{"id":"https://openalex.org/W4377263989","doi":"https://doi.org/10.1016/j.biopha.2023.114844","title":"Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway","display_name":"Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4377263989","doi":"https://doi.org/10.1016/j.biopha.2023.114844","pmid":"https://pubmed.ncbi.nlm.nih.gov/37224750"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2023.114844","doi":"https://doi.org/10.1016/j.biopha.2023.114844","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.114844","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2023.114844","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075117721","display_name":"Lei Gu","orcid":"https://orcid.org/0000-0002-6547-5459","observed_orcids":["https://orcid.org/0000-0002-6547-5459"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Gu","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0002-6547-5459","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037706705","display_name":"Xin He","orcid":"https://orcid.org/0000-0003-0991-7563","observed_orcids":["https://orcid.org/0000-0003-0991-7563"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin He","raw_affiliation_strings":["Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0003-0991-7563","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017251216","display_name":"Yanqiu Zhang","orcid":"https://orcid.org/0000-0001-5972-5370","observed_orcids":["https://orcid.org/0000-0001-5972-5370"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanqiu Zhang","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0001-5972-5370","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101655018","display_name":"Shenglan Li","orcid":"https://orcid.org/0000-0002-3117-2601","observed_orcids":["https://orcid.org/0000-0002-3117-2601"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenglan Li","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0002-3117-2601","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101642939","display_name":"Jie Tang","orcid":"https://orcid.org/0000-0002-3538-4433","observed_orcids":["https://orcid.org/0000-0002-3538-4433"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Tang","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089872805","display_name":"Ruixue Ma","orcid":"https://orcid.org/0000-0003-0284-1789","observed_orcids":["https://orcid.org/0000-0003-0284-1789"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruixue Ma","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0003-0284-1789","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100762288","display_name":"Xinyi Yang","orcid":"https://orcid.org/0000-0001-8565-4238","observed_orcids":["https://orcid.org/0000-0001-8565-4238","https://orcid.org/0000-0002-5060-2080"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Yang","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015241142","display_name":"Hao Huang","orcid":"https://orcid.org/0000-0001-9051-4483","observed_orcids":["https://orcid.org/0000-0001-9051-4483"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Huang","raw_affiliation_strings":["Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, China","Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, China","Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China"],"raw_orcid":"https://orcid.org/0000-0001-9051-4483","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Cell Biology, School of Life Sciences, Central South University, Changsha 410013, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051578682","display_name":"Yu Peng","orcid":"https://orcid.org/0000-0001-6953-7816","observed_orcids":["https://orcid.org/0000-0001-6953-7816"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Peng","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050895821","display_name":"Yanyun Xie","orcid":"https://orcid.org/0000-0002-2985-6414","observed_orcids":["https://orcid.org/0000-0002-2985-6414"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyun Xie","raw_affiliation_strings":["Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]},{"raw_affiliation_string":"National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049334764","display_name":"Zhangzhe Peng","orcid":"https://orcid.org/0009-0002-0804-3921","observed_orcids":["https://orcid.org/0009-0002-0804-3921"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhangzhe Peng","raw_affiliation_strings":["Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: pengzhangzhe@csu.edu.cn","Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: pengzhangzhe@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]},{"raw_affiliation_string":"National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101662467","display_name":"Jie Meng","orcid":"https://orcid.org/0000-0002-4402-1589","observed_orcids":["https://orcid.org/0000-0002-4402-1589"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Meng","raw_affiliation_strings":["Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Respirology, Third Xiangya Hospital, Central South University, Changsha 410013, China","Department of Respirology, Third Xiangya Hospital, Central South University, Changsha 410013, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Respirology, Third Xiangya Hospital, Central South University, Changsha 410013, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Respirology, Third Xiangya Hospital, Central South University, Changsha 410013, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]},{"raw_affiliation_string":"National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083483109","display_name":"Gaoyun Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaoyun Hu","raw_affiliation_strings":["Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; Faculty of Pharmaceutical Sciences, Central South University, Changsha 410013, China","Faculty of Pharmaceutical Sciences, Central South University, Changsha 410013, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; Faculty of Pharmaceutical Sciences, Central South University, Changsha 410013, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Central South University, Changsha 410013, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707258","display_name":"Lijian Tao","orcid":"https://orcid.org/0000-0003-0816-7588","observed_orcids":["https://orcid.org/0000-0003-0816-7588"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijian Tao","raw_affiliation_strings":["Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076993228","display_name":"Xiaowei Liu","orcid":"https://orcid.org/0000-0002-0064-6990","observed_orcids":["https://orcid.org/0000-0002-0064-6990"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Liu","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110686994","display_name":"Huixiang Yang","orcid":"https://orcid.org/0000-0001-5467-2927","observed_orcids":["https://orcid.org/0000-0001-5467-2927","https://orcid.org/0009-0001-4435-5327"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huixiang Yang","raw_affiliation_strings":["Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address: yang_hx430@csu.edu.cn","Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China. Electronic address: yang_hx430@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"Hunan Key Lab of Organ Fibrosis, Changsha 410008, China","institution_ids":[]},{"raw_affiliation_string":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]},{"raw_affiliation_string":"National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049334764","https://openalex.org/A5110686994"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":3050,"currency":"USD","value_usd":3050},"apc_paid":{"value":3050,"currency":"USD","value_usd":3050},"fwci":5.5127,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.96783342,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"164","issue":null,"first_page":"114844","last_page":"114844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hepatocyte-apoptosis","display_name":"hepatocyte apoptosis","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6230000257492065},{"id":"https://openalex.org/keywords/il-17-signaling","display_name":"IL-17 signaling","score":0.9509999752044678},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.703559160232544},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6476771831512451},{"id":"https://openalex.org/C2778073123","wikidata":"https://www.wikidata.org/wiki/Q378498","display_name":"Anisomycin","level":3,"score":0.6310915350914001},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.548349916934967},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.5338669419288635},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5226611495018005},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5103091597557068},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5036739706993103},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.46461641788482666},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4555872082710266},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44786542654037476},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.42560896277427673},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.4206855893135071},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.41736680269241333},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3247697353363037},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2453753650188446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23254066705703735},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2154848873615265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2131408452987671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2093248963356018},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17514726519584656}],"mesh":[{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000082","descriptor_name":"Acetaminophen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000841","descriptor_name":"Anisomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000873","descriptor_name":"Anthracenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011728","descriptor_name":"Pyridones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopha.2023.114844","doi":"https://doi.org/10.1016/j.biopha.2023.114844","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.114844","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:37224750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37224750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3a3da7fc4abd45b5a61f79312c9f7fc8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3a3da7fc4abd45b5a61f79312c9f7fc8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicine & Pharmacotherapy, Vol 164, Iss , Pp 114844- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2023.114844","doi":"https://doi.org/10.1016/j.biopha.2023.114844","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.114844","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1786626133","display_name":null,"funder_award_id":"81873585","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2038773980","display_name":null,"funder_award_id":"82070651","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5052099728","display_name":null,"funder_award_id":"2022JJ10100","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G7632924420","display_name":null,"funder_award_id":"82173877","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G829237617","display_name":null,"funder_award_id":"82090024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8702140091","display_name":null,"funder_award_id":"2021SK2015","funder_id":"https://openalex.org/F4320316344","funder_display_name":"Key Project of Research and Development Plan of Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320316344","display_name":"Key Project of Research and Development Plan of Hunan Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320330206","display_name":"Science and Technology Program of Hunan Province","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W224670283","https://openalex.org/W1542737599","https://openalex.org/W1967173904","https://openalex.org/W1969981758","https://openalex.org/W1990006823","https://openalex.org/W1991966831","https://openalex.org/W1994795656","https://openalex.org/W2010475904","https://openalex.org/W2025605620","https://openalex.org/W2043420998","https://openalex.org/W2043738708","https://openalex.org/W2057261336","https://openalex.org/W2066018449","https://openalex.org/W2070108227","https://openalex.org/W2073820873","https://openalex.org/W2074545478","https://openalex.org/W2086714780","https://openalex.org/W2104614292","https://openalex.org/W2123662524","https://openalex.org/W2128103046","https://openalex.org/W2140976433","https://openalex.org/W2157305642","https://openalex.org/W2174763143","https://openalex.org/W2378581637","https://openalex.org/W2529405505","https://openalex.org/W2538034557","https://openalex.org/W2558163233","https://openalex.org/W2570845590","https://openalex.org/W2575447090","https://openalex.org/W2592870091","https://openalex.org/W2611962854","https://openalex.org/W2614484469","https://openalex.org/W2614738659","https://openalex.org/W2732818861","https://openalex.org/W2740721062","https://openalex.org/W2767233641","https://openalex.org/W2772781313","https://openalex.org/W2785817960","https://openalex.org/W2800988230","https://openalex.org/W2803843947","https://openalex.org/W2927221756","https://openalex.org/W2939249740","https://openalex.org/W2957836220","https://openalex.org/W2982418079","https://openalex.org/W2986644059","https://openalex.org/W2994648584","https://openalex.org/W3002174151","https://openalex.org/W3006729845","https://openalex.org/W3012667847","https://openalex.org/W3045794918","https://openalex.org/W3082857523","https://openalex.org/W3097125557","https://openalex.org/W3133565378","https://openalex.org/W3174786989","https://openalex.org/W3184667393","https://openalex.org/W4200420632","https://openalex.org/W4210858469","https://openalex.org/W4211175126","https://openalex.org/W4296821950","https://openalex.org/W6608817834"],"related_works":["https://openalex.org/W2157806770","https://openalex.org/W1976732428","https://openalex.org/W1987710520","https://openalex.org/W2000666134","https://openalex.org/W2028896927","https://openalex.org/W2107947237","https://openalex.org/W2898766851","https://openalex.org/W102358633","https://openalex.org/W2417895049","https://openalex.org/W3010145749"],"abstract_inverted_index":{"AIMS:":[0],"Acute":[1],"liver":[2,138],"failure":[3],"(ALF)":[4],"is":[5,27],"a":[6,44,85,243],"life-threatening":[7],"disease":[8],"characterized":[9],"by":[10,130,181,189,230],"abrupt":[11],"and":[12,16,54,71,78,81,93,118,139,151,156,194,206,210],"extensive":[13],"hepatic":[14,89],"necrosis":[15],"apoptosis,":[17,112],"resulting":[18],"in":[19,52,100,122,132,136,157,213,234],"high":[20],"mortality.":[21],"The":[22,174],"approved":[23],"drug,":[24],"N-acetylcysteine":[25],"(NAC),":[26],"only":[28,170],"effective":[29],"for":[30,99,247],"acetaminophen":[31],"(APAP)-associated":[32],"ALF":[33,51,60,108,228],"at":[34],"the":[35,137,202],"early":[36],"stage.":[37],"Thus,":[38],"we":[39],"investigate":[40],"whether":[41],"fluorofenidone":[42],"(AKF-PD),":[43],"novel":[45,244],"antifibrosis":[46],"pyridone":[47],"agent,":[48],"protects":[49],"against":[50,227],"mice":[53],"explore":[55],"its":[56],"underlying":[57],"mechanisms.":[58],"METHODS:":[59],"mouse":[61,95],"models":[62],"were":[63,73,97],"established":[64],"using":[65],"APAP":[66,131,231],"or":[67,232],"lipopolysaccharide/D-galactosamine":[68],"(LPS/D-Gal).":[69],"Anisomycin":[70],"SP600125":[72,169],"used":[74,98],"as":[75,84],"JNK":[76,172,207],"activator":[77],"inhibitor,":[79],"respectively,":[80],"NAC":[82],"served":[83],"positive":[86],"control.":[87],"Mouse":[88],"cell":[90],"line":[91],"AML12":[92,133],"primary":[94],"hepatocytes":[96],"vitro":[101,155],"studies.":[102],"RESULTS:":[103],"AKF-PD":[104,125,147,162,178,184,224,240],"pretreatment":[105,185],"alleviated":[106,126],"APAP-induced":[107,164],"with":[109,218],"decreased":[110,191],"necrosis,":[111],"reactive":[113],"oxygen":[114],"species":[115],"(ROS)":[116],"markers,":[117],"mitochondrial":[119,127],"permeability":[120],"transition":[121],"liver.":[123],"Additionally,":[124],"ROS":[128,192],"stimulated":[129],"cells.":[134],"RNA-sequencing":[135],"subsequent":[140],"gene":[141],"set":[142],"enrichment":[143],"analysis":[144],"showed":[145],"that":[146,161],"significantly":[148],"impacted":[149],"MAPK":[150],"IL-17":[152],"pathway.":[153,239],"In":[154,222],"vivo":[158],"studies":[159],"demonstrated":[160],"inhibited":[163,171,201],"phosphorylation":[165,203],"of":[166,177,204,215],"MKK4/JNK,":[167],"while":[168],"phosphorylation.":[173],"protective":[175],"effect":[176],"was":[179],"abolished":[180,186],"anisomycin.":[182],"Similarly,":[183],"hepatotoxicity":[187],"caused":[188,229],"LPS/D-Gal,":[190,233],"levels,":[193],"diminished":[195],"inflammation.":[196],"Furthermore,":[197],"unlike":[198],"NAC,":[199],"AKF-PD,":[200],"MKK4":[205],"upon":[208],"pretreatment,":[209],"improved":[211],"survival":[212],"cases":[214],"LPS/D-Gal-induced":[216],"mortality":[217],"delayed":[219],"dosing.":[220],"CONCLUSIONS:":[221],"summary,":[223],"can":[225],"protect":[226],"part,":[235],"via":[236],"regulating":[237],"MKK4/JNK":[238],"might":[241],"be":[242],"candidate":[245],"drug":[246],"ALF.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}