{"id":"https://openalex.org/W4378746643","doi":"https://doi.org/10.1021/acs.biomac.3c00257","title":"Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth","display_name":"Collagen-Laponite Nanoclay Hydrogels for Tumor Spheroid Growth","publication_year":2023,"publication_date":"2023-05-30","ids":{"openalex":"https://openalex.org/W4378746643","doi":"https://doi.org/10.1021/acs.biomac.3c00257","pmid":"https://pubmed.ncbi.nlm.nih.gov/37249509","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10265657"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biomac.3c00257","doi":"https://doi.org/10.1021/acs.biomac.3c00257","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00257","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1021/acs.biomac.3c00257","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019721762","display_name":"Pilar Alam\u00e1n\u2010D\u00edez","orcid":"https://orcid.org/0000-0003-1958-4432","observed_orcids":["https://orcid.org/0000-0003-1958-4432"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4405260899","display_name":"Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n","ror":"https://ror.org/04eqgej32","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318","https://openalex.org/I4405260899"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Pilar Alam\u00e1n-D\u00edez","raw_affiliation_strings":["Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1958-4432","affiliations":[{"raw_affiliation_string":"Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021288574","display_name":"Carlos Borau","orcid":"https://orcid.org/0000-0002-3784-1140","observed_orcids":["https://orcid.org/0000-0002-3784-1140"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4405260899","display_name":"Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n","ror":"https://ror.org/04eqgej32","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318","https://openalex.org/I4405260899"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Borau","raw_affiliation_strings":["Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088986209","display_name":"Pedro Enrique Guerrero","orcid":"https://orcid.org/0000-0003-2612-9235","observed_orcids":["https://orcid.org/0000-0003-2612-9235"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4405260899","display_name":"Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n","ror":"https://ror.org/04eqgej32","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318","https://openalex.org/I4405260899"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pedro Enrique Guerrero","raw_affiliation_strings":["Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050300672","display_name":"H. Amaveda","orcid":"https://orcid.org/0000-0003-2212-447X","observed_orcids":["https://orcid.org/0000-0003-2212-447X"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210132055","display_name":"Instituto de Nanociencia y Materiales de Arag\u00f3n","ror":"https://ror.org/031n2c920","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I255234318","https://openalex.org/I4210132055"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Hippolyte Amaveda","raw_affiliation_strings":["Aragon Institute of Nanoscience and Materials (INMA), University of Zaragoza & CSIC, Zaragoza, Aragon 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aragon Institute of Nanoscience and Materials (INMA), University of Zaragoza & CSIC, Zaragoza, Aragon 50018, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I255234318","https://openalex.org/I4210132055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031402166","display_name":"Mario Mora","orcid":"https://orcid.org/0000-0003-4747-7327","observed_orcids":["https://orcid.org/0000-0003-4747-7327"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210132055","display_name":"Instituto de Nanociencia y Materiales de Arag\u00f3n","ror":"https://ror.org/031n2c920","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I255234318","https://openalex.org/I4210132055"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mario Mora","raw_affiliation_strings":["Aragon Institute of Nanoscience and Materials (INMA), University of Zaragoza & CSIC, Zaragoza, Aragon 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aragon Institute of Nanoscience and Materials (INMA), University of Zaragoza & CSIC, Zaragoza, Aragon 50018, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I255234318","https://openalex.org/I4210132055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041096908","display_name":"Jos\u00e9 Mar\u00eda Fraile","orcid":"https://orcid.org/0000-0002-0136-5138","observed_orcids":["https://orcid.org/0000-0002-0136-5138"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210087524","display_name":"Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea","ror":"https://ror.org/002smyt64","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I255234318","https://openalex.org/I4210087524"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Mar\u00eda Fraile","raw_affiliation_strings":["Institute of Chemical synthesis and Homogeneous Catalysis (ISQCH), University of Zaragoza & CSIC, Zaragoza, Aragon 50009, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical synthesis and Homogeneous Catalysis (ISQCH), University of Zaragoza & CSIC, Zaragoza, Aragon 50009, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I255234318","https://openalex.org/I4210087524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034275921","display_name":"Elena Garc\u00eda\u2010Gareta","orcid":"https://orcid.org/0000-0001-7062-9099","observed_orcids":["https://orcid.org/0000-0001-7062-9099"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4405260899","display_name":"Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n","ror":"https://ror.org/04eqgej32","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318","https://openalex.org/I4405260899"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Elena Garc\u00eda-Gareta","raw_affiliation_strings":["Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, WC1E 6BT, United Kingdom","Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029758603","display_name":"Jos\u00e9 Manuel Garc\u00eda\u2010Aznar","orcid":"https://orcid.org/0000-0002-9864-7683","observed_orcids":["https://orcid.org/0000-0002-9864-7683"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4405260899","display_name":"Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n","ror":"https://ror.org/04eqgej32","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318","https://openalex.org/I4405260899"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Manuel Garc\u00eda-Aznar","raw_affiliation_strings":["Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057527024","display_name":"Mar\u0131\u0301a \u00c1ngeles P\u00e9rez","orcid":"https://orcid.org/0000-0002-2901-4188","observed_orcids":["https://orcid.org/0000-0002-2901-4188"]},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4405260899","display_name":"Instituto de Investigaci\u00f3n en Ingenier\u00eda de Arag\u00f3n","ror":"https://ror.org/04eqgej32","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318","https://openalex.org/I4405260899"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda \u00c1ngeles P\u00e9rez","raw_affiliation_strings":["Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multiscale in Mechanical and Biological Engineering, Arag\u00f3n Institute of Engineering Research (I3A) & Arag\u00f3n Institute of Healthcare Research (IIS Arag\u00f3n), Department of Mechanical Engineering, University of Zaragoza, Zaragoza, 50018, Spain","institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5019721762"],"corresponding_institution_ids":["https://openalex.org/I255234318","https://openalex.org/I4210136512","https://openalex.org/I4405260899"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":2.5197,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.90285845,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"24","issue":"6","first_page":"2879","last_page":"2891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.586899995803833,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.3882000148296356,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.8669999837875366},{"id":"https://openalex.org/keywords/collagen-hydrogel","display_name":"collagen gel","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.9330000281333923},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hydrogel-rheology","display_name":"hydrogel rheology","score":0.7820000052452087},{"id":"https://openalex.org/keywords/mechanical-properties-of-hydrogels","display_name":"hydrogel mechanical properties","score":0.7540000081062317},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.9147423505783081},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7827023267745972},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.7086530327796936},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.591645359992981},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4754045903682709},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4511888325214386},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.43693313002586365},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4155419170856476},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.39881110191345215},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2742277979850769},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.22849944233894348},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.18544593453407288},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.13239508867263794},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11920943856239319},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11116060614585876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09081453084945679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017640","descriptor_name":"Silicates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018874","descriptor_name":"Spheroids, Cellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1021/acs.biomac.3c00257","doi":"https://doi.org/10.1021/acs.biomac.3c00257","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00257","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},{"id":"doi:10.31224/3620","doi":"https://doi.org/10.31224/3620","is_oa":true,"landing_page_url":"https://doi.org/10.31224/3620","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10265657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10265657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Text"},{"id":"pmid:37249509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37249509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/343213","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/343213","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:zaguan.unizar.es:126545","doi":null,"is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/126545","pdf_url":null,"source":{"id":"https://openalex.org/S4306401812","display_name":"Zaguan (University of Zaragoza Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1021/acs.biomac.3c00257","doi":"https://doi.org/10.1021/acs.biomac.3c00257","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00257","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2059455725","display_name":null,"funder_award_id":"PID2020-113819RB-I00","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G2558747001","display_name":"Individual and Collective Migration of the Immune Cellular System","funder_award_id":"101018587","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G39894239","display_name":null,"funder_award_id":"2018\u201022","funder_id":"https://openalex.org/F4320326208","funder_display_name":"Gobierno de Arag\u00f3n"},{"id":"https://openalex.org/G4175812583","display_name":"PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers","funder_award_id":"826494","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5534379386","display_name":null,"funder_award_id":"Topic SC1-DTH-07-2018, PRIMAGE grant agreement no:","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G58498806","display_name":null,"funder_award_id":"Topic SC1-DTH-07-2018","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7241574985","display_name":null,"funder_award_id":"PID2021-125762NB-I00.","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G8132523857","display_name":null,"funder_award_id":"PID2021-122409OB-C21","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320324111","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28"},{"id":"https://openalex.org/F4320326208","display_name":"Gobierno de Arag\u00f3n","ror":"https://ror.org/0425pg203"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320336769","display_name":"Institute of Engineering Research, Seoul National University","ror":"https://ror.org/04scsat82"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W436205860","https://openalex.org/W641954586","https://openalex.org/W1553969354","https://openalex.org/W1970167146","https://openalex.org/W1976332099","https://openalex.org/W1989978553","https://openalex.org/W2002756356","https://openalex.org/W2003839270","https://openalex.org/W2005104009","https://openalex.org/W2026340289","https://openalex.org/W2032965689","https://openalex.org/W2043739827","https://openalex.org/W2072758154","https://openalex.org/W2080739630","https://openalex.org/W2086310075","https://openalex.org/W2099052265","https://openalex.org/W2111440433","https://openalex.org/W2116040950","https://openalex.org/W2126006830","https://openalex.org/W2168890863","https://openalex.org/W2171283890","https://openalex.org/W2236643502","https://openalex.org/W2321178842","https://openalex.org/W2413682132","https://openalex.org/W2418686488","https://openalex.org/W2460593466","https://openalex.org/W2512347727","https://openalex.org/W2561015208","https://openalex.org/W2775339123","https://openalex.org/W2781877987","https://openalex.org/W2795533901","https://openalex.org/W2796291037","https://openalex.org/W2800187340","https://openalex.org/W2801929954","https://openalex.org/W2804098126","https://openalex.org/W2805573626","https://openalex.org/W2806054482","https://openalex.org/W2808528042","https://openalex.org/W2809403352","https://openalex.org/W2888232470","https://openalex.org/W2891828966","https://openalex.org/W2901963114","https://openalex.org/W2902565834","https://openalex.org/W2903458582","https://openalex.org/W2927791423","https://openalex.org/W2969389119","https://openalex.org/W2981069761","https://openalex.org/W2990681219","https://openalex.org/W3006231048","https://openalex.org/W3036053451","https://openalex.org/W3037883425","https://openalex.org/W3041482856","https://openalex.org/W3097206347","https://openalex.org/W3133304393","https://openalex.org/W3159130412","https://openalex.org/W3167935525","https://openalex.org/W3200603256","https://openalex.org/W3210575985","https://openalex.org/W4221116131","https://openalex.org/W4225005528","https://openalex.org/W4230240787","https://openalex.org/W4295159834","https://openalex.org/W4296753321","https://openalex.org/W4297347447","https://openalex.org/W4303415894","https://openalex.org/W4308934301"],"related_works":["https://openalex.org/W4384699100","https://openalex.org/W2807387796","https://openalex.org/W7172412051","https://openalex.org/W2516180878","https://openalex.org/W4417524450","https://openalex.org/W1644727092","https://openalex.org/W3117579167","https://openalex.org/W4401251073","https://openalex.org/W2902718561","https://openalex.org/W2900086601"],"abstract_inverted_index":{"The":[0],"extracellular":[1],"matrix":[2],"(ECM)":[3],"plays":[4],"an":[5],"important":[6],"regulatory":[7],"role":[8,39],"in":[9,23,44,57,115],"the":[10,38,71,89,92,106,126],"development":[11,46],"and":[12,19,32,47,83,86,104,111,121],"progression":[13],"of":[14,40,91,108,129],"tumoral":[15],"tissue.":[16],"Its":[17],"functions":[18],"properties":[20,85,128],"are":[21],"crucial":[22],"determining":[24],"tumor":[25,51,63,96,113],"cell":[26],"behavior":[27],"such":[28],"as":[29],"invasion,":[30],"migration,":[31],"malignancy":[33],"development.":[34],"Our":[35,99],"study":[36],"explores":[37],"collagen":[41,79,93,131],"type":[42],"I":[43],"cancer":[45,116],"spread":[48],"using":[49],"engineered":[50,112],"models":[52,114],"like":[53],"multicellular":[54],"spheroids":[55],"grown":[56],"collagen-based":[58],"hydrogels":[59,80],"to":[60,69,78,124],"simulate":[61],"early":[62],"formation.":[64],"We":[65],"employ":[66],"microfluidic":[67],"techniques":[68],"test":[70],"hypothesis":[72],"that":[73],"(i)":[74],"adding":[75],"Laponite":[76],"nanoclay":[77],"modifies":[81],"mechanical":[82,127],"rheological":[84],"(ii)":[87],"changing":[88],"stiffness":[90],"microenvironment":[94],"affects":[95],"spheroid":[97],"growth.":[98],"findings":[100],"support":[101],"our":[102],"theories":[103],"suggest":[105],"use":[107],"ECM":[109],"components":[110],"research,":[117],"offering":[118],"a":[119],"biocompatible":[120],"biomimetic":[122],"method":[123],"tailor":[125],"conventional":[130],"hydrogels.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-05-31T00:00:00"}
