.org/0000-0003-4657-1506"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengli Ding","raw_affiliation_strings":["Xilis, Inc., Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xilis, Inc., Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057490235","display_name":"Carolyn Glass","orcid":"https://orcid.org/0000-0002-8850-9906","observed_orcids":["https://orcid.org/0000-0002-8850-9906"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn Glass","raw_affiliation_strings":["Duke University Department of Anesthesiology, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University Department of Anesthesiology, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077864353","display_name":"William R. Jeck","orcid":"https://orcid.org/0000-0003-0257-4529","observed_orcids":["https://orcid.org/0000-0003-0257-4529"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Jeck","raw_affiliation_strings":["Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043593421","display_name":"Shannon J. McCall","orcid":"https://orcid.org/0000-0003-3957-061X","observed_orcids":["https://orcid.org/0000-0003-3957-061X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon J. McCall","raw_affiliation_strings":["Department of Pathology, Duke University Medical Center, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Duke University Medical Center, Durham, NC","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050528758","display_name":"Georgia Marie Beasley","orcid":"https://orcid.org/0000-0001-6387-9030","observed_orcids":["https://orcid.org/0000-0001-6387-9030"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4390039326","display_name":"Duke Cancer Institute","ror":"https://ror.org/04vt65461","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4390039326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georgia Beasley","raw_affiliation_strings":["Duke Cancer Institute, Duke University, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Cancer Institute, Duke University, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4390039326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014363589","display_name":"Rajat Mohindra","orcid":"https://orcid.org/0009-0000-4233-5210","observed_orcids":["https://orcid.org/0009-0000-4233-5210"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Rajat Mohindra","raw_affiliation_strings":["F. Hoffmann-La Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084803094","display_name":"Shiaowen David Hsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiaowen David Hsu","raw_affiliation_strings":["XILIS, Inc., Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"XILIS, Inc., Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084564240","display_name":"G. Scott Chandler","orcid":"https://orcid.org/0000-0001-5339-9906","observed_orcids":["https://orcid.org/0000-0001-5339-9906"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"G Scott Chandler","raw_affiliation_strings":["F. Hoffmann-La Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023687769","display_name":"Xiling Shen","orcid":"https://orcid.org/0000-0002-4978-3531","observed_orcids":["https://orcid.org/0000-0002-4978-3531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiling Shen","raw_affiliation_strings":["Xilis, Inc., Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xilis, Inc., Durham, NC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057418067","display_name":"Adrian B. Roth","orcid":"https://orcid.org/0000-0003-3164-3300","observed_orcids":["https://orcid.org/0000-0003-3164-3300"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrian B Roth","raw_affiliation_strings":["Roche, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roche, Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"last","author":{"id":null,"display_name":"ASCO Authors' Group","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ASCO Authors' Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"2588","last_page":"2588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cutaneous-immune-related-adverse-events","display_name":"cutaneous immune-related adverse events","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/microfluidic-organoids","display_name":"microfluidic organoids","score":0.6340000033378601},{"id":"https://openalex.org/keywords/toxicity-assessment","display_name":"toxicity prediction","score":0.5230000019073486},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6209999918937683},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.5870000123977661},{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":0.9480000138282776},{"id":"https://openalex.org/keywords/psoriatic-dermatitis","display_name":"psoriatic dermatitis","score":0.7590000033378601},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"personalized medicine","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9068043231964111},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5546676516532898},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.5054006576538086},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5048671364784241},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5040873289108276},{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.499619722366333},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.4959462583065033},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4914137125015259},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.48562827706336975},{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.4414719343185425},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41880857944488525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37531712651252747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3658548593521118},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3173428177833557},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.24589845538139343},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.15395453572273254}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.2588","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.2588","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.2588","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3193583429","https://openalex.org/W2122536851","https://openalex.org/W1970734801","https://openalex.org/W2083264940","https://openalex.org/W2361302679","https://openalex.org/W4249208820","https://openalex.org/W2376842615","https://openalex.org/W2030003565","https://openalex.org/W4387254835","https://openalex.org/W2405873495"],"abstract_inverted_index":{"2588":[0],"Background:":[1],"Immunotherapies,":[2],"including":[3],"immune":[4,150,318],"checkpoint":[5],"inhibitors":[6],"(ICI),":[7],"have":[8,46,64,81,111],"revolutionized":[9],"the":[10,27,58,146,180,191,217,249,262,269,275,307,313,335,339],"treatment":[11],"of":[12,37,201,226,243,254,272,297,315],"many":[13,23,53],"cancers,":[14],"producing":[15],"significant":[16],"improvements":[17],"in":[18,20,33,73,82,137,166,238],"survival":[19,71],"patients":[21,106,337],"with":[22,67,179,210,229],"different":[24],"cancers.":[25],"However,":[26],"intended":[28],"anti-tumor":[29],"effects":[30],"also":[31],"result":[32],"a":[34,49,93,116,316],"unique":[35],"form":[36],"autoimmunity,":[38],"known":[39],"as":[40,48],"immune-related":[41],"adverse":[42],"events":[43],"(irAEs),":[44],"which":[45,105],"emerged":[47],"limiting":[50],"factor":[51],"for":[52,95,301,323,353],"immunotherapies.":[54],"Cutaneous":[55],"irAEs":[56,109,196,222],"(cirAEs),":[57],"most":[59],"frequently":[60],"occurring":[61],"ICI\u2013related":[62],"toxicities,":[63],"been":[65],"associated":[66,228],"improved":[68,112],"efficacy":[69,300,326,345],"and":[70,80,89,99,141,163,170,182,197,204,223,233,299,327,346,348],"but,":[72],"their":[74],"severe":[75],"forms,":[76],"require":[77],"systemic":[78],"steroids":[79],"cases":[83],"led":[84],"to":[85,168,248,310],"premature":[86],"ICI":[87,169,325,344],"discontinuation":[88],"fatality.":[90],"There":[91],"is":[92,306],"need":[94],"both":[96,138],"robust":[97],"biomarkers":[98],"adequate":[100],"models":[101],"that":[102,120,144,188,214,261],"effectively":[103],"predict":[104,268],"who":[107],"develop":[108],"may":[110,290,349],"outcomes.":[113],"Methods:":[114],"Using":[115,155],"microfluidic":[117],"droplet":[118],"technology":[119,289],"generates":[121],"\"mini\"":[122],"patient-derived":[123,317],"organoids":[124],"called":[125],"MicroOrganoSpheres":[126],"(MOS),":[127],"we":[128,158],"successfully":[129],"generated":[130,240,251],"skin":[131,134,140,143,149,160,181,195,205,221,242,253,263,320,332],"MOS":[132,184,189,206,215,239,250,264,276,333],"from":[133,241,252,334],"biopsy":[135,285],"samples":[136],"healthy":[139],"tumor-involved":[142],"sustain":[145],"original":[147],"patient":[148,202,211,246],"microenvironment":[151],"over":[152],"three":[153],"weeks.":[154],"this":[156,287],"model,":[157],"assessed":[159],"cell":[161],"toxicity":[162,271,328,347],"cytokine":[164],"release":[165],"response":[167],"targeted":[171],"therapies.":[172],"Results:":[173],"Clinical":[174],"responses":[175],"were":[176,236],"largely":[177],"consistent":[178],"tumor":[183,331],"assay":[185,277],"readouts,":[186],"indicating":[187,213],"recapitulates":[190,216],"potential":[192,218],"association":[193,219,342],"between":[194,220,343],"efficacy.":[198,224],"Matched":[199,330],"pairs":[200],"melanoma":[203],"showed":[207],"good":[208],"concordance":[209],"outcome":[212],"Enrichment":[225],"genes":[227],"atopic":[230],"dermatitis,":[231],"vitiligo,":[232],"psoriatic":[234],"dermatitis":[235],"observed":[237,341],"an":[244,255],"ICI-sensitive":[245],"compared":[247],"ICI-resistant":[256],"patient.":[257],"These":[258],"results":[259],"indicated":[260],"platform":[265],"can":[266,278],"potentially":[267],"dermatological":[270],"ICI.":[273],"As":[274],"be":[279],"completed":[280],"within":[281],"12":[282],"days":[283],"after":[284],"acquisition,":[286],"novel":[288],"enable":[291],"personalized":[292],"medicine":[293],"approaches":[294],"by":[295],"prediction":[296],"cirAEs":[298],"individual":[302],"patients.":[303],"Conclusions:":[304],"This":[305],"first":[308],"study":[309],"date":[311],"demonstrating":[312],"application":[314],"competent":[319],"model":[321],"deployable":[322],"assessing":[324],"response.":[329],"same":[336],"recapitulated":[338],"clinically":[340],"provide":[350],"key":[351],"indicators":[352],"prospective":[354],"irAE-predicting":[355],"clinical":[356],"trials.":[357]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2025-10-10T00:00:00"}
