{"id":"https://openalex.org/W4378070914","doi":"https://doi.org/10.1016/j.drudis.2023.103641","title":"Modulating GPCR and 14-3-3 protein interactions: Prospects for CNS drug discovery","display_name":"Modulating GPCR and 14-3-3 protein interactions: Prospects for CNS drug discovery","publication_year":2023,"publication_date":"2023-05-24","ids":{"openalex":"https://openalex.org/W4378070914","doi":"https://doi.org/10.1016/j.drudis.2023.103641","pmid":"https://pubmed.ncbi.nlm.nih.gov/37236523","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10524340"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2023.103641","doi":"https://doi.org/10.1016/j.drudis.2023.103641","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drudis.2023.103641","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.drudis.2023.103641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010816146","display_name":"Sathapana Kongsamut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177880774","display_name":"Drew University","ror":"https://ror.org/04gds4h28","country_code":"US","type":"education","lineage":["https://openalex.org/I177880774"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sathapana Kongsamut","raw_affiliation_strings":["Research Institute for Scientists Emeriti, Drew University, 36 Madison Avenue, Madison, NJ 07940, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for Scientists Emeriti, Drew University, 36 Madison Avenue, Madison, NJ 07940, USA","institution_ids":["https://openalex.org/I177880774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101739600","display_name":"Haifeng Eishingdrelo","orcid":"https://orcid.org/0000-0001-7205-1008","observed_orcids":["https://orcid.org/0000-0001-7205-1008"]},"institutions":[{"id":"https://openalex.org/I4210104331","display_name":"BioInvenu (United States)","ror":"https://ror.org/00xsqes49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210104331"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haifeng Eishingdrelo","raw_affiliation_strings":["BioInvenu, 50 Williams Parkway, Unit A2, East Hanover, NJ 07936, USA. Electronic address: haifeng.eishingdrelo@bioinvenu.com","BioInvenu, 50 Williams Parkway, Unit A2, East Hanover, NJ 07936, USA"],"raw_orcid":"https://orcid.org/0000-0001-7205-1008","affiliations":[{"raw_affiliation_string":"BioInvenu, 50 Williams Parkway, Unit A2, East Hanover, NJ 07936, USA. Electronic address: haifeng.eishingdrelo@bioinvenu.com","institution_ids":["https://openalex.org/I4210104331"]},{"raw_affiliation_string":"BioInvenu, 50 Williams Parkway, Unit A2, East Hanover, NJ 07936, USA","institution_ids":["https://openalex.org/I4210104331"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101739600"],"corresponding_institution_ids":["https://openalex.org/I4210104331"],"apc_list":{"value":4820,"currency":"USD","value_usd":4820},"apc_paid":{"value":4820,"currency":"USD","value_usd":4820},"fwci":0.2373,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.2098849,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"28","issue":"8","first_page":"103641","last_page":"103641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13526","display_name":"14-3-3 protein interactions","score":0.25760000944137573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":1.0},{"id":"https://openalex.org/keywords/14-3-3-proteins","display_name":"14-3-3 proteins","score":1.0},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8859999775886536},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.640999972820282},{"id":"https://openalex.org/keywords/beta-arrestin-signaling","display_name":"\u03b2-arrestin signaling","score":0.8019999861717224},{"id":"https://openalex.org/keywords/gpcr-trafficking","display_name":"GPCR trafficking","score":0.8019999861717224},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.765999972820282},{"id":"https://openalex.org/keywords/cns-drug-discovery","display_name":"CNS drug discovery","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.9494494795799255},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.7421717643737793},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5640349388122559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5289269089698792},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5212143659591675},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.48338404297828674},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46836721897125244},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.4231865704059601},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3857668936252594},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2290242612361908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21692916750907898}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.drudis.2023.103641","doi":"https://doi.org/10.1016/j.drudis.2023.103641","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drudis.2023.103641","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:37236523","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37236523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10524340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10524340","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10524340/pdf/nihms-1904181.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Drug Discov Today","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.drudis.2023.103641","doi":"https://doi.org/10.1016/j.drudis.2023.103641","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.drudis.2023.103641","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5464654658","display_name":null,"funder_award_id":"R43 DA050264","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G702834194","display_name":"Novel tools for investigating GPCR-mediated 14-3-3 signaling pathway","funder_award_id":"R44MH108203","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8901973289","display_name":"Screen molecules modulating MOR trafficking with a newly developed MOR/14-3-3 bioassay.","funder_award_id":"1r43da050264-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W159582862","https://openalex.org/W280845565","https://openalex.org/W1965878499","https://openalex.org/W1977146061","https://openalex.org/W1978840845","https://openalex.org/W1979499609","https://openalex.org/W2008977389","https://openalex.org/W2009467084","https://openalex.org/W2010144291","https://openalex.org/W2016629089","https://openalex.org/W2016880575","https://openalex.org/W2018651892","https://openalex.org/W2031302686","https://openalex.org/W2032268866","https://openalex.org/W2036569576","https://openalex.org/W2037234701","https://openalex.org/W2037686809","https://openalex.org/W2042054309","https://openalex.org/W2042400152","https://openalex.org/W2045201777","https://openalex.org/W2046284005","https://openalex.org/W2048168473","https://openalex.org/W2050892986","https://openalex.org/W2056632572","https://openalex.org/W2058285654","https://openalex.org/W2059258112","https://openalex.org/W2064059449","https://openalex.org/W2071075259","https://openalex.org/W2071815275","https://openalex.org/W2072529095","https://openalex.org/W2093632219","https://openalex.org/W2096576561","https://openalex.org/W2098347554","https://openalex.org/W2100733798","https://openalex.org/W2101526772","https://openalex.org/W2109623416","https://openalex.org/W2110844810","https://openalex.org/W2116265895","https://openalex.org/W2124233112","https://openalex.org/W2135512519","https://openalex.org/W2144491728","https://openalex.org/W2144573431","https://openalex.org/W2160313474","https://openalex.org/W2169615676","https://openalex.org/W2266139113","https://openalex.org/W2524115874","https://openalex.org/W2601465249","https://openalex.org/W2611441394","https://openalex.org/W2754467525","https://openalex.org/W2796856423","https://openalex.org/W2808301300","https://openalex.org/W2908774974","https://openalex.org/W2965910825","https://openalex.org/W2978479061","https://openalex.org/W3015123576","https://openalex.org/W3087245412","https://openalex.org/W3091831470","https://openalex.org/W3092386371","https://openalex.org/W3109327568","https://openalex.org/W3117360023","https://openalex.org/W3118648763","https://openalex.org/W3155245221","https://openalex.org/W3179469168","https://openalex.org/W3181930852","https://openalex.org/W3193390072","https://openalex.org/W4220966128","https://openalex.org/W4291288751","https://openalex.org/W4297493645","https://openalex.org/W4297493663","https://openalex.org/W4321033185","https://openalex.org/W6606522047","https://openalex.org/W6658708272"],"related_works":["https://openalex.org/W2032268866","https://openalex.org/W2524115874","https://openalex.org/W2965910825","https://openalex.org/W4291288751","https://openalex.org/W4416231397","https://openalex.org/W3190404262","https://openalex.org/W7135599220","https://openalex.org/W7135939069","https://openalex.org/W2124158754","https://openalex.org/W2020359801"],"abstract_inverted_index":{"The":[0],"activation":[1],"of":[2,9,18,22,27,66,79,105],"G-protein-coupled":[3],"receptors":[4],"(GPCRs)":[5],"triggers":[6],"a":[7,16,75,86],"series":[8],"protein-protein":[10],"interaction":[11],"events":[12],"that":[13],"subsequently":[14],"induce":[15],"chain":[17],"reactions,":[19],"including":[20],"alteration":[21],"receptor":[23],"structures,":[24],"phosphorylation,":[25],"recruitment":[26],"associated":[28],"proteins,":[29],"protein":[30,70,97],"trafficking":[31,91],"and":[32,50,58,92,108],"gene":[33],"expression.":[34],"Multiple":[35],"GPCR":[36,90,106],"signaling":[37,98],"transduction":[38,81],"pathways":[39,45],"are":[40,46],"evident":[41],"-":[42],"two":[43],"well-studied":[44],"the":[47,103],"GPCR-mediated":[48,95],"G-protein":[49],"\u03b2-arrestin":[51],"pathways.":[52],"Recently,":[53],"ligand-induced":[54],"interactions":[55],"between":[56],"GPCRs":[57,67],"14-3-3":[59,69,83,96],"proteins":[60,84],"have":[61],"been":[62],"demonstrated.":[63],"This":[64],"linking":[65],"to":[68],"signal":[71,80,93],"hubs":[72],"opens":[73],"up":[74],"whole":[76],"new":[77],"realm":[78],"possibilities.":[82],"play":[85],"key":[87],"part":[88],"in":[89],"transduction.":[94],"can":[99],"be":[100],"harnessed":[101],"for":[102],"study":[104],"function":[107],"therapeutics.":[109]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-25T00:00:00"}
