{"id":"https://openalex.org/W4378215552","doi":"https://doi.org/10.1158/1078-0432.23183863.v1","title":"Supplementary Fig. 5 from Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial","display_name":"Supplementary Fig. 5 from Intravenous N-Acetylcysteine to Prevent Cisplatin-Induced Hearing Loss in Children: A Nonrandomized Controlled Phase I Trial","publication_year":2023,"publication_date":"2023-05-25","ids":{"openalex":"https://openalex.org/W4378215552","doi":"https://doi.org/10.1158/1078-0432.23183863.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.23183863.v1","doi":"https://doi.org/10.1158/1078-0432.23183863.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.23183863.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.23183863.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031092064","display_name":"Etan Orgel","orcid":"https://orcid.org/0000-0002-1487-6818","observed_orcids":["https://orcid.org/0000-0002-1487-6818"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Etan Orgel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1487-6818","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087837618","display_name":"Kristin R. Knight","orcid":"https://orcid.org/0000-0002-5701-3537","observed_orcids":["https://orcid.org/0000-0002-5701-3537"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin R. Knight","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5701-3537","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068806685","display_name":"Yueh\u2010Yun Chi","orcid":"https://orcid.org/0000-0002-9197-5684","observed_orcids":["https://orcid.org/0000-0002-9197-5684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yueh-Yun Chi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9197-5684","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060869564","display_name":"Jemily Malvar","orcid":"https://orcid.org/0000-0002-5481-6780","observed_orcids":["https://orcid.org/0000-0002-5481-6780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jemily Malvar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5481-6780","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028130799","display_name":"Teresa Rushing","orcid":"https://orcid.org/0000-0002-3655-7957","observed_orcids":["https://orcid.org/0000-0002-3655-7957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Rushing","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3655-7957","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078897768","display_name":"Victoria Mena","orcid":"https://orcid.org/0009-0006-3996-2284","observed_orcids":["https://orcid.org/0009-0006-3996-2284"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victoria Mena","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-3996-2284","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035415354","display_name":"Laurie S. Eisenberg","orcid":"https://orcid.org/0009-0000-0568-4462","observed_orcids":["https://orcid.org/0009-0000-0568-4462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laurie S. Eisenberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-0568-4462","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075134742","display_name":"Shahrad Rod Rassekh","orcid":"https://orcid.org/0000-0001-8005-2641","observed_orcids":["https://orcid.org/0000-0001-8005-2641"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shahrad R. Rassekh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8005-2641","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040356803","display_name":"Colin J. Ross","orcid":"https://orcid.org/0000-0003-1476-7037","observed_orcids":["https://orcid.org/0000-0003-1476-7037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin J.D. Ross","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1476-7037","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029848373","display_name":"Erika N. Scott","orcid":"https://orcid.org/0000-0003-4660-7206","observed_orcids":["https://orcid.org/0000-0003-4660-7206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika N. Scott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4660-7206","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026635936","display_name":"Michael Noel Neely","orcid":"https://orcid.org/0000-0002-1675-8276","observed_orcids":["https://orcid.org/0000-0002-1675-8276"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Neely","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1675-8276","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014536479","display_name":"Edward A. Neuwelt","orcid":"https://orcid.org/0000-0002-6679-6203","observed_orcids":["https://orcid.org/0000-0002-6679-6203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward A. Neuwelt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6679-6203","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048805399","display_name":"Leslie L. Muldoon","orcid":"https://orcid.org/0000-0001-5583-2304","observed_orcids":["https://orcid.org/0000-0001-5583-2304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslie L. Muldoon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5583-2304","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087224572","display_name":"David R. Freyer","orcid":"https://orcid.org/0000-0001-5280-990X","observed_orcids":["https://orcid.org/0000-0001-5280-990X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R. Freyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5280-990X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cisplatin-induced-hearing-loss","display_name":"cisplatin-induced hearing loss","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ototoxicity-prevention","display_name":"ototoxicity prevention","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pediatric-chemotherapy","display_name":"pediatric chemotherapy","score":0.578000009059906},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C2777847592","wikidata":"https://www.wikidata.org/wiki/Q375613","display_name":"Acetylcysteine","level":3,"score":0.8278200030326843},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.6666975021362305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5360897183418274},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.42155835032463074},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.41807034611701965},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4062117636203766},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2534789741039276},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1631629467010498},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.15912804007530212},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.12578058242797852},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07031136751174927},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.23183863.v1","doi":"https://doi.org/10.1158/1078-0432.23183863.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.23183863.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/23183863","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Fig_5_from_Intravenous_N-Acetylcysteine_to_Prevent_Cisplatin-Induced_Hearing_Loss_in_Children_A_Nonrandomized_Controlled_Phase_I_Trial/23183863","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.23183863.v1","doi":"https://doi.org/10.1158/1078-0432.23183863.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.23183863.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402817750","https://openalex.org/W4367840089","https://openalex.org/W4378215297","https://openalex.org/W4410092682","https://openalex.org/W2762058888","https://openalex.org/W4389152528","https://openalex.org/W1755671302","https://openalex.org/W4220991666","https://openalex.org/W2159499687","https://openalex.org/W4407143006"],"abstract_inverted_index":{"Supplementary":[0],"Fig.":[1],"5":[2],"Progression-free":[3],"survival":[4],"in":[5],"NAC":[6],"treated":[7],"and":[8],"observation":[9],"patients":[10]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-05-26T00:00:00"}