{"id":"https://openalex.org/W4378675128","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5730035","title":"Lipoprotein lipase activation is a novel vascular anti-contractile mechanism that is lost in aging","display_name":"Lipoprotein lipase activation is a novel vascular anti-contractile mechanism that is lost in aging","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4378675128","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5730035"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2023.38.s1.5730035","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5730035","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2023.38.s1.5730035","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Emily Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Emily Wilson","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002374824","display_name":"Tiago Januario Da Costa","orcid":"https://orcid.org/0000-0003-0780-4290","observed_orcids":["https://orcid.org/0000-0003-0780-4290"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiago Costa","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002866759","display_name":"Milene Tavares Fontes","orcid":"https://orcid.org/0000-0003-4325-5153","observed_orcids":["https://orcid.org/0000-0003-4325-5153"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Milene Fontes","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007044090","display_name":"Emily W. Waigi","orcid":"https://orcid.org/0000-0003-3829-6508","observed_orcids":["https://orcid.org/0000-0003-3829-6508"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Waigi","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Townsend","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066255017","display_name":"Joseph A. McQuail","orcid":"https://orcid.org/0000-0003-4431-8582","observed_orcids":["https://orcid.org/0000-0003-4431-8582"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph McQuail","raw_affiliation_strings":["Department of Pharmacology, Physiology, and Neuroscience, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Physiology, and Neuroscience, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022191748","display_name":"Camilla Ferreira Wenceslau","orcid":"https://orcid.org/0000-0002-0815-3568","observed_orcids":["https://orcid.org/0000-0002-0815-3568"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camilla Wenceslau","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028006240","display_name":"Cameron Grant McCarthy","orcid":"https://orcid.org/0000-0002-1380-779X","observed_orcids":["https://orcid.org/0000-0002-1380-779X"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cameron McCarthy","raw_affiliation_strings":["Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Translational Research Center and Department of Cell Biology and Anatomy, Columbia, South Carolina, United States","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14176953,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9369999766349792},{"id":"https://openalex.org/keywords/perivascular-adipose-tissue","display_name":"perivascular adipose tissue","score":0.8640000224113464},{"id":"https://openalex.org/keywords/vascular-aging","display_name":"vascular aging","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mesenteric-resistance-arteries","display_name":"mesenteric resistance arteries","score":0.828000009059906},{"id":"https://openalex.org/keywords/no-1886","display_name":"NO-1886","score":0.8679999709129333},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.5529999732971191},{"id":"https://openalex.org/keywords/vascular-stiffness","display_name":"vascular stiffness","score":0.3880000114440918},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.6309999823570251},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7078253626823425},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.700537383556366},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.5923891067504883},{"id":"https://openalex.org/C2779941686","wikidata":"https://www.wikidata.org/wiki/Q6947930","display_name":"Myograph","level":3,"score":0.5792707204818726},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.47921305894851685},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4676596224308014},{"id":"https://openalex.org/C2777952589","wikidata":"https://www.wikidata.org/wiki/Q421910","display_name":"Phenylephrine","level":3,"score":0.4494009017944336},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.4398258328437805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4265879988670349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.368832528591156},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.3294562101364136},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.12415984272956848},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.11276903748512268},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.11118727922439575},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2023.38.s1.5730035","doi":"https://doi.org/10.1152/physiol.2023.38.s1.5730035","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2023.38.s1.5730035","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4378675195","https://openalex.org/W4403397767","https://openalex.org/W2256176686","https://openalex.org/W2409962489","https://openalex.org/W2414901601","https://openalex.org/W2071379436","https://openalex.org/W4387529145","https://openalex.org/W7120749649","https://openalex.org/W4226287541","https://openalex.org/W2905411595"],"abstract_inverted_index":{"Increasing":[0],"incidence":[1],"of":[2,22,46,84,87,112,133,183,199,235,273,280,340],"cardiovascular":[3],"events":[4],"with":[5,97,146,343],"age":[6,98,200],"can":[7],"be":[8,52],"attributed":[9],"to":[10,54,70,107,224],"the":[11,38,42,80,109,130,179,232,278,362,367,397],"natural":[12],"deterioration":[13],"in":[14,100,114,178,196,237,275,277,288,331,377,396],"organ":[15],"function,":[16],"and":[17,31,34,44,49,57,61,82,99,148,166,213,256,309,335,373],"manifests":[18],"through":[19],"a":[20,85,169],"range":[21],"vascular":[23,333],"phenotypes":[24],"that":[25,122,324],"include,":[26],"endothelial":[27],"dysfunction,":[28],"hypercontractility,":[29],"stiffening":[30],"remodeling,":[32],"inflammation,":[33],"oxidative":[35],"stress.":[36],"Given":[37],"aging":[39],"global":[40],"population,":[41],"identification":[43],"translation":[45],"novel":[47,337],"mechanisms":[48],"therapeutics":[50],"will":[51],"essential":[53],"increase":[55],"longevity":[56],"prevent":[58],"premature":[59],"death":[60],"disability.":[62],"Physiologically,":[63],"perivascular":[64],"adipose":[65],"tissue":[66],"(PVAT)":[67],"is":[68,361,374],"known":[69],"impact":[71],"vasculature":[72],"by":[73,79],"exerting":[74],"an":[75,271,327],"anti-contractile":[76,88,94,110,131,194,233,338],"effect":[77,111,132,195,230,234,272],"mediated":[78],"biosynthesis":[81],"liberation":[83],"myriad":[86],"molecules":[89],"(e.g.,":[90],"adipokines).":[91],"However,":[92],"this":[93,140,322,336,390],"function":[95],"declines":[96],"related":[101],"diseases.":[102],"Therefore,":[103],"our":[104,225],"study":[105],"aimed":[106],"restore":[108],"PVAT":[113,134,191,236],"arteries":[115,144],"from":[116,154],"aged":[117,136,159],"animals.":[118],"Specifically,":[119,282],"we":[120,269],"predicted":[121],"increasing":[123],"lipoprotein":[124],"lipase":[125],"(LPL)":[126],"activity":[127],"would":[128],"reinstate":[129],"on":[135,168,231],"arteries.":[137],"To":[138],"assess":[139],"hypothesis,":[141,226],"mesenteric":[142],"resistance":[143],"(MRA),":[145],"(+)":[147],"without":[149],"(-)":[150],"PVAT,":[151],"were":[152,176],"isolated":[153],"male":[155],"Fisher":[156],"344":[157],"rats":[158,241,294],"3":[160],"(3M)":[161],"or":[162,181,239,385],"16":[163],"months":[164],"(16M)":[165],"mounted":[167],"wire":[170],"myograph.":[171],"Phenylephrine":[172],"(PE)":[173],"concentration-response":[174],"curves":[175],"measured":[177],"presence":[180],"absence":[182,279],"LPL":[184,325,341],"activator,":[185],"NO-1886":[186,227,274,283],"(Ibrolipim,":[187],"10uM).":[188],"As":[189],"expected,":[190],"exerted":[192],"significant":[193],"MRA,":[197],"regardless":[198],"[PE":[201,242,295],"100uM":[202,243,296],"(%),":[203,244,297],"3M":[204,208,238,245,250,289,298,303],"(-PVAT):":[205,215],"112.4\u00b113.3":[206,301],"vs.":[207,217,249,261,302,314],"(+PVAT):":[209,219],"27.6\u00b128.5":[210],"{Figure":[211,221,254,266,307,319],"1.a.}":[212],"16M":[214,218,240,257,262,293,310,315],"115.4\u00b123.1":[216,313],"35.0\u00b134.1":[220],"1.b.}].":[222],"Contrary":[223],"had":[228],"no":[229,382],"(+PVAT":[246,251,258,263],"+vehicle):":[247,259,300,312],"30.0\u00b134.3":[248],"+NO-1886):":[252,264,305,317],"47.9\u00b129.8":[253],"1.c.}":[255],"48.6\u00b142.3":[260],"60.0\u00b136.9":[265],"1.d.}].":[267],"Surprisingly,":[268],"observed":[270],"MRA":[276],"PVAT.":[281],"significantly":[284],"decreased":[285],"phenylephrine-induced":[286],"contraction":[287,334],"rats,":[290],"but":[291],"not":[292,394],"(-PVAT":[299,304,311,316],"37.8\u00b122.2":[306],"1.e.}":[308],"103.1\u00b123.1":[318],"1.f.}].":[320],"Overall,":[321],"suggests":[323],"has":[326],"important":[328],"physiological":[329],"role":[330],"controlling":[332],"mechanism":[339],"diminishes":[342],"biological":[344],"age.":[345],"Funding:":[346],"NHLBI":[347],"(R00HL151889),":[348],"NIGMS":[349],"(1P20GM103641":[350],"-":[351],"Pilot":[352],"Project),":[353],"NIA":[354],"(K01AG061263),":[355],"UofSC":[356],"SOM":[357],"(Startup":[358],"funds)":[359],"This":[360],"full":[363],"abstract":[364],"presented":[365],"at":[366],"American":[368],"Physiology":[369,392],"Summit":[370],"2023":[371],"meeting":[372],"only":[375],"available":[376,388],"HTML":[378],"format.":[379],"There":[380],"are":[381],"additional":[383,386],"versions":[384],"content":[387],"for":[389],"abstract.":[391],"was":[393],"involved":[395],"peer":[398],"review":[399],"process.":[400]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-30T00:00:00"}
