{"id":"https://openalex.org/W4378746493","doi":"https://doi.org/10.1093/nar/gkad439","title":"Enhanced nonenzymatic RNA copying with in-situ activation of short oligonucleotides","display_name":"Enhanced nonenzymatic RNA copying with in-situ activation of short oligonucleotides","publication_year":2023,"publication_date":"2023-05-30","ids":{"openalex":"https://openalex.org/W4378746493","doi":"https://doi.org/10.1093/nar/gkad439","pmid":"https://pubmed.ncbi.nlm.nih.gov/37247941","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10359593"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkad439","doi":"https://doi.org/10.1093/nar/gkad439","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad439","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad439/50475432/gkad439.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad439/50475432/gkad439.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077669722","display_name":"Dian Ding","orcid":"https://orcid.org/0000-0001-9046-7816","observed_orcids":["https://orcid.org/0000-0001-9046-7816"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dian Ding","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street , Cambridge , MA 02138 , USA","Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street , Boston , MA 02114 , USA"],"raw_orcid":"https://orcid.org/0000-0001-9046-7816","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street , Cambridge , MA 02138 , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street , Boston , MA 02114 , USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027721257","display_name":"Stephanie J. Zhang","orcid":"https://orcid.org/0000-0001-6308-5257","observed_orcids":["https://orcid.org/0000-0001-6308-5257"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie J Zhang","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street , Cambridge , MA 02138 , USA","Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street , Boston , MA 02114 , USA"],"raw_orcid":"https://orcid.org/0000-0001-6308-5257","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street , Cambridge , MA 02138 , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street , Boston , MA 02114 , USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4405271026"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023274897","display_name":"Jack W. Szostak","orcid":"https://orcid.org/0000-0003-4131-1203","observed_orcids":["https://orcid.org/0000-0003-4131-1203"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405271026","display_name":"Center for Computational and Integrative Biology, Massachusetts General Hospital","ror":"https://ror.org/01qt3xv71","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271026"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jack W Szostak","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street , Cambridge , MA 02138 , USA","Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur , Boston , MA 02115 , USA","Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street , Boston , MA 02114 , USA","Howard Hughes Medical Institute, Department of Chemistry, The University of Chicago , Chicago , IL 60637 , USA"],"raw_orcid":"https://orcid.org/0000-0003-4131-1203","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street , Cambridge , MA 02138 , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School , 77 Avenue Louis Pasteur , Boston , MA 02115 , USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital , 185 Cambridge Street , Boston , MA 02114 , USA","institution_ids":["https://openalex.org/I4210087915","https://openalex.org/I4405271026"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Chemistry, The University of Chicago , Chicago , IL 60637 , USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023274897"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I40347166","https://openalex.org/I4210087915","https://openalex.org/I4405271026"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.6487,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82608909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"51","issue":"13","first_page":"6528","last_page":"6539"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-aminoimidazole","display_name":"2-aminoimidazole","score":0.75},{"id":"https://openalex.org/keywords/freeze-thaw-cycles","display_name":"freeze-thaw cycles","score":0.8050000071525574},{"id":"https://openalex.org/keywords/eutectic-phase","display_name":"eutectic phase","score":0.7950000166893005},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.8970000147819519},{"id":"https://openalex.org/keywords/prebiotic-chemistry","display_name":"prebiotic chemistry","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9072960615158081},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.8477913737297058},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.734552264213562},{"id":"https://openalex.org/C2779151265","wikidata":"https://www.wikidata.org/wiki/Q1156791","display_name":"Copying","level":2,"score":0.6054063439369202},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5929246544837952},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.4544943869113922},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44255438446998596},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3815501034259796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3528933823108673},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24882712960243225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.235215425491333},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.1932424008846283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1245947778224945},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016337","descriptor_name":"RNA, Catalytic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/gkad439","doi":"https://doi.org/10.1093/nar/gkad439","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad439","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad439/50475432/gkad439.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.12.536642","doi":"https://doi.org/10.1101/2023.04.12.536642","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.12.536642","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/12/2023.04.12.536642.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10359593","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10359593","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10359593/pdf/gkad439.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:37247941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37247941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkad439","doi":"https://doi.org/10.1093/nar/gkad439","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad439","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad439/50475432/gkad439.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2648730350","display_name":null,"funder_award_id":"290363","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"},{"id":"https://openalex.org/G5063143151","display_name":"Nonenzymatic RNA Replication","funder_award_id":"2104708","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378746493.pdf","grobid_xml":"https://content.openalex.org/works/W4378746493.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1559168336","https://openalex.org/W1976379862","https://openalex.org/W1989791524","https://openalex.org/W1990942508","https://openalex.org/W2004448140","https://openalex.org/W2019718142","https://openalex.org/W2035016120","https://openalex.org/W2046558616","https://openalex.org/W2062019095","https://openalex.org/W2068866177","https://openalex.org/W2106665330","https://openalex.org/W2133830966","https://openalex.org/W2135443960","https://openalex.org/W2467190354","https://openalex.org/W2512565170","https://openalex.org/W2599712977","https://openalex.org/W2726371753","https://openalex.org/W2762359702","https://openalex.org/W2788051187","https://openalex.org/W2790554722","https://openalex.org/W2810582007","https://openalex.org/W2892140782","https://openalex.org/W2918005410","https://openalex.org/W2941270675","https://openalex.org/W2978780344","https://openalex.org/W3036183050","https://openalex.org/W3049126441","https://openalex.org/W3081179777","https://openalex.org/W3092111049","https://openalex.org/W3137797076","https://openalex.org/W3195562267","https://openalex.org/W4206447438","https://openalex.org/W4225529261","https://openalex.org/W4229741828","https://openalex.org/W4232210604","https://openalex.org/W4360821355","https://openalex.org/W4379469142"],"related_works":["https://openalex.org/W4225529261","https://openalex.org/W3025679535","https://openalex.org/W3049126441","https://openalex.org/W2467190354","https://openalex.org/W4210360699","https://openalex.org/W4412977544","https://openalex.org/W2583079108","https://openalex.org/W4412370725","https://openalex.org/W2903924133","https://openalex.org/W3083243880"],"abstract_inverted_index":{"The":[0],"nonenzymatic":[1,95,147],"copying":[2,110,149,168],"of":[3,46,131,180,183],"RNA":[4,19,23,167],"is":[5],"thought":[6],"to":[7,42,64,74,84,145,166],"have":[8,26],"been":[9],"necessary":[10],"for":[11,94],"the":[12,22,43,77,129,151,161,181],"transition":[13],"between":[14],"prebiotic":[15,32],"chemistry":[16,39,122,165],"and":[17,102,127],"ribozyme-catalyzed":[18],"replication":[20],"in":[21,150,160,172],"World.":[24],"We":[25,137],"previously":[27],"shown":[28],"that":[29,118,140,157],"a":[30,87,173],"potentially":[31],"nucleotide":[33],"activation":[34,164],"pathway":[35,162],"based":[36],"on":[37],"phospho-Passerini":[38,121],"can":[40,169],"lead":[41,144],"efficient":[44,146],"synthesis":[45],"2-aminoimidazole":[47],"activated":[48,58],"mononucleotides":[49,82],"when":[50],"carried":[51],"out":[52],"under":[53],"freeze-thaw":[54,135],"cycling":[55],"conditions.":[56],"Such":[57],"nucleotides":[59],"react":[60],"with":[61],"each":[62],"other":[63],"form":[65],"5'-5'":[66,88],"2-aminoimidazolium":[67,89],"bridged":[68],"dinucleotides,":[69],"enabling":[70],"template-directed":[71],"primer":[72,96],"extension":[73],"occur":[75,170],"within":[76],"same":[78,152],"reaction":[79,153],"mixture.":[80,154],"However,":[81],"linked":[83],"oligonucleotides":[85,126],"by":[86],"bridge":[90],"are":[91],"superior":[92],"substrates":[93],"extension;":[97],"their":[98,103],"higher":[99,104],"intrinsic":[100],"reactivity":[101],"template":[105,109,148],"affinity":[106],"enable":[107],"faster":[108],"at":[111],"lower":[112],"substrate":[113],"concentrations.":[114],"Here":[115],"we":[116],"show":[117],"eutectic":[119],"phase":[120],"efficiently":[123],"activates":[124],"short":[125],"promotes":[128],"formation":[130],"monomer-bridged-oligonucleotide":[132],"species":[133],"during":[134],"cycles.":[136],"then":[138],"demonstrate":[139],"in-situ":[141],"generated":[142],"monomer-bridged-oligonucleotides":[143],"Our":[155],"demonstration":[156],"multiple":[158],"steps":[159],"from":[163],"together":[171],"single":[174],"complex":[175],"environment":[176],"simplifies":[177],"this":[178],"aspect":[179],"origin":[182],"life.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-31T00:00:00"}
