{"id":"https://openalex.org/W4379280959","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.8553","title":"Genomic comparison of MET exon 14 skipping and MET amplified non-small cell lung cancer.","display_name":"Genomic comparison of MET exon 14 skipping and MET amplified non-small cell lung cancer.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379280959","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.8553"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.8553","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.8553","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.8553","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063529211","display_name":"Rachel L. Minne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Minne","raw_affiliation_strings":["Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051735034","display_name":"Natalie Y. Luo","orcid":"https://orcid.org/0009-0003-3766-7052","observed_orcids":["https://orcid.org/0009-0003-3766-7052"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie Luo","raw_affiliation_strings":["University of Wisconsin\u2013Madison, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin\u2013Madison, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002970130","display_name":"Anne M. Traynor","orcid":"https://orcid.org/0000-0001-5790-3815","observed_orcids":["https://orcid.org/0000-0001-5790-3815"]},"institutions":[{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M. Traynor","raw_affiliation_strings":["University of Wisconsin-Madison Carbone Cancer Center, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin-Madison Carbone Cancer Center, Madison, WI","institution_ids":["https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082787985","display_name":"Minxuan Huang","orcid":"https://orcid.org/0000-0001-5551-586X","observed_orcids":["https://orcid.org/0000-0001-5551-586X"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minxuan Huang","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011740457","display_name":"Luisina De Tullio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luisina De Tullio","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113698084","display_name":"Jen Godden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen Godden","raw_affiliation_strings":["Tempus Labs, Inc., Franklin, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Franklin, WI","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044955842","display_name":"Melissa C. Stoppler","orcid":"https://orcid.org/0009-0005-6260-5798","observed_orcids":["https://orcid.org/0009-0005-6260-5798"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Conrad Stoppler","raw_affiliation_strings":["Tempus Labs, Inc., Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc., Chicago, IL","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073175528","display_name":"Randall J. Kimple","orcid":"https://orcid.org/0000-0001-8336-8000","observed_orcids":["https://orcid.org/0000-0001-8336-8000"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall J. Kimple","raw_affiliation_strings":["University of Wisconsin, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin, Madison, WI","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":null,"display_name":"Andrew Baschnagel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Baschnagel","raw_affiliation_strings":["Department of Human Oncology, Madison, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, Madison, WI","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"8553","last_page":"8553"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/met-exon-14-skipping","display_name":"MET exon 14 skipping","score":0.9549999833106995},{"id":"https://openalex.org/keywords/met-amplification","display_name":"MET amplification","score":0.8939999938011169},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/copy-number-gain","display_name":"copy number gain","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-genomic-landscape","display_name":"tumor genomic landscape","score":0.6060000061988831},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.699999988079071},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.7879999876022339},{"id":"https://openalex.org/keywords/immune-cell-composition","display_name":"immune cell composition","score":0.6480000019073486},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.5540000200271606},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cftr","display_name":"CFTR","score":0.460999995470047},{"id":"https://openalex.org/keywords/wnt2","display_name":"Wnt2","score":0.6000000238418579},{"id":"https://openalex.org/keywords/keap1","display_name":"Keap1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/stk11","display_name":"STK11","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-resistance","display_name":"tyrosine kinase inhibitor resistance","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6705915927886963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6493011116981506},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6004972457885742},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5819477438926697},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5405892133712769},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5283157229423523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5077310800552368},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49813342094421387},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.49443817138671875},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.46034055948257446},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4324158728122711},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42653200030326843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40801945328712463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33004066348075867},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.2905682325363159},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.283393919467926},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2472291886806488}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.8553","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.8553","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.8553","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4396812207","https://openalex.org/W4393089581","https://openalex.org/W4379281357","https://openalex.org/W4414535867","https://openalex.org/W2901062444","https://openalex.org/W4289335944","https://openalex.org/W4296642233","https://openalex.org/W2769395880","https://openalex.org/W2230948985","https://openalex.org/W2466657922"],"abstract_inverted_index":{"8553":[0],"Background:":[1],"In":[2,297],"non-small":[3],"cell":[4],"lung":[5],"cancer":[6],"(NSCLC),":[7],"the":[8,68,155,196,232,240,313],"MET":[9,24,44,50,75,118,130,141,222],"tyrosine":[10,85],"kinase":[11,86],"receptor":[12,34],"can":[13,55,81],"be":[14,56,82,190],"dysregulated":[15],"by":[16],"mutations":[17,131],"and/or":[18],"gene":[19,149,224],"amplification.":[20],"The":[21,145],"most":[22],"common":[23],"mutation":[25],"is":[26],"in":[27,213,228,309,322,329],"exon":[28],"14":[29],"(METex14),":[30],"leading":[31],"to":[32,48,61,66,189,217,247,317],"impaired":[33],"degradation":[35],"and":[36,52,54,73,128,140,173,192,202,219,239,278,283,291,312,332],"increased":[37,251],"MET-mediated":[38],"signaling":[39,51],"causing":[40],"sustained":[41],"tumor":[42,198,205],"proliferation.":[43],"amplification":[45,119],"also":[46],"leads":[47],"continued":[49],"oncogenesis":[53],"a":[57],"mechanism":[58],"of":[59,71,79,102,147,163,235,243,253,286,302],"resistance":[60],"targeted":[62,83],"therapy.":[63],"We":[64,89],"sought":[65],"compare":[67],"genomic":[69],"landscape":[70,315],"METex14":[72,115,184,194,214,305],"high-level":[74],"amplified":[76],"tumors,":[77],"both":[78],"which":[80],"with":[84,97,154,183],"inhibitors.":[87],"Methods:":[88],"analyzed":[90],"18,047":[91],"NSCLC":[92,319,331],"tumors":[93,177,215,306],"(any":[94],"stage/subtype)":[95],"sequenced":[96],"Tempus":[98],"xT":[99],"assay":[100],"(DNA-seq":[101],"648":[103],"genes":[104],"at":[105],"500x":[106],"coverage,":[107],"full":[108],"transcriptome":[109],"RNA-seq).":[110],"Tumors":[111],"were":[112,136,178,185,211],"queried":[113],"for":[114],"mutations,":[116],"high":[117],"(METamp),":[120],"defined":[121],"as":[122],"copy":[123],"number":[124],"gain":[125],"(CNG)":[126],"\u226510,":[127],"other":[129],"(METother).":[132],"Immuno-oncology":[133],"(IO)":[134],"biomarkers":[135,311],"compared":[137,152,216,316],"across":[138],"MET-altered":[139,303,330],"wild-type":[142],"(METwt)":[143],"groups.":[144],"prevalence":[146,252,285],"somatic":[148,314],"alterations":[150],"was":[151,226],"similarly":[153],"false-discovery":[156],"rate":[157],"(FDR)":[158],"adjustment.":[159],"Results:":[160],"A":[161],"total":[162],"276":[164],"(1.53%)":[165],"METex14,":[166,248],"138":[167],"(0.76%)":[168],"METamp,":[169],"27":[170],"(0.15%)":[171],"METother,":[172],"17,606":[174],"(97.56%)":[175],"METwt":[176,220],"identified.":[179],"Across":[180],"groups,":[181],"patients":[182],"older,":[186],"more":[187],"likely":[188],"female,":[191],"nonsmokers.":[193],"exhibited":[195,231,250,307],"lowest":[197,203,233],"mutational":[199],"burden":[200,206],"(TMB)":[201],"neoantigen":[204],"(NTB).":[207],"PD-L1":[208],"positivity":[209],"rates":[210],"higher":[212],"METamp":[218,230,249],"tumors.":[221,320],"log10":[223],"expression":[225],"highest":[227,241],"METamp.":[229],"proportion":[234,242],"CD4":[236],"T":[237],"cells":[238],"NK":[244],"cells.":[245],"Compared":[246],"TP53":[254],"(83%":[255],"vs":[256,260,264,272,276,281],"37%),":[257],"TFEC":[258],"(46%":[259],"1.1%),":[261],"CFTR":[262],"(37%":[263],"1.4%),":[265,282],"EGFR":[266],"(31%":[267],"vs.":[268,289,294],"7.6%),":[269],"WNT2":[270],"(11%":[271],"0.4%),":[273],"KEAP1":[274],"(14%":[275],"0.7%),":[277],"STK11":[279],"(8%":[280],"decreased":[284],"MDM2":[287],"(4.3%":[288],"14%),":[290],"FRS2":[292],"(2.9%":[293],"12%).":[295],"Conclusions:":[296],"this":[298],"large":[299],"population-based":[300],"analysis":[301],"NSCLC,":[304],"differences":[308],"IO":[310],"non-METex14":[318],"Variations":[321],"immune":[323],"profiles":[324],"may":[325],"affect":[326],"immunotherapy":[327],"selection":[328],"require":[333],"further":[334],"exploration.":[335],"[Table:":[336],"see":[337],"text]":[338]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2023-06-05T00:00:00"}
