{"id":"https://openalex.org/W4377968960","doi":"https://doi.org/10.1016/j.jmoldx.2023.05.001","title":"MICon Contamination Detection Workflow for Next-Generation Sequencing Laboratories Using Microhaplotype Loci and Supervised Learning","display_name":"MICon Contamination Detection Workflow for Next-Generation Sequencing Laboratories Using Microhaplotype Loci and Supervised Learning","publication_year":2023,"publication_date":"2023-05-24","ids":{"openalex":"https://openalex.org/W4377968960","doi":"https://doi.org/10.1016/j.jmoldx.2023.05.001","pmid":"https://pubmed.ncbi.nlm.nih.gov/37236547"},"language":"en","primary_location":{"id":"doi:10.1016/j.jmoldx.2023.05.001","doi":"https://doi.org/10.1016/j.jmoldx.2023.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmoldx.2023.05.001","pdf_url":"http://www.jmdjournal.org/article/S1525157823001058/pdf","source":{"id":"https://openalex.org/S48180145","display_name":"Journal of Molecular Diagnostics","issn_l":"1525-1578","issn":["1525-1578","1943-7811"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Molecular Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jmdjournal.org/article/S1525157823001058/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040165594","display_name":"Jagadheshwar Balan","orcid":"https://orcid.org/0000-0002-8291-4054","observed_orcids":["https://orcid.org/0000-0002-8291-4054"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jagadheshwar Balan","raw_affiliation_strings":["Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota. Electronic address: balan.jagadheshwar@mayo.edu","Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-8291-4054","affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota. Electronic address: balan.jagadheshwar@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071863123","display_name":"Tejaswi Koganti","orcid":"https://orcid.org/0000-0002-7733-6480","observed_orcids":["https://orcid.org/0000-0002-7733-6480"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tejaswi Koganti","raw_affiliation_strings":["Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-7733-6480","affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020528376","display_name":"Shubham Basu","orcid":"https://orcid.org/0000-0002-4509-9046","observed_orcids":["https://orcid.org/0000-0002-4509-9046"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubham Basu","raw_affiliation_strings":["Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064924647","display_name":"Michelle A. Dina","orcid":"https://orcid.org/0000-0002-1695-0241","observed_orcids":["https://orcid.org/0000-0002-1695-0241"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle A. Dina","raw_affiliation_strings":["Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-1695-0241","affiliations":[{"raw_affiliation_string":"Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092008124","display_name":"Cody J. Artymiuk","orcid":"https://orcid.org/0000-0003-0342-6181","observed_orcids":["https://orcid.org/0000-0003-0342-6181"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cody J. Artymiuk","raw_affiliation_strings":["Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0003-0342-6181","affiliations":[{"raw_affiliation_string":"Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011053726","display_name":"Emily G. Barr Fritcher","orcid":"https://orcid.org/0000-0001-8052-563X","observed_orcids":["https://orcid.org/0000-0001-8052-563X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily G. Barr Fritcher","raw_affiliation_strings":["Molecular Technologies Laboratory and Anatomic Pathology Division, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0001-8052-563X","affiliations":[{"raw_affiliation_string":"Molecular Technologies Laboratory and Anatomic Pathology Division, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092008125","display_name":"Katie E. Halverson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie E. Halverson","raw_affiliation_strings":["Biospecimen Accessioning and Processing Laboratory, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biospecimen Accessioning and Processing Laboratory, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102076849","display_name":"Xianglin Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianglin Wu","raw_affiliation_strings":["Clinical Genomics Sequencing Laboratory, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Genomics Sequencing Laboratory, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039319315","display_name":"Garrett Jenkinson","orcid":"https://orcid.org/0000-0003-2548-098X","observed_orcids":["https://orcid.org/0000-0003-2548-098X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garrett Jenkinson","raw_affiliation_strings":["Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0003-2548-098X","affiliations":[{"raw_affiliation_string":"Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112698052","display_name":"David S. Viswanatha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David S. Viswanatha","raw_affiliation_strings":["Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota. Electronic address: viswanatha.david@mayo.edu","Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota. Electronic address: viswanatha.david@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Molecular Hematopathology Laboratory and Hematopathology Division, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040165594","https://openalex.org/A5112698052"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.6799,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.60088865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"25","issue":"8","first_page":"602","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.6098999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.2791000008583069,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/variant-allele-frequency","display_name":"variant allele frequency","score":0.9629999995231628},{"id":"https://openalex.org/keywords/somatic-variant-calling","display_name":"somatic variant calling","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C112570922","wikidata":"https://www.wikidata.org/wiki/Q60528603","display_name":"Contamination","level":2,"score":0.5500530004501343},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.5413347482681274},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4842655062675476},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.47769930958747864},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.44521552324295044},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4433031678199768},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4276212453842163},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.35537129640579224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31899046897888184},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2415023148059845},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.18986660242080688},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.1855160892009735},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12244248390197754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.091839998960495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069553","descriptor_name":"Supervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007753","descriptor_name":"Laboratories","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jmoldx.2023.05.001","doi":"https://doi.org/10.1016/j.jmoldx.2023.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmoldx.2023.05.001","pdf_url":"http://www.jmdjournal.org/article/S1525157823001058/pdf","source":{"id":"https://openalex.org/S48180145","display_name":"Journal of Molecular Diagnostics","issn_l":"1525-1578","issn":["1525-1578","1943-7811"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Molecular Diagnostics","raw_type":"journal-article"},{"id":"pmid:37236547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37236547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of molecular diagnostics : JMD","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jmoldx.2023.05.001","doi":"https://doi.org/10.1016/j.jmoldx.2023.05.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jmoldx.2023.05.001","pdf_url":"http://www.jmdjournal.org/article/S1525157823001058/pdf","source":{"id":"https://openalex.org/S48180145","display_name":"Journal of Molecular Diagnostics","issn_l":"1525-1578","issn":["1525-1578","1943-7811"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Molecular Diagnostics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320338408","display_name":"Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377968960.pdf","grobid_xml":"https://content.openalex.org/works/W4377968960.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W2099328768","https://openalex.org/W2101234009","https://openalex.org/W2122825543","https://openalex.org/W2127041368","https://openalex.org/W2135073764","https://openalex.org/W2137199056","https://openalex.org/W2566723262","https://openalex.org/W2597490071","https://openalex.org/W2618851150","https://openalex.org/W2800777678","https://openalex.org/W2808951788","https://openalex.org/W2892741787","https://openalex.org/W2895453763","https://openalex.org/W2904691599","https://openalex.org/W2914895890","https://openalex.org/W2939955626","https://openalex.org/W2962897394","https://openalex.org/W3029661147","https://openalex.org/W3093528466","https://openalex.org/W3120466736","https://openalex.org/W4394666350"],"related_works":["https://openalex.org/W4403071443","https://openalex.org/W3115528482","https://openalex.org/W2912105219","https://openalex.org/W3160937480","https://openalex.org/W3100277421","https://openalex.org/W4392714520","https://openalex.org/W7100458951","https://openalex.org/W6999252714","https://openalex.org/W2993767513","https://openalex.org/W2099328768"],"abstract_inverted_index":{"Innovation":[0],"in":[1,55,72,76,97,118,123,146],"sequencing":[2,88,120,149],"instrumentation":[3],"is":[4],"increasing":[5],"the":[6,12,19,65,113,133,179,188],"per-batch":[7],"data":[8],"volumes":[9],"and":[10,29,94],"decreasing":[11],"per-base":[13],"costs.":[14],"Multiplexed":[15],"chemistry":[16],"protocols":[17],"after":[18],"addition":[20],"of":[21,43,51,107,142,176,192],"index":[22],"tags":[23],"have":[24,82,112,152],"further":[25],"contributed":[26],"to":[27,115,135],"efficient":[28],"cost-effective":[30],"sequencer":[31],"utilization.":[32],"With":[33],"these":[34],"pooled":[35],"processing":[36],"strategies,":[37],"however,":[38,122],"comes":[39],"an":[40,185],"increased":[41],"risk":[42,50],"sample":[44,58],"contamination.":[45],"Sample":[46],"contamination":[47,103,109,160],"poses":[48],"a":[49,56,158,171],"missing":[52],"critical":[53],"variants":[54,62,93,101],"patient":[57],"or":[59],"wrongly":[60],"reporting":[61,141],"derived":[63],"from":[64],"contaminant,":[66],"which":[67,77],"are":[68,128],"particularly":[69],"relevant":[70],"issues":[71],"oncology":[73],"specimen":[74],"testing":[75],"low":[78],"variant":[79,130,167],"allele":[80,168],"frequencies":[81],"clinical":[83,140],"relevance.":[84],"Small":[85],"custom-targeted":[86],"next-generation":[87,148],"(NGS)":[89],"panels":[90],"yield":[91],"limited":[92],"pose":[95],"challenges":[96],"delineating":[98],"true":[99],"somatic":[100],"versus":[102],"calls.":[104],"A":[105],"number":[106],"popular":[108],"identification":[110],"tools":[111,134],"ability":[114],"perform":[116,136],"well":[117],"whole-genome/exome":[119],"data;":[121],"smaller":[124],"gene":[125],"panels,":[126,150],"there":[127],"fewer":[129],"candidates":[131],"for":[132],"accurately.":[137],"To":[138],"prevent":[139],"potentially":[143],"contaminated":[144],"samples":[145],"small":[147],"we":[151],"developed":[153],"MICon":[154],"(Microhaplotype":[155],"Contamination":[156],"detection),":[157],"novel":[159],"detection":[161],"model":[162,180],"that":[163],"uses":[164],"microhaplotype":[165],"site":[166],"frequencies.":[169],"In":[170],"heterogeneous":[172],"hold-out":[173],"test":[174],"cohort":[175],"210":[177],"samples,":[178],"displayed":[181],"state-of-the-art":[182],"performance":[183],"with":[184],"area":[186],"under":[187],"receiver-operating":[189],"characteristic":[190],"curve":[191],"0.995.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-25T00:00:00"}