{"id":"https://openalex.org/W4378909331","doi":"https://doi.org/10.3390/ph16060813","title":"Extra-Gonadal and Non-Canonical Effects of FSH in Males","display_name":"Extra-Gonadal and Non-Canonical Effects of FSH in Males","publication_year":2023,"publication_date":"2023-05-30","ids":{"openalex":"https://openalex.org/W4378909331","doi":"https://doi.org/10.3390/ph16060813","pmid":"https://pubmed.ncbi.nlm.nih.gov/37375761","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10300833"},"language":"en","primary_location":{"id":"doi:10.3390/ph16060813","doi":"https://doi.org/10.3390/ph16060813","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph16060813","pdf_url":"https://www.mdpi.com/1424-8247/16/6/813/pdf?version=1685446318","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/16/6/813/pdf?version=1685446318","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072096811","display_name":"Matteo Spaziani","orcid":"https://orcid.org/0000-0001-5645-5766","observed_orcids":["https://orcid.org/0000-0001-5645-5766"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Spaziani","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045588732","display_name":"Francesco Carlomagno","orcid":"https://orcid.org/0000-0001-5611-4101","observed_orcids":["https://orcid.org/0000-0001-5611-4101"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Carlomagno","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5611-4101","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089732936","display_name":"Marta Tenuta","orcid":"https://orcid.org/0000-0002-7476-0737","observed_orcids":["https://orcid.org/0000-0002-7476-0737"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marta Tenuta","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7476-0737","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082001651","display_name":"Franz Federico Sesti","orcid":"https://orcid.org/0000-0003-3850-627X","observed_orcids":["https://orcid.org/0000-0003-3850-627X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franz Sesti","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3850-627X","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043863764","display_name":"Francesco Angelini","orcid":"https://orcid.org/0000-0002-0052-6956","observed_orcids":["https://orcid.org/0000-0002-0052-6956"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Angelini","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020440606","display_name":"Ilaria Bonaventura","orcid":"https://orcid.org/0000-0002-9333-5189","observed_orcids":["https://orcid.org/0000-0002-9333-5189"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ilaria Bonaventura","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101423746","display_name":"Davide Ferrari","orcid":"https://orcid.org/0009-0004-3803-4350","observed_orcids":["https://orcid.org/0009-0004-3803-4350"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Davide Ferrari","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":"https://orcid.org/0009-0004-3803-4350","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025863268","display_name":"Chiara Tarantino","orcid":"https://orcid.org/0000-0001-8326-851X","observed_orcids":["https://orcid.org/0000-0001-8326-851X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Tarantino","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064944598","display_name":"Marco Fiore","orcid":"https://orcid.org/0000-0001-6806-9715","observed_orcids":["https://orcid.org/0000-0001-6806-9715"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Fiore","raw_affiliation_strings":["Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-6806-9715","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044667398","display_name":"Carla Petrella","orcid":"https://orcid.org/0000-0003-0651-1816","observed_orcids":["https://orcid.org/0000-0003-0651-1816"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Petrella","raw_affiliation_strings":["Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0651-1816","affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Cell Biology (IBBC-CNR), Department of Sensory Organs, Sapienza University of Rome, 00185 Rome, Italy","institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011068319","display_name":"Luigi Tarani","orcid":"https://orcid.org/0000-0001-5958-9364","observed_orcids":["https://orcid.org/0000-0001-5958-9364"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Tarani","raw_affiliation_strings":["Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5958-9364","affiliations":[{"raw_affiliation_string":"Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026433786","display_name":"Daniele Gianfrilli","orcid":"https://orcid.org/0000-0002-2682-8266","observed_orcids":["https://orcid.org/0000-0002-2682-8266"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniele Gianfrilli","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021035754","display_name":"Carlotta Pozza","orcid":"https://orcid.org/0000-0002-1147-6114","observed_orcids":["https://orcid.org/0000-0002-1147-6114"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Carlotta Pozza","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1147-6114","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, 00185 Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021035754","https://openalex.org/A5064944598"],"corresponding_institution_ids":["https://openalex.org/I4210155236","https://openalex.org/I861853513"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.9477,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.67420814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"16","issue":"6","first_page":"813","last_page":"813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.28220000863075256,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.16869999468326569,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/fsh-receptor","display_name":"FSH receptor","score":0.9340000152587891},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.45899999141693115},{"id":"https://openalex.org/keywords/bone-resorption","display_name":"bone resorption","score":0.8360000252723694},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.7329999804496765},{"id":"https://openalex.org/keywords/metabolic-outcomes","display_name":"metabolic outcomes","score":0.6690000295639038},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.8370000123977661},{"id":"https://openalex.org/keywords/recombinant-fsh","display_name":"recombinant FSH","score":0.671999990940094},{"id":"https://openalex.org/keywords/fsh-beta-subunit","display_name":"FSH beta subunit","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5780981183052063},{"id":"https://openalex.org/C29390026","wikidata":"https://www.wikidata.org/wiki/Q14904760","display_name":"Follicle-stimulating hormone receptor","level":5,"score":0.5772861838340759},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5576479434967041},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5365737676620483},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5345124006271362},{"id":"https://openalex.org/C2779279165","wikidata":"https://www.wikidata.org/wiki/Q200774","display_name":"Follicle-stimulating hormone","level":4,"score":0.5323470234870911},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.5198105573654175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5158376097679138},{"id":"https://openalex.org/C2781068068","wikidata":"https://www.wikidata.org/wiki/Q195614","display_name":"Sertoli cell","level":3,"score":0.49808692932128906},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.4893054664134979},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.43129295110702515},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42994141578674316},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.42094382643699646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37794214487075806},{"id":"https://openalex.org/C123765429","wikidata":"https://www.wikidata.org/wiki/Q36961","display_name":"Spermatogenesis","level":2,"score":0.3592570424079895},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.19959214329719543},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.16476121544837952},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15312102437019348},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14167234301567078},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10757389664649963},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.3390/ph16060813","doi":"https://doi.org/10.3390/ph16060813","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph16060813","pdf_url":"https://www.mdpi.com/1424-8247/16/6/813/pdf?version=1685446318","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10300833","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10300833","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10300833/pdf/pharmaceuticals-16-00813.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmid:37375761","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37375761","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1681988","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11573/1681988","pdf_url":"https://iris.uniroma1.it/bitstream/11573/1681988/1/Spaziani_Extra-Gonadal-and-Non-Canonical-Effects-of-FSH-in%20Males_2023.pdf","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6d22911f04524499841abc259ec486f5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6d22911f04524499841abc259ec486f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 16, Iss 6, p 813 (2023)","raw_type":"article"},{"id":"pmh:oai:iris.uniecampus.it:11389/62718","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11389/62718","pdf_url":null,"source":{"id":"https://openalex.org/S4306400077","display_name":"IRIS eCampus Telematic University (Universit\u00e0 degli Studi eCampus)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I167322064","host_organization_name":"Universit\u00e0 degli Studi eCampus","host_organization_lineage":["https://openalex.org/I167322064"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:it.cnr:prodotti:484336","doi":null,"is_oa":false,"landing_page_url":"https://publications.cnr.it/doc/484336","pdf_url":null,"source":{"id":"https://openalex.org/S7407055101","display_name":"CNR ExploRA","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"info:cnr-pdr/source/autori:Spaziani, Matteo; Carlomagno, Francesco; Tenuta, Marta; Sesti, Franz; Angelini, Francesco; Bonaventura, Ilaria; Ferrari, Davide; Tarantino, Chiara; Fiore, Marco; Petrella, Carla; Tarani, Luigi; Gianfrilli, Daniele; Pozza, Carlotta/titolo:Extra-Gonadal and Non-Canonical Effects of FSH in Males/doi:10.3390%2Fph16060813/rivista:Pharmaceuticals (Basel)/anno:2023/pagina_da:/pagina_a:/intervallo_pagine:/volume:16","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ph16060813","doi":"https://doi.org/10.3390/ph16060813","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph16060813","pdf_url":"https://www.mdpi.com/1424-8247/16/6/813/pdf?version=1685446318","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378909331.pdf","grobid_xml":"https://content.openalex.org/works/W4378909331.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W1527580044","https://openalex.org/W1543604790","https://openalex.org/W1646958083","https://openalex.org/W1834366147","https://openalex.org/W1967523984","https://openalex.org/W1968198282","https://openalex.org/W1969356144","https://openalex.org/W1975137245","https://openalex.org/W1975912804","https://openalex.org/W1978972640","https://openalex.org/W1984150458","https://openalex.org/W1987968238","https://openalex.org/W1988860947","https://openalex.org/W1990652341","https://openalex.org/W1991867027","https://openalex.org/W1999187583","https://openalex.org/W2003226042","https://openalex.org/W2009207591","https://openalex.org/W2011798764","https://openalex.org/W2013019376","https://openalex.org/W2015202654","https://openalex.org/W2015337086","https://openalex.org/W2018141522","https://openalex.org/W2020438145","https://openalex.org/W2022455607","https://openalex.org/W2024865991","https://openalex.org/W2025213528","https://openalex.org/W2026726238","https://openalex.org/W2029992524","https://openalex.org/W2043941151","https://openalex.org/W2043998420","https://openalex.org/W2047822635","https://openalex.org/W2055313367","https://openalex.org/W2062617850","https://openalex.org/W2064543792","https://openalex.org/W2066198870","https://openalex.org/W2073393447","https://openalex.org/W2075616541","https://openalex.org/W2076480166","https://openalex.org/W2077204758","https://openalex.org/W2078127917","https://openalex.org/W2085202924","https://openalex.org/W2089907071","https://openalex.org/W2090399386","https://openalex.org/W2092505499","https://openalex.org/W2092850262","https://openalex.org/W2093221871","https://openalex.org/W2099037568","https://openalex.org/W2103441192","https://openalex.org/W2107164350","https://openalex.org/W2112379688","https://openalex.org/W2119221073","https://openalex.org/W2120306129","https://openalex.org/W2139495612","https://openalex.org/W2141426010","https://openalex.org/W2145687923","https://openalex.org/W2146321385","https://openalex.org/W2156870364","https://openalex.org/W2160947972","https://openalex.org/W2165316559","https://openalex.org/W2176045468","https://openalex.org/W2259572715","https://openalex.org/W2299481077","https://openalex.org/W2317206656","https://openalex.org/W2317673748","https://openalex.org/W2317733570","https://openalex.org/W2400953310","https://openalex.org/W2402884496","https://openalex.org/W2472095272","https://openalex.org/W2481841179","https://openalex.org/W2595019777","https://openalex.org/W2596675526","https://openalex.org/W2614881600","https://openalex.org/W2618352462","https://openalex.org/W2735579573","https://openalex.org/W2787417549","https://openalex.org/W2792590877","https://openalex.org/W2802235090","https://openalex.org/W2885277203","https://openalex.org/W2899466832","https://openalex.org/W2904418872","https://openalex.org/W2904555930","https://openalex.org/W2914178167","https://openalex.org/W2920058042","https://openalex.org/W2965469792","https://openalex.org/W3011520050","https://openalex.org/W3013723415","https://openalex.org/W3014675778","https://openalex.org/W3017325695","https://openalex.org/W3037425074","https://openalex.org/W3089599993","https://openalex.org/W3097838955","https://openalex.org/W3110099106","https://openalex.org/W3111400034","https://openalex.org/W3111465651","https://openalex.org/W3113330330","https://openalex.org/W3178440845","https://openalex.org/W3195186618","https://openalex.org/W3199470119","https://openalex.org/W3208716367","https://openalex.org/W4214551448","https://openalex.org/W4280597149","https://openalex.org/W4289860941","https://openalex.org/W4308834857"],"related_works":["https://openalex.org/W2916541037","https://openalex.org/W4310566869","https://openalex.org/W4404551658","https://openalex.org/W2164039628","https://openalex.org/W4289860941","https://openalex.org/W3032139357","https://openalex.org/W7204968736","https://openalex.org/W2084800864","https://openalex.org/W3013723415","https://openalex.org/W2914178167"],"abstract_inverted_index":{"Recombinant":[0],"follicle-stimulating":[1],"hormone":[2],"(FSH)":[3],"is":[4,14,28,146,200,205],"commonly":[5],"used":[6,17],"for":[7,194],"the":[8,120,150,167,170,181,189,192,209],"treatment":[9],"of":[10,30,45,152,166,173],"female":[11],"infertility":[12],"and":[13,38,59,112,139,202,214],"increasingly":[15],"being":[16],"in":[18,57,66,128,149,154,175,185,197],"males":[19],"as":[20,22,132],"well,":[21],"recommended":[23],"by":[24,48,95],"notable":[25],"guidelines.":[26],"FSH":[27,79,104,123,153,174],"composed":[29],"an":[31],"\u03b1":[32],"subunit,":[33,41],"shared":[34],"with":[35,50,109,177],"other":[36],"hormones,":[37],"a":[39,116,163,178],"\u03b2":[40],"which":[42],"confers":[43],"specificity":[44],"biological":[46],"action":[47],"interacting":[49],"its":[51],"surface":[52],"receptor":[53],"(FSHR),":[54],"predominantly":[55],"located":[56],"granulosa":[58],"Sertoli":[60],"cells.":[61],"However,":[62],"FSHRs":[63,133],"also":[64,125],"exist":[65],"extra-gonadal":[67,82,171],"tissues,":[68],"indicating":[69],"potential":[70,193],"effects":[71,172,213],"beyond":[72],"male":[73],"fertility.":[74],"Emerging":[75],"evidence":[76],"suggests":[77],"that":[78],"may":[80,140],"have":[81,106],"effects,":[83],"including":[84],"on":[85,100,119,136,169,180],"bone":[86,93],"metabolism,":[87],"where":[88],"it":[89],"appears":[90],"to":[91,97,161,207],"stimulate":[92],"resorption":[94],"binding":[96],"specific":[98],"receptors":[99],"osteoclasts.":[101],"Additionally,":[102],"higher":[103],"levels":[105],"been":[107,126],"associated":[108],"worse":[110],"metabolic":[111],"cardiovascular":[113,121],"outcomes,":[114],"suggesting":[115],"possible":[117],"impact":[118],"system.":[122],"has":[124],"implicated":[127],"immune":[129,137],"response":[130],"modulation,":[131],"are":[134],"expressed":[135],"cells":[138],"influence":[141],"inflammatory":[142],"response.":[143],"Furthermore,":[144],"there":[145],"growing":[147],"interest":[148],"role":[151],"prostate":[155],"cancer":[156],"progression.":[157],"This":[158],"paper":[159],"aims":[160],"provide":[162],"comprehensive":[164],"analysis":[165],"literature":[168],"men,":[176],"focus":[179],"often-conflicting":[182],"results":[183],"reported":[184],"this":[186,198],"field.":[187],"Despite":[188],"contradictory":[190],"findings,":[191],"future":[195],"development":[196],"area":[199],"substantial,":[201],"further":[203],"research":[204],"needed":[206],"elucidate":[208],"mechanisms":[210],"underlying":[211],"these":[212],"their":[215],"clinical":[216],"implications.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-06-01T00:00:00"}