{"id":"https://openalex.org/W4379280565","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.12040","title":"Associations of frailty with overall survival (OS) and functional decline among older adults with non\u2013small-cell lung cancer (NSCLC) receiving chemotherapy, immunotherapy, and/or targeted therapy.","display_name":"Associations of frailty with overall survival (OS) and functional decline among older adults with non\u2013small-cell lung cancer (NSCLC) receiving chemotherapy, immunotherapy, and/or targeted therapy.","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4379280565","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.12040"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.12040","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.12040","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.12040","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.16_suppl.12040","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.16_suppl.12040","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104807003","display_name":"Howard Jinsoo Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Jinsoo Lee","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025363657","display_name":"Louise Christie Walter","orcid":"https://orcid.org/0000-0002-9642-6238","observed_orcids":["https://orcid.org/0000-0002-9642-6238"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise Christie Walter","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060040205","display_name":"Alexander Kingsbury Smith","orcid":"https://orcid.org/0000-0002-9276-0861","observed_orcids":["https://orcid.org/0000-0002-9276-0861"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander K. Smith","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056587253","display_name":"Ying Shi","orcid":"https://orcid.org/0000-0002-5680-7255","observed_orcids":["https://orcid.org/0000-0002-5680-7255"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Shi","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015624122","display_name":"W. John Boscardin","orcid":"https://orcid.org/0000-0003-3121-9526","observed_orcids":["https://orcid.org/0000-0003-3121-9526"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. John Boscardin","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112361229","display_name":"Harvey Jay Cohen","orcid":"https://orcid.org/0009-0008-3602-2750","observed_orcids":["https://orcid.org/0009-0008-3602-2750"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey Jay Cohen","raw_affiliation_strings":["Duke University School of Medicine, Durham, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University School of Medicine, Durham, NC","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024199124","display_name":"Grant Richard Williams","orcid":"https://orcid.org/0000-0003-4294-5232","observed_orcids":["https://orcid.org/0000-0003-4294-5232"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant Richard Williams","raw_affiliation_strings":["University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060181822","display_name":"Sandra Zeng","orcid":"https://orcid.org/0000-0001-8609-6338","observed_orcids":["https://orcid.org/0000-0001-8609-6338"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Zeng","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006468163","display_name":"Carolyn Jean Presley","orcid":"https://orcid.org/0000-0002-2607-5639","observed_orcids":["https://orcid.org/0000-0002-2607-5639"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carolyn J Presley","raw_affiliation_strings":["Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH","institution_ids":["https://openalex.org/I2802841970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073150706","display_name":"Allison M. Magnuson","orcid":"https://orcid.org/0000-0002-0968-8265","observed_orcids":["https://orcid.org/0000-0002-0968-8265"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison Magnuson","raw_affiliation_strings":["University of Rochester Medical Center, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038508194","display_name":"Supriya Gupta Mohile","orcid":"https://orcid.org/0000-0003-0867-327X","observed_orcids":["https://orcid.org/0000-0003-0867-327X"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Supriya Gupta Mohile","raw_affiliation_strings":["University of Rochester Medical Center, Rochester, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester Medical Center, Rochester, NY","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008898393","display_name":"Surbhi Singhal","orcid":"https://orcid.org/0000-0003-4307-319X","observed_orcids":["https://orcid.org/0000-0003-4307-319X"]},"institutions":[{"id":"https://openalex.org/I4210105015","display_name":"Stanford Health Care","ror":"https://ror.org/019wqcg20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210105015","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surbhi Singhal","raw_affiliation_strings":["Stanford Hospital & Clinics, Stanford, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Hospital & Clinics, Stanford, CA","institution_ids":["https://openalex.org/I4210105015","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057143164","display_name":"Carling Jade Ursem","orcid":"https://orcid.org/0000-0003-4845-0564","observed_orcids":["https://orcid.org/0000-0003-4845-0564"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carling Jade Ursem","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048303931","display_name":"Ana I. Velazquez Ma\u00f1ana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana I. Velazquez Manana","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055548058","display_name":"Matthew A. Gubens","orcid":"https://orcid.org/0000-0002-6482-1954","observed_orcids":["https://orcid.org/0000-0002-6482-1954"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew A. Gubens","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010032300","display_name":"Collin Michael Blakely","orcid":"https://orcid.org/0000-0001-8134-3651","observed_orcids":["https://orcid.org/0000-0001-8134-3651"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Collin M. Blakely","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027172182","display_name":"Claire K. Mulvey","orcid":"https://orcid.org/0000-0002-7880-8507","observed_orcids":["https://orcid.org/0000-0002-7880-8507"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Mulvey","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009173792","display_name":"Greg M. Allen","orcid":"https://orcid.org/0000-0002-0032-8140","observed_orcids":["https://orcid.org/0000-0002-0032-8140"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg M. Allen","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008566454","display_name":"Jonathan M. L. Ostrem","orcid":"https://orcid.org/0000-0001-9085-1615","observed_orcids":["https://orcid.org/0000-0001-9085-1615"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Ostrem","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070958912","display_name":"Melisa L. Wong","orcid":"https://orcid.org/0000-0001-6390-6959","observed_orcids":["https://orcid.org/0000-0001-6390-6959"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melisa L. Wong","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"16_suppl","first_page":"12040","last_page":"12040"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9890000224113464},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9750000238418579},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8519999980926514},{"id":"https://openalex.org/keywords/functional-decline","display_name":"functional decline","score":0.9750000238418579},{"id":"https://openalex.org/keywords/frailty-index","display_name":"frailty index","score":0.7269999980926514},{"id":"https://openalex.org/keywords/geriatric-assessment","display_name":"geriatric assessment","score":0.843999981880188},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.7269999980926514},{"id":"https://openalex.org/keywords/instrumental-activities-of-daily-living","display_name":"instrumental activities of daily living","score":0.878000020980835},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/geriatric-oncology","display_name":"geriatric oncology","score":0.6790000200271606},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.3479999899864197},{"id":"https://openalex.org/keywords/socioeconomic-inequality","display_name":"socioeconomic disparities","score":0.4560000002384186},{"id":"https://openalex.org/keywords/health-insurance","display_name":"health insurance","score":0.34700000286102295},{"id":"https://openalex.org/keywords/prior-surgery","display_name":"prior surgery","score":0.492000013589859},{"id":"https://openalex.org/keywords/chemoimmunotherapy","display_name":"chemoimmunotherapy","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9441919326782227},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5943270921707153},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5780988335609436},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5645338892936707},{"id":"https://openalex.org/C2777319248","wikidata":"https://www.wikidata.org/wiki/Q5550843","display_name":"Geriatric oncology","level":3,"score":0.5469413995742798},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4540662169456482},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43366432189941406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4298717677593231},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.428838312625885},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.42563414573669434},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42005887627601624},{"id":"https://openalex.org/C2776534028","wikidata":"https://www.wikidata.org/wiki/Q1141363","display_name":"Medicaid","level":3,"score":0.4189004898071289},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.06941491365432739},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2023.41.16_suppl.12040","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.12040","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.12040","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.16_suppl.12040","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2023.41.16_suppl.12040","doi":"https://doi.org/10.1200/jco.2023.41.16_suppl.12040","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1200/jco.2023.41.16_suppl.12040","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2023.41.16_suppl.12040","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379280565.pdf","grobid_xml":"https://content.openalex.org/works/W4379280565.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405220104","https://openalex.org/W4281733650","https://openalex.org/W4400240749","https://openalex.org/W2569848933","https://openalex.org/W2758221850","https://openalex.org/W2890883049","https://openalex.org/W2813082543","https://openalex.org/W4318206256","https://openalex.org/W2767947163","https://openalex.org/W4220889936"],"abstract_inverted_index":{"12040":[0],"Background:":[1],"Among":[2,192],"older":[3,39,357,382],"adults":[4,40,53,358,383],"with":[5,41,56,65,184,229,246,359,384],"cancer":[6],"receiving":[7,43,362],"chemotherapy,":[8,60],"frailty":[9,37,86,105,110,162,183,242],"indices":[10],"can":[11],"predict":[12],"poor":[13,391],"outcomes":[14,132,186,392],"including":[15,88],"survival":[16,156],"and":[17,25,73,78,93,142,164,212,223,236,266,285,316,368,400],"toxicity.":[18],"Given":[19],"the":[20,33,180,202],"increasing":[21],"use":[22],"of":[23,36,148,182,217,376,390],"immunotherapy":[24],"targeted":[26,63,206],"therapy":[27,64,364,378],"to":[28,107,158,178,300,326,393],"treat":[29],"NSCLC,":[30],"we":[31],"assessed":[32],"prognostic":[34,353],"importance":[35],"among":[38,356],"NSCLC":[42,58,239,361,386],"systemic":[44,363,377],"therapy.":[45],"Methods:":[46],"This":[47],"multi-site":[48],"prospective":[49],"cohort":[50],"study":[51],"enrolled":[52],"age":[54,196,247],"\u226565":[55],"advanced":[57,360,385],"starting":[59],"immunotherapy,":[61,209],"and/or":[62],"non-curative":[66],"intent.":[67],"Patients":[68],"completed":[69],"geriatric":[70,91],"assessments":[71],"pretreatment":[72,89],"at":[74,387],"1,":[75],"2,":[76],"4,":[77],"6":[79],"months.":[80],"We":[81,113,152,173],"constructed":[82],"a":[83,154,307],"47-item":[84],"deficit-accumulation":[85],"index":[87],"demographic,":[90],"assessment,":[92],"clinical":[94],"factors":[95],"using":[96],"established":[97],"methodology.":[98],"Frailty":[99,226,351,372],"scores":[100],"ranged":[101],"from":[102],"0":[103],"(no":[104],"deficits)":[106],"1":[108],"(all":[109],"deficits":[111],"present).":[112],"categorized":[114],"patients":[115,218,295,322],"as":[116],"robust":[117,260,301,339],"(":[118],"<":[119],"0.2),":[120],"pre-frail":[121,276],"(0.2-0.34),":[122],"or":[123,248,348],"frail":[124,270,286],"(\u22650.35).":[125],"The":[126],"primary":[127],"outcome":[128],"was":[129,197,227,243,253],"OS.":[130],"Secondary":[131],"included":[133],"treatment-related":[134],"grade":[135,308],"\u22653":[136,309],"adverse":[137],"events":[138],"(AE),":[139],"unplanned":[140,314],"hospitalization,":[141,315],"functional":[143],"decline":[144,329],"in":[145,346],"instrumental":[146],"activities":[147],"daily":[149],"living":[150],"(IADL).":[151],"conducted":[153],"Kaplan-Meier":[155],"analysis":[157],"estimate":[159],"OS":[160,252,298,355],"by":[161],"group":[163],"Cox":[165],"proportional":[166],"hazards":[167],"models":[168,177],"adjusting":[169,187],"for":[170,188,259,264,269,273,354],"treatment":[171,189,249,274,366],"type.":[172,190,250],"used":[174],"logistic":[175],"regression":[176],"evaluate":[179],"association":[181],"secondary":[185],"Results:":[191],"149":[193],"patients,":[194,261,340],"median":[195],"73":[198],"(range":[199],"65-94).":[200],"During":[201,303],"study,":[203],"32%":[204],"received":[205],"therapy,":[207],"29%":[208,305],"27%":[210],"chemoimmunotherapy,":[211],"12%":[213],"chemotherapy.":[214],"Overall":[215],"43%":[216],"were":[219,323,343],"robust,":[220],"38%":[221],"pre-frail,":[222,265],"19%":[224],"frail.":[225],"associated":[228,245],"Asian":[230],"race,":[231],"lower":[232],"education,":[233],"Medicaid":[234],"insurance,":[235],"no":[237,344],"prior":[238],"surgery.":[240],"Notably,":[241],"not":[244,257],"Median":[251],"18.7":[254],"months":[255,263,268],"overall:":[256],"reached":[258],"8.9":[262],"5.6":[267],"patients.":[271,302],"Adjusting":[272],"type,":[275],"(HR":[277,287,330],"2.11,":[278],"95%":[279,289,332],"CI":[280,290,333],"1.24-3.60;":[281],"p":[282,292,335],"=":[283,293,336],"0.006)":[284],"2.86,":[288],"1.52-5.39;":[291],"0.001)":[294],"had":[296,312],"worse":[297],"compared":[299],"treatment,":[304],"developed":[306,318],"AE,":[310],"31%":[311],"an":[313],"41%":[317],"IADL":[319,328,370],"decline.":[320,371],"Pre-frail/frail":[321],"more":[324],"likely":[325],"develop":[327],"2.18,":[331],"1.02-4.68;":[334],"0.04)":[337],"than":[338],"but":[341],"there":[342],"differences":[345],"toxicity":[347],"hospitalization.":[349],"Conclusions:":[350],"is":[352],"across":[365],"types":[367],"predicted":[369],"assessment":[373],"before":[374],"initiation":[375],"may":[379],"help":[380],"identify":[381],"higher":[388],"risk":[389],"inform":[394],"decision":[395],"making,":[396],"individualize":[397],"anticipatory":[398],"guidance,":[399],"optimize":[401],"supportive":[402],"care.":[403]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-06-05T00:00:00"}