{"id":"https://openalex.org/W4379260705","doi":"https://doi.org/10.1016/j.jlr.2023.100399","title":"Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs","display_name":"Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs","publication_year":2023,"publication_date":"2023-06-03","ids":{"openalex":"https://openalex.org/W4379260705","doi":"https://doi.org/10.1016/j.jlr.2023.100399","pmid":"https://pubmed.ncbi.nlm.nih.gov/37276940","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10394386"},"language":"en","primary_location":{"id":"doi:10.1016/j.jlr.2023.100399","doi":"https://doi.org/10.1016/j.jlr.2023.100399","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2023.100399","pdf_url":"http://www.jlr.org/article/S002222752300072X/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jlr.org/article/S002222752300072X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086947603","display_name":"Timo Schmitz","orcid":"https://orcid.org/0000-0002-3619-0438","observed_orcids":["https://orcid.org/0000-0002-3619-0438"]},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Timo Schmitz","raw_affiliation_strings":["Medical Faculty, University of Augsburg, Augsburg, Germany. Electronic address: timo.schmitz@med.uni-augsburg.de","Medical Faculty, University of Augsburg, Augsburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3619-0438","affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Augsburg, Augsburg, Germany. Electronic address: timo.schmitz@med.uni-augsburg.de","institution_ids":["https://openalex.org/I179225836"]},{"raw_affiliation_string":"Medical Faculty, University of Augsburg, Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057401555","display_name":"Dennis Freuer","orcid":"https://orcid.org/0000-0001-7188-9087","observed_orcids":["https://orcid.org/0000-0001-7188-9087"]},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dennis Freuer","raw_affiliation_strings":["Medical Faculty, University of Augsburg, Augsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Augsburg, Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019884390","display_name":"Jakob Linseisen","orcid":"https://orcid.org/0000-0002-9386-382X","observed_orcids":["https://orcid.org/0000-0002-9386-382X"]},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jakob Linseisen","raw_affiliation_strings":["Medical Faculty, University of Augsburg, Augsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Augsburg, Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052223589","display_name":"Christa Meisinger","orcid":"https://orcid.org/0000-0002-9026-6544","observed_orcids":["https://orcid.org/0000-0002-9026-6544"]},"institutions":[{"id":"https://openalex.org/I179225836","display_name":"University of Augsburg","ror":"https://ror.org/03p14d497","country_code":"DE","type":"education","lineage":["https://openalex.org/I179225836"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christa Meisinger","raw_affiliation_strings":["Medical Faculty, University of Augsburg, Augsburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Faculty, University of Augsburg, Augsburg, Germany","institution_ids":["https://openalex.org/I179225836"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086947603"],"corresponding_institution_ids":["https://openalex.org/I179225836"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":3034,"currency":"EUR","value_usd":3272},"fwci":2.4119,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89620019,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"64","issue":"7","first_page":"100399","last_page":"100399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.801800012588501,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.09690000116825104,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.049300000071525574,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.925000011920929},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.9890000224113464},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.8569999933242798},{"id":"https://openalex.org/keywords/igd","display_name":"IgD","score":0.4729999899864197},{"id":"https://openalex.org/keywords/naive-b-cells","display_name":"naive B cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cd25","display_name":"CD25","score":0.6370000243186951},{"id":"https://openalex.org/keywords/cd127","display_name":"CD127","score":0.8980000019073486},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.550000011920929},{"id":"https://openalex.org/keywords/mega-study","display_name":"MEGA study","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7019860744476318},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6522615551948547},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5571494102478027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5084332823753357},{"id":"https://openalex.org/C48010095","wikidata":"https://www.wikidata.org/wiki/Q79447","display_name":"Immunoglobulin D","level":4,"score":0.49990105628967285},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.4898543059825897},{"id":"https://openalex.org/C123982805","wikidata":"https://www.wikidata.org/wiki/Q6046964","display_name":"Interleukin-7 receptor","level":5,"score":0.45228880643844604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4383479654788971},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4236510694026947},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.41374292969703674},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40623337030410767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3838875889778137},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3810276985168457},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.23222187161445618}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jlr.2023.100399","doi":"https://doi.org/10.1016/j.jlr.2023.100399","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2023.100399","pdf_url":"http://www.jlr.org/article/S002222752300072X/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10394386","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10394386","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10394386/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:37276940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37276940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:uni-augsburg.opus-bayern.de:104796","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1047960","pdf_url":"https://opus.bibliothek.uni-augsburg.de/opus4/files/104796/1-s2.0-S002222752300072X-main.pdf","source":{"id":"https://openalex.org/S4306400930","display_name":"OPUS (Augsburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119916105","host_organization_name":"Augsburg University","host_organization_lineage":["https://openalex.org/I119916105"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:23318fef166e4c0bbdc3aa0a84e7bf79","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/23318fef166e4c0bbdc3aa0a84e7bf79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 64, Iss 7, Pp 100399- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jlr.2023.100399","doi":"https://doi.org/10.1016/j.jlr.2023.100399","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2023.100399","pdf_url":"http://www.jlr.org/article/S002222752300072X/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4379260705.pdf","grobid_xml":"https://content.openalex.org/works/W4379260705.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1560277370","https://openalex.org/W1567420244","https://openalex.org/W1971338943","https://openalex.org/W2020405150","https://openalex.org/W2037062908","https://openalex.org/W2045799105","https://openalex.org/W2046551442","https://openalex.org/W2049828276","https://openalex.org/W2076819781","https://openalex.org/W2089016354","https://openalex.org/W2121812620","https://openalex.org/W2151829671","https://openalex.org/W2156964052","https://openalex.org/W2162819001","https://openalex.org/W2253000841","https://openalex.org/W2749237115","https://openalex.org/W2784936327","https://openalex.org/W2801235164","https://openalex.org/W2944723988","https://openalex.org/W2945558492","https://openalex.org/W3039810691","https://openalex.org/W3042872342","https://openalex.org/W3048226838","https://openalex.org/W3085515718","https://openalex.org/W3159756909","https://openalex.org/W3201902111","https://openalex.org/W4313324526"],"related_works":["https://openalex.org/W2478658436","https://openalex.org/W7127408160","https://openalex.org/W1972722719","https://openalex.org/W3199768949","https://openalex.org/W3209536057","https://openalex.org/W2606927708","https://openalex.org/W2366846320","https://openalex.org/W4380795508","https://openalex.org/W3087638984","https://openalex.org/W4206824505"],"abstract_inverted_index":{"Blood":[0],"lipids":[1],"play":[2],"a":[3,79,234],"major":[4],"role":[5],"in":[6,63,208],"the":[7,60,107,114,147,165,185,209,241],"manifestation":[8],"of":[9,59,81,117,150,155,167,189,211,240,243],"cardiovascular":[10],"diseases.":[11],"Recent":[12],"research":[13],"suggested":[14],"that":[15,127],"there":[16,28],"are":[17],"connections":[18],"between":[19,32,67,109,220],"cholesterol":[20,34,111,130,141,179,202],"levels":[21,35,203],"and":[22,38,40,45,69,113,120,160,191,213,223,236],"immunological":[23],"alterations.":[24],"We":[25,125],"investigated":[26],"whether":[27],"is":[29],"an":[30,217],"association":[31,229],"serum":[33],"(total,":[36],"HDL,":[37],"LDL)":[39],"immune":[41,137,224],"cells":[42,48,94,169,195],"(B":[43],"cell":[44,138,186],"regulatory":[46],"T":[47,158,173],"[Tregs]).":[49],"The":[50],"analysis":[51],"was":[52],"based":[53],"on":[54,170],"data":[55],"from":[56],"231":[57],"participants":[58,72],"MEGA":[61],"study":[62],"Augsburg,":[64],"Germany,":[65],"recruited":[66],"2018":[68],"2021.":[70],"Most":[71],"were":[73,91,95,123,132,181,204],"examined":[74],"two":[75],"different":[76],"times":[77],"within":[78],"period":[80],"9":[82],"months.":[83],"At":[84],"every":[85],"visit,":[86],"fasting":[87],"venous":[88],"blood":[89,110],"samples":[90],"taken.":[92],"Immune":[93],"analyzed":[96],"immediately":[97],"afterward":[98],"using":[99],"flow":[100],"cytometry.":[101],"Using":[102],"multivariable-adjusted":[103],"linear":[104],"regression":[105],"models,":[106],"associations":[108,145],"concentrations":[112,131],"relative":[115,148],"quantity":[116],"several":[118],"B-cell":[119,212],"Treg":[121,214],"subsets":[122,215],"analyzed.":[124],"found":[126],"particularly":[128],"HDL":[129,140,178,201],"significantly":[133],"associated":[134,183,205],"to":[135],"some":[136],"subpopulations:":[139],"showed":[142],"significant":[143],"positive":[144],"with":[146,184,192,206],"frequency":[149],"CD25++":[151],"Tregs":[152,162],"(as":[153],"proportion":[154,166],"all":[156,171],"CD4+CD25++":[157],"cells)":[159],"conventional":[161],"(defined":[163],"as":[164],"CD25+CD127-":[168],"CD45RA-CD4+":[172],"cells).":[174,198],"Regarding":[175],"B":[176,194,197],"cells,":[177],"values":[180],"inversely":[182],"surface":[187],"expression":[188],"IgD":[190],"na\u00efve":[193],"(CD27-IgD+":[196],"In":[199],"conclusion,":[200],"modifications":[207],"composition":[210],"demonstrating":[216],"important":[218],"interconnection":[219],"lipid":[221],"metabolism":[222],"system.":[225],"Knowledge":[226],"about":[227],"this":[228],"might":[230],"be":[231],"crucial":[232],"for":[233],"deeper":[235],"more":[237],"comprehensive":[238],"understanding":[239],"pathophysiology":[242],"atherosclerosis.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-06-04T00:00:00"}
