{"id":"https://openalex.org/W4378903457","doi":"https://doi.org/10.3390/metabo13060710","title":"A Spectrum of Age- and Gender-Dependent Lower Urinary Tract Phenotypes in Three Mouse Models of Type 2 Diabetes","display_name":"A Spectrum of Age- and Gender-Dependent Lower Urinary Tract Phenotypes in Three Mouse Models of Type 2 Diabetes","publication_year":2023,"publication_date":"2023-05-31","ids":{"openalex":"https://openalex.org/W4378903457","doi":"https://doi.org/10.3390/metabo13060710","pmid":"https://pubmed.ncbi.nlm.nih.gov/37367868","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10304708"},"language":"en","primary_location":{"id":"doi:10.3390/metabo13060710","doi":"https://doi.org/10.3390/metabo13060710","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo13060710","pdf_url":"https://www.mdpi.com/2218-1989/13/6/710/pdf?version=1685604311","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2218-1989/13/6/710/pdf?version=1685604311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081825830","display_name":"Bryce MacIver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryce MacIver","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053537873","display_name":"Erica M. Bien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica M. Bien","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023349336","display_name":"Mariana G. de Oliveira","orcid":"https://orcid.org/0000-0003-2226-2530","observed_orcids":["https://orcid.org/0000-0003-2226-2530"]},"institutions":[{"id":"https://openalex.org/I181391015","display_name":"Universidade Estadual de Campinas (UNICAMP)","ror":"https://ror.org/04wffgt70","country_code":"BR","type":"education","lineage":["https://openalex.org/I181391015"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mariana G. de Oliveira","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-970, SP, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2226-2530","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas 13083-970, SP, Brazil","institution_ids":["https://openalex.org/I181391015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087929660","display_name":"Warren G. Hill","orcid":"https://orcid.org/0000-0002-2772-7264","observed_orcids":["https://orcid.org/0000-0002-2772-7264"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Warren G. Hill","raw_affiliation_strings":["Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA"],"raw_orcid":"https://orcid.org/0000-0002-2772-7264","affiliations":[{"raw_affiliation_string":"Laboratory of Voiding Dysfunction, Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087929660"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":1.2513,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.77983539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"13","issue":"6","first_page":"710","last_page":"710"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-bladder-dysfunction","display_name":"diabetic bladder dysfunction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/lower-urinary-tract-symptoms","display_name":"lower urinary tract symptoms","score":0.8519999980926514},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/diabetic-mouse-model","display_name":"diabetic mouse model","score":0.7620000243186951},{"id":"https://openalex.org/keywords/polyuria","display_name":"polyuria","score":0.7739999890327454},{"id":"https://openalex.org/keywords/voiding-frequency","display_name":"voiding frequency","score":0.6169999837875366},{"id":"https://openalex.org/keywords/urinary-incontinence","display_name":"urinary incontinence","score":0.7269999980926514},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6290000081062317},{"id":"https://openalex.org/keywords/age-dependent-phenotype","display_name":"age-dependent phenotype","score":0.7120000123977661},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8949999809265137},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2780180277","wikidata":"https://www.wikidata.org/wiki/Q1124286","display_name":"Polyuria","level":3,"score":0.9614136219024658},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7269942164421082},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7024917602539062},{"id":"https://openalex.org/C175768497","wikidata":"https://www.wikidata.org/wiki/Q105726","display_name":"Urination","level":3,"score":0.6670597791671753},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.6305769681930542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5442872047424316},{"id":"https://openalex.org/C2778721985","wikidata":"https://www.wikidata.org/wiki/Q1183680","display_name":"Decompensation","level":2,"score":0.5401896238327026},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5066421627998352},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5041748285293579},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.4728448987007141},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.43483883142471313},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.36260437965393066},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/metabo13060710","doi":"https://doi.org/10.3390/metabo13060710","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo13060710","pdf_url":"https://www.mdpi.com/2218-1989/13/6/710/pdf?version=1685604311","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10304708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10304708","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10304708/pdf/metabolites-13-00710.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Text"},{"id":"pmid:37367868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37367868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b4f0452012ea4856b51f748a63723ef0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4f0452012ea4856b51f748a63723ef0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Metabolites, Vol 13, Iss 6, p 710 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/metabo13060710","doi":"https://doi.org/10.3390/metabo13060710","is_oa":true,"landing_page_url":"https://doi.org/10.3390/metabo13060710","pdf_url":"https://www.mdpi.com/2218-1989/13/6/710/pdf?version=1685604311","source":{"id":"https://openalex.org/S2764402194","display_name":"Metabolites","issn_l":"2218-1989","issn":["2218-1989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Metabolites","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5554123950","display_name":null,"funder_award_id":"DK076169 and #18AU3876","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5582937778","display_name":"Coordinating and Bioinformatics Unit for the MMPC/DiaComp","funder_award_id":"U24DK076169","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320308605","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378903457.pdf","grobid_xml":"https://content.openalex.org/works/W4378903457.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1509260098","https://openalex.org/W1560861249","https://openalex.org/W1575643753","https://openalex.org/W1862356881","https://openalex.org/W1963556985","https://openalex.org/W1977180230","https://openalex.org/W1978490662","https://openalex.org/W1980185328","https://openalex.org/W1984915918","https://openalex.org/W1988613836","https://openalex.org/W1993879464","https://openalex.org/W1995375315","https://openalex.org/W1997152320","https://openalex.org/W2007506971","https://openalex.org/W2009101571","https://openalex.org/W2012680765","https://openalex.org/W2015842924","https://openalex.org/W2040621723","https://openalex.org/W2061391601","https://openalex.org/W2063768742","https://openalex.org/W2064409098","https://openalex.org/W2083563859","https://openalex.org/W2095711182","https://openalex.org/W2101563809","https://openalex.org/W2125551301","https://openalex.org/W2129045643","https://openalex.org/W2134725999","https://openalex.org/W2144234445","https://openalex.org/W2145584014","https://openalex.org/W2152048331","https://openalex.org/W2167484346","https://openalex.org/W2170136030","https://openalex.org/W2288256636","https://openalex.org/W2560176107","https://openalex.org/W2811171782","https://openalex.org/W2901438234","https://openalex.org/W2936961731","https://openalex.org/W2971226483","https://openalex.org/W2989177129","https://openalex.org/W3014881638","https://openalex.org/W3026506096","https://openalex.org/W3088598953","https://openalex.org/W3136779476","https://openalex.org/W3168373598","https://openalex.org/W4287377771","https://openalex.org/W4292185448","https://openalex.org/W4293280744","https://openalex.org/W4296664055","https://openalex.org/W4313472914","https://openalex.org/W4321375786"],"related_works":["https://openalex.org/W2989177129","https://openalex.org/W2293525231","https://openalex.org/W1466739912","https://openalex.org/W3088598953","https://openalex.org/W4225255964","https://openalex.org/W2053565228","https://openalex.org/W1969364946","https://openalex.org/W1883775029","https://openalex.org/W1981228465","https://openalex.org/W6910212156"],"abstract_inverted_index":{"Lower":[0],"urinary":[1],"tract":[2],"symptoms":[3,205],"are":[4,16,210],"extremely":[5,139],"common":[6],"in":[7,28,54,148,160,174,207],"people":[8],"with":[9,195],"diabetes":[10],"and":[11,71,82,84,136,209],"obesity,":[12],"but":[13,193],"the":[14,34,41,126,211,215],"causes":[15],"unclear.":[17],"Furthermore,":[18],"it":[19],"has":[20],"proven":[21],"difficult":[22],"to":[23,36,49,78,217],"reliably":[24],"demonstrate":[25],"bladder":[26,52,94,129,220],"dysfunction":[27,53,95,130],"diabetic":[29,51,219],"mouse":[30,58],"models,":[31],"thus":[32],"limiting":[33],"ability":[35],"gain":[37],"mechanistic":[38],"insights.":[39],"Therefore,":[40],"main":[42],"objective":[43],"of":[44,60,68,107,179,214],"this":[45],"experimental":[46],"study":[47,218],"was":[48,168],"characterize":[50],"three":[55,216],"promising":[56],"polygenic":[57],"models":[59],"type":[61],"2":[62],"diabetes.":[63],"We":[64,198],"performed":[65],"periodic":[66],"assessments":[67],"glucose":[69,111,140],"tolerance":[70],"micturition":[72],"(void":[73],"spot":[74],"assay)":[75],"for":[76],"eight":[77,183],"twelve":[79,97],"months.":[80,98,133],"Males":[81,142],"females":[83,115,127,137],"high-fat":[85],"diets":[86],"were":[87,101,116,138,187],"tested.":[88],"NONcNZO10/LtJ":[89],"mice":[90,202],"did":[91],"not":[92],"develop":[93],"over":[96,131],"TALLYHO/JngJ":[99],"males":[100,120,135],"severely":[102],"hyperglycemic":[103],"from":[104],"two":[105],"months":[106,153,165],"age":[108],"(fasted":[109],"blood":[110],"~550":[112],"mg/dL),":[113],"while":[114],"moderately":[117],"so.":[118],"Although":[119],"exhibited":[121,128,143],"polyuria,":[122,144],"neither":[123],"they":[124],"nor":[125],"nine":[132],"KK.Cg-Ay/J":[134,200],"intolerant.":[141],"a":[145,157,171],"significant":[146],"increase":[147,173],"voiding":[149,161],"frequency":[150,162],"at":[151],"four":[152],"(compensation),":[154],"followed":[155],"by":[156,163,170],"rapid":[158],"drop":[159],"six":[164],"(decompensation)":[166],"which":[167],"accompanied":[169],"dramatic":[172],"urine":[175],"leakage,":[176],"indicating":[177],"loss":[178],"outlet":[180],"control.":[181],"At":[182],"months,":[184],"male":[185,201],"bladders":[186],"dilated.":[188],"Females":[189],"also":[190],"developed":[191],"polyuria":[192],"compensated":[194],"larger":[196],"voids.":[197],"conclude":[199],"recapitulate":[203],"key":[204],"noted":[206],"patients":[208],"best":[212],"model":[213],"dysfunction.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-06-01T00:00:00"}