{"id":"https://openalex.org/W4377093660","doi":"https://doi.org/10.3390/v15051198","title":"Efficiency of Interferon-\u03b3 in Activating Dendritic Cells and Its Potential Synergy with Toll-like Receptor Agonists","display_name":"Efficiency of Interferon-\u03b3 in Activating Dendritic Cells and Its Potential Synergy with Toll-like Receptor Agonists","publication_year":2023,"publication_date":"2023-05-19","ids":{"openalex":"https://openalex.org/W4377093660","doi":"https://doi.org/10.3390/v15051198","pmid":"https://pubmed.ncbi.nlm.nih.gov/37243284","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10224459"},"language":"en","primary_location":{"id":"doi:10.3390/v15051198","doi":"https://doi.org/10.3390/v15051198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15051198","pdf_url":"https://www.mdpi.com/1999-4915/15/5/1198/pdf?version=1684561076","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4915/15/5/1198/pdf?version=1684561076","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114073183","display_name":"Yuanzhi Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanzhi Bian","raw_affiliation_strings":["Department of Biological Systems Engineering, College of Agriculture and Life Sciences & College of Engineering, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, College of Agriculture and Life Sciences & College of Engineering, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091666689","display_name":"Debra L. Walter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debra L. Walter","raw_affiliation_strings":["Department of Biological Systems Engineering, College of Agriculture and Life Sciences & College of Engineering, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, College of Agriculture and Life Sciences & College of Engineering, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101480352","display_name":"Chenming Zhang","orcid":"https://orcid.org/0000-0002-6770-5334","observed_orcids":["https://orcid.org/0000-0002-6770-5334"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chenming Zhang","raw_affiliation_strings":["Department of Biological Systems Engineering, College of Agriculture and Life Sciences & College of Engineering, Virginia Tech, Blacksburg, VA 24061, USA"],"raw_orcid":"https://orcid.org/0000-0002-6770-5334","affiliations":[{"raw_affiliation_string":"Department of Biological Systems Engineering, College of Agriculture and Life Sciences & College of Engineering, Virginia Tech, Blacksburg, VA 24061, USA","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101480352"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":1.745,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.84343434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"5","first_page":"1198","last_page":"1198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dendritic-cell-activation","display_name":"dendritic cell activation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.9929999709129333},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.9079999923706055},{"id":"https://openalex.org/keywords/resiquimod","display_name":"resiquimod","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.8410000205039978},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.9539999961853027},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.44999998807907104},{"id":"https://openalex.org/keywords/murine-dendritic-cells","display_name":"murine dendritic cells","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7730069160461426},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.6984286904335022},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.6824129819869995},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5766534805297852},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.49202534556388855},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.49168187379837036},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4854345917701721},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46821168065071106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45323798060417175},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4418870210647583},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43986836075782776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43545907735824585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3914009630680084},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3165621757507324},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05887538194656372}],"mesh":[{"descriptor_ui":"D000276","descriptor_name":"Adjuvants, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/v15051198","doi":"https://doi.org/10.3390/v15051198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15051198","pdf_url":"https://www.mdpi.com/1999-4915/15/5/1198/pdf?version=1684561076","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10224459","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10224459","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10224459/pdf/viruses-15-01198.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmid:37243284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37243284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/115216","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/115216","pdf_url":"https://vtechworks.lib.vt.edu/bitstreams/2bcd40ae-b5eb-42d2-8285-bb43079b6f9c/download","source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"},{"id":"pmh:oai:doaj.org/article:174397637e24489a9a1049254524cae5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/174397637e24489a9a1049254524cae5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 15, Iss 5, p 1198 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/v15051198","doi":"https://doi.org/10.3390/v15051198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15051198","pdf_url":"https://www.mdpi.com/1999-4915/15/5/1198/pdf?version=1684561076","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5791608505","display_name":"Novel nanovaccines against opioid use disorders","funder_award_id":"UG3DA048775","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8188116603","display_name":null,"funder_award_id":"#2021-08581","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377093660.pdf","grobid_xml":"https://content.openalex.org/works/W4377093660.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W995521720","https://openalex.org/W1530235393","https://openalex.org/W1636634945","https://openalex.org/W1673799980","https://openalex.org/W1786654010","https://openalex.org/W1964269606","https://openalex.org/W1981603866","https://openalex.org/W1982580075","https://openalex.org/W1992685641","https://openalex.org/W2000770184","https://openalex.org/W2010936391","https://openalex.org/W2016430217","https://openalex.org/W2017749666","https://openalex.org/W2028065414","https://openalex.org/W2033023829","https://openalex.org/W2036807187","https://openalex.org/W2039028514","https://openalex.org/W2041747503","https://openalex.org/W2055948574","https://openalex.org/W2063490958","https://openalex.org/W2077291760","https://openalex.org/W2078844752","https://openalex.org/W2084185832","https://openalex.org/W2091129202","https://openalex.org/W2092288031","https://openalex.org/W2106196303","https://openalex.org/W2106546073","https://openalex.org/W2111435630","https://openalex.org/W2116650389","https://openalex.org/W2117503116","https://openalex.org/W2128728706","https://openalex.org/W2133402546","https://openalex.org/W2140649634","https://openalex.org/W2150769574","https://openalex.org/W2152701218","https://openalex.org/W2162229819","https://openalex.org/W2314697488","https://openalex.org/W2348389929","https://openalex.org/W2397329584","https://openalex.org/W2470298560","https://openalex.org/W2514929667","https://openalex.org/W2598119627","https://openalex.org/W2735527928","https://openalex.org/W2752159622","https://openalex.org/W2770628447","https://openalex.org/W2890087043","https://openalex.org/W2913970879","https://openalex.org/W2921693673","https://openalex.org/W2943197912","https://openalex.org/W2948076980","https://openalex.org/W2983235264","https://openalex.org/W3011494554","https://openalex.org/W3028481751","https://openalex.org/W3046365383","https://openalex.org/W3047840042","https://openalex.org/W3111912998","https://openalex.org/W3122174179","https://openalex.org/W3123792988","https://openalex.org/W3144140615","https://openalex.org/W3171561485","https://openalex.org/W3177104437","https://openalex.org/W3193445073","https://openalex.org/W4212832265","https://openalex.org/W4226069917","https://openalex.org/W4246077736"],"related_works":["https://openalex.org/W4385686679","https://openalex.org/W1482804468","https://openalex.org/W1985498297","https://openalex.org/W1789706509","https://openalex.org/W2131811425","https://openalex.org/W4281768987","https://openalex.org/W2006065188","https://openalex.org/W1585397838","https://openalex.org/W2034981483","https://openalex.org/W1972850472"],"abstract_inverted_index":{"Interferon-\u03b3":[0],"(IFN-\u03b3)":[1],"is":[2,257],"a":[3,26,127,151,167,183,246],"cytokine":[4],"that":[5,31,224],"plays":[6],"an":[7,124],"important":[8],"role":[9],"in":[10,14],"immune":[11,20,40],"regulation,":[12],"especially":[13],"the":[15,43,57,77,93,107,118,134,145,155,159,171,212,249,261],"activation":[16,91,125,189,239],"and":[17,38,47,62,81,92,133,226,240],"differentiation":[18,130],"of":[19,28,59,79,129,136,154,175,186,252,263],"cells.":[21],"Toll-like":[22],"receptors":[23,30],"(TLRs)":[24],"are":[25],"family":[27],"pattern-recognition":[29],"sense":[32],"structural":[33],"motifs":[34],"related":[35],"to":[36,42,55,75,87,170,235,259],"pathogens":[37],"alert":[39],"cells":[41,101,120,138,215],"invasion.":[44],"Both":[45],"IFN-\u03b3":[46,80,105,148,176,191,197,225],"TLR":[48,82,108,160,227],"agonists":[49,83,161,228],"have":[50],"been":[51],"used":[52],"as":[53,232],"immunoadjuvants":[54],"augment":[56],"efficacy":[58],"cancer":[60],"immunotherapies":[61],"vaccines":[63],"against":[64],"infectious":[65],"diseases":[66],"or":[67,114,180],"psychoactive":[68],"compounds.":[69],"In":[70,97],"this":[71],"study,":[72],"we":[73],"aimed":[74],"explore":[76],"potential":[78],"being":[84],"applied":[85,231],"simultaneously":[86],"boost":[88],"dendritic":[89,100,119,156,187,237],"cell":[90,188,205,238],"subsequent":[94],"antigen":[95,241],"presentation.":[96,242],"brief,":[98],"murine":[99],"were":[102,121],"treated":[103],"with":[104,177,198],"and/or":[106],"agonists,":[109],"polyinosinic-polycytidylic":[110],"acid":[111],"(poly":[112],"I:C),":[113],"resiquimod":[115],"(R848).":[116],"Next,":[117],"stained":[122],"for":[123],"marker,":[126],"cluster":[128],"86":[131],"(CD86),":[132],"percentage":[135],"CD86-positive":[137,214],"was":[139,208],"measured":[140],"by":[141,162,217],"flow":[142],"cytometry.":[143],"From":[144],"cytometric":[146],"analysis,":[147],"efficiently":[149],"stimulated":[150],"considerable":[152],"number":[153],"cells,":[157],"while":[158],"themselves":[163],"could":[164,229],"merely":[165],"activate":[166],"few":[168],"compared":[169],"control.":[172],"The":[173],"combination":[174],"poly":[178,201],"I:C":[179,202],"R848":[181],"triggered":[182],"higher":[184,210],"amount":[185],"than":[190,211],"alone.":[192],"For":[193],"instance,":[194],"10":[195,218],"ng/mL":[196,219],"100":[199],"\u00b5g/mL":[200],"achieved":[203],"59.1%":[204],"activation,":[206],"which":[207],"significantly":[209],"33.4%":[213],"obtained":[216],"IFN-\u03b3.":[220],"These":[221],"results":[222],"suggested":[223],"be":[230,245],"complementary":[233],"systems":[234],"promote":[236],"There":[243],"might":[244],"synergy":[247],"between":[248],"two":[250],"classes":[251],"molecules,":[253],"but":[254],"further":[255],"investigation":[256],"warranted":[258],"ascertain":[260],"interaction":[262],"their":[264],"promotive":[265],"activities.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-20T00:00:00"}