{"id":"https://openalex.org/W4378676129","doi":"https://doi.org/10.1093/ehjci/jead115","title":"The role of papillary muscle abnormalities in hypertrophic cardiomyopathy: a new paradigm shift?","display_name":"The role of papillary muscle abnormalities in hypertrophic cardiomyopathy: a new paradigm shift?","publication_year":2023,"publication_date":"2023-05-30","ids":{"openalex":"https://openalex.org/W4378676129","doi":"https://doi.org/10.1093/ehjci/jead115","pmid":"https://pubmed.ncbi.nlm.nih.gov/37248791"},"language":"en","primary_location":{"id":"doi:10.1093/ehjci/jead115","doi":"https://doi.org/10.1093/ehjci/jead115","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ehjci/jead115","pdf_url":null,"source":{"id":"https://openalex.org/S64942916","display_name":"European Heart Journal - Cardiovascular Imaging","issn_l":"2047-2404","issn":["2047-2404","2047-2412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Cardiovascular Imaging","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065172718","display_name":"Alexandra Toste","orcid":"https://orcid.org/0000-0002-5649-1561","observed_orcids":["https://orcid.org/0000-0002-5649-1561"]},"institutions":[{"id":"https://openalex.org/I4210128540","display_name":"Hospital da Luz","ror":"https://ror.org/03jpm9j23","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210128540"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Alexandra Toste","raw_affiliation_strings":["Hospital da Luz Cardiology Department Av Lus\u00edada , 100 1500-650 Lisbon, Portugal","Nova Medical School , Campo M\u00e1rtires da Patria 130, 1169-056 Lisbon , Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital da Luz Cardiology Department Av Lus\u00edada , 100 1500-650 Lisbon, Portugal","institution_ids":["https://openalex.org/I4210128540"]},{"raw_affiliation_string":"Nova Medical School , Campo M\u00e1rtires da Patria 130, 1169-056 Lisbon , Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034263910","display_name":"Nuno Miguel Cardim","orcid":"https://orcid.org/0000-0002-3812-4872","observed_orcids":["https://orcid.org/0000-0002-3812-4872"]},"institutions":[{"id":"https://openalex.org/I4403386557","display_name":"Hospital CUF Descobertas","ror":"https://ror.org/05gsnx339","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4403386557"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Nuno Cardim","raw_affiliation_strings":["Cardiology Department Hospital CUF- Descobertas, Rua M\u00e1rio Botas , 1998-018 Lisbon , Portugal","Nova Medical School , Campo M\u00e1rtires da Patria 130, 1169-056 Lisbon , Portugal"],"raw_orcid":"https://orcid.org/0000-0002-3812-4872","affiliations":[{"raw_affiliation_string":"Cardiology Department Hospital CUF- Descobertas, Rua M\u00e1rio Botas , 1998-018 Lisbon , Portugal","institution_ids":["https://openalex.org/I4403386557"]},{"raw_affiliation_string":"Nova Medical School , Campo M\u00e1rtires da Patria 130, 1169-056 Lisbon , Portugal","institution_ids":["https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034263910"],"corresponding_institution_ids":["https://openalex.org/I4403386557","https://openalex.org/I83558840"],"apc_list":{"value":4137,"currency":"EUR","value_usd":4475},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"8","first_page":"1017","last_page":"1018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/apical-hypertrophic-cardiomyopathy","display_name":"apical hypertrophic cardiomyopathy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/mitral-valve-abnormalities","display_name":"mitral valve anomaly","score":0.8299999833106995},{"id":"https://openalex.org/keywords/left-ventricular-outflow-tract-obstruction","display_name":"left ventricular outflow tract obstruction","score":0.9679999947547913},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.7979999780654907},{"id":"https://openalex.org/keywords/sarcomere-gene-variants","display_name":"sarcomere gene variants","score":0.7900000214576721},{"id":"https://openalex.org/keywords/phenotypic-heterogeneity","display_name":"phenotypic heterogeneity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cardiac-magnetic-resonance","display_name":"cardiac magnetic resonance","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.6813420057296753},{"id":"https://openalex.org/C2777274916","wikidata":"https://www.wikidata.org/wiki/Q1913658","display_name":"Papillary muscle","level":2,"score":0.5986591577529907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4257136583328247},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.36062338948249817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32593590021133423},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.2954891622066498}],"mesh":[{"descriptor_ui":"D000092183","descriptor_name":"Apical Hypertrophic Cardiomyopathy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010210","descriptor_name":"Papillary Muscles","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/ehjci/jead115","doi":"https://doi.org/10.1093/ehjci/jead115","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ehjci/jead115","pdf_url":null,"source":{"id":"https://openalex.org/S64942916","display_name":"European Heart Journal - Cardiovascular Imaging","issn_l":"2047-2404","issn":["2047-2404","2047-2412"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal - Cardiovascular Imaging","raw_type":"journal-article"},{"id":"pmid:37248791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37248791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal. Cardiovascular Imaging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1987736934","https://openalex.org/W2101427309","https://openalex.org/W2159695243","https://openalex.org/W2403269601","https://openalex.org/W2604837394","https://openalex.org/W2938448662","https://openalex.org/W4281623961","https://openalex.org/W4367299399"],"related_works":["https://openalex.org/W4367299399","https://openalex.org/W2159695243","https://openalex.org/W2143905164","https://openalex.org/W1975012641","https://openalex.org/W37770187","https://openalex.org/W2058065697","https://openalex.org/W2130941120","https://openalex.org/W3172198594","https://openalex.org/W2161140087","https://openalex.org/W3000657320"],"abstract_inverted_index":{"This":[0],"editorial":[1],"refers":[2],"to":[3,189,202,219],"\u2018Apical":[4],"papillary":[5],"muscle":[6,161],"displacement":[7],"is":[8,56,83,99],"a":[9,13,57,86,111,138,221],"prevalent":[10],"feature":[11],"and":[12,126,154,156,158,175,196],"phenotypic":[14,118],"precursor":[15],"of":[16,43,53,79,92,97,114,172,224,233],"apical":[17,167],"hypertrophic":[18],"cardiomyopathy\u2019,":[19],"by":[20,132],"D.":[21],"Filomena":[22],"et":[23],"al.,":[24],"https://doi.org/10.1093/ehjci/jead078.":[25],"Hypertrophic":[26,116],"cardiomyopathy":[27,117],"(HCM)":[28],"has":[29],"been":[30],"known":[31],"as":[32],"the":[33,46,50,123,179,225],"most":[34],"common":[35,140],"genetic":[36,81],"heart":[37],"disease,":[38,60],"with":[39,61,71,213,215],"an":[40],"estimated":[41],"prevalence":[42],"1:2001":[44],"in":[45,65,89,110,200],"general":[47],"population.":[48],"From":[49],"molecular":[51],"point":[52],"view,":[54],"it":[55],"very":[58,139],"heterogeneous":[59],"pathogenic":[62],"variants":[63],"described":[64],"almost":[66],"all":[67],"sarcomere":[68],"proteins,":[69],"mainly":[70],"autosomal":[72],"dominant":[73],"(AD)":[74],"transmission.2":[75],"The":[76],"diagnostic":[77],"power":[78],"current":[80],"testing":[82],"modest,":[84],"identifying":[85],"causal":[87],"gene":[88],"approximately":[90],"half":[91],"HCM":[93,98,143,208,214],"patients.2":[94],"Clinical":[95],"diagnosis":[96],"based":[100],"on":[101],"otherwise":[102],"unexplained":[103],"left":[104,190],"ventricular":[105,191],"hypertrophy,":[106,169,204],"which":[107,229],"may":[108,120,187,230],"present":[109],"wide":[112],"variety":[113],"patterns.3":[115],"heterogeneity":[119],"also":[121],"involve":[122],"mitral":[124,181],"valve":[125,146,182],"its":[127],"apparatus,":[128],"whose":[129],"abnormalities,":[130],"depicted":[131],"cardiac":[133],"magnetic":[134],"resonance":[135],"(CMR),":[136],"are":[137],"finding":[141],"among":[142],"patients.":[144,209],"Mitral":[145],"abnormalities":[147,163],"include":[148,164],"leaflet":[149],"and/or":[150,166],"chordal":[151],"elongation,":[152],"dysplasia":[153],"prolapse,":[155],"laxity":[157],"hypermobility.3":[159],"Papillary":[160],"(PM)":[162],"anterior":[165,180],"displacement,":[168],"bifidity,":[170],"presence":[171],"accessory":[173],"PM,":[174],"direct":[176],"insertion":[177],"into":[178],"leaflet.4":[183],"Altogether,":[184],"these":[185],"factors":[186],"contribute":[188],"outflow":[192],"tract":[193],"(LVOT)":[194],"obstruction":[195],"should":[197],"be":[198,231],"addressed,":[199],"addition":[201],"septal":[203,234],"when":[205],"treating":[206],"obstructive":[207],"In":[210],"fact,":[211],"patients":[212],"abnormal":[216],"PM":[217],"seem":[218],"have":[220],"higher":[222],"degree":[223],"resting":[226],"LVOT":[227],"gradient,":[228],"independent":[232],"thickness.5":[235]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-30T00:00:00"}