{"id":"https://openalex.org/W4377264054","doi":"https://doi.org/10.1016/j.jvs.2023.03.470","title":"Histone Demethylase JARID1C/KDM5C Regulates Th17 T Cells in Diabetic Wounds by Increasing IL-6 Expression in Plasmacytoid Dendritic Cells","display_name":"Histone Demethylase JARID1C/KDM5C Regulates Th17 T Cells in Diabetic Wounds by Increasing IL-6 Expression in Plasmacytoid Dendritic Cells","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4377264054","doi":"https://doi.org/10.1016/j.jvs.2023.03.470"},"language":"en","primary_location":{"id":"doi:10.1016/j.jvs.2023.03.470","doi":"https://doi.org/10.1016/j.jvs.2023.03.470","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jvs.2023.03.470","pdf_url":"http://www.jvascsurg.org/article/S0741521423009849/pdf","source":{"id":"https://openalex.org/S104135014","display_name":"Journal of Vascular Surgery","issn_l":"0741-5214","issn":["0741-5214","1085-875X","1097-6809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jvascsurg.org/article/S0741521423009849/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022084087","display_name":"Christopher O. Audu","orcid":"https://orcid.org/0000-0002-4183-8825","observed_orcids":["https://orcid.org/0000-0002-4183-8825"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Audu","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044281693","display_name":"William James Melvin","orcid":"https://orcid.org/0000-0002-3241-5919","observed_orcids":["https://orcid.org/0000-0002-3241-5919"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Melvin","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007680139","display_name":"Kevin Dale Mangum","orcid":"https://orcid.org/0000-0003-2838-7094","observed_orcids":["https://orcid.org/0000-0003-2838-7094"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Mangum","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055856676","display_name":"Sriganesh B. Sharma","orcid":"https://orcid.org/0000-0003-3551-2578","observed_orcids":["https://orcid.org/0000-0003-3551-2578"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriganesh Sharma","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015253891","display_name":"Sonya Wolf","orcid":"https://orcid.org/0000-0003-3626-9274","observed_orcids":["https://orcid.org/0000-0003-3626-9274"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonya Wolf","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003195041","display_name":"Katherine Ann Gallagher","orcid":"https://orcid.org/0000-0002-8791-6980","observed_orcids":["https://orcid.org/0000-0002-8791-6980"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Gallagher","raw_affiliation_strings":["University of Michigan Medical Center, Ann Arbor, MI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center, Ann Arbor, MI","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":4010,"currency":"USD","value_usd":4010},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06854324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"77","issue":"6","first_page":"e342","last_page":"e342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-demethylase","display_name":"histone demethylase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/diabetic-wound-healing","display_name":"diabetic wound healing","score":0.7829999923706055},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/il-6-expression","display_name":"IL-6 expression","score":0.9079999923706055},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.54816734790802},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.5184847712516785},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.473433256149292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43932589888572693},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43793758749961853},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43449410796165466},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.43110933899879456},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4263479709625244},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3885566294193268},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37361353635787964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3535522222518921},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0811537504196167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jvs.2023.03.470","doi":"https://doi.org/10.1016/j.jvs.2023.03.470","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jvs.2023.03.470","pdf_url":"http://www.jvascsurg.org/article/S0741521423009849/pdf","source":{"id":"https://openalex.org/S104135014","display_name":"Journal of Vascular Surgery","issn_l":"0741-5214","issn":["0741-5214","1085-875X","1097-6809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Surgery","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jvs.2023.03.470","doi":"https://doi.org/10.1016/j.jvs.2023.03.470","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jvs.2023.03.470","pdf_url":"http://www.jvascsurg.org/article/S0741521423009849/pdf","source":{"id":"https://openalex.org/S104135014","display_name":"Journal of Vascular Surgery","issn_l":"0741-5214","issn":["0741-5214","1085-875X","1097-6809"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Vascular Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377264054.pdf","grobid_xml":"https://content.openalex.org/works/W4377264054.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3011810360","https://openalex.org/W3208381529","https://openalex.org/W2040595224","https://openalex.org/W2033247628","https://openalex.org/W4281663868","https://openalex.org/W2962360935","https://openalex.org/W2003221198","https://openalex.org/W4389098973","https://openalex.org/W2108753275","https://openalex.org/W2030397414"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}