{"id":"https://openalex.org/W4378348182","doi":"https://doi.org/10.3389/fphar.2023.1154743","title":"Nephroprotective mechanisms of Rhizoma Chuanxiong and Radix et Rhizoma Rhei against acute renal injury and renal fibrosis based on network pharmacology and experimental validation","display_name":"Nephroprotective mechanisms of Rhizoma Chuanxiong and Radix et Rhizoma Rhei against acute renal injury and renal fibrosis based on network pharmacology and experimental validation","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W4378348182","doi":"https://doi.org/10.3389/fphar.2023.1154743","pmid":"https://pubmed.ncbi.nlm.nih.gov/37229255","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10203597"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2023.1154743","doi":"https://doi.org/10.3389/fphar.2023.1154743","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2023.1154743","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fphar.2023.1154743","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100362045","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-1945-1584","observed_orcids":["https://orcid.org/0000-0003-1945-1584"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102437892","display_name":"Tonglu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tonglu Li","raw_affiliation_strings":["Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081016578","display_name":"Zongping Li","orcid":"https://orcid.org/0000-0002-6079-8339","observed_orcids":["https://orcid.org/0000-0002-6079-8339"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zongping Li","raw_affiliation_strings":["Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075748361","display_name":"Zhiyong Song","orcid":"https://orcid.org/0000-0002-2552-5239","observed_orcids":["https://orcid.org/0000-0002-2552-5239"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Song","raw_affiliation_strings":["Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072983863","display_name":"Xuezhong Gong","orcid":"https://orcid.org/0000-0002-4496-7972","observed_orcids":["https://orcid.org/0000-0002-4496-7972"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuezhong Gong","raw_affiliation_strings":["Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072983863"],"corresponding_institution_ids":["https://openalex.org/I4210098460"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":4.6411,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.95397816,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"14","issue":null,"first_page":"1154743","last_page":"1154743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.711899995803833,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.19699999690055847,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chuanxiong-rhizoma","display_name":"Rhizoma Chuanxiong","score":0.9729999899864197},{"id":"https://openalex.org/keywords/rhei-radix-et-rhizoma","display_name":"Radix et Rhizoma Rhei","score":0.9359999895095825},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9319999814033508},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.9509999752044678},{"id":"https://openalex.org/keywords/aloe-emodin","display_name":"aloe-emodin","score":0.8889999985694885},{"id":"https://openalex.org/keywords/catechins","display_name":"catechins","score":0.8700000047683716},{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.9599999785423279},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.9940000176429749},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.8560000061988831},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.7919999957084656},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4790000021457672},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tubular-epithelial-cells","display_name":"tubular epithelial cells","score":0.7170000076293945},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6510732769966125},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6260746121406555},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5883764624595642},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5703549385070801},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.5429378151893616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5045362710952759},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5043817758560181},{"id":"https://openalex.org/C2778248515","wikidata":"https://www.wikidata.org/wiki/Q4348178","display_name":"Emodin","level":2,"score":0.48375749588012695},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.44956398010253906},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4249553680419922},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3249010741710663},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30756253004074097},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18126264214515686},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14956700801849365},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14571228623390198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fphar.2023.1154743","doi":"https://doi.org/10.3389/fphar.2023.1154743","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2023.1154743","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10203597","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10203597","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10203597/pdf/fphar-14-1154743.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Pharmacol","raw_type":"Text"},{"id":"pmid:37229255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37229255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:47b15824ca984e22aaeebdc4fa1b5e38","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47b15824ca984e22aaeebdc4fa1b5e38","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2023.1154743","doi":"https://doi.org/10.3389/fphar.2023.1154743","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2023.1154743","pdf_url":null,"source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3165799629","display_name":null,"funder_award_id":"2021-2023","funder_id":"https://openalex.org/F4320317789","funder_display_name":"Shanghai Municipal Health Commission"},{"id":"https://openalex.org/G3193396747","display_name":null,"funder_award_id":"2021\u20132023","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3526987538","display_name":null,"funder_award_id":"81873280","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5195330193","display_name":null,"funder_award_id":"82074387","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5608103779","display_name":null,"funder_award_id":"2021-2023","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G590125206","display_name":null,"funder_award_id":"20Y21902200","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G6894747904","display_name":null,"funder_award_id":"20Y21902200","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317789","display_name":"Shanghai Municipal Health Commission","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1890766043","https://openalex.org/W1965699247","https://openalex.org/W1972949428","https://openalex.org/W1991997670","https://openalex.org/W2016179633","https://openalex.org/W2026274122","https://openalex.org/W2033637369","https://openalex.org/W2037544714","https://openalex.org/W2038358991","https://openalex.org/W2066113694","https://openalex.org/W2087627594","https://openalex.org/W2093260830","https://openalex.org/W2095931316","https://openalex.org/W2104916446","https://openalex.org/W2121963310","https://openalex.org/W2124679671","https://openalex.org/W2130542877","https://openalex.org/W2132304265","https://openalex.org/W2133465414","https://openalex.org/W2136709241","https://openalex.org/W2146081758","https://openalex.org/W2146512944","https://openalex.org/W2150906270","https://openalex.org/W2156935689","https://openalex.org/W2158217645","https://openalex.org/W2159675211","https://openalex.org/W2162151166","https://openalex.org/W2165901902","https://openalex.org/W2169605843","https://openalex.org/W2211041313","https://openalex.org/W2220742453","https://openalex.org/W2238892474","https://openalex.org/W2309065281","https://openalex.org/W2344169552","https://openalex.org/W2608333216","https://openalex.org/W2742084580","https://openalex.org/W2753916497","https://openalex.org/W2761927741","https://openalex.org/W2764162783","https://openalex.org/W2789964320","https://openalex.org/W2792870066","https://openalex.org/W2884509042","https://openalex.org/W2891652983","https://openalex.org/W2897245733","https://openalex.org/W2900460035","https://openalex.org/W2916095365","https://openalex.org/W2944989241","https://openalex.org/W2950233604","https://openalex.org/W2973523639","https://openalex.org/W2983166786","https://openalex.org/W2995148032","https://openalex.org/W2996643387","https://openalex.org/W3003245890","https://openalex.org/W3015312982","https://openalex.org/W3016622249","https://openalex.org/W3093586967","https://openalex.org/W3097145107","https://openalex.org/W3107527779","https://openalex.org/W3112376646","https://openalex.org/W3134165399","https://openalex.org/W3185008715","https://openalex.org/W3197482787","https://openalex.org/W3204445870","https://openalex.org/W3209089090","https://openalex.org/W3210331473","https://openalex.org/W4211157472","https://openalex.org/W4220699429","https://openalex.org/W4225253438","https://openalex.org/W4294808964"],"related_works":["https://openalex.org/W4281567647","https://openalex.org/W4406864119","https://openalex.org/W4405842381","https://openalex.org/W4386830730","https://openalex.org/W4413371248","https://openalex.org/W7119513057","https://openalex.org/W7124446084","https://openalex.org/W4413996966","https://openalex.org/W4413100109","https://openalex.org/W4411326472"],"abstract_inverted_index":{"The":[0,38,109,167],"molecular":[1],"mechanisms":[2],"of":[3,92,111,124,144,161,171],"Rhizoma":[4,12],"Chuanxiong":[5,84,152,189],"(Chuanxiong,":[6],"CX)":[7],"and":[8,21,35,45,53,57,75,85,96,128,141,153,169,190,198,203],"Rhei":[9],"Radix":[10],"et":[11],"(Dahuang,":[13],"DH)":[14],"in":[15,28,98,130,174],"treating":[16],"acute":[17,101,134,200],"kidney":[18,102,135,201],"injury":[19,103,136,202],"(AKI)":[20],"subsequent":[22],"renal":[23,204],"fibrosis":[24,205],"(RF)":[25],"were":[26,48,59,72,138,146],"investigated":[27],"this":[29],"study":[30],"by":[31,206],"applying":[32],"network":[33],"pharmacology":[34],"experimental":[36],"validation.":[37],"results":[39,110],"showed":[40,66,114],"that":[41,67,83,115,188],"aloe-emodin,":[42],"(\u2212)-catechin,":[43],"beta-sitosterol,":[44],"folic":[46],"acid":[47],"the":[49,60,68,73,90,118,121,131,142,158,179],"core":[50,61],"active":[51],"ingredients,":[52],"TP53,":[54],"AKT1,":[55],"CSF1R,":[56],"TGFBR1":[58],"target":[62],"genes.":[63],"Enrichment":[64],"analyses":[65],"key":[69],"signaling":[70,77],"pathways":[71],"MAPK":[74],"IL-17":[76],"pathways.":[78],"In":[79,182],"vivo":[80],"experiments":[81],"confirmed":[82],"Dahuang":[86,154,191],"pretreatments":[87],"significantly":[88,139,147,156],"inhibited":[89],"levels":[91,123,143,160],"SCr,":[93],"BUN,":[94],"UNAG,":[95],"UGGT":[97],"contrast":[99,132],"media-induced":[100,133],"(CIAKI)":[104],"rats":[105],"(p":[106,149,164],"<":[107,150,165],"0.001).":[108,151],"Western":[112],"blotting":[113],"compared":[116],"with":[117],"control":[119],"group,":[120],"protein":[122],"p-p38/p38":[125],"MAPK,":[126],"p53,":[127],"Bax":[129],"group":[137],"increased,":[140],"Bcl-2":[145],"reduced":[148],"interventions":[155],"reversed":[157],"expression":[159,173],"these":[162],"proteins":[163],"0.01).":[166],"localization":[168],"quantification":[170],"p-p53":[172],"immunohistochemistry":[175],"technology":[176],"also":[177,186],"support":[178],"aforementioned":[180],"results.":[181],"conclusion,":[183],"our":[184],"data":[185],"suggest":[187],"may":[192],"inhibit":[193],"tubular":[194],"epithelial":[195],"cell":[196],"apoptosis":[197],"improve":[199],"inhibiting":[207],"p38":[208],"MAPK/p53":[209],"signaling.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":7}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-05-27T00:00:00"}
