{"id":"https://openalex.org/W4377042425","doi":"https://doi.org/10.4103/ijo.ijo_1748_22","title":"Efficacy and safety analysis of intravitreal bio-similar products of bevacizumab in patients with macular edema because of retinal diseases","display_name":"Efficacy and safety analysis of intravitreal bio-similar products of bevacizumab in patients with macular edema because of retinal diseases","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4377042425","doi":"https://doi.org/10.4103/ijo.ijo_1748_22","pmid":"https://pubmed.ncbi.nlm.nih.gov/37203082","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10391473"},"language":"en","primary_location":{"id":"doi:10.4103/ijo.ijo_1748_22","doi":"https://doi.org/10.4103/ijo.ijo_1748_22","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijo.ijo_1748_22","pdf_url":null,"source":{"id":"https://openalex.org/S191336577","display_name":"Indian Journal of Ophthalmology","issn_l":"0301-4738","issn":["0301-4738","1998-3689"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4103/ijo.ijo_1748_22","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046802571","display_name":"Ruchi Agarwal","orcid":"https://orcid.org/0000-0002-5451-132X","observed_orcids":["https://orcid.org/0000-0002-5451-132X"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ruchi Agarwal","raw_affiliation_strings":["Department of Ophthalmology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027829077","display_name":"Sanjiv Kumar Gupta","orcid":"https://orcid.org/0000-0002-8543-2915","observed_orcids":["https://orcid.org/0000-0002-8543-2915"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sanjiv K Gupta","raw_affiliation_strings":["Department of Ophthalmology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India","Prof. Sanjiv K Gupta, Professor, Department of Ophthalmology, King George Medical University, Lucknow, Uttar Pradesh, India. E-mail: [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]},{"raw_affiliation_string":"Prof. Sanjiv K Gupta, Professor, Department of Ophthalmology, King George Medical University, Lucknow, Uttar Pradesh, India. E-mail: [email\u00a0protected]","institution_ids":["https://openalex.org/I280994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038205761","display_name":"Siddharth Agrawal","orcid":"https://orcid.org/0000-0002-1156-5205","observed_orcids":["https://orcid.org/0000-0002-1156-5205"]},"institutions":[{"id":"https://openalex.org/I280994","display_name":"King George's Medical University","ror":"https://ror.org/00gvw6327","country_code":"IN","type":"education","lineage":["https://openalex.org/I280994"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Siddharth Agrawal","raw_affiliation_strings":["Department of Ophthalmology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I280994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027829077"],"corresponding_institution_ids":["https://openalex.org/I280994"],"apc_list":null,"apc_paid":null,"fwci":1.5428,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.78743714,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"71","issue":"5","first_page":"2066","last_page":"2070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11377","display_name":"Retinal and Macular Surgery","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab-biosimilar","display_name":"bevacizumab biosimilar","score":0.9010000228881836},{"id":"https://openalex.org/keywords/intravitreal-injection","display_name":"intravitreal injection","score":0.9919999837875366},{"id":"https://openalex.org/keywords/macular-edema","display_name":"macular edema","score":0.9700000286102295},{"id":"https://openalex.org/keywords/retinal-disease","display_name":"retinal disease","score":0.9470000267028809},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/visual-acuity","display_name":"visual acuity","score":0.7170000076293945},{"id":"https://openalex.org/keywords/central-subfield-thickness","display_name":"central subfield thickness","score":0.875},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.6389999985694885},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7950000166893005},{"id":"https://openalex.org/keywords/endophthalmitis","display_name":"endophthalmitis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.9649999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9528236985206604},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.7152630090713501},{"id":"https://openalex.org/C2780347916","wikidata":"https://www.wikidata.org/wiki/Q1813737","display_name":"Macular edema","level":3,"score":0.6797205805778503},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.672574520111084},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.6488654017448425},{"id":"https://openalex.org/C2777235844","wikidata":"https://www.wikidata.org/wiki/Q1294912","display_name":"Endophthalmitis","level":2,"score":0.6292436718940735},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5377964973449707},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5350326895713806},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5059534907341003},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.47508135437965393},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.44436296820640564},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2593303918838501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10733690857887268},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07024970650672913}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005451","descriptor_name":"Fluorescein Angiography","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058449","descriptor_name":"Intravitreal Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4103/ijo.ijo_1748_22","doi":"https://doi.org/10.4103/ijo.ijo_1748_22","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijo.ijo_1748_22","pdf_url":null,"source":{"id":"https://openalex.org/S191336577","display_name":"Indian Journal of Ophthalmology","issn_l":"0301-4738","issn":["0301-4738","1998-3689"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10391473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10391473","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10391473/pdf/IJO-71-2066.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Ophthalmol","raw_type":"Text"},{"id":"pmid:37203082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37203082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of ophthalmology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:93ffe71fc5a5412fbb2fa338536596d0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/93ffe71fc5a5412fbb2fa338536596d0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Indian Journal of Ophthalmology, Vol 71, Iss 5, Pp 2066-2070 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4103/ijo.ijo_1748_22","doi":"https://doi.org/10.4103/ijo.ijo_1748_22","is_oa":true,"landing_page_url":"https://doi.org/10.4103/ijo.ijo_1748_22","pdf_url":null,"source":{"id":"https://openalex.org/S191336577","display_name":"Indian Journal of Ophthalmology","issn_l":"0301-4738","issn":["0301-4738","1998-3689"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377042425.pdf","grobid_xml":"https://content.openalex.org/works/W4377042425.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1481978003","https://openalex.org/W1974777756","https://openalex.org/W2011717780","https://openalex.org/W2017200441","https://openalex.org/W2059547624","https://openalex.org/W2081633887","https://openalex.org/W2083207244","https://openalex.org/W2089118764","https://openalex.org/W2110888030","https://openalex.org/W2131089858","https://openalex.org/W2154073405","https://openalex.org/W2157769714","https://openalex.org/W2171962482","https://openalex.org/W2293809486","https://openalex.org/W2738996050","https://openalex.org/W2765216186","https://openalex.org/W2898444405","https://openalex.org/W2901929903","https://openalex.org/W2934745788","https://openalex.org/W2958724362","https://openalex.org/W3123973412","https://openalex.org/W3149261074"],"related_works":["https://openalex.org/W6911345446","https://openalex.org/W4391897917","https://openalex.org/W3030873261","https://openalex.org/W2244163141","https://openalex.org/W2013671556","https://openalex.org/W3149261074","https://openalex.org/W2030362969","https://openalex.org/W7144546810","https://openalex.org/W3042163294","https://openalex.org/W2129793174"],"abstract_inverted_index":{"Purpose:":[0],"The":[1,100,111,172],"purpose":[2],"of":[3,15,18,27,42,51,86,92,103,126,135,155,243,246,249,254,258],"this":[4,160],"study":[5],"was":[6,34,106,119,147,162],"to":[7,70,184,203],"evaluate":[8],"retrospectively":[9],"the":[10,62,72,80,98,104,141,190,212,239,252],"efficacy":[11,240],"and":[12,65,74,140,189,241],"safety":[13,81,242],"profile":[14,82],"intravitreal":[16,49,244],"injection":[17,245],"bevacizumab":[19,53,250],"bio-similar":[20,52,247],"product":[21],"Zybev(Z)":[22],"for":[23,79,169,251],"macular":[24,39,255],"edema":[25,40,256],"because":[26,41,257],"retinal":[28,43,63,259],"diseases.":[29,260],"Methods:":[30],"A":[31,90],"retrospective":[32,234],"analysis":[33,235],"conducted":[35],"on":[36],"patients":[37,94,105],"with":[38,129,152],"diseases,":[44],"who":[45],"had":[46,219],"been":[47],"administered":[48],"injections":[50],"at":[54,144],"a":[55,84,130,153],"tertiary":[56],"eye":[57],"care":[58],"center.":[59],"Changes":[60],"in":[61,97,224],"thickness":[64,133,176],"visual":[66,116],"acuity":[67,117],"were":[68,77,95],"evaluated":[69],"judge":[71],"efficacy,":[73],"adverse":[75],"events":[76],"noted":[78],"over":[83],"period":[85,214],"6":[87,145],"weeks.":[88],"Results:":[89],"total":[91],"104":[93],"included":[96],"study.":[99],"mean":[101,112,173,191],"age":[102],"53":[107],"\u00b1":[108,121,137,149,157,181,186,201,205],"13.5":[109],"years.":[110],"pre-injection":[113,183],"best":[114],"corrected":[115],"(BCVA)":[118],"1.32":[120],"0.70":[122],"log":[123],"minimum":[124],"angle":[125],"resolution":[127],"(logMAR)":[128],"central":[131],"subfield":[132],"(CST)":[134],"429.26":[136],"204.30":[138],"\u03bcm,":[139],"post-injection":[142],"BCVA":[143],"weeks":[146],"1.13":[148],"0.71":[150],"logMAR":[151],"CST":[154],"302.26":[156],"104.50":[158],"\u03bcm;":[159],"change":[161],"statistically":[163],"significant":[164],"(":[165,207],"P":[166,208],"<":[167,209],"0.05)":[168],"all":[170],"groups.":[171],"average":[174,192],"cube":[175,193],"(\u03bcm)":[177],"decreased":[178,198],"from":[179,199],"11.85":[180],"1.96":[182],"10.52":[185],"1.75":[187],"post-injection,":[188],"volume":[194],"(mm":[195],"3":[196],")":[197],"329.30":[200],"54.35":[202],"302.23":[204],"49.56":[206],"0.05).":[210],"During":[211],"follow-up":[213],"after":[215],"injection,":[216],"no":[217],"patient":[218],"inflammation,":[220],"endophthalmitis,":[221],"an":[222],"increase":[223],"intra-ocular":[225],"pressure,":[226],"or":[227],"systemic":[228],"side":[229],"effects.":[230],"Conclusion:":[231],"This":[232],"short-term":[233],"provides":[236],"evidence":[237],"regarding":[238],"products":[248],"treatment":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-05-19T00:00:00"}
