{"id":"https://openalex.org/W4377939161","doi":"https://doi.org/10.1158/1078-0432.ccr-23-0410","title":"A Phase 1/2 Multicenter Randomized Trial of Local Ablation plus Toripalimab versus Toripalimab Alone for Previously Treated Unresectable Hepatocellular Carcinoma","display_name":"A Phase 1/2 Multicenter Randomized Trial of Local Ablation plus Toripalimab versus Toripalimab Alone for Previously Treated Unresectable Hepatocellular Carcinoma","publication_year":2023,"publication_date":"2023-05-24","ids":{"openalex":"https://openalex.org/W4377939161","doi":"https://doi.org/10.1158/1078-0432.ccr-23-0410","pmid":"https://pubmed.ncbi.nlm.nih.gov/37223896"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-23-0410","doi":"https://doi.org/10.1158/1078-0432.ccr-23-0410","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-23-0410","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042059876","display_name":"Chunhui Zhou","orcid":"https://orcid.org/0000-0002-1612-4898","observed_orcids":["https://orcid.org/0000-0002-1612-4898"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunhui Zhou","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-1612-4898","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083960636","display_name":"Yan Li","orcid":"https://orcid.org/0009-0002-0817-0525","observed_orcids":["https://orcid.org/0009-0002-0817-0525"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]},{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["3Department of Vascular and Tumor Intervention, the First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0002-0817-0525","affiliations":[{"raw_affiliation_string":"3Department of Vascular and Tumor Intervention, the First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha, China","institution_ids":["https://openalex.org/I14992734","https://openalex.org/I4210104845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033707375","display_name":"Jiaping Li","orcid":"https://orcid.org/0000-0003-2927-8877","observed_orcids":["https://orcid.org/0000-0003-2927-8877","https://orcid.org/0000-0001-7624-9484","https://orcid.org/0000-0002-8217-8165","https://orcid.org/0000-0001-7802-7738"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaping Li","raw_affiliation_strings":["4Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-2927-8877","affiliations":[{"raw_affiliation_string":"4Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022105113","display_name":"Botian Song","orcid":"https://orcid.org/0000-0002-8434-4905","observed_orcids":["https://orcid.org/0000-0002-8434-4905"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Botian Song","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-8434-4905","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010377145","display_name":"Hanfeng Li","orcid":"https://orcid.org/0009-0008-3140-6915","observed_orcids":["https://orcid.org/0009-0008-3140-6915"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanfeng Li","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0009-0008-3140-6915","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037195175","display_name":"Bin Liang","orcid":"https://orcid.org/0000-0002-6130-8629","observed_orcids":["https://orcid.org/0000-0002-6130-8629"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Liang","raw_affiliation_strings":["5Department of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-6130-8629","affiliations":[{"raw_affiliation_string":"5Department of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Changsha, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088645687","display_name":"Shanzhi Gu","orcid":"https://orcid.org/0009-0003-7599-1208","observed_orcids":["https://orcid.org/0009-0003-7599-1208"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanzhi Gu","raw_affiliation_strings":["6Department of Interventional Radiology, Hunan Cancer Hospital of Xiangya School, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0003-7599-1208","affiliations":[{"raw_affiliation_string":"6Department of Interventional Radiology, Hunan Cancer Hospital of Xiangya School, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042630620","display_name":"Haiping Li","orcid":"https://orcid.org/0009-0008-9565-4977","observed_orcids":["https://orcid.org/0009-0008-9565-4977"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiping Li","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0009-0008-9565-4977","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069717994","display_name":"Changyong Chen","orcid":"https://orcid.org/0000-0001-9769-0041","observed_orcids":["https://orcid.org/0000-0001-9769-0041"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changyong Chen","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0001-9769-0041","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037963302","display_name":"Sai Li","orcid":"https://orcid.org/0000-0003-3727-5449","observed_orcids":["https://orcid.org/0000-0003-3727-5449"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sai Li","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-3727-5449","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045998898","display_name":"Changli Peng","orcid":"https://orcid.org/0009-0002-5115-6331","observed_orcids":["https://orcid.org/0009-0002-5115-6331"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changli Peng","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0009-0002-5115-6331","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048575345","display_name":"Fei Liu","orcid":"https://orcid.org/0000-0002-8122-2902","observed_orcids":["https://orcid.org/0000-0002-8122-2902"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Liu","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-8122-2902","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044412495","display_name":"Juxiong Xiao","orcid":"https://orcid.org/0009-0004-3241-3392","observed_orcids":["https://orcid.org/0009-0004-3241-3392"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juxiong Xiao","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0009-0004-3241-3392","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045224461","display_name":"Xueying Long","orcid":"https://orcid.org/0000-0002-3457-4147","observed_orcids":["https://orcid.org/0000-0002-3457-4147"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xueying Long","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-3457-4147","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036024661","display_name":"Ping Li","orcid":"https://orcid.org/0009-0002-4678-3947","observed_orcids":["https://orcid.org/0009-0002-4678-3947"]},"institutions":[{"id":"https://openalex.org/I14992734","display_name":"Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/05qfq0x09","country_code":"CN","type":"education","lineage":["https://openalex.org/I14992734"]},{"id":"https://openalex.org/I4210104845","display_name":"First Affiliated Hospital of Hunan University of Traditional Chinese Medicine","ror":"https://ror.org/01ffek432","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104845"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Li","raw_affiliation_strings":["3Department of Vascular and Tumor Intervention, the First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0002-4678-3947","affiliations":[{"raw_affiliation_string":"3Department of Vascular and Tumor Intervention, the First Affiliated Hospital, Hunan University of Traditional Chinese Medicine, Changsha, China","institution_ids":["https://openalex.org/I14992734","https://openalex.org/I4210104845"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069485392","display_name":"Zhengping Xiong","orcid":"https://orcid.org/0009-0008-6196-3077","observed_orcids":["https://orcid.org/0009-0008-6196-3077"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengping Xiong","raw_affiliation_strings":["6Department of Interventional Radiology, Hunan Cancer Hospital of Xiangya School, Central South University, Changsha, China"],"raw_orcid":"https://orcid.org/0009-0008-6196-3077","affiliations":[{"raw_affiliation_string":"6Department of Interventional Radiology, Hunan Cancer Hospital of Xiangya School, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003551877","display_name":"Xiaoping Yi","orcid":"https://orcid.org/0000-0002-4220-1981","observed_orcids":["https://orcid.org/0000-0002-4220-1981"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Yi","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-4220-1981","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101629772","display_name":"Weihua Liao","orcid":"https://orcid.org/0000-0002-1926-3527","observed_orcids":["https://orcid.org/0000-0002-1926-3527"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Liao","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-1926-3527","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025195435","display_name":"Liangrong Shi","orcid":"https://orcid.org/0000-0003-4398-6159","observed_orcids":["https://orcid.org/0000-0003-4398-6159"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liangrong Shi","raw_affiliation_strings":["1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China"],"raw_orcid":"https://orcid.org/0000-0003-4398-6159","affiliations":[{"raw_affiliation_string":"1Department of Radiology, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"2National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha, China","institution_ids":["https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025195435"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":null,"apc_paid":null,"fwci":3.0226,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.92711045,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"15","first_page":"2816","last_page":"2825"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toripalimab","display_name":"toripalimab","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/local-ablation","display_name":"local ablation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.48100000619888306},{"id":"https://openalex.org/keywords/treatment-schedule","display_name":"treatment schedule","score":0.5080000162124634},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8550000190734863},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.8579999804496765},{"id":"https://openalex.org/keywords/treatment-related-pneumonitis","display_name":"treatment-related pneumonitis","score":0.7979999780654907},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8418319225311279},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6992876529693604},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6448567509651184},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.6225352883338928},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5598806738853455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5399749875068665},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5037776827812195},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4595884084701538},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39617106318473816},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3846069276332855},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32556265592575073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-23-0410","doi":"https://doi.org/10.1158/1078-0432.ccr-23-0410","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-23-0410","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:37223896","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37223896","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Randomized Controlled Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G4090141215","display_name":null,"funder_award_id":"81773234","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G539625072","display_name":null,"funder_award_id":"C2019189","funder_id":"https://openalex.org/F4320317581","funder_display_name":"Health Commission of Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320317581","display_name":"Health Commission of Hunan Province","ror":null},{"id":"https://openalex.org/F4320319721","display_name":"Shanghai Junshi Biosciences","ror":"https://ror.org/0057zjh84"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W2029409133","https://openalex.org/W2052730188","https://openalex.org/W2079586464","https://openalex.org/W2116796222","https://openalex.org/W2288738065","https://openalex.org/W2513820391","https://openalex.org/W2546700240","https://openalex.org/W2606367731","https://openalex.org/W2805592007","https://openalex.org/W2909533581","https://openalex.org/W2911646196","https://openalex.org/W2947130797","https://openalex.org/W2954094199","https://openalex.org/W2967113395","https://openalex.org/W2979941292","https://openalex.org/W2981596557","https://openalex.org/W2989703847","https://openalex.org/W2999298357","https://openalex.org/W3000172834","https://openalex.org/W3008514541","https://openalex.org/W3025022288","https://openalex.org/W3044786201","https://openalex.org/W3080889076","https://openalex.org/W3080978805","https://openalex.org/W3092246078","https://openalex.org/W3121807241","https://openalex.org/W3128646645","https://openalex.org/W3147110368","https://openalex.org/W3152534107","https://openalex.org/W3190270536","https://openalex.org/W4205882487","https://openalex.org/W4206689836","https://openalex.org/W4210334057","https://openalex.org/W4213235877","https://openalex.org/W4214915284","https://openalex.org/W6769320083"],"related_works":["https://openalex.org/W3203307533","https://openalex.org/W4205752274","https://openalex.org/W4381095203","https://openalex.org/W4389279847","https://openalex.org/W4379281679","https://openalex.org/W3172122778","https://openalex.org/W3181229664","https://openalex.org/W4387473422","https://openalex.org/W4205833447","https://openalex.org/W3121550943"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"assess":[2],"the":[3,25,85,128,235],"safety":[4,246],"and":[5,28,80,120,169,197,210],"efficacy":[6,237],"of":[7,69,94,131],"local":[8,47],"ablation":[9,48,231],"plus":[10,232],"PD-1":[11],"inhibitor":[12],"toripalimab":[13,39,51,145,183,233,241],"in":[14],"previously":[15,226],"treated":[16,227],"unresectable":[17,228],"hepatocellular":[18],"carcinoma":[19],"(HCC).":[20],"PATIENTS":[21],"AND":[22],"METHODS:":[23],"In":[24,185,223],"multicenter,":[26],"two-stage,":[27],"randomized":[29],"phase":[30],"1/2":[31],"trial,":[32],"patients":[33,96,134,154,189,224],"were":[34,97],"randomly":[35],"assigned":[36],"to":[37,73],"receive":[38],"alone":[40,146],"(240":[41],"mg,":[42],"every":[43],"3":[44,56,205],"weeks),":[45],"subtotal":[46,230],"followed":[49],"by":[50],"starting":[52],"on":[53,60],"post-ablation":[54,61],"day":[55,62],"(Schedule":[57,64],"D3),":[58],"or":[59,206],"14":[63],"D14).":[65],"The":[66],"first":[67],"endpoint":[68,87],"stage":[70,89,100,124],"1":[71],"was":[72,121],"determine":[74],"which":[75],"combination":[76],"schedule":[77],"could":[78],"continue":[79],"progression-free":[81],"survival":[82,172],"(PFS)":[83],"as":[84,180,238],"primary":[86],"for":[88,114,123],"1/2.":[90],"RESULTS:":[91],"A":[92],"total":[93],"146":[95],"recruited.":[98],"During":[99],"1,":[101],"Schedule":[102,112,136,156,195,201,215],"D3":[103,137,157,216],"achieved":[104],"numerically":[105],"higher":[106,141],"objective":[107],"response":[108],"rate":[109],"(ORR)":[110],"than":[111,143],"D14":[113,202],"non-ablation":[115],"lesions":[116],"(37.5%":[117],"vs.":[118,148,163,174],"31.3%),":[119],"chosen":[122],"2":[125],"evaluation.":[126],"For":[127],"entire":[129],"cohort":[130],"both":[132],"stages,":[133],"with":[135,144,155,182,190,194,200,214,225,240,243],"had":[138,158],"a":[139],"significantly":[140],"ORR":[142],"(33.8%":[147],"16.9%;":[149],"P":[150,166,177],"=":[151,178],"0.027).":[152],"Moreover,":[153],"improved":[159,234],"median":[160,170],"PFS":[161],"(7.1":[162],"3.8":[164],"months;":[165,176],"<":[167],"0.001)":[168],"overall":[171],"(18.4":[173],"13.2":[175],"0.005),":[179],"compared":[181,239],"alone.":[184],"addition,":[186],"six":[187],"(9%)":[188],"toripalimab,":[191],"eight":[192],"(12%)":[193],"D3,":[196],"4":[198,207],"(25%)":[199],"developed":[203],"grade":[204,218],"adverse":[208],"events,":[209],"one":[211],"patient":[212],"(2%)":[213],"manifested":[217],"5":[219],"treatment-related":[220],"pneumonitis.":[221],"CONCLUSIONS:":[222],"HCC,":[229],"clinical":[236],"alone,":[242],"an":[244],"acceptable":[245],"profile.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-05-25T00:00:00"}
