{"id":"https://openalex.org/W4378217841","doi":"https://doi.org/10.4314/rejhs.v11i2.5","title":"Comparison of the efficacy of atracurium pretreatment versus magnesium sulphate for prevention of suxamethonium-induced fasciculation and post-operative myalgia","display_name":"Comparison of the efficacy of atracurium pretreatment versus magnesium sulphate for prevention of suxamethonium-induced fasciculation and post-operative myalgia","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4378217841","doi":"https://doi.org/10.4314/rejhs.v11i2.5"},"language":"en","primary_location":{"id":"doi:10.4314/rejhs.v11i2.5","doi":"https://doi.org/10.4314/rejhs.v11i2.5","is_oa":true,"landing_page_url":"http://dx.doi.org/10.4314/rejhs.v11i2.5","pdf_url":"https://www.ajol.info/index.php/rejhs/article/download/248018/234575","source":{"id":"https://openalex.org/S4210209638","display_name":"Research Journal of Health Sciences","issn_l":"2360-7793","issn":["2360-7793","2467-8252"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":"https://openalex.org/P4310311025","host_organization_name":"Osun State University","host_organization_lineage":["https://openalex.org/P4310311025"],"host_organization_lineage_names":["Osun State University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Health Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ajol.info/index.php/rejhs/article/download/248018/234575","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114052598","display_name":"Emmanuel Oladayo Folami","orcid":"https://orcid.org/0000-0003-1503-1208","observed_orcids":["https://orcid.org/0000-0003-1503-1208"]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]},{"id":"https://openalex.org/I35601441","display_name":"Osun State University","ror":"https://ror.org/00e16h982","country_code":"NG","type":"education","lineage":["https://openalex.org/I35601441"]},{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]},{"id":"https://openalex.org/I45711476","display_name":"Obafemi Awolowo University","ror":"https://ror.org/04snhqa82","country_code":"NG","type":"education","lineage":["https://openalex.org/I45711476"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"E.O. Folami","raw_affiliation_strings":["Faculty of Basic medical Sciences , Osun State University , Osogbo , Nigeria","Faculty of Clinical Sciences, LAUTECH, Ogbomoso, Nigeria","Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria","Faculty of Clinical Sciences, Osun State University, Osogbo, Nigeria","Faculty of Clinical sciences, University of Ilorin, Ilorin, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Basic medical Sciences , Osun State University , Osogbo , Nigeria","institution_ids":["https://openalex.org/I35601441"]},{"raw_affiliation_string":"Faculty of Clinical Sciences, LAUTECH, Ogbomoso, Nigeria","institution_ids":["https://openalex.org/I45230691"]},{"raw_affiliation_string":"Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria","institution_ids":["https://openalex.org/I45711476"]},{"raw_affiliation_string":"Faculty of Clinical Sciences, Osun State University, Osogbo, Nigeria","institution_ids":["https://openalex.org/I35601441"]},{"raw_affiliation_string":"Faculty of Clinical sciences, University of Ilorin, Ilorin, Nigeria","institution_ids":["https://openalex.org/I134542131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112715827","display_name":"Tokunbo Olumide Olajumoke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T.O. Olajumoke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110395065","display_name":"IK Kolawole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35601441","display_name":"Osun State University","ror":"https://ror.org/00e16h982","country_code":"NG","type":"education","lineage":["https://openalex.org/I35601441"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"I.K. Kolawole","raw_affiliation_strings":["Faculty of Clinical Sciences , Osun State University , Osogbo , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Clinical Sciences , Osun State University , Osogbo , Nigeria","institution_ids":["https://openalex.org/I35601441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109350884","display_name":"Anne E. Ojo","orcid":"https://orcid.org/0000-0003-0384-448X","observed_orcids":["https://orcid.org/0000-0003-0384-448X"]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"A.K. Ojo","raw_affiliation_strings":["Faculty of Clinical Sciences , LAUTECH , Ogbomoso , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Clinical Sciences , LAUTECH , Ogbomoso , Nigeria","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070910541","display_name":"S. A. Raji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"S.A. Raji","raw_affiliation_strings":["Faculty of Clinical sciences , University of Ilorin , Ilorin , Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Clinical sciences , University of Ilorin , Ilorin , Nigeria","institution_ids":["https://openalex.org/I134542131"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056252149","display_name":"R.O. Folami","orcid":"https://orcid.org/0009-0000-7935-2153","observed_orcids":["https://orcid.org/0009-0000-7935-2153"]},"institutions":[{"id":"https://openalex.org/I35601441","display_name":"Osun State University","ror":"https://ror.org/00e16h982","country_code":"NG","type":"education","lineage":["https://openalex.org/I35601441"]},{"id":"https://openalex.org/I45711476","display_name":"Obafemi Awolowo University","ror":"https://ror.org/04snhqa82","country_code":"NG","type":"education","lineage":["https://openalex.org/I45711476"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"R.O. Folami","raw_affiliation_strings":["Faculty of Clinical Sciences , Obafemi Awolowo University , Ile-Ife , Nigeria","Faculty of Basic medical Sciences, Osun State University, Osogbo, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Clinical Sciences , Obafemi Awolowo University , Ile-Ife , Nigeria","institution_ids":["https://openalex.org/I45711476"]},{"raw_affiliation_string":"Faculty of Basic medical Sciences, Osun State University, Osogbo, Nigeria","institution_ids":["https://openalex.org/I35601441"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":150,"currency":"USD","value_usd":150},"apc_paid":{"value":150,"currency":"USD","value_usd":150},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11973109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"2","first_page":"119","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/succinylcholine","display_name":"succinylcholine","score":0.9729999899864197},{"id":"https://openalex.org/keywords/atracurium","display_name":"atracurium","score":0.8080000281333923},{"id":"https://openalex.org/keywords/magnesium-sulfate","display_name":"magnesium sulfate","score":1.0},{"id":"https://openalex.org/keywords/fasciculations","display_name":"fasciculations","score":0.8560000061988831},{"id":"https://openalex.org/keywords/postoperative-myalgia","display_name":"postoperative myalgia","score":0.9700000286102295},{"id":"https://openalex.org/keywords/rapid-sequence-induction","display_name":"rapid sequence induction","score":0.8949999809265137},{"id":"https://openalex.org/keywords/depolarizing-muscle-relaxants","display_name":"depolarizing muscle relaxants","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pretreatment","display_name":"pretreatment","score":0.5460000038146973},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.48899999260902405}],"concepts":[{"id":"https://openalex.org/C2778970341","wikidata":"https://www.wikidata.org/wiki/Q1397878","display_name":"Fasciculation","level":2,"score":0.9866420030593872},{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.9766267538070679},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8521785736083984},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5936363935470581},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.47917547821998596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33968794345855713}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4314/rejhs.v11i2.5","doi":"https://doi.org/10.4314/rejhs.v11i2.5","is_oa":true,"landing_page_url":"http://dx.doi.org/10.4314/rejhs.v11i2.5","pdf_url":"https://www.ajol.info/index.php/rejhs/article/download/248018/234575","source":{"id":"https://openalex.org/S4210209638","display_name":"Research Journal of Health Sciences","issn_l":"2360-7793","issn":["2360-7793","2467-8252"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":"https://openalex.org/P4310311025","host_organization_name":"Osun State University","host_organization_lineage":["https://openalex.org/P4310311025"],"host_organization_lineage_names":["Osun State University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Health Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4314/rejhs.v11i2.5","doi":"https://doi.org/10.4314/rejhs.v11i2.5","is_oa":true,"landing_page_url":"http://dx.doi.org/10.4314/rejhs.v11i2.5","pdf_url":"https://www.ajol.info/index.php/rejhs/article/download/248018/234575","source":{"id":"https://openalex.org/S4210209638","display_name":"Research Journal of Health Sciences","issn_l":"2360-7793","issn":["2360-7793","2467-8252"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jpps-2"],"host_organization":"https://openalex.org/P4310311025","host_organization_name":"Osun State University","host_organization_lineage":["https://openalex.org/P4310311025"],"host_organization_lineage_names":["Osun State University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Journal of Health Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4378217841.pdf","grobid_xml":"https://content.openalex.org/works/W4378217841.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W55750778","https://openalex.org/W1972595169","https://openalex.org/W2027515785","https://openalex.org/W2038496507","https://openalex.org/W2045673330","https://openalex.org/W2059617820","https://openalex.org/W2062980982","https://openalex.org/W2078872090","https://openalex.org/W2087488583","https://openalex.org/W2104152244","https://openalex.org/W2137495765","https://openalex.org/W2161931304","https://openalex.org/W2376615509","https://openalex.org/W2397855248","https://openalex.org/W2398364058","https://openalex.org/W4233086576","https://openalex.org/W4253093669"],"related_works":["https://openalex.org/W2381377734","https://openalex.org/W2887812776","https://openalex.org/W4378217841","https://openalex.org/W2063882534","https://openalex.org/W2336640109","https://openalex.org/W2129470006","https://openalex.org/W2391332520","https://openalex.org/W2397855248","https://openalex.org/W3013050310","https://openalex.org/W2355282582"],"abstract_inverted_index":{"Background:":[0],"Suxamethonium":[1],"remains":[2],"the":[3,12,29,53,102],"best":[4],"option":[5],"for":[6,34],"rapid":[7],"sequence":[8],"induction,":[9],"it":[10,191],"is":[11],"only":[13],"depolarizing":[14],"muscle":[15,41],"relaxant":[16,42],"in":[17,115,119,125,138,144,159,167,187,200,203,209],"clinical":[18],"use.":[19],"However,":[20],"fasciculation":[21,54,98,113,133,158,233],"and":[22,43,55,95,104,122,181,206,222,234],"myalgia":[23,56,108,175,197,217,236],"are":[24],"frequent":[25],"adverse":[26],"effects":[27],"of":[28,65,70,97,106,132,150,153,157,215],"drug.":[30],"Myalgia":[31],"can":[32],"last":[33],"several":[35],"days":[36],"with":[37,57],"associated":[38],"discomfort.":[39],"Non-depolarizing":[40],"magnesium":[44,88],"sulphate":[45,89,227],"have":[46],"been":[47],"tried":[48],"as":[49,99,101],"pretreatments":[50],"to":[51,78,136],"attenuate":[52],"varying":[58],"results.Methods:":[59],"A":[60,121,143,161,205],"double":[61],"blind,":[62],"randomized":[63],"study":[64],"100":[66],"adult":[67],"surgical":[68],"patients":[69,118,124,185,202,208],"ASA":[71],"I":[72],"or":[73,86],"II":[74],"Class":[75],"were":[76,109],"recruited":[77],"receive":[79],"either":[80],"intravenous":[81,87],"atracurium":[82,238],"(0.05mg/kg)":[83],"(Group":[84],"A)":[85],"(30mg/kg)(Group":[90],"B).":[91],"The":[92,130,213],"occurrence,":[93],"severity":[94,105,131,214],"duration":[96,156],"well":[100],"occurrence":[103],"post-operative":[107,216],"also":[110,146],"recorded.Results:":[111],"Muscle":[112],"occurred":[114],"39":[116],"(78%)":[117],"Group":[120,126,139,142,160],"27(54%)":[123],"B":[127,140,169],"(p=":[128,172],"0.001).":[129,173],"was":[134,176,198,224],"mild":[135],"moderate":[137],"while":[141,183],"addition":[145],"recorded":[147,218],"some":[148],"cases":[149],"severe":[151],"episodes":[152],"fasciculation.":[154],"Mean":[155],"waslonger":[162],"(28.48":[163],"\u00b1":[164],"1.07sec)":[165],"than":[166,237],"group":[168,204,210],"(19.44\u00b1":[170],"1.93seconds)":[171],"Post-operative":[174],"not":[177],"experienced":[178],"at":[179,192,220,231],"6hrs":[180],"48hrs,":[182],"2":[184],"(1":[186],"each":[188],"Group)":[189],"had":[190],"12hrs.":[193],"At":[194],"24hrs,":[195],"postoperative":[196,235],"present":[199],"13(26%)":[201],"5(10%)":[207],"B,":[211],"(p=0.043).":[212],"both":[219],"12hrs":[221],"24hrs":[223],"mild.Conclusion:":[225],"Magnesium":[226],"demonstrated":[228],"better":[229],"efficacy":[230],"reducing":[232]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}