{"id":"https://openalex.org/W4378602148","doi":"https://doi.org/10.20944/preprints202305.1827.v1","title":"Leveraging Data from Spontaneous Animal Disease Models to Streamline Pharmaceutical Research: A Tale of Two Species","display_name":"Leveraging Data from Spontaneous Animal Disease Models to Streamline Pharmaceutical Research: A Tale of Two Species","publication_year":2023,"publication_date":"2023-05-26","ids":{"openalex":"https://openalex.org/W4378602148","doi":"https://doi.org/10.20944/preprints202305.1827.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202305.1827.v1","doi":"https://doi.org/10.20944/preprints202305.1827.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202305.1827.v1","pdf_url":"https://www.preprints.org/manuscript/202305.1827/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/manuscript/202305.1827/v1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031092581","display_name":"Jonathan Paul Mochel","orcid":"https://orcid.org/0000-0002-0997-3111","observed_orcids":["https://orcid.org/0000-0002-0997-3111","https://orcid.org/0000-0003-4349-1842"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jonathan P Mochel","raw_affiliation_strings":["Iowa State University College of Veterinary Medicine, Ames, IA, U.S"],"raw_orcid":"https://orcid.org/0000-0002-0997-3111","affiliations":[{"raw_affiliation_string":"Iowa State University College of Veterinary Medicine, Ames, IA, U.S","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062945808","display_name":"Karin Allenspach","orcid":"https://orcid.org/0000-0002-2168-5809","observed_orcids":["https://orcid.org/0000-0002-2168-5809"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin Allenspach","raw_affiliation_strings":["Iowa State University College of Veterinary Medicine, Ames, IA, U.S"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iowa State University College of Veterinary Medicine, Ames, IA, U.S","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031092581"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/veterinary-drug-development","display_name":"veterinary drug development","score":0.6439999938011169},{"id":"https://openalex.org/keywords/drug-attrition","display_name":"drug attrition","score":0.6859999895095825},{"id":"https://openalex.org/keywords/human-veterinary-medicine-collaboration","display_name":"human-veterinary medicine collaboration","score":0.7039999961853027},{"id":"https://openalex.org/keywords/in-silico-modeling","display_name":"in silico modeling","score":0.6129999756813049},{"id":"https://openalex.org/keywords/chatgpt","display_name":"ChatGPT","score":0.7990000247955322},{"id":"https://openalex.org/keywords/comparative-pharmacology","display_name":"comparative pharmacology","score":0.5509999990463257},{"id":"https://openalex.org/keywords/canine-model","display_name":"canine model","score":0.3790000081062317},{"id":"https://openalex.org/keywords/zebrafish-model","display_name":"zebrafish model","score":0.4950000047683716},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.35600000619888306},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C134448949","wikidata":"https://www.wikidata.org/wiki/Q1384274","display_name":"Expediting","level":2,"score":0.8043798208236694},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.6595083475112915},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6263324618339539},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.522132933139801},{"id":"https://openalex.org/C2776190711","wikidata":"https://www.wikidata.org/wiki/Q7398663","display_name":"Safety pharmacology","level":3,"score":0.5045696496963501},{"id":"https://openalex.org/C2779652045","wikidata":"https://www.wikidata.org/wiki/Q507443","display_name":"Pharmaceutical industry","level":2,"score":0.4797471761703491},{"id":"https://openalex.org/C2780553607","wikidata":"https://www.wikidata.org/wiki/Q684868","display_name":"Attrition","level":2,"score":0.47673356533050537},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.45147955417633057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4434356689453125},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4167676866054535},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3966406583786011},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39377039670944214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33777692914009094},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.32930347323417664},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.23880717158317566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17333245277404785},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14411836862564087},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12649595737457275},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.20944/preprints202305.1827.v1","doi":"https://doi.org/10.20944/preprints202305.1827.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202305.1827.v1","pdf_url":"https://www.preprints.org/manuscript/202305.1827/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:dr.lib.iastate.edu:20.500.12876/GvqXLjQw","doi":null,"is_oa":false,"landing_page_url":"https://dr.lib.iastate.edu/handle/20.500.12876/GvqXLjQw","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.20944/preprints202305.1827.v1","raw_type":"preprint"}],"best_oa_location":{"id":"doi:10.20944/preprints202305.1827.v1","doi":"https://doi.org/10.20944/preprints202305.1827.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202305.1827.v1","pdf_url":"https://www.preprints.org/manuscript/202305.1827/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378602148.pdf","grobid_xml":"https://content.openalex.org/works/W4378602148.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1618969794","https://openalex.org/W1837584675","https://openalex.org/W1843386835","https://openalex.org/W1988559554","https://openalex.org/W2008704689","https://openalex.org/W2014281284","https://openalex.org/W2015796769","https://openalex.org/W2019637349","https://openalex.org/W2037555056","https://openalex.org/W2046891147","https://openalex.org/W2053608807","https://openalex.org/W2059931557","https://openalex.org/W2064349256","https://openalex.org/W2065540447","https://openalex.org/W2065667765","https://openalex.org/W2067758828","https://openalex.org/W2074280408","https://openalex.org/W2079244895","https://openalex.org/W2110062302","https://openalex.org/W2124210118","https://openalex.org/W2137241963","https://openalex.org/W2138184370","https://openalex.org/W2144294011","https://openalex.org/W2150435288","https://openalex.org/W2152136948","https://openalex.org/W2155415193","https://openalex.org/W2159334576","https://openalex.org/W2161243330","https://openalex.org/W2169963604","https://openalex.org/W2184767680","https://openalex.org/W2273267066","https://openalex.org/W2282335838","https://openalex.org/W2315431476","https://openalex.org/W2520071633","https://openalex.org/W2564241908","https://openalex.org/W2746653107","https://openalex.org/W2767053399","https://openalex.org/W2769599060","https://openalex.org/W2774212947","https://openalex.org/W2794085009","https://openalex.org/W2794596423","https://openalex.org/W2800580693","https://openalex.org/W2801063062","https://openalex.org/W2804506591","https://openalex.org/W2893429695","https://openalex.org/W2900464975","https://openalex.org/W2904087431","https://openalex.org/W2905330024","https://openalex.org/W2941080670","https://openalex.org/W2953190776","https://openalex.org/W2954279236","https://openalex.org/W2956479787","https://openalex.org/W2996531254","https://openalex.org/W2997817424","https://openalex.org/W3008937982","https://openalex.org/W3016594809","https://openalex.org/W3026182383","https://openalex.org/W3048201207","https://openalex.org/W3085218709","https://openalex.org/W3127952885","https://openalex.org/W3138905382","https://openalex.org/W3206798151","https://openalex.org/W3211082276","https://openalex.org/W3213676173","https://openalex.org/W3215857683","https://openalex.org/W4206888178","https://openalex.org/W4210432799","https://openalex.org/W4214831079","https://openalex.org/W4283028457","https://openalex.org/W4286209076","https://openalex.org/W4287490451","https://openalex.org/W4318832083","https://openalex.org/W4322100317","https://openalex.org/W4323294673","https://openalex.org/W4367323606","https://openalex.org/W4378602148"],"related_works":["https://openalex.org/W7125935166","https://openalex.org/W4409203956","https://openalex.org/W2769599060","https://openalex.org/W2334703889","https://openalex.org/W7165796054","https://openalex.org/W3043746766","https://openalex.org/W3187073605","https://openalex.org/W2604940472","https://openalex.org/W2000053231","https://openalex.org/W4213440079"],"abstract_inverted_index":{"According":[0],"to":[1,19,42,45,57,81,102,130,143,191,296,304,321,346,376,404,410],"data":[2,155,224],"from":[3,14,116,157,318,420],"the":[4,7,43,54,59,83,141,199,207,219,273,279,298,315,319,361,382,394,412],"U.S":[5],"FDA,":[6],"likelihood":[8],"of":[9,34,86,167,202,215,221,281,311,337,366,381,385,396,408],"a":[10,30,70,231,305,308,378],"new":[11],"drug":[12,146,176],"progressing":[13],"Phase":[15,38],"I":[16],"clinical":[17,47,117,127,159,216],"trials":[18,118],"market":[20,322],"approval":[21],"is":[22,112],"only":[23],"8%":[24],"(DiMasi":[25],"et":[26,105,162,240],"al.,":[27,106,163,241],"2016).":[28],"Furthermore,":[29],"significant":[31],"attrition":[32,209],"rate":[33],"35%":[35],"occurs":[36],"during":[37],"II":[39],"studies":[40,160],"due":[41],"failure":[44],"demonstrate":[46],"efficacy":[48],"(Arrowsmith,":[49],"2011).":[50],"These":[51],"statistics":[52],"underscore":[53],"urgent":[55],"need":[56],"reassess":[58],"current":[60],"research":[61,92,356],"and":[62,124,153,178,223,227,253,258,268,278,283],"development":[63,147,177,280],"(R&D)":[64],"paradigm.":[65],"To":[66,391],"address":[67],"this":[68,137,244,330,372],"challenge,":[69],"promising":[71],"approach":[72,138,246],"called":[73],"reverse":[74,168,290,340],"translational":[75,169,291,341],"pharmacology":[76,170,292],"(RTP)":[77],"has":[78,343],"emerged,":[79],"aiming":[80],"enhance":[82,198],"predictive":[84,200],"value":[85,384,395],"preclinical":[87,203],"models":[88,96,185],"used":[89,345],"in":[90,119,194,212,236,354,388,398],"biomedical":[91],"by":[93,148],"leveraging":[94,149],"animal":[95,184],"that":[97,113,186],"spontaneously":[98],"develop":[99,188],"analogous":[100],"diseases":[101,189,338],"humans":[103],"(Schneider":[104,161,239],"2018).":[107,164,242],"The":[108,165],"rationale":[109],"behind":[110],"RTP":[111],"knowledge":[114,222],"gained":[115],"canines":[120],"can":[121,197,271],"subsequently":[122],"inform":[123],"guide":[125],"human":[126,158,226],"trials,":[128],"leading":[129],"improved":[131],"outcomes":[132],"for":[133,174,275,286],"both":[134,237],"species.":[135,328],"Additionally,":[136],"capitalizes":[139],"on":[140],"opportunity":[142],"stimulate":[144],"veterinary":[145,228,259],"pharmacokinetic":[150],"(PK),":[151],"efficacy,":[152],"safety":[154],"obtained":[156],"application":[166],"holds":[171],"immense":[172],"potential":[173],"expediting":[175],"advancing":[179],"medical":[180],"knowledge.":[181],"By":[182,264],"employing":[183],"naturally":[187],"akin":[190],"those":[192],"found":[193],"humans,":[195],"researchers":[196],"capacity":[201],"models,":[204],"thereby":[205],"mitigating":[206],"high":[208],"rates":[210],"encountered":[211],"later":[213],"stages":[214],"trials.":[217],"Moreover,":[218],"exchange":[220],"between":[225,251],"medicine":[229],"engenders":[230],"synergistic":[232],"relationship,":[233],"fostering":[234,249],"progress":[235],"domains":[238],"As":[243],"innovative":[245],"gains":[247],"momentum,":[248],"collaborations":[250],"basic":[252],"clinician":[254],"scientists,":[255],"pharmaceutical":[256,348],"companies,":[257],"professionals":[260],"becomes":[261],"increasingly":[262],"imperative.":[263],"sharing":[265],"resources,":[266],"expertise,":[267],"findings,":[269],"we":[270,333,401],"pave":[272],"way":[274],"groundbreaking":[276],"discoveries":[277],"safe":[282],"efficacious":[284],"treatments":[285],"diverse":[287],"diseases.":[288],"Embracing":[289],"offers":[293],"an":[294],"avenue":[295],"redefine":[297],"R&D":[299],"paradigm,":[300],"bringing":[301],"us":[302],"closer":[303],"future":[306],"where":[307,339],"higher":[309],"proportion":[310],"drugs":[312],"successfully":[313],"traverse":[314],"arduous":[316],"path":[317],"laboratory":[320,357],"approval,":[323],"ultimately":[324],"benefiting":[325],"patients":[326],"across":[327],"In":[329,369],"brief":[331,379],"commentary,":[332],"highlight":[334],"four":[335],"examples":[336],"modeling":[342],"been":[344],"support":[347],"research,":[349],"including":[350],"some":[351,406],"applications":[352],"developed":[353],"our":[355],"(SMART":[358],"Pharmacology)":[359],"at":[360],"Iowa":[362],"State":[363],"University":[364],"College":[365],"Veterinary":[367],"Medicine.":[368],"doing":[370],"so,":[371],"report":[373],"also":[374],"seeks":[375],"provide":[377],"overview":[380],"heuristic":[383],"computational":[386],"approaches":[387],"comparative":[389],"research.":[390],"further":[392],"illustrate":[393],"these":[397],"silico":[399],"approaches,":[400],"deliberately":[402],"chose":[403],"employ":[405],"features":[407],"ChatGPT":[409],"produce":[411],"present":[413],"summary":[414],"(OpenAI.":[415],"(2023).":[416],"GPT-3.5":[417],"[ChatGPT].":[418],"Retrieved":[419],"https://openai.com).":[421]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-05-29T00:00:00"}