{"id":"https://openalex.org/W4379280977","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e18843","title":"Real-world effectiveness of prophylactic tixagevimab-cilgavimab monoclonal antibodies on incidence and severity of COVID-19 infection in patients with cancer.","display_name":"Real-world effectiveness of prophylactic tixagevimab-cilgavimab monoclonal antibodies on incidence and severity of COVID-19 infection in patients with cancer.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379280977","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e18843"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.e18843","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e18843","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18843","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Maryam Naser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Naser","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024182964","display_name":"Prarthna V Bhardwaj","orcid":"https://orcid.org/0000-0001-5444-1010","observed_orcids":["https://orcid.org/0000-0001-5444-1010"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prarthna V Bhardwaj","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092083211","display_name":"Fatima Zahid Warriach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatima Zahid Warriach","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050506089","display_name":"Yamna Jadoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yamna Jadoon","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020576799","display_name":"Kush Gupta","orcid":"https://orcid.org/0000-0002-5962-5879","observed_orcids":["https://orcid.org/0000-0002-5962-5879"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kush Gupta","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071013217","display_name":"Vida Rastegar","orcid":"https://orcid.org/0000-0002-9042-010X","observed_orcids":["https://orcid.org/0000-0002-9042-010X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vida Rastegar","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055259135","display_name":"Chandravathi Loke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandravathi Loke","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034818374","display_name":"Sudeep K Siddappa Malleshappa","orcid":"https://orcid.org/0000-0002-2850-5794","observed_orcids":["https://orcid.org/0000-0002-2850-5794"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudeep Kumar Siddappa Malleshappa","raw_affiliation_strings":["University of Massachusetts Chan Medical School - Baystate, Springfield, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Chan Medical School - Baystate, Springfield, MA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"e18843","last_page":"e18843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11296","display_name":"COVID-19 and healthcare impacts","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0632999986410141,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tixagevimab-cilgavimab","display_name":"tixagevimab/cilgavimab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/evusheld","display_name":"Evusheld","score":0.9670000076293945},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.8050000071525574},{"id":"https://openalex.org/keywords/pre-exposure-prophylaxis","display_name":"pre-exposure prophylaxis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.828000009059906},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.652999997138977},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.9070000052452087},{"id":"https://openalex.org/keywords/covid-19-incidence","display_name":"COVID-19 incidence","score":0.8539999723434448},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8429999947547913},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.6129999756813049},{"id":"https://openalex.org/keywords/anti-cd20-therapy","display_name":"anti-CD20 therapy","score":0.7429999709129333},{"id":"https://openalex.org/keywords/nirmatrelvir-ritonavir","display_name":"nirmatrelvir/ritonavir","score":0.7179999947547913},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9446794986724854},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6886951923370361},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6006056666374207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5853967666625977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5717516541481018},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.49654823541641235},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4646669626235962},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.45779117941856384},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.43917742371559143},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2272840440273285},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17768654227256775},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.e18843","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.e18843","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18843","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405578193","https://openalex.org/W4389766336","https://openalex.org/W4389532414","https://openalex.org/W4416625161","https://openalex.org/W4313523254","https://openalex.org/W4406923690","https://openalex.org/W4395958639","https://openalex.org/W4367174776","https://openalex.org/W4390613593","https://openalex.org/W4386832081"],"abstract_inverted_index":{"e18843":[0],"Background:":[1],"Mortality":[2],"rate":[3,139],"secondary":[4],"to":[5,13,143,197,345,355],"COVID-19":[6,66,98,144,293,331],"in":[7,67,80,83,109,154,337,361],"patients":[8,68,113,152,189,212,260,275,290,306,362],"with":[9,19,36,69,114,125,160,193,221,239,276,282,297,318,363],"cancer":[10,115],"is":[11],"estimated":[12],"be":[14,343,356],">":[15],"10%":[16],"after":[17,72,287],"vaccination,":[18],"an":[20,194,215],"increased":[21],"risk":[22],"of":[23,50,63,90,97,134,140,164,199,205,214,218,224,254,257,272,311,330,348],"infection":[24],"and":[25,95,122,145,177,226,279,324,359],"hospitalization":[26,141],"The":[27],"FDA":[28],"granted":[29],"emergency":[30],"use":[31],"approval":[32],"for":[33,309],"pre-exposure":[34],"prophylaxis":[35],"tixagevimab-cilgavimab":[37],"(Evusheld)based":[38],"on":[39,65,92,112],"preliminary":[40],"results":[41],"from":[42,202],"the":[43,48,51,61,75,81,88,93,150,180,185,240,252,258,298,328,338,346],"PROVENT":[44,339],"trial":[45],"conducted":[46,104],"before":[47],"emergence":[49],"Omicron":[52,73],"variant.":[53],"However,":[54],"there":[55],"are":[56],"limited":[57],"real-world":[58],"studies":[59],"investigating":[60],"impact":[62,89],"Evusheld":[64,91,118,333,349],"cancer,":[70],"especially":[71],"became":[74],"most":[76,241],"common":[77,242,358],"circulating":[78],"variant":[79],"US":[82],"Nov":[84],"2021.":[85],"We":[86,103],"assessed":[87],"incidence":[94,133,329],"severity":[96],"at":[99,251],"our":[100,110],"institution.":[101],"Methods:":[102],"a":[105,126,161,169,222,228],"retrospective":[106],"descriptive":[107],"study":[108,186],"institution":[111],"who":[116,291],"received":[117,179,261,266,285],"between":[119],"Dec":[120],"2021":[121],"Mar":[123],"2022":[124],"6":[127],"month":[128],"follow-up.":[129],"Primary":[130],"outcome":[131],"was":[132,334],"COVID-19.":[135,233],"Secondary":[136],"outcomes":[137],"included":[138,153],"related":[142],"associated":[146],"mortality.":[147],"Results:":[148],"Of":[149],"228":[151],"this":[155],"study,":[156],"90%":[157],"were":[158,173,209,213,247,294,307],"White":[159],"median":[162],"age":[163,217],"67":[165],"years,":[166],"67%":[167],"had":[168,231,235,292,314],"hematologic":[170,236,364],"malignancy,":[171],"98%":[172],"vaccinated":[174],"against":[175,350],"COVID-19,":[176,192,310],"72.8%":[178],"recommended":[181],"300mg":[182],"dosing":[183],"during":[184],"period.":[187],"Thirty-one":[188],"(13.6%)":[190],"developed":[191],"average":[195,216],"time":[196,253],"diagnosis":[198],"43":[200],"days":[201],"receiving":[203,248,300],"Evusheld,":[204],"whom":[206,312],"26":[207],"(83%)":[208],"symptomatic.":[210],"Infected":[211],"60":[219],"years":[220],"BMI":[223],"26,":[225],"only":[227,267],"minority":[229],"(3.2%)":[230],"prior":[232],"Most":[234,246,265],"malignancies":[237],"(77.4%),":[238],"being":[243],"non-Hodgkin":[244],"lymphoma.":[245],"chemotherapy":[249],"(68%)":[250],"diagnosis.":[255,288],"Third":[256],"affected":[259],"ani-CD20":[262],"treatment":[263],"(32%).":[264],"150":[268],"mg":[269],"dose":[270],"(80.6%)":[271],"Evusheld.":[273],"8(33%)":[274],"hematological":[277,315,319],"malignancy":[278,284,320],"3":[280,301],"(42%)":[281],"solid":[283],"Paxlovid":[286],"All":[289],"previously":[295],"vaccinated,":[296],"majority":[299],"doses":[302],"(64.5%).":[303],"Five":[304],"(16%)":[305],"hospitalized":[308],"4":[313],"malignancy;":[316],"one":[317],"required":[321],"mechanical":[322],"ventilation":[323],"died.":[325],"Conclusions:":[326],"Overall,":[327],"following":[332],"higher":[335],"than":[336],"trial.":[340],"This":[341],"could":[342],"attributed":[344],"ineffectiveness":[347],"new":[351],"variants.":[352],"Infections":[353],"appeared":[354],"more":[357],"severe":[360],"malignancies.":[365],"[Table:":[366],"see":[367],"text]":[368]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-06-05T00:00:00"}