{"id":"https://openalex.org/W4378349643","doi":"https://doi.org/10.1007/s13205-023-03636-6","title":"Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges","display_name":"Vinca alkaloids as a potential cancer therapeutics: recent update and future challenges","publication_year":2023,"publication_date":"2023-05-24","ids":{"openalex":"https://openalex.org/W4378349643","doi":"https://doi.org/10.1007/s13205-023-03636-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/37251731","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10209376"},"language":"en","primary_location":{"id":"doi:10.1007/s13205-023-03636-6","doi":"https://doi.org/10.1007/s13205-023-03636-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13205-023-03636-6","pdf_url":null,"source":{"id":"https://openalex.org/S4210190239","display_name":"3 Biotech","issn_l":"2190-5738","issn":["2190-5738","2190-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10209376/pdf/13205_2023_Article_3636.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056570590","display_name":"Aditya Banyal","orcid":"https://orcid.org/0000-0001-9217-761X","observed_orcids":["https://orcid.org/0000-0001-9217-761X"]},"institutions":[{"id":"https://openalex.org/I4210133311","display_name":"Shoolini University","ror":"https://ror.org/02xe2fg84","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210133311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aditya Banyal","raw_affiliation_strings":["Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India","institution_ids":["https://openalex.org/I4210133311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039207032","display_name":"Shubham Kumar Tiwari","orcid":"https://orcid.org/0000-0002-7278-6714","observed_orcids":["https://orcid.org/0000-0002-7278-6714"]},"institutions":[{"id":"https://openalex.org/I4405274630","display_name":"IMS Ghaziabad","ror":"https://ror.org/022ae6971","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405274630"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubham Tiwari","raw_affiliation_strings":["IMS Engineering College, Ghaziabad, Uttar Pradesh, 201009, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMS Engineering College, Ghaziabad, Uttar Pradesh, 201009, India","institution_ids":["https://openalex.org/I4405274630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037641574","display_name":"Aparajita Sharma","orcid":"https://orcid.org/0000-0002-9305-0167","observed_orcids":["https://orcid.org/0000-0002-9305-0167"]},"institutions":[{"id":"https://openalex.org/I4210133311","display_name":"Shoolini University","ror":"https://ror.org/02xe2fg84","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210133311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aparajita Sharma","raw_affiliation_strings":["Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India","institution_ids":["https://openalex.org/I4210133311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045601267","display_name":"Ishita Chanana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133311","display_name":"Shoolini University","ror":"https://ror.org/02xe2fg84","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210133311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ishita Chanana","raw_affiliation_strings":["Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India","institution_ids":["https://openalex.org/I4210133311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086059551","display_name":"Sanjay K. S. Patel","orcid":"https://orcid.org/0000-0003-1658-0911","observed_orcids":["https://orcid.org/0000-0003-1658-0911"]},"institutions":[{"id":"https://openalex.org/I24062138","display_name":"Konkuk University","ror":"https://ror.org/025h1m602","country_code":"KR","type":"education","lineage":["https://openalex.org/I24062138"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sanjay Kumar Singh Patel","raw_affiliation_strings":["Department of Chemical Engineering, Konkuk University, 1 Hwayang-Dong, Gwangjin-Gu, Seoul, 143-701, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Konkuk University, 1 Hwayang-Dong, Gwangjin-Gu, Seoul, 143-701, South Korea","institution_ids":["https://openalex.org/I24062138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002249543","display_name":"Saurabh Kulshrestha","orcid":"https://orcid.org/0000-0003-0351-9425","observed_orcids":["https://orcid.org/0000-0003-0351-9425"]},"institutions":[{"id":"https://openalex.org/I4210133311","display_name":"Shoolini University","ror":"https://ror.org/02xe2fg84","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210133311"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saurabh Kulshrestha","raw_affiliation_strings":["Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India","institution_ids":["https://openalex.org/I4210133311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022295353","display_name":"Pradeep Kumar","orcid":"https://orcid.org/0000-0002-1563-8360","observed_orcids":["https://orcid.org/0000-0002-1563-8360"]},"institutions":[{"id":"https://openalex.org/I4210133311","display_name":"Shoolini University","ror":"https://ror.org/02xe2fg84","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210133311"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Pradeep Kumar","raw_affiliation_strings":["Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India"],"raw_orcid":"https://orcid.org/0000-0002-1563-8360","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Faculty of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India","institution_ids":["https://openalex.org/I4210133311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5022295353"],"corresponding_institution_ids":["https://openalex.org/I4210133311"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":2.3091,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.90494522,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"13","issue":"6","first_page":"211","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.3522999882698059,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":0.3522999882698059,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.19840000569820404,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.07829999923706055,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vinca-alkaloids","display_name":"vinca alkaloids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9700000286102295},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":1.0},{"id":"https://openalex.org/keywords/vindesine","display_name":"vindesine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vinflunine","display_name":"vinflunine","score":1.0},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endophytes","display_name":"endophytes","score":0.5730000138282776},{"id":"https://openalex.org/keywords/microbial-production","display_name":"microbial production","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.722000002861023},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.460999995470047},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.7200000286102295},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2777096885","wikidata":"https://www.wikidata.org/wiki/Q220925","display_name":"Vinca","level":2,"score":0.9831395149230957},{"id":"https://openalex.org/C2779321808","wikidata":"https://www.wikidata.org/wiki/Q416660","display_name":"Vindesine","level":5,"score":0.8255318999290466},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.7977883815765381},{"id":"https://openalex.org/C2776553716","wikidata":"https://www.wikidata.org/wiki/Q3559405","display_name":"Vinca alkaloid","level":5,"score":0.7771018743515015},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5713363885879517},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.49291396141052246},{"id":"https://openalex.org/C2776387010","wikidata":"https://www.wikidata.org/wiki/Q408717","display_name":"Eribulin","level":5,"score":0.4397219717502594},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37592706084251404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.349010169506073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30155885219573975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1359577178955078},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10146781802177429},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.0},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s13205-023-03636-6","doi":"https://doi.org/10.1007/s13205-023-03636-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13205-023-03636-6","pdf_url":null,"source":{"id":"https://openalex.org/S4210190239","display_name":"3 Biotech","issn_l":"2190-5738","issn":["2190-5738","2190-572X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10209376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10209376","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10209376/pdf/13205_2023_Article_3636.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"Text"},{"id":"pmid:37251731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37251731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10209376","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10209376","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10209376/pdf/13205_2023_Article_3636.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3 Biotech","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378349643.pdf","grobid_xml":"https://content.openalex.org/works/W4378349643.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W15130276","https://openalex.org/W87269140","https://openalex.org/W1002487401","https://openalex.org/W1516737592","https://openalex.org/W1546134915","https://openalex.org/W1556429708","https://openalex.org/W1566005643","https://openalex.org/W1568814144","https://openalex.org/W1586881149","https://openalex.org/W1667651110","https://openalex.org/W1847513783","https://openalex.org/W1887659457","https://openalex.org/W1967807712","https://openalex.org/W1969171959","https://openalex.org/W1969654418","https://openalex.org/W1969926777","https://openalex.org/W1970699966","https://openalex.org/W1974842306","https://openalex.org/W1977805668","https://openalex.org/W1983347917","https://openalex.org/W1983496231","https://openalex.org/W1985741407","https://openalex.org/W1987686562","https://openalex.org/W1988171478","https://openalex.org/W1991452107","https://openalex.org/W1993062033","https://openalex.org/W1996331958","https://openalex.org/W1997953737","https://openalex.org/W2002692802","https://openalex.org/W2003169606","https://openalex.org/W2003228352","https://openalex.org/W2003579148","https://openalex.org/W2008118175","https://openalex.org/W2013206317","https://openalex.org/W2017343996","https://openalex.org/W2018671039","https://openalex.org/W2021009957","https://openalex.org/W2034676634","https://openalex.org/W2037174072","https://openalex.org/W2041190905","https://openalex.org/W2042172246","https://openalex.org/W2042598293","https://openalex.org/W2043618186","https://openalex.org/W2044180484","https://openalex.org/W2046255241","https://openalex.org/W2047453476","https://openalex.org/W2052435626","https://openalex.org/W2059454816","https://openalex.org/W2060049931","https://openalex.org/W2060921851","https://openalex.org/W2061938790","https://openalex.org/W2063356925","https://openalex.org/W2064885466","https://openalex.org/W2066465524","https://openalex.org/W2072149928","https://openalex.org/W2072874043","https://openalex.org/W2075772198","https://openalex.org/W2076266168","https://openalex.org/W2077576626","https://openalex.org/W2088468317","https://openalex.org/W2091181960","https://openalex.org/W2091224013","https://openalex.org/W2091505367","https://openalex.org/W2102116016","https://openalex.org/W2103286528","https://openalex.org/W2105945817","https://openalex.org/W2107100864","https://openalex.org/W2110133792","https://openalex.org/W2117436302","https://openalex.org/W2120322088","https://openalex.org/W2136266267","https://openalex.org/W2137183387","https://openalex.org/W2139388578","https://openalex.org/W2140097914","https://openalex.org/W2144217762","https://openalex.org/W2150115483","https://openalex.org/W2152817797","https://openalex.org/W2155176893","https://openalex.org/W2159356563","https://openalex.org/W2162960688","https://openalex.org/W2165073656","https://openalex.org/W2165785619","https://openalex.org/W2208296613","https://openalex.org/W2293069240","https://openalex.org/W2317906320","https://openalex.org/W2319280819","https://openalex.org/W2338544942","https://openalex.org/W2407285556","https://openalex.org/W2419087510","https://openalex.org/W2419222424","https://openalex.org/W2541026916","https://openalex.org/W2565647299","https://openalex.org/W2603263749","https://openalex.org/W2624972177","https://openalex.org/W2741271627","https://openalex.org/W2746450705","https://openalex.org/W2747359867","https://openalex.org/W2789706157","https://openalex.org/W2801317575","https://openalex.org/W2805586762","https://openalex.org/W2810294944","https://openalex.org/W2895263852","https://openalex.org/W2899995514","https://openalex.org/W2901749071","https://openalex.org/W2901793231","https://openalex.org/W2931555111","https://openalex.org/W2983136628","https://openalex.org/W2984690752","https://openalex.org/W2990921223","https://openalex.org/W3000451288","https://openalex.org/W3008019918","https://openalex.org/W3010211463","https://openalex.org/W3034993153","https://openalex.org/W3137186329","https://openalex.org/W3164075292","https://openalex.org/W4205586680","https://openalex.org/W4210738594","https://openalex.org/W4211071303","https://openalex.org/W4213362193","https://openalex.org/W4220722634","https://openalex.org/W4232624341","https://openalex.org/W4281836397","https://openalex.org/W4299333187","https://openalex.org/W4300773906"],"related_works":["https://openalex.org/W2810294944","https://openalex.org/W7162285345","https://openalex.org/W6894114685","https://openalex.org/W7108440897","https://openalex.org/W7172003014","https://openalex.org/W7217847212","https://openalex.org/W7024565985","https://openalex.org/W2523277769","https://openalex.org/W7084141642","https://openalex.org/W3037627544"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":48},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-05-27T00:00:00"}
