{"id":"https://openalex.org/W4377982091","doi":"https://doi.org/10.1016/j.heliyon.2023.e16561","title":"Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook","display_name":"Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook","publication_year":2023,"publication_date":"2023-05-24","ids":{"openalex":"https://openalex.org/W4377982091","doi":"https://doi.org/10.1016/j.heliyon.2023.e16561","pmid":"https://pubmed.ncbi.nlm.nih.gov/37260890","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10227328"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2023.e16561","doi":"https://doi.org/10.1016/j.heliyon.2023.e16561","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2023.e16561","pdf_url":"http://www.cell.com/article/S2405844023037684/pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2405844023037684/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040641528","display_name":"Sachin S. Gaikwad","orcid":"https://orcid.org/0000-0001-8910-1366","observed_orcids":["https://orcid.org/0000-0001-8910-1366"]},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sachin S. Gaikwad","raw_affiliation_strings":["Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India","Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India"],"raw_orcid":"https://orcid.org/0000-0001-8910-1366","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India","institution_ids":["https://openalex.org/I878213199"]},{"raw_affiliation_string":"Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072219897","display_name":"Yogita Y. Morade","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yogita Y. Morade","raw_affiliation_strings":["Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042672853","display_name":"Akshada M. Kothule","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akshada M. Kothule","raw_affiliation_strings":["Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024334196","display_name":"Sanjay Jayprakash Kshirsagar","orcid":"https://orcid.org/0000-0002-7063-6640","observed_orcids":["https://orcid.org/0000-0002-7063-6640"]},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanjay J. Kshirsagar","raw_affiliation_strings":["Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India"],"raw_orcid":"https://orcid.org/0000-0002-7063-6640","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India","institution_ids":["https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046654088","display_name":"Umesh Dilip Laddha","orcid":"https://orcid.org/0000-0002-4038-3953","observed_orcids":["https://orcid.org/0000-0002-4038-3953"]},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Umesh D. Laddha","raw_affiliation_strings":["Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, MET's Institute of Pharmacy, Affiliated to Savitribai Phule Pune University, Bhujbal Knowledge City, Adgaon, Nashik 422003, India","institution_ids":["https://openalex.org/I878213199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033811410","display_name":"Kishor Sahebrao Salunkhe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kishor S. Salunkhe","raw_affiliation_strings":["Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Sanjivani College of Pharmaceutical Education and Research, At Sahajanandnagar, Post-Shinganapur, Tal-Kopargaon, Dist-Ahmednagar, Maharashtra 423603, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040641528"],"corresponding_institution_ids":["https://openalex.org/I878213199"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":1.3879,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.84199134,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"6","first_page":"e16561","last_page":"e16561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.725600004196167,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.15189999341964722,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.07559999823570251,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytosomes","display_name":"phytosomes","score":1.0},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.9380000233650208},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.8679999709129333},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.8240000009536743},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.7239999771118164},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/drug-release-mechanism","display_name":"drug release mechanism","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.7910128235816956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6437724828720093},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5798519253730774},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.547002375125885},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49656516313552856},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47623732686042786},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.463360071182251},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42026031017303467},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38899311423301697},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3282928168773651},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11083167791366577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10236802697181702}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.heliyon.2023.e16561","doi":"https://doi.org/10.1016/j.heliyon.2023.e16561","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2023.e16561","pdf_url":"http://www.cell.com/article/S2405844023037684/pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10227328","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10227328","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10227328/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmid:37260890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37260890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2023.e16561","doi":"https://doi.org/10.1016/j.heliyon.2023.e16561","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2023.e16561","pdf_url":"http://www.cell.com/article/S2405844023037684/pdf","source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377982091.pdf","grobid_xml":"https://content.openalex.org/works/W4377982091.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1417291594","https://openalex.org/W1901595265","https://openalex.org/W1979412780","https://openalex.org/W1983964788","https://openalex.org/W1992539125","https://openalex.org/W1996194206","https://openalex.org/W2017740792","https://openalex.org/W2053446727","https://openalex.org/W2061444430","https://openalex.org/W2092352245","https://openalex.org/W2117715855","https://openalex.org/W2129868701","https://openalex.org/W2146629016","https://openalex.org/W2167284803","https://openalex.org/W2177957280","https://openalex.org/W2273780641","https://openalex.org/W2559816317","https://openalex.org/W2606610310","https://openalex.org/W2613424718","https://openalex.org/W2619735591","https://openalex.org/W2620796872","https://openalex.org/W2623556215","https://openalex.org/W2763672830","https://openalex.org/W2765700039","https://openalex.org/W2794764992","https://openalex.org/W2801002215","https://openalex.org/W2802570850","https://openalex.org/W2809344197","https://openalex.org/W2884383626","https://openalex.org/W2890398220","https://openalex.org/W2913164571","https://openalex.org/W2929489925","https://openalex.org/W2953241523","https://openalex.org/W2998868057","https://openalex.org/W3000069095","https://openalex.org/W3002322026","https://openalex.org/W3003422685","https://openalex.org/W3015274953","https://openalex.org/W3015783759","https://openalex.org/W3016280944","https://openalex.org/W3025420172","https://openalex.org/W3026425601","https://openalex.org/W3048559705","https://openalex.org/W3085828118","https://openalex.org/W3091043182","https://openalex.org/W3100856180","https://openalex.org/W3111514541","https://openalex.org/W3115713062","https://openalex.org/W3115742047","https://openalex.org/W3165143074","https://openalex.org/W3165697652","https://openalex.org/W3180178271","https://openalex.org/W3189680533","https://openalex.org/W3201628694","https://openalex.org/W3205360088","https://openalex.org/W3207608595","https://openalex.org/W3209738867","https://openalex.org/W3217136747","https://openalex.org/W4200318786","https://openalex.org/W4205583609","https://openalex.org/W4205851075","https://openalex.org/W4206273713","https://openalex.org/W4221040717","https://openalex.org/W4221079541","https://openalex.org/W4225565073","https://openalex.org/W4234003606","https://openalex.org/W4245526896","https://openalex.org/W4248254746","https://openalex.org/W4296700638","https://openalex.org/W6784152586","https://openalex.org/W6806026325"],"related_works":["https://openalex.org/W4399747433","https://openalex.org/W4393952745","https://openalex.org/W4391280807","https://openalex.org/W4400502603","https://openalex.org/W4383568505","https://openalex.org/W4405430190","https://openalex.org/W2613424718","https://openalex.org/W4393309628","https://openalex.org/W4407155729","https://openalex.org/W7118187008"],"abstract_inverted_index":{"One":[0],"of":[1,5,47,61,100,107,119,140,145,162,194,204,216,228,234,241],"the":[2,8,59,95,108,117,143,158,195,200,214,222,235],"major":[3,236],"causes":[4],"death":[6],"on":[7,175,199],"globe":[9],"is":[10],"cancer.":[11,217],"It":[12],"has":[13,22,54],"remained":[14],"a":[15,207],"significant":[16],"obstacle":[17],"for":[18,32,137,210],"current":[19],"therapies":[20],"and":[21,90,92,97,125,160,183,202,226,254],"not":[23],"yet":[24],"been":[25,70],"effectively":[26],"treated.":[27],"Conventional":[28],"treatment":[29,53,215,262],"strategies":[30],"available":[31],"cancer":[33,52,63,189,261],"such":[34],"as":[35,178,180,206],"surgery,":[36],"chemotherapy,":[37],"radiation":[38],"therapy":[39],"etc.":[40],"have":[41,69,73,244],"severe":[42],"adverse":[43],"effects.":[44],"The":[45],"use":[46,203],"herbal":[48,102,211,237],"active":[49,67,238],"constituents":[50,212,239],"in":[51,75,81,122,188,213,260],"tremendous":[55],"potential":[56],"to":[57,72,86,115,156,258],"increase":[58,87,157],"effectiveness":[60],"conventional":[62,177],"therapy.":[64],"Natural":[65],"plant":[66],"components":[68],"reported":[71],"strong":[74],"vitro":[76],"pharmacological":[77],"activity":[78,248],"but":[79],"narrow":[80],"vivo":[82],"absorption.":[83],"In":[84],"order":[85],"their":[88,127],"bioavailability":[89],"absorption":[91],"get":[93],"around":[94],"drawbacks":[96],"negative":[98],"effects":[99],"traditional":[101],"extracts,":[103],"Phytosomes":[104,147],"are":[105,135,148,249,263],"one":[106],"growing":[109],"nanotechnologies":[110],"that":[111,152],"can":[112,153],"be":[113,154],"used":[114,187],"improve":[116],"miscibility":[118],"bioactive":[120],"phytoconstituents":[121],"lipid-rich":[123],"barriers":[124],"overcome":[126],"poor":[128],"bioavailability.":[129],"Many":[130],"novel":[131,166,181],"drug":[132,167,229],"delivery":[133,139,168],"carriers":[134],"employed":[136,155],"targeted":[138],"phytoconstituent":[141],"at":[142],"site":[144],"action.":[146],"well-known":[149],"biocompatible":[150],"nanocarriers":[151],"solubility":[159],"permeability":[161],"phytopharmaceuticals":[163],"among":[164],"various":[165,176,184],"systems":[169],"(NDDS).":[170],"This":[171],"review":[172],"mainly":[173],"focused":[174],"well":[179],"approaches":[182],"Nano":[185],"carrier":[186,209],"therapies.":[190],"Also":[191],"comprising":[192],"summary":[193],"most":[196],"recent":[197],"research":[198],"development":[201],"phytosomes":[205],"better":[208],"Additionally":[218],"provides":[219],"information":[220],"about":[221],"formulation,":[223],"characterization":[224],"technique":[225],"mechanism":[227],"release":[230],"from":[231],"phytosome.":[232],"Some":[233],"made":[240],"phytosome":[242,259],"which":[243],"shown":[245],"proven":[246],"anticancer":[247],"also":[250,264],"studied.":[251],"Finally,":[252],"challenges":[253],"future":[255],"perspective":[256],"related":[257],"discussed.":[265]},"counts_by_year":[{"year":2026,"cited_by_count":17},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":5}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-05-25T00:00:00"}