{"id":"https://openalex.org/W4378611367","doi":"https://doi.org/10.1093/sleep/zsad077.0202","title":"0202 Sleep Deprivation: Cognitive Decline and Hippocampal Neuroinflammation","display_name":"0202 Sleep Deprivation: Cognitive Decline and Hippocampal Neuroinflammation","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4378611367","doi":"https://doi.org/10.1093/sleep/zsad077.0202"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/zsad077.0202","doi":"https://doi.org/10.1093/sleep/zsad077.0202","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsad077.0202","pdf_url":"https://academic.oup.com/sleep/article-pdf/46/Supplement_1/A89/50467045/zsad077.0202.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/sleep/article-pdf/46/Supplement_1/A89/50467045/zsad077.0202.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017680132","display_name":"Laura K. Olsen","orcid":"https://orcid.org/0000-0002-3577-9769","observed_orcids":["https://orcid.org/0000-0002-3577-9769"]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Olsen","raw_affiliation_strings":["Air Force Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Laboratory","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092040268","display_name":"Hunter McCubbins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter McCubbins","raw_affiliation_strings":["Air Force Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Laboratory","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012627514","display_name":"Raquel J. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raquel Moore","raw_affiliation_strings":["Air Force Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Laboratory","institution_ids":["https://openalex.org/I1280414376"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079215088","display_name":"Nathan M. Gargas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257593","display_name":"Naval Medical Research Unit DAYTON","ror":"https://ror.org/05egqah77","country_code":"US","type":"government","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141","https://openalex.org/I4405257593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Gargas","raw_affiliation_strings":["Naval Medical Research Unit Dayton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naval Medical Research Unit Dayton","institution_ids":["https://openalex.org/I4405257593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064201755","display_name":"Joyce G. Rohan","orcid":"https://orcid.org/0000-0001-5102-6639","observed_orcids":["https://orcid.org/0000-0001-5102-6639"]},"institutions":[{"id":"https://openalex.org/I4405257593","display_name":"Naval Medical Research Unit DAYTON","ror":"https://ror.org/05egqah77","country_code":"US","type":"government","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141","https://openalex.org/I4405257593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Rohan","raw_affiliation_strings":["Naval Medical Research Unit Dayton"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Naval Medical Research Unit Dayton","institution_ids":["https://openalex.org/I4405257593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071139212","display_name":"Candice N. Hatcher-Solis","orcid":"https://orcid.org/0000-0003-3084-2789","observed_orcids":["https://orcid.org/0000-0003-3084-2789"]},"institutions":[{"id":"https://openalex.org/I1280414376","display_name":"United States Air Force Research Laboratory","ror":"https://ror.org/02e2egq70","country_code":"US","type":"facility","lineage":["https://openalex.org/I1280414376","https://openalex.org/I1330347796","https://openalex.org/I4210102105","https://openalex.org/I4389425425"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Candice Hatcher-Solis","raw_affiliation_strings":["Air Force Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Air Force Research Laboratory","institution_ids":["https://openalex.org/I1280414376"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4018,"currency":"USD","value_usd":4018},"apc_paid":null,"fwci":0.1494,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42095409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"46","issue":"Supplement_1","first_page":"A89","last_page":"A90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.5170999765396118,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"sleep deprivation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8420000076293945},{"id":"https://openalex.org/keywords/hippocampal-neuroinflammation","display_name":"hippocampal inflammation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9229999780654907},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cxcl1","display_name":"CXCL1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/novel-object-recognition","display_name":"novel object recognition","score":0.8320000171661377},{"id":"https://openalex.org/keywords/passive-avoidance","display_name":"passive avoidance","score":0.8519999980926514},{"id":"https://openalex.org/keywords/declarative-memory","display_name":"declarative memory","score":0.8090000152587891},{"id":"https://openalex.org/keywords/neuroinflammation-biomarkers","display_name":"neuroinflammation biomarkers","score":0.7009999752044678},{"id":"https://openalex.org/keywords/sleep-and-cognition","display_name":"sleep and cognition","score":0.5920000076293945},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4300000071525574},{"id":"https://openalex.org/keywords/iba1","display_name":"Iba1","score":0.753000020980835},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/proinflammatory-chemokines","display_name":"inflammatory chemokines","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7851841449737549},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.7688858509063721},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7231099605560303},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.565041184425354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5358328819274902},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.5353876352310181},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5177971124649048},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.490092396736145},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.47741782665252686},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.33689308166503906},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.1477069854736328},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.06426796317100525},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/sleep/zsad077.0202","doi":"https://doi.org/10.1093/sleep/zsad077.0202","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsad077.0202","pdf_url":"https://academic.oup.com/sleep/article-pdf/46/Supplement_1/A89/50467045/zsad077.0202.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/sleep/zsad077.0202","doi":"https://doi.org/10.1093/sleep/zsad077.0202","is_oa":true,"landing_page_url":"https://doi.org/10.1093/sleep/zsad077.0202","pdf_url":"https://academic.oup.com/sleep/article-pdf/46/Supplement_1/A89/50467045/zsad077.0202.pdf","source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SLEEP","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8876996369","display_name":null,"funder_award_id":"N00014","funder_id":"https://openalex.org/F4320337345","funder_display_name":"Office of Naval Research"}],"funders":[{"id":"https://openalex.org/F4320333591","display_name":"Multidisciplinary University Research Initiative","ror":null},{"id":"https://openalex.org/F4320337345","display_name":"Office of Naval Research","ror":"https://ror.org/00rk2pe57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378611367.pdf","grobid_xml":"https://content.openalex.org/works/W4378611367.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2753493120","https://openalex.org/W3113939951","https://openalex.org/W4400742003","https://openalex.org/W4385603847","https://openalex.org/W2086098771","https://openalex.org/W3209553814","https://openalex.org/W4400798412","https://openalex.org/W2969172532","https://openalex.org/W2187603047","https://openalex.org/W3179268784"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"A":[2],"highly":[3],"conserved":[4],"biological":[5],"process,":[6],"sleep":[7],"is":[8,289],"imperative":[9],"for":[10],"healthy":[11],"brain":[12],"function.":[13],"Sleep":[14],"deprivation":[15],"(SD)":[16],"disrupts":[17],"cognition":[18],"and":[19,68,95,105,114,145,161,218],"increases":[20],"susceptibility":[21],"to":[22,28,122,256,267],"neurological":[23],"disorders.":[24],"The":[25,116],"first":[26],"step":[27],"developing":[29],"mitigation":[30],"strategies,":[31],"this":[32,271],"study":[33],"investigated":[34],"mechanisms":[35],"underlying":[36],"sleep-induced":[37],"cognitive":[38,73,139,228,302],"impairment,":[39],"including":[40],"hippocampal":[41,85,165,199,245],"neuroinflammation.":[42],"Methods":[43],"All":[44],"animal":[45],"activities":[46],"were":[47,110],"approved":[48],"under":[49],"an":[50],"IACUC":[51],"protocol.":[52],"Male":[53],"Sprague-Dawley":[54],"rats":[55,135,206],"(N":[56],"=":[57,76,93,100],"50)":[58],"underwent":[59],"120":[60],"h":[61,131],"of":[62,84,125,150,157,184,194,210,239,244],"SD.":[63],"Novel":[64],"Object":[65],"Recognition":[66],"(NOR)":[67],"Passive-Avoidance":[69],"Task":[70],"(PAT)":[71],"assessed":[72],"performance":[74,140,279],"(n":[75],"6-12),":[77],"followed":[78],"by":[79],"humane":[80],"euthanization.":[81],"Protein":[82],"analysis":[83,203],"tissue":[86],"was":[87,120,167,177,188,230],"performed":[88],"using":[89,112],"immunohistochemistry":[90],"(IHC,":[91],"n":[92,99],"3-6)":[94],"enzyme-linked":[96],"immunoassay":[97],"(ELISA,":[98],"8-13).":[101],"Microglia":[102],"(Iba-1":[103],"marker)":[104,108],"astrocyte":[106],"(GFAP":[107],"populations":[109],"quantified":[111],"IHC":[113],"ImageJ.":[115],"ELISA":[117,202],"V-PLEX":[118],"assay":[119],"used":[121],"assess":[123],"concentration":[124],"pro-/anti-inflammatory":[126],"mediators.":[127],"Results":[128],"Tested":[129],"24":[130],"after":[132,247,269],"training,":[133],"SD":[134,170,205,248],"had":[136,207],"significantly":[137],"lower":[138],"in":[141,153,175,180,192,197,223,236,258,296],"NOR":[142],"(p<":[143,147,159,163],"0.05)":[144,160,164,217],"PAT":[146],"0.01).":[148],"Percentage":[149],"Iba-1+":[151],"microglia":[152,176,234,252,282,294],"the":[154,181,224,240,297],"stratum":[155],"radiatum":[156],"CA1":[158],"CA2":[162],"subregions":[166,238],"higher":[168,208],"among":[169],"rats.":[171],"This":[172],"SD-induced":[173,227,278,301],"increase":[174,268],"not":[178,276],"found":[179,204],"pyramidal":[182],"layer":[183],"CA1/2/3":[185],"(p>0.05).":[186,201],"There":[187],"no":[189],"SD-associated":[190],"change":[191],"percentage":[193],"GFAP+":[195],"astrocytes":[196],"any":[198],"subregion":[200],"levels":[209],"pro-inflammatory":[211,293],"chemokine":[212],"ligand":[213],"1":[214],"(CXCL1,":[215],"p<":[216],"anti-inflammatory":[219,273],"interleukin-10":[220],"(IL-10,":[221],"p=0.07)":[222],"hippocampus.":[225,241],"Conclusion":[226],"impairment":[229],"associated":[231],"with":[232],"increased":[233],"presence":[235],"CA1/2":[237,251,298],"Increased":[242],"expression":[243],"CXCL1":[246],"indicates":[249],"these":[250,286],"are":[253],"pro-inflammatory,":[254],"leading":[255],"neuroinflammation":[257],"regions":[259],"that":[260,291],"mediate":[261],"declarative":[262],"memory.":[263],"Although":[264],"IL-10":[265],"trended":[266],"SD,":[270],"neuroprotective":[272],"factor":[274],"did":[275],"prevent":[277,300],"decline":[280],"or":[281],"recruitment.":[283],"Based":[284],"on":[285],"findings,":[287],"it":[288],"suggested":[290],"blocking":[292],"pathways":[295],"may":[299],"dysfunction.":[303],"Support":[304],"(if":[305],"any)":[306],"AFOSR":[307],"grant":[308],"20RHCOR04":[309]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-05-29T00:00:00"}
