{"id":"https://openalex.org/W4377820409","doi":"https://doi.org/10.1158/1055-9965.c.6660307","title":"Data from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System","display_name":"Data from Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System","publication_year":2023,"publication_date":"2023-05-23","ids":{"openalex":"https://openalex.org/W4377820409","doi":"https://doi.org/10.1158/1055-9965.c.6660307"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6660307","doi":"https://doi.org/10.1158/1055-9965.c.6660307","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6660307","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6660307","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050268192","display_name":"Christopher T.V. Swain","orcid":"https://orcid.org/0000-0002-0158-2511","observed_orcids":["https://orcid.org/0000-0002-0158-2511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher T.V. Swain","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0158-2511","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011944041","display_name":"Ann E. Drummond","orcid":"https://orcid.org/0000-0002-2183-6013","observed_orcids":["https://orcid.org/0000-0002-2183-6013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann E. Drummond","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2183-6013","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040933938","display_name":"Roger Laughlin Milne","orcid":"https://orcid.org/0000-0001-5764-7268","observed_orcids":["https://orcid.org/0000-0001-5764-7268","https://orcid.org/0000-0002-9387-7586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger L. Milne","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5764-7268","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018723032","display_name":"Dallas R. English","orcid":"https://orcid.org/0000-0001-7828-8188","observed_orcids":["https://orcid.org/0000-0001-7828-8188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dallas R. English","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7828-8188","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067671429","display_name":"Kristy A. Brown","orcid":"https://orcid.org/0000-0003-3382-5546","observed_orcids":["https://orcid.org/0000-0003-3382-5546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristy A. Brown","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3382-5546","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038895489","display_name":"Jamie E. Chong","orcid":"https://orcid.org/0000-0002-3709-8246","observed_orcids":["https://orcid.org/0000-0002-3709-8246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jamie E. Chong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3709-8246","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036061447","display_name":"Tina L. Skinner","orcid":"https://orcid.org/0000-0002-5704-2741","observed_orcids":["https://orcid.org/0000-0002-5704-2741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tina L. Skinner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5704-2741","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086003083","display_name":"Eline H. van Roekel","orcid":"https://orcid.org/0000-0002-9402-2029","observed_orcids":["https://orcid.org/0000-0002-9402-2029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eline H. van Roekel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9402-2029","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035871654","display_name":"Melissa M. Moore","orcid":"https://orcid.org/0000-0002-3869-1949","observed_orcids":["https://orcid.org/0000-0002-3869-1949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa M. Moore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3869-1949","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036589831","display_name":"Tom R. Gaunt","orcid":"https://orcid.org/0000-0003-0924-3247","observed_orcids":["https://orcid.org/0000-0003-0924-3247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom R. Gaunt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0924-3247","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065571043","display_name":"Richard Michael Martin","orcid":"https://orcid.org/0000-0002-7992-7719","observed_orcids":["https://orcid.org/0000-0002-7992-7719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard M. Martin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7992-7719","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003737642","display_name":"Sarah Jane Lewis","orcid":"https://orcid.org/0000-0003-4311-6890","observed_orcids":["https://orcid.org/0000-0003-4311-6890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah J. Lewis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4311-6890","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064878925","display_name":"Brigid Mary Lynch","orcid":"https://orcid.org/0000-0001-8060-547X","observed_orcids":["https://orcid.org/0000-0001-8060-547X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brigid M. Lynch","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8060-547X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.5365999937057495,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.2937000095844269,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.14380000531673431,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.9940000176429749},{"id":"https://openalex.org/keywords/insulin-igf-1-signaling","display_name":"insulin/IGF-1 signaling","score":0.9110000133514404},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8479999899864197},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8479999899864197},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.9229999780654907},{"id":"https://openalex.org/keywords/fasting-insulin","display_name":"fasting insulin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/exercise-intervention","display_name":"exercise intervention","score":0.6179999709129333},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.574999988079071},{"id":"https://openalex.org/keywords/homa-ir","display_name":"HOMA-IR","score":0.7540000081062317},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7953590154647827},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6748108267784119},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6077284216880798},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5976553559303284},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5606224536895752},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5016894340515137},{"id":"https://openalex.org/C2779901538","wikidata":"https://www.wikidata.org/wiki/Q6816584","display_name":"Mendelian randomization","level":5,"score":0.4921504855155945},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.46306413412094116},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4615023732185364},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3656708002090454},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.272724449634552},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22289153933525085},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2039550244808197},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06733965873718262},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05305337905883789},{"id":"https://openalex.org/C2993967602","wikidata":"https://www.wikidata.org/wiki/Q5532932","display_name":"Genetic variants","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1055-9965.c.6660307","doi":"https://doi.org/10.1158/1055-9965.c.6660307","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6660307","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1055-9965.c.6660307.v1","doi":"https://doi.org/10.1158/1055-9965.c.6660307.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6660307.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6660307","doi":"https://doi.org/10.1158/1055-9965.c.6660307","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6660307","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4311519900","https://openalex.org/W4377820397","https://openalex.org/W4311519915","https://openalex.org/W2895909641","https://openalex.org/W3166953454","https://openalex.org/W2038938843","https://openalex.org/W2599405628","https://openalex.org/W2054982993","https://openalex.org/W4361948176","https://openalex.org/W2531454615"],"abstract_inverted_index":{"Abstract":[0],"Physical":[1,129],"activity":[2,43,112,130,167],"may":[3],"reduce":[4],"the":[5,15,39,73,85,89,104,119,142,163,188,192],"risk":[6],"of":[7,41,54,68,75,88,144,165,187,191],"developing":[8],"breast":[9],"cancer":[10,196],"via":[11],"its":[12],"effect":[13,65,138,164],"on":[14,44,139,168],"insulin/insulin-like":[16],"growth":[17],"factor":[18],"(IGF)":[19],"signaling":[20,46],"system.":[21],"A":[22],"systematic":[23],"review":[24],"searched":[25],"for":[26,106,123,151],"randomized":[27],"controlled":[28],"trials":[29],"(RCT),":[30],"Mendelian":[31,100],"randomization":[32,101],"and":[33,52,72,79,126,154,170,178],"prospective":[34],"cohort":[35],"studies":[36,102],"that":[37,110],"examined":[38],"effects":[40],"physical":[42,111,166,193],"insulin/IGF":[45],"[IGFs,":[47],"their":[48],"binding":[49],"proteins":[50],"(IGFBP),":[51],"markers":[53],"insulin":[55,153,155,177,179],"resistance]":[56],"in":[57,172,175],"adult":[58],"women.":[59,173],"Meta-analyses":[60,108],"were":[61],"performed":[62],"to":[63,83,161],"generate":[64],"estimates.":[66],"Risk":[67],"bias":[69],"was":[70,135,148],"assessed,":[71],"Grading":[74],"Recommendations":[76],"Assessment,":[77],"Development,":[78],"Evaluation":[80],"system":[81],"used":[82],"determine":[84],"overall":[86],"quality":[87],"evidence.":[90],"Fifty-eight":[91],"RCTs":[92],"met":[93,103],"our":[94],"inclusion":[95],"criteria,":[96],"no":[97,136],"observational":[98],"or":[99,141],"criteria":[105],"inclusion.":[107],"indicated":[109],"interventions":[113],"(vs.":[114],"control)":[115],"reduced":[116],"fasting":[117,127,152,176],"insulin,":[118],"Homeostatic":[120],"Model":[121],"Assessment":[122],"Insulin":[124],"Resistance":[125],"glucose.":[128],"increased":[131],"IGF-1,":[132],"but":[133],"there":[134],"clear":[137],"IGFBP-3":[140],"ratio":[143],"IGF-1:IGFBP-3.":[145],"Strong":[146],"evidence":[147],"only":[149],"established":[150],"resistance.":[156],"Further":[157],"research":[158],"is":[159],"needed":[160],"examine":[162],"C-peptide":[169],"HBA1c":[171],"Reductions":[174],"resistance":[180],"following":[181],"exercise":[182],"suggest":[183],"some":[184],"biological":[185],"plausibility":[186],"first":[189],"part":[190],"activity\u2013insulin/IGF":[194],"signaling\u2013breast":[195],"pathway.":[197],"See":[198],"related":[199],"article":[200],"by":[201],"Drummond":[202],"et":[203],"al.,":[204],"p.":[205],"2116":[206]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-05-24T00:00:00"}
