{"id":"https://openalex.org/W4377263811","doi":"https://doi.org/10.1016/j.biopha.2023.114880","title":"Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity","display_name":"Therapeutic effects of methimazole on 3,4-methylenedioxymethamphetamine-induced hyperthermia and serotonergic neurotoxicity","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4377263811","doi":"https://doi.org/10.1016/j.biopha.2023.114880","pmid":"https://pubmed.ncbi.nlm.nih.gov/37224751"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2023.114880","doi":"https://doi.org/10.1016/j.biopha.2023.114880","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.114880","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4377263811"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.biopha.2023.114880","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026654568","display_name":"I\u2010Hsun Li","orcid":"https://orcid.org/0000-0002-2824-4774","observed_orcids":["https://orcid.org/0000-0002-2824-4774"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Hsun Li","raw_affiliation_strings":["Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan","School of Pharmacy, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874"]},{"raw_affiliation_string":"School of Pharmacy, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053095070","display_name":"Tsung\u2013Ta Liu","orcid":"https://orcid.org/0000-0002-8865-0272","observed_orcids":["https://orcid.org/0000-0002-8865-0272"]},"institutions":[{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Ta Liu","raw_affiliation_strings":["School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan","Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan","School of Pharmacy, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, National Defense Medical Center, Taipei, Taiwan; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]},{"raw_affiliation_string":"School of Pharmacy, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying-Chen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114150738","display_name":"Fu Jen Catholic University","ror":"https://ror.org/04je98850","country_code":"TW","type":"education","lineage":["https://openalex.org/I114150738"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Chen Chen","raw_affiliation_strings":["Department of Pharmacy, Fu Jen Catholic University Hospital, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Fu Jen Catholic University Hospital, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I114150738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091140923","display_name":"Sheng\u2010Huang Hsiao","orcid":"https://orcid.org/0000-0003-3024-1289","observed_orcids":["https://orcid.org/0000-0003-3024-1289"]},"institutions":[{"id":"https://openalex.org/I3020248675","display_name":"Taipei Municipal YangMing Hospital","ror":"https://ror.org/047n4ns40","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020248675"]},{"id":"https://openalex.org/I4210119487","display_name":"Taipei City Hospital","ror":"https://ror.org/02gzfb532","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210119487"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sheng-Huang Hsiao","raw_affiliation_strings":["Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Taipei City Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I3020248675","https://openalex.org/I4210119487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054109168","display_name":"Hao-Yuan Hung","orcid":"https://orcid.org/0000-0001-6455-3032","observed_orcids":["https://orcid.org/0000-0001-6455-3032"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hao-Yuan Hung","raw_affiliation_strings":["Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-6455-3032","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078953102","display_name":"Li-Yun Fann","orcid":"https://orcid.org/0000-0001-9800-3987","observed_orcids":["https://orcid.org/0000-0001-9800-3987"]},"institutions":[{"id":"https://openalex.org/I3020248675","display_name":"Taipei Municipal YangMing Hospital","ror":"https://ror.org/047n4ns40","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020248675"]},{"id":"https://openalex.org/I4210119487","display_name":"Taipei City Hospital","ror":"https://ror.org/02gzfb532","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210119487"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Yun Fann","raw_affiliation_strings":["Department of Nursing, Taipei City Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, Taipei City Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I3020248675","https://openalex.org/I4210119487"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000264069","display_name":"Jui\u2010Hu Shih","orcid":"https://orcid.org/0000-0001-7884-1246","observed_orcids":["https://orcid.org/0000-0001-7884-1246"]},"institutions":[{"id":"https://openalex.org/I1293718874","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I1293718874"]},{"id":"https://openalex.org/I68171755","display_name":"National Defense Medical Center","ror":"https://ror.org/02bn97g32","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I68171755"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jui-Hu Shih","raw_affiliation_strings":["Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Electronic address: jtlovehl@gmail.com","Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan","School of Pharmacy, National Defense Medical Center, Taipei, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-7884-1246","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. Electronic address: jtlovehl@gmail.com","institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"]},{"raw_affiliation_string":"Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I1293718874"]},{"raw_affiliation_string":"School of Pharmacy, National Defense Medical Center, Taipei, Taiwan","institution_ids":["https://openalex.org/I68171755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5000264069"],"corresponding_institution_ids":["https://openalex.org/I1293718874","https://openalex.org/I68171755"],"apc_list":{"value":3050,"currency":"USD","value_usd":3050},"apc_paid":{"value":3050,"currency":"USD","value_usd":3050},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"164","issue":null,"first_page":"114880","last_page":"114880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.4934000074863434,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.4934000074863434,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.14920000731945038,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mdma","display_name":"MDMA","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ecstasy","display_name":"ecstasy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/serotonergic-neurotoxicity","display_name":"serotonergic neurotoxicity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.8500000238418579},{"id":"https://openalex.org/keywords/peripheral-vasodilation","display_name":"peripheral vasodilation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/skeletal-muscle-glucose-uptake","display_name":"skeletal muscle glucose uptake","score":0.9020000100135803},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.7649999856948853},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6489999890327454},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C2780876324","wikidata":"https://www.wikidata.org/wiki/Q69488","display_name":"MDMA","level":2,"score":0.9471805095672607},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.8051154613494873},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.7554594278335571},{"id":"https://openalex.org/C2779949491","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Hyperthermia","level":2,"score":0.7116857767105103},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.617077112197876},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5460891127586365},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5335800051689148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5185557007789612},{"id":"https://openalex.org/C2779488553","wikidata":"https://www.wikidata.org/wiki/Q625143","display_name":"Ecstasy","level":2,"score":0.4472813308238983},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4414157569408417},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.41184136271476746},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4098217785358429},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37503498792648315},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34293270111083984},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.1370495855808258},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.09130454063415527},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008713","descriptor_name":"Methimazole","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018817","descriptor_name":"N-Methyl-3,4-methylenedioxyamphetamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2023.114880","doi":"https://doi.org/10.1016/j.biopha.2023.114880","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.114880","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:37224751","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37224751","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopha.2023.114880","doi":"https://doi.org/10.1016/j.biopha.2023.114880","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopha.2023.114880","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & Pharmacotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1263365892","display_name":null,"funder_award_id":"TSGH-E-112264","funder_id":"https://openalex.org/F4320326425","funder_display_name":"Tri-Service General Hospital"},{"id":"https://openalex.org/G2713316857","display_name":null,"funder_award_id":"MND-MAB-D-111100","funder_id":"https://openalex.org/F4320322828","funder_display_name":"Ministry of National Defense, People's Republic of China"},{"id":"https://openalex.org/G3098682243","display_name":null,"funder_award_id":"NSTC111\u20132314-B-016\u2013022","funder_id":"https://openalex.org/F2461203286","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G3662052727","display_name":null,"funder_award_id":"TSGH-E-112265","funder_id":"https://openalex.org/F4320326425","funder_display_name":"Tri-Service General Hospital"},{"id":"https://openalex.org/G6552995576","display_name":null,"funder_award_id":"MND-MAB- D-112101","funder_id":"https://openalex.org/F4320322828","funder_display_name":"Ministry of National Defense, People's Republic of China"},{"id":"https://openalex.org/G8922776248","display_name":null,"funder_award_id":"NSTC110\u20132314-B-016\u2013030-MY3","funder_id":"https://openalex.org/F2461203286","funder_display_name":"National Science and Technology Council"}],"funders":[{"id":"https://openalex.org/F2461203286","display_name":"National Science and Technology Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322828","display_name":"Ministry of National Defense, People's Republic of China","ror":"https://ror.org/03t0a5k13"},{"id":"https://openalex.org/F4320326425","display_name":"Tri-Service General Hospital","ror":"https://ror.org/007h4qe29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1260236800","https://openalex.org/W1532905017","https://openalex.org/W1554160015","https://openalex.org/W1634219725","https://openalex.org/W1726902760","https://openalex.org/W1810864195","https://openalex.org/W1886032183","https://openalex.org/W1974639269","https://openalex.org/W1983693385","https://openalex.org/W1992055761","https://openalex.org/W1993294559","https://openalex.org/W1994498842","https://openalex.org/W1998999302","https://openalex.org/W2000691783","https://openalex.org/W2004785232","https://openalex.org/W2008017098","https://openalex.org/W2008098037","https://openalex.org/W2009275235","https://openalex.org/W2019801054","https://openalex.org/W2024868516","https://openalex.org/W2031910202","https://openalex.org/W2041798451","https://openalex.org/W2048841731","https://openalex.org/W2064595979","https://openalex.org/W2078704741","https://openalex.org/W2082669257","https://openalex.org/W2083048709","https://openalex.org/W2083754020","https://openalex.org/W2110549109","https://openalex.org/W2157908805","https://openalex.org/W2163413903","https://openalex.org/W2197078876","https://openalex.org/W2199386545","https://openalex.org/W2269062364","https://openalex.org/W2413430220","https://openalex.org/W2461432396","https://openalex.org/W2560491655","https://openalex.org/W2564911043","https://openalex.org/W2592968515","https://openalex.org/W2883043654","https://openalex.org/W2899708555","https://openalex.org/W2919604118","https://openalex.org/W2942808530","https://openalex.org/W3129536098","https://openalex.org/W3137775583","https://openalex.org/W3203209150","https://openalex.org/W3207752026","https://openalex.org/W3210391214","https://openalex.org/W4243225672","https://openalex.org/W4283524247","https://openalex.org/W4311027217","https://openalex.org/W4323871036","https://openalex.org/W6676503462"],"related_works":["https://openalex.org/W2057528351","https://openalex.org/W2051893590","https://openalex.org/W2082383749","https://openalex.org/W2133439321","https://openalex.org/W3033135173","https://openalex.org/W2031457279","https://openalex.org/W2038890629","https://openalex.org/W1960526592","https://openalex.org/W1972491768","https://openalex.org/W1987847811"],"abstract_inverted_index":{"3,4-methylenedioxymethamphetamine":[0],"(MDMA)":[1],"is":[2],"a":[3],"popular":[4],"recreational":[5],"drug,":[6],"however":[7],"over":[8],"200":[9],"studies":[10],"demonstrate":[11],"that":[12,114],"acute":[13],"(e.g.":[14,19],"hyperthermia,":[15],"rhabdomyolysis)":[16],"and":[17,83,99,169,187],"chronic":[18],"neurotoxicity)":[20],"toxicity":[21],"effects":[22,58],"of":[23,34,46,59,137,175,185],"MDMA":[24,62,115,141],"were":[25,70],"observed":[26],"in":[27,50,65,167,196],"different":[28],"animals.":[29],"Methimazole":[30],"(MMI),":[31],"an":[32],"inhibitor":[33],"thyroid":[35],"hormone":[36],"synthesis,":[37],"was":[38,93,124,146],"found":[39,94],"to":[40,55,95,199],"significantly":[41],"reduce":[42],"the":[43,57,88,101,135,151,197],"HSP72":[44],"expression":[45],"heat":[47,102],"stress":[48],"induced":[49,63,116],"fibroblasts.":[51],"Hence,":[52],"we":[53],"attempted":[54],"understand":[56],"MMI":[60,92,127,176],"on":[61],"changes":[64],"vivo.":[66],"Male":[67],"SD":[68],"rats":[69],"randomly":[71],"divided":[72],"into":[73],"four":[74],"groups":[75],"as":[76,180],"follows:(a)":[77],"water-saline":[78],"(b)":[79],"water-MDMA":[80],"(c)":[81],"MMI-saline":[82,170],"(d)":[84],"MMI-MDMA":[85,168],"group.":[86],"In":[87],"temperature":[89],"analysis":[90],"test,":[91,157],"alleviate":[96],"MDMA-induced":[97],"hyperthermia":[98],"increase":[100],"loss":[103],"index":[104],"(HLI),":[105],"revealing":[106],"its":[107,204],"peripheral":[108],"vasodilation":[109],"effect.":[110],"PET":[111],"experiment":[112],"suggested":[113],"elevated":[117],"glucose":[118],"uptake":[119],"by":[120,126,140,148],"skeletal":[121],"muscles,":[122],"which":[123,145],"resolved":[125],"pretreatment.":[128],"IHC":[129],"staining":[130],"(serotonin":[131,142],"transporter,":[132],"SERT)":[133],"showed":[134,159],"evidence":[136,202],"neurotoxicity":[138,186],"caused":[139],"fiber":[143],"loss),":[144],"alleviated":[147],"MMI.":[149],"Furthermore,":[150],"animal":[152],"behaviour":[153],"test":[154],"(forced":[155],"swimming":[156,161],"FST)":[158],"higher":[160],"time":[162,166],"but":[163],"lower":[164],"immobility":[165],"groups.":[171],"Taken":[172],"together,":[173],"treatment":[174],"shows":[177],"benefits":[178],"such":[179],"lowered":[181],"body":[182],"temperature,":[183],"alleviation":[184],"excited":[188],"behaviour.":[189],"However,":[190],"further":[191],"investigations":[192],"should":[193],"be":[194],"conducted":[195],"future":[198],"provide":[200],"in-depth":[201],"for":[203],"clinical":[205],"use.":[206]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2023-05-23T00:00:00"}