{"id":"https://openalex.org/W4378675853","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5734558","title":"Factors involved in fibrosis of colorectal tissue due to chronic ulcerative colitis","display_name":"Factors involved in fibrosis of colorectal tissue due to chronic ulcerative colitis","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4378675853","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5734558"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2023.38.s1.5734558","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5734558","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2023.38.s1.5734558","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068561789","display_name":"Kikuko Amagase","orcid":"https://orcid.org/0000-0002-7767-5028","observed_orcids":["https://orcid.org/0000-0002-7767-5028"]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kikuko Amagase","raw_affiliation_strings":["Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan","institution_ids":["https://openalex.org/I135768898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050072819","display_name":"Reiichiro Sasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiichiro Sasaki","raw_affiliation_strings":["Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan","institution_ids":["https://openalex.org/I135768898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080163852","display_name":"Nahla Hamouda","orcid":"https://orcid.org/0000-0002-9436-9583","observed_orcids":["https://orcid.org/0000-0002-9436-9583"]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nahla Hamouda","raw_affiliation_strings":["Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan","institution_ids":["https://openalex.org/I135768898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019023038","display_name":"Issei Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Issei Ikeda","raw_affiliation_strings":["Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ritsumeikan University, Graduate School of Pharmaceutical Sciences, Kusatsu, Shiga, Japan","institution_ids":["https://openalex.org/I135768898"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102517483","display_name":"Yuu Adachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135768898","display_name":"Ritsumeikan University","ror":"https://ror.org/0197nmd03","country_code":"JP","type":"education","lineage":["https://openalex.org/I135768898","https://openalex.org/I4390039241"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuu Adachi","raw_affiliation_strings":["Ritsumeikan University, College of Pharmaceutical Sciences, Kusatsu, Shiga, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ritsumeikan University, College of Pharmaceutical Sciences, Kusatsu, Shiga, Japan","institution_ids":["https://openalex.org/I135768898"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068561789"],"corresponding_institution_ids":["https://openalex.org/I135768898"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":0.878000020980835},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7459999918937683},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.890999972820282},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.8799999952316284},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rhoa-rock-signaling-pathway","display_name":"RhoA/ROCK signaling","score":0.703000009059906},{"id":"https://openalex.org/keywords/ras-mek-erk-pathway","display_name":"Ras/MEK/ERK pathway","score":0.9580000042915344},{"id":"https://openalex.org/keywords/periostin","display_name":"periostin","score":0.8180000185966492},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7450000047683716},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.5759999752044678},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5170000195503235},{"id":"https://openalex.org/keywords/intestinal-strictures","display_name":"intestinal stenosis","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7386699914932251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7347379922866821},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6918922662734985},{"id":"https://openalex.org/C163031210","wikidata":"https://www.wikidata.org/wiki/Q3325848","display_name":"Masson's trichrome stain","level":3,"score":0.5632221698760986},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.557075023651123},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.5097174048423767},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.46559938788414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4607056677341461},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44019803404808044},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.4321975111961365},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.42604196071624756},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36826393008232117},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.18236136436462402},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12625905871391296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2023.38.s1.5734558","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5734558","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1152/physiol.2023.38.s1.5734558","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390654163","https://openalex.org/W4313200432","https://openalex.org/W4413451117","https://openalex.org/W4402488945","https://openalex.org/W1776077816","https://openalex.org/W2044071195","https://openalex.org/W3199029722","https://openalex.org/W7135220515","https://openalex.org/W1950165330","https://openalex.org/W4280552273"],"abstract_inverted_index":{"Background":[0],"&":[1,141],"Aim:":[2],"Chronic":[3],"and":[4,12,30,40,45,106,116,135,178,183,197,210,214,232,270,286,296,309,383,387,397,426,433,460],"persistent":[5,31],"inflammation":[6],"such":[7],"as":[8,185,359,361,369],"in":[9,283,305,313,317,350,356,365,370,388,436,464,483],"ulcerative":[10,57,75],"colitis":[11,76,422],"Crohn's":[13],"disease":[14],"may":[15,24,119],"lead":[16,48],"to":[17,49,129,170,190,221,344,407,418],"excessive":[18],"fibrosis":[19,46,69,427],"of":[20,37,42,52,67,74,91,132,173,194,225,228,275,341,379,400,421,445],"the":[21,35,50,86,92,100,103,107,114,192,223,243,261,284,306,318,345,366,371,389,398,408,437,449,454,484],"intestine,":[22],"which":[23],"cause":[25,419],"intestinal":[26,28,43],"dysfunction,":[27],"stricture,":[29],"diarrhea.":[32],"Focusing":[33],"on":[34,332],"regulation":[36],"inflammation,":[38],"repair":[39],"regeneration":[41],"tissues,":[44,288],"will":[47],"proposal":[51],"a":[53,71,130,156,171,310],"new":[54],"treatment":[55,328,413],"for":[56,95,151,166,202,256,476],"colitis.":[58],"In":[59,83,260],"this":[60,477],"study,":[61],"we":[62,126],"established":[63],"an":[64],"experimental":[65],"model":[66,73,131],"colorectal":[68],"using":[70],"mouse":[72],"induced":[77],"with":[78,99,216,414,423,428],"dextran":[79],"sulfate":[80],"sodium":[81],"(DSS).":[82],"addition,":[84],"since":[85],"TGF-\u03b2":[87],"signaling":[88],"pathway,":[89,102,105,109],"one":[90,167],"important":[93],"pathways":[94,118],"fibrotic":[96,123],"diseases,":[97],"interacts":[98],"SMAD":[101],"Ras/MEK-ERK":[104],"Rho-ROCK":[108],"statin":[110],"drugs":[111],"that":[112],"inhibit":[113],"Ras":[115],"Rho":[117],"be":[120],"useful":[121],"against":[122],"diseases.":[124],"Therefore,":[125],"administered":[127,252],"pravastatin":[128,250,367,390],"fibrosing":[133],"enterocolitis":[134],"investigated":[136],"its":[137],"pathophysiological":[138],"effects.":[139],"Materials":[140],"Methods:":[142],"Male":[143],"C57BL/6N":[144],"mice":[145],"were":[146,181,219,234,363],"given":[147],"DSS":[148,245,262,415],"ad":[149],"libitum":[150],"7":[152],"days,":[153],"followed":[154],"by":[155,236],"14-day":[157],"rest":[158,240],"period":[159,241],"(drinking":[160],"sterile":[161],"water).":[162],"This":[163,447],"was":[164,200,251,385,394,403,416,480],"repeated":[165],"cycle":[168],"up":[169],"maximum":[172],"three":[174],"cycles.":[175],"Body":[176],"weight":[177,272,338],"fecal":[179],"condition":[180],"measured":[182],"expressed":[184],"Disease":[186],"Activity":[187],"Index":[188],"(DAI)":[189],"analyze":[191],"degree":[193,224],"inflammation.":[195],"Hematoxylin":[196],"eosin":[198],"staining":[199,213,279,291,299,322],"performed":[201,220],"histological":[203],"examination.":[204],"On":[205,374],"Day":[206,375],"63,":[207,376],"Masson":[208,289],"trichrome":[209,290],"picrosirius":[211,297],"red":[212,298],"immunostaining":[215],"periostin":[217,325,362],"antibody":[218],"examine":[222],"fibrosis.":[226],"Expression":[227],"SMAD3,":[229],"SMAD4,":[230,381],"TIMP-1,":[231,382],"Rock1/RhoA":[233,384,401],"analyzed":[235],"western":[237],"blotting.":[238],"Fourteen-day":[239],"following":[242],"third":[244],"drinking":[246,263],"(Day":[247],"49-Day":[248],"63),":[249],"orally":[253],"once":[254],"daily":[255],"14":[257],"days.":[258],"Results:":[259],"group,":[264,368,391],"DAI":[265],"increased,":[266],"colon":[267,276,334,342],"length":[268],"shortened,":[269],"wet":[271,337],"per":[273,339],"cm":[274,340],"increased.":[277],"HE":[278],"showed":[280,292,300,323],"lymphocyte":[281],"infiltration":[282,425],"mucosal":[285,319],"submucosal":[287,307,357],"increased":[293,301,324,377,396,429],"collagen":[294,304,316,351,355,432],"fibers,":[295,352],"type":[302,314,353,430],"I":[303,354,431],"tissue":[308],"marked":[311],"increase":[312],"III":[315],"layer.":[320],"Immunohistochemical":[321],"expression.":[326],"Pravastatin":[327],"had":[329],"no":[330,443,469],"effect":[331],"DAI,":[333],"length,":[335],"or":[336,472],"compared":[343,406],"vehicle":[346,372,409],"group.":[347,373,410],"Significant":[348],"increases":[349],"tissue,":[358],"well":[360],"observed":[364],"expression":[378,393,402,435],"p-SMAD3,":[380],"observed,":[386],"p-SMAD3":[392],"further":[395],"percentage":[399],"significantly":[404],"decreased":[405],"Conclusion:":[411],"Repeated":[412],"shown":[417],"exacerbation":[420],"lymphocytic":[424],"TIMP":[434],"colonic":[438],"submuc":[439],"The":[440],"authors":[441],"declare":[442],"conflict":[444],"interest.":[446],"is":[448,461],"full":[450],"abstract":[451],"presented":[452],"at":[453],"American":[455],"Physiology":[456,479],"Summit":[457],"2023":[458],"meeting":[459],"only":[462],"available":[463,475],"HTML":[465],"format.":[466],"There":[467],"are":[468],"additional":[470,473],"versions":[471],"content":[474],"abstract.":[478],"not":[481],"involved":[482],"peer":[485],"review":[486],"process.":[487]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-05-30T00:00:00"}
