{"id":"https://openalex.org/W4377940947","doi":"https://doi.org/10.1038/s41467-023-38555-w","title":"Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication","display_name":"Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication","publication_year":2023,"publication_date":"2023-05-23","ids":{"openalex":"https://openalex.org/W4377940947","doi":"https://doi.org/10.1038/s41467-023-38555-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37221161","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10206067"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-38555-w","doi":"https://doi.org/10.1038/s41467-023-38555-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-38555-w","pdf_url":"https://www.nature.com/articles/s41467-023-38555-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-38555-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054910363","display_name":"Quentin Durieux Trouilleton","orcid":"https://orcid.org/0000-0001-5913-7296","observed_orcids":["https://orcid.org/0000-0001-5913-7296"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210152516","display_name":"Institut de Biologie Structurale","ror":"https://ror.org/04szabx38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210091409","https://openalex.org/I4210096427","https://openalex.org/I4210113668","https://openalex.org/I4210152516","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Quentin Durieux Trouilleton","raw_affiliation_strings":["Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France"],"raw_orcid":"https://orcid.org/0000-0001-5913-7296","affiliations":[{"raw_affiliation_string":"Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210152516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064496367","display_name":"Sergio Barata-Garc\u00eda","orcid":"https://orcid.org/0000-0002-4863-9327","observed_orcids":["https://orcid.org/0000-0002-4863-9327"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sergio Barata-Garc\u00eda","raw_affiliation_strings":["Aix-Marseille Universit\u00e9, CNRS, AFMB UMR, 7257, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, CNRS, AFMB UMR, 7257, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021678036","display_name":"Beno\u00eet Arragain","orcid":"https://orcid.org/0000-0002-5593-4682","observed_orcids":["https://orcid.org/0000-0002-5593-4682"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210111092","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/01zjc6908","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210111092","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210152516","display_name":"Institut de Biologie Structurale","ror":"https://ror.org/04szabx38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210091409","https://openalex.org/I4210096427","https://openalex.org/I4210113668","https://openalex.org/I4210152516","https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Beno\u00eet Arragain","raw_affiliation_strings":["European Molecular Biology Laboratory (EMBL), Grenoble, France","Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France"],"raw_orcid":"https://orcid.org/0000-0002-5593-4682","affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory (EMBL), Grenoble, France","institution_ids":["https://openalex.org/I4210111092"]},{"raw_affiliation_string":"Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210152516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028719594","display_name":"Juan Reguera","orcid":"https://orcid.org/0000-0003-4977-7948","observed_orcids":["https://orcid.org/0000-0003-4977-7948"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]},{"id":"https://openalex.org/I4210146787","display_name":"Architecture et Fonction des Macromol\u00e9cules Biologiques","ror":"https://ror.org/04jm8zw14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210146787"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Juan Reguera","raw_affiliation_strings":["Aix-Marseille Universit\u00e9, CNRS, AFMB UMR, 7257, Marseille, France. juan.reguera@inserm.fr","INSERM, AFMB UMR, 7257, Marseille, France. juan.reguera@inserm.fr","Aix-Marseille Universit\u00e9, CNRS, AFMB UMR, 7257, Marseille, France"],"raw_orcid":"https://orcid.org/0000-0003-4977-7948","affiliations":[{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, CNRS, AFMB UMR, 7257, Marseille, France. juan.reguera@inserm.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"INSERM, AFMB UMR, 7257, Marseille, France. juan.reguera@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210146787"]},{"raw_affiliation_string":"Aix-Marseille Universit\u00e9, CNRS, AFMB UMR, 7257, Marseille, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I21491767","https://openalex.org/I4210146787"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025863416","display_name":"H\u00e9l\u00e8ne Malet","orcid":"https://orcid.org/0000-0002-2834-7386","observed_orcids":["https://orcid.org/0000-0002-2834-7386"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I185839726","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266","country_code":"FR","type":"education","lineage":["https://openalex.org/I185839726"]},{"id":"https://openalex.org/I2738703131","display_name":"Commissariat \u00e0 l'\u00c9nergie Atomique et aux \u00c9nergies Alternatives","ror":"https://ror.org/00jjx8s55","country_code":"FR","type":"government","lineage":["https://openalex.org/I2738703131"]},{"id":"https://openalex.org/I4210152516","display_name":"Institut de Biologie Structurale","ror":"https://ror.org/04szabx38","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210091409","https://openalex.org/I4210096427","https://openalex.org/I4210113668","https://openalex.org/I4210152516","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"H\u00e9l\u00e8ne Malet","raw_affiliation_strings":["Institut Universitaire de France (IUF), Paris, France. helene.malet@ibs.fr","Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France. helene.malet@ibs.fr","Institut Universitaire de France (IUF), Paris, France"],"raw_orcid":"https://orcid.org/0000-0002-2834-7386","affiliations":[{"raw_affiliation_string":"Institut Universitaire de France (IUF), Paris, France. helene.malet@ibs.fr","institution_ids":["https://openalex.org/I185839726"]},{"raw_affiliation_string":"Univ. Grenoble Alpes, CNRS, CEA, IBS, F-38000, Grenoble, France. helene.malet@ibs.fr","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210152516","https://openalex.org/I899635006"]},{"raw_affiliation_string":"Institut Universitaire de France (IUF), Paris, France","institution_ids":["https://openalex.org/I185839726"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5025863416","https://openalex.org/A5028719594"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I185839726","https://openalex.org/I21491767","https://openalex.org/I2738703131","https://openalex.org/I4210146787","https://openalex.org/I4210152516","https://openalex.org/I899635006"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":2.5308,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.92911715,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"2954","last_page":"2954"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.3449999988079071,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.33180001378059387,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.19480000436306,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hantaan-virus","display_name":"Hantaan virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rna-dependent-rna-polymerase","display_name":"RNA-dependent RNA polymerase","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hantaviridae","display_name":"Hantaviridae","score":0.9520000219345093},{"id":"https://openalex.org/keywords/viral-genome-replication","display_name":"viral genome replication","score":0.7639999985694885},{"id":"https://openalex.org/keywords/polymerase-structure","display_name":"polymerase structure","score":0.6930000185966492},{"id":"https://openalex.org/keywords/elongation","display_name":"elongation","score":0.574999988079071},{"id":"https://openalex.org/keywords/antiviral-drug-targets","display_name":"antiviral drug targets","score":0.6919999718666077},{"id":"https://openalex.org/keywords/zoonoses","display_name":"zoonoses","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.7833110094070435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6220540404319763},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.5733144879341125},{"id":"https://openalex.org/C41258723","wikidata":"https://www.wikidata.org/wiki/Q2919111","display_name":"RNA-dependent RNA polymerase","level":4,"score":0.5611680746078491},{"id":"https://openalex.org/C25281209","wikidata":"https://www.wikidata.org/wiki/Q3502188","display_name":"RNA polymerase I","level":5,"score":0.5320380926132202},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4879757761955261},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.4258272051811218},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4187925457954407},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.40470319986343384},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.29042142629623413},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25198155641555786},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.25095635652542114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12885043025016785},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09226414561271667},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.09069693088531494}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012328","descriptor_name":"RNA Viruses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018063","descriptor_name":"Hantaan virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-023-38555-w","doi":"https://doi.org/10.1038/s41467-023-38555-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-38555-w","pdf_url":"https://www.nature.com/articles/s41467-023-38555-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10206067","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10206067","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10206067/pdf/41467_2023_Article_38555.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37221161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37221161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04129164v1","doi":null,"is_oa":true,"landing_page_url":"https://amu.hal.science/hal-04129164","pdf_url":"https://amu.hal.science/hal-04129164v1/file/s41467-023-38555-w.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 2023, 14 (1), pp.2954. &#x27E8;10.1038/s41467-023-38555-w&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38555-w","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-38555-w","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:cd476297db014ccdaa24dac8c8991fb6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cd476297db014ccdaa24dac8c8991fb6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-38555-w","doi":"https://doi.org/10.1038/s41467-023-38555-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-38555-w","pdf_url":"https://www.nature.com/articles/s41467-023-38555-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1064512522","display_name":null,"funder_award_id":"UAR 3518 CNRS-CEA-UGA-EMBL","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1088207598","display_name":null,"funder_award_id":"ANR-17-EURE-0003","funder_id":"https://openalex.org/F4320326245","funder_display_name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes"},{"id":"https://openalex.org/G1513157868","display_name":"CBH-EUR-GS","funder_award_id":"ANR-17-EURE-0003","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1825864493","display_name":null,"funder_award_id":"ANR-10-INBS-05-02","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2277544366","display_name":null,"funder_award_id":"ANR-17-EURE-0003","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G2447855386","display_name":null,"funder_award_id":"ANR-10- INBS-05","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G256544642","display_name":null,"funder_award_id":"ANR-17-EURE-0003","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G2659019386","display_name":null,"funder_award_id":"ANR-17-EURE-","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G2911514573","display_name":null,"funder_award_id":"ANR-10-INBS-05\u201302","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G3010527862","display_name":null,"funder_award_id":"ANR\u201019","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G3509114830","display_name":null,"funder_award_id":"ANR-10-INBS-05-02","funder_id":"https://openalex.org/F4320326245","funder_display_name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes"},{"id":"https://openalex.org/G4460985483","display_name":null,"funder_award_id":"ANR-10-INBS-0.5","funder_id":"https://openalex.org/F4320327185","funder_display_name":"French Infrastructure for Integrated Structural Biology"},{"id":"https://openalex.org/G4789698507","display_name":"Integrated structural characterization of highly pathogenic bunyavirus replication machineries","funder_award_id":"ANR-19-CE11-0024","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6803667113","display_name":null,"funder_award_id":"ANR-17","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6891474181","display_name":null,"funder_award_id":"ANR-17-EURE-0003","funder_id":"https://openalex.org/F4320315862","funder_display_name":"Infrastructures en Biologie Sant\u00e9 et Agronomie"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G796440745","display_name":null,"funder_award_id":"ANR-10-INBS-05-02","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"},{"id":"https://openalex.org/G8305889996","display_name":null,"funder_award_id":"ANR-10-INBS-05-02","funder_id":"https://openalex.org/F4320315862","funder_display_name":"Infrastructures en Biologie Sant\u00e9 et Agronomie"},{"id":"https://openalex.org/G8548513469","display_name":null,"funder_award_id":"UAR 3518 CNRS-CEA-UGA-EMBL","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"}],"funders":[{"id":"https://openalex.org/F4320315862","display_name":"Infrastructures en Biologie Sant\u00e9 et Agronomie","ror":"https://ror.org/054q97b08"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320320887","display_name":"European Synchrotron Radiation Facility","ror":"https://ror.org/02550n020"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320322893","display_name":"Institut Universitaire de France","ror":"https://ror.org/055khg266"},{"id":"https://openalex.org/F4320326245","display_name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","ror":"https://ror.org/00kd6pz94"},{"id":"https://openalex.org/F4320327185","display_name":"French Infrastructure for Integrated Structural Biology","ror":"https://ror.org/045sst074"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377940947.pdf","grobid_xml":"https://content.openalex.org/works/W4377940947.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1857763546","https://openalex.org/W1897525734","https://openalex.org/W2008954911","https://openalex.org/W2027847351","https://openalex.org/W2035503835","https://openalex.org/W2047399603","https://openalex.org/W2098475932","https://openalex.org/W2104234755","https://openalex.org/W2119473061","https://openalex.org/W2128230863","https://openalex.org/W2132629607","https://openalex.org/W2132926880","https://openalex.org/W2140387095","https://openalex.org/W2144081223","https://openalex.org/W2149360962","https://openalex.org/W2154666681","https://openalex.org/W2168974130","https://openalex.org/W2426189081","https://openalex.org/W2428988826","https://openalex.org/W2485464167","https://openalex.org/W2587625522","https://openalex.org/W2731784911","https://openalex.org/W2734356283","https://openalex.org/W2765322245","https://openalex.org/W2786390877","https://openalex.org/W2791856914","https://openalex.org/W2911120043","https://openalex.org/W2932873695","https://openalex.org/W2950248657","https://openalex.org/W2952236080","https://openalex.org/W2952257850","https://openalex.org/W3012230159","https://openalex.org/W3016886041","https://openalex.org/W3017151919","https://openalex.org/W3018351784","https://openalex.org/W3042367840","https://openalex.org/W3048560933","https://openalex.org/W3159177617","https://openalex.org/W3165060889","https://openalex.org/W3177828909","https://openalex.org/W3211533652","https://openalex.org/W3213779066","https://openalex.org/W3216452123","https://openalex.org/W4211007515","https://openalex.org/W4221031253","https://openalex.org/W4317209121"],"related_works":["https://openalex.org/W4405170958","https://openalex.org/W4392749852","https://openalex.org/W4230917734","https://openalex.org/W4308950134","https://openalex.org/W2136131226","https://openalex.org/W2981616424","https://openalex.org/W1987254578","https://openalex.org/W2025517515","https://openalex.org/W428107017","https://openalex.org/W7213626177"],"abstract_inverted_index":{"Hantaviruses":[0],"are":[1],"causing":[2],"life-threatening":[3],"zoonotic":[4],"infections":[5],"in":[6,36,96],"humans.":[7],"Their":[8],"tripartite":[9],"negative-stranded":[10],"RNA":[11,60,77,113],"genome":[12],"is":[13],"replicated":[14],"by":[15],"the":[16,24,27,57,71,74,79,90,97,107,121,130],"multi-functional":[17],"viral":[18,59,76,112],"RNA-dependent":[19],"RNA-polymerase.":[20],"Here":[21],"we":[22],"describe":[23],"structure":[25,42,88,127],"of":[26,52,56,73,92,109,124,142,147],"Hantaan":[28,63],"virus":[29,64],"polymerase":[30,53,65,80,103,126],"core":[31,104],"and":[32,67,106,128],"establish":[33],"conditions":[34],"for":[35,83,139],"vitro":[37],"replication":[38],"activity.":[39],"The":[40,86],"apo":[41],"adopts":[43],"an":[44],"inactive":[45],"conformation":[46],"that":[47],"involves":[48],"substantial":[49],"folding":[50],"rearrangement":[51],"motifs.":[54],"Binding":[55],"5'":[58],"promoter":[61],"triggers":[62],"reorganization":[66],"activation.":[68],"It":[69],"induces":[70],"recruitment":[72],"3'":[75,111],"towards":[78],"active":[81,98],"site":[82,99],"prime-and-realign":[84],"initiation.":[85],"elongation":[87],"reveals":[89],"formation":[91],"a":[93,110,136],"template/product":[94],"duplex":[95],"cavity":[100],"concomitant":[101],"with":[102],"widening":[105],"opening":[108],"secondary":[114],"binding":[115],"site.":[116],"Altogether,":[117],"these":[118],"elements":[119],"reveal":[120],"molecular":[122],"specificities":[123],"Hantaviridae":[125],"uncover":[129],"mechanisms":[131],"underlying":[132],"replication.":[133],"They":[134],"provide":[135],"solid":[137],"framework":[138],"future":[140],"development":[141],"antivirals":[143],"against":[144],"this":[145],"group":[146],"emerging":[148],"pathogens.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-25T00:00:00"}
