{"id":"https://openalex.org/W4377293258","doi":"https://doi.org/10.1038/s41467-023-38679-z","title":"Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy","display_name":"Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4377293258","doi":"https://doi.org/10.1038/s41467-023-38679-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/37217527","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10203215"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-38679-z","doi":"https://doi.org/10.1038/s41467-023-38679-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-38679-z","pdf_url":"https://www.nature.com/articles/s41467-023-38679-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-38679-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011498884","display_name":"Weiyue Ban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyue Ban","raw_affiliation_strings":["Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032107299","display_name":"Mengchi Sun","orcid":"https://orcid.org/0000-0002-7457-3499","observed_orcids":["https://orcid.org/0000-0002-7457-3499"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengchi Sun","raw_affiliation_strings":["School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075594880","display_name":"Hanwei Huang","orcid":"https://orcid.org/0000-0001-5238-8594","observed_orcids":["https://orcid.org/0000-0001-5238-8594","https://orcid.org/0009-0003-3980-1198"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanwei Huang","raw_affiliation_strings":["Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040988785","display_name":"Wanxu Huang","orcid":"https://orcid.org/0000-0002-9159-3678","observed_orcids":["https://orcid.org/0000-0002-9159-3678"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanxu Huang","raw_affiliation_strings":["Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0002-9159-3678","affiliations":[{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047913733","display_name":"Siwei Pan","orcid":"https://orcid.org/0000-0002-8027-9341","observed_orcids":["https://orcid.org/0000-0002-8027-9341"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siwei Pan","raw_affiliation_strings":["Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355001","display_name":"Pengfei Liu","orcid":"https://orcid.org/0000-0002-4177-709X","observed_orcids":["https://orcid.org/0000-0002-4177-709X","https://orcid.org/0000-0003-0172-189X"]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Liu","raw_affiliation_strings":["Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025505256","display_name":"B. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingwu Li","raw_affiliation_strings":["Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020205036","display_name":"Zhenguo Cheng","orcid":"https://orcid.org/0000-0001-6375-3438","observed_orcids":["https://orcid.org/0000-0001-6375-3438"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenguo Cheng","raw_affiliation_strings":["Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450052, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420129","display_name":"Zhonggui He","orcid":"https://orcid.org/0000-0002-5907-3875","observed_orcids":["https://orcid.org/0000-0002-5907-3875","https://orcid.org/0000-0003-4536-0731","https://orcid.org/0000-0002-4172-7527"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhonggui He","raw_affiliation_strings":["Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China","institution_ids":["https://openalex.org/I103890011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077759445","display_name":"Funan Liu","orcid":"https://orcid.org/0000-0003-4762-8279","observed_orcids":["https://orcid.org/0000-0003-4762-8279"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Funan Liu","raw_affiliation_strings":["Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China. fnliu@cmu.edu.cn","Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. fnliu@cmu.edu.cn","Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0003-4762-8279","affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China. fnliu@cmu.edu.cn","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]},{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. fnliu@cmu.edu.cn","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, China Medical University, Ministry of Education, Shenyang, 110001, Liaoning, China","institution_ids":["https://openalex.org/I4210140515","https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019330832","display_name":"Jin Sun","orcid":"https://orcid.org/0000-0001-5470-1599","observed_orcids":["https://orcid.org/0000-0001-5470-1599","https://orcid.org/0000-0002-7494-3963"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Sun","raw_affiliation_strings":["Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. sunjin@syphu.edu.cn","Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0001-5470-1599","affiliations":[{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China. sunjin@syphu.edu.cn","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, China","institution_ids":["https://openalex.org/I103890011"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019330832","https://openalex.org/A5077759445"],"corresponding_institution_ids":["https://openalex.org/I103890011","https://openalex.org/I4210140515","https://openalex.org/I91656880"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":14.3931,"has_fulltext":true,"cited_by_count":116,"citation_normalized_percentile":{"value":0.9956835,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"2933","last_page":"2933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.36500000953674316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.36500000953674316,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.32839998602867126,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.18400000035762787,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bacterial-outer-membrane-vesicles","display_name":"bacterial outer membrane vesicles","score":0.9789999723434448},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pyranose-oxidase","display_name":"pyranose oxidase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hydrogen-peroxide-production","display_name":"hydrogen peroxide production","score":0.777999997138977},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.921999990940094},{"id":"https://openalex.org/keywords/immunosuppressive-tumor-microenvironment","display_name":"immunosuppressive tumor microenvironment","score":0.7480000257492065},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.3089999854564667}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9256578087806702},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.8899414539337158},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.6308847665786743},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.582142174243927},{"id":"https://openalex.org/C49744831","wikidata":"https://www.wikidata.org/wiki/Q600121","display_name":"Virotherapy","level":4,"score":0.5723724365234375},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5636197924613953},{"id":"https://openalex.org/C2777877232","wikidata":"https://www.wikidata.org/wiki/Q17144704","display_name":"Immunogenic cell death","level":4,"score":0.5064796209335327},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5059253573417664},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49779486656188965},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4899984896183014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4078066349029541},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39150136709213257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32829219102859497},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.24805647134780884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1805436611175537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0672362744808197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000080943","descriptor_name":"Bacterial Outer Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D050130","descriptor_name":"Oncolytic Virotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050504","descriptor_name":"Oncolytic Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-023-38679-z","doi":"https://doi.org/10.1038/s41467-023-38679-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-38679-z","pdf_url":"https://www.nature.com/articles/s41467-023-38679-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10203215","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10203215","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10203215/pdf/41467_2023_Article_38679.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37217527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37217527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38679-z","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-38679-z","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:6919a0edf7874583ba33724a87614d24","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6919a0edf7874583ba33724a87614d24","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)","raw_type":"article"},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/441674","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10072/441674","pdf_url":null,"source":{"id":"https://openalex.org/S7407064376","display_name":"Griffith Research Online","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-38679-z","doi":"https://doi.org/10.1038/s41467-023-38679-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-38679-z","pdf_url":"https://www.nature.com/articles/s41467-023-38679-z.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4521355759","display_name":null,"funder_award_id":"81803442","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4901043678","display_name":null,"funder_award_id":"2022-BS-157","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G7365705904","display_name":null,"funder_award_id":"2021YFA0909900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7647509717","display_name":null,"funder_award_id":"No. 2022-BS-157","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"},{"id":"https://openalex.org/G7912274264","display_name":null,"funder_award_id":"82073777","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377293258.pdf","grobid_xml":"https://content.openalex.org/works/W4377293258.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1913328895","https://openalex.org/W2089768104","https://openalex.org/W2095308362","https://openalex.org/W2108234281","https://openalex.org/W2138207763","https://openalex.org/W2179438025","https://openalex.org/W2339844244","https://openalex.org/W2735390215","https://openalex.org/W2767171253","https://openalex.org/W2770305738","https://openalex.org/W2898598946","https://openalex.org/W2947367516","https://openalex.org/W2964849163","https://openalex.org/W2984628891","https://openalex.org/W3012532724","https://openalex.org/W3037121839","https://openalex.org/W3092306917","https://openalex.org/W3096932658","https://openalex.org/W3136819448","https://openalex.org/W3148011207","https://openalex.org/W3175752499","https://openalex.org/W3181724709","https://openalex.org/W4200413360","https://openalex.org/W4213324290","https://openalex.org/W4220823462","https://openalex.org/W4280550884","https://openalex.org/W4317103569"],"related_works":["https://openalex.org/W7167925433","https://openalex.org/W2574392926","https://openalex.org/W7214708047","https://openalex.org/W7131617883","https://openalex.org/W4401247809","https://openalex.org/W4308393800","https://openalex.org/W581540643","https://openalex.org/W2735390215","https://openalex.org/W3203157223","https://openalex.org/W4280550884"],"abstract_inverted_index":{"Abstract":[0],"Oncolytic":[1],"adenovirus":[2],"(Ad)":[3],"infection":[4],"promotes":[5],"intracellular":[6],"autophagy":[7],"in":[8,69,117,140,144],"tumors.":[9],"This":[10,101],"could":[11,30],"kill":[12],"cancer":[13,142],"cells":[14],"and":[15,106],"contribute":[16],"to":[17,33,64,122],"Ads-mediated":[18],"anticancer":[19],"immunity.":[20],"However,":[21],"the":[22,59,88,132,148],"low":[23],"intratumoral":[24,73],"content":[25],"of":[26,62,91],"intravenously":[27],"delivered":[28],"Ads":[29,46,115],"be":[31],"insufficient":[32],"efficiently":[34],"activate":[35],"tumor":[36,77,108,119,134],"over-autophagy.":[37],"Herein,":[38],"we":[39],"report":[40],"bacterial":[41],"outer":[42],"membrane":[43],"vesicles":[44],"(OMVs)-encapsulating":[45],"as":[47],"microbial":[48,99],"nanocomposites":[49],"that":[50],"are":[51,127],"engineered":[52],"for":[53,130],"autophagy-cascade-augmented":[54],"immunotherapy.":[55,156],"Biomineral":[56],"shells":[57],"cover":[58],"surface":[60],"antigens":[61],"OMVs":[63,126],"slow":[65],"their":[66],"clearance":[67],"during":[68],"vivo":[70],"circulation,":[71],"enhancing":[72],"accumulation.":[74],"After":[75],"entering":[76],"cells,":[78,120],"there":[79],"is":[80],"excessive":[81],"H":[82],"2":[83,85,96],"O":[84],"accumulation":[86],"through":[87],"catalytic":[89],"effect":[90],"overexpressed":[92],"pyranose":[93],"oxidase":[94],"(P":[95],"O)":[97],"from":[98],"nanocomposite.":[100],"increases":[102],"oxidative":[103],"stress":[104],"levels":[105],"triggers":[107],"autophagy.":[109,124],"The":[110],"autophagy-induced":[111],"autophagosomes":[112],"further":[113],"promote":[114],"replication":[116],"infected":[118],"leading":[121],"Ads-overactivated":[123],"Moreover,":[125],"powerful":[128],"immunostimulants":[129],"remolding":[131],"immunosuppressive":[133],"microenvironment,":[135],"facilitating":[136],"antitumor":[137],"immune":[138],"response":[139],"preclinical":[141],"models":[143],"female":[145],"mice.":[146],"Therefore,":[147],"present":[149],"autophagy-cascade-boosted":[150],"immunotherapeutic":[151],"method":[152],"can":[153],"expand":[154],"OVs-based":[155]},"counts_by_year":[{"year":2026,"cited_by_count":40},{"year":2025,"cited_by_count":32},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-05-23T00:00:00"}
