{"id":"https://openalex.org/W4377030299","doi":"https://doi.org/10.1016/j.etap.2023.104152","title":"Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood","display_name":"Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood","publication_year":2023,"publication_date":"2023-05-18","ids":{"openalex":"https://openalex.org/W4377030299","doi":"https://doi.org/10.1016/j.etap.2023.104152","pmid":"https://pubmed.ncbi.nlm.nih.gov/37209889","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10457458"},"language":"en","primary_location":{"id":"doi:10.1016/j.etap.2023.104152","doi":"https://doi.org/10.1016/j.etap.2023.104152","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2023.104152","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1382668923000947","source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S1382668923000947","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038474918","display_name":"Chris S. Elcombe","orcid":"https://orcid.org/0000-0002-7869-0123","observed_orcids":["https://orcid.org/0000-0002-7869-0123"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Chris S. Elcombe","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: c.elcombe.1@research.gla.ac.uk","School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: c.elcombe.1@research.gla.ac.uk","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022506015","display_name":"Ana Monteiro","orcid":"https://orcid.org/0000-0003-2349-9716","observed_orcids":["https://orcid.org/0000-0003-2349-9716"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ana Monteiro","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101489195","display_name":"Mohammad Ghasemzadeh\u2010Hasankolaei","orcid":"https://orcid.org/0000-0003-2053-5566","observed_orcids":["https://orcid.org/0000-0003-2053-5566"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mohammad Ghasemzadeh-Hasankolaei","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029119143","display_name":"Vasantha Padmanabhan","orcid":"https://orcid.org/0000-0002-8443-7212","observed_orcids":["https://orcid.org/0000-0002-8443-7212"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasantha Padmanabhan","raw_affiliation_strings":["Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA","Department of Pediatrics, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034466381","display_name":"Richard G. Lea","orcid":"https://orcid.org/0000-0002-6793-3601","observed_orcids":["https://orcid.org/0000-0002-6793-3601"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Lea","raw_affiliation_strings":["University of Nottingham, Sutton Bonington Campus, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Sutton Bonington Campus, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043984013","display_name":"Kevin D. Sinclair","orcid":"https://orcid.org/0000-0002-6375-215X","observed_orcids":["https://orcid.org/0000-0002-6375-215X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin D. Sinclair","raw_affiliation_strings":["University of Nottingham, Sutton Bonington Campus, Loughborough, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Nottingham, Sutton Bonington Campus, Loughborough, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050826731","display_name":"Neil P. Evans","orcid":"https://orcid.org/0000-0001-7395-3222","observed_orcids":["https://orcid.org/0000-0001-7395-3222"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil P. Evans","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046931094","display_name":"Michelle Bellingham","orcid":"https://orcid.org/0000-0002-3646-8989","observed_orcids":["https://orcid.org/0000-0002-3646-8989"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Michelle Bellingham","raw_affiliation_strings":["School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: Michelle.Bellingham@glasgow.ac.uk","School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK. Electronic address: Michelle.Bellingham@glasgow.ac.uk","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038474918","https://openalex.org/A5046931094"],"corresponding_institution_ids":["https://openalex.org/I7882870"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":1.0543,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68053028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"100","issue":null,"first_page":"104152","last_page":"104152"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.4957999885082245,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.4684999883174896,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/environmental-mixtures","display_name":"environmental mixtures","score":0.9169999957084656},{"id":"https://openalex.org/keywords/prenatal-exposure","display_name":"prenatal exposure","score":0.7670000195503235},{"id":"https://openalex.org/keywords/testicular-dysgenesis-syndrome","display_name":"testicular dysgenesis","score":0.656000018119812},{"id":"https://openalex.org/keywords/creb1","display_name":"CREB1","score":0.996999979019165},{"id":"https://openalex.org/keywords/bcl11a","display_name":"BCL11A","score":0.9990000128746033},{"id":"https://openalex.org/keywords/foxp2","display_name":"FOXP2","score":1.0},{"id":"https://openalex.org/keywords/seminiferous-tubule-degeneration","display_name":"seminiferous tubule degeneration","score":0.9200000166893005},{"id":"https://openalex.org/keywords/male-reproductive-health","display_name":"male reproductive health","score":0.5709999799728394},{"id":"https://openalex.org/keywords/developmental-toxicity","display_name":"developmental toxicity","score":0.4009999930858612},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.5329999923706055},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.762161910533905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6164506673812866},{"id":"https://openalex.org/C67283656","wikidata":"https://www.wikidata.org/wiki/Q2587899","display_name":"Fecundity","level":3,"score":0.5858556628227234},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5355209112167358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49548137187957764},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.49239838123321533},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.48576119542121887},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.45465564727783203},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.42610305547714233},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3785095810890198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2110273838043213},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08724254369735718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08694496750831604},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.etap.2023.104152","doi":"https://doi.org/10.1016/j.etap.2023.104152","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2023.104152","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1382668923000947","source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"doi:10.1101/2022.12.09.519746","doi":"https://doi.org/10.1101/2022.12.09.519746","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.09.519746","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/12/2022.12.09.519746.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37209889","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37209889","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:21376723","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2023.104152","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10457458","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10457458","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10457458/pdf/nihms-1926302.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Environ Toxicol Pharmacol","raw_type":"Text"},{"id":"pmh:oai:eprints.gla.ac.uk:299273","doi":null,"is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/299273/1/299273.pdf","pdf_url":"https://eprints.gla.ac.uk/299273/1/299273.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":{"id":"doi:10.1016/j.etap.2023.104152","doi":"https://doi.org/10.1016/j.etap.2023.104152","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.etap.2023.104152","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1382668923000947","source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5682792106","display_name":"Transgenerational consequences of pre-conceptional and in utero exposure to real-life chemical mixtures on fertility and metabolic health","funder_award_id":"R01ES030374","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000914956","display_name":"Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)","funder_award_id":"P30ES017885","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377030299.pdf","grobid_xml":"https://content.openalex.org/works/W4377030299.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1475381583","https://openalex.org/W1516021641","https://openalex.org/W1533653469","https://openalex.org/W1820419641","https://openalex.org/W1953739912","https://openalex.org/W1967149342","https://openalex.org/W1969151122","https://openalex.org/W1975165380","https://openalex.org/W1978070663","https://openalex.org/W1979294947","https://openalex.org/W1984976342","https://openalex.org/W1991122693","https://openalex.org/W1997204431","https://openalex.org/W2001775267","https://openalex.org/W2006321057","https://openalex.org/W2006441375","https://openalex.org/W2011118373","https://openalex.org/W2021022064","https://openalex.org/W2024381206","https://openalex.org/W2026405662","https://openalex.org/W2030742472","https://openalex.org/W2042795604","https://openalex.org/W2042979886","https://openalex.org/W2049341175","https://openalex.org/W2058611139","https://openalex.org/W2059121174","https://openalex.org/W2068634056","https://openalex.org/W2069338844","https://openalex.org/W2076907803","https://openalex.org/W2077137288","https://openalex.org/W2084670210","https://openalex.org/W2087119313","https://openalex.org/W2092410857","https://openalex.org/W2106925175","https://openalex.org/W2109475331","https://openalex.org/W2112391605","https://openalex.org/W2114104545","https://openalex.org/W2124733101","https://openalex.org/W2140211014","https://openalex.org/W2144382327","https://openalex.org/W2159055057","https://openalex.org/W2171423639","https://openalex.org/W2511585516","https://openalex.org/W2562820765","https://openalex.org/W2620217714","https://openalex.org/W2739446247","https://openalex.org/W2758928570","https://openalex.org/W2896740407","https://openalex.org/W2897405470","https://openalex.org/W2899969172","https://openalex.org/W2911024863","https://openalex.org/W2912245568","https://openalex.org/W2945883683","https://openalex.org/W2991641984","https://openalex.org/W3044968004","https://openalex.org/W3135878293","https://openalex.org/W3157629925","https://openalex.org/W3206521502","https://openalex.org/W4200571602","https://openalex.org/W4205507419","https://openalex.org/W4211061583","https://openalex.org/W4246869778","https://openalex.org/W4283162474","https://openalex.org/W4288051342","https://openalex.org/W4309099580","https://openalex.org/W6808915283"],"related_works":["https://openalex.org/W4283162474","https://openalex.org/W6969192080","https://openalex.org/W3157629925","https://openalex.org/W4205507419","https://openalex.org/W4399431121","https://openalex.org/W7118107696","https://openalex.org/W4310804870","https://openalex.org/W4404055601","https://openalex.org/W1516021641","https://openalex.org/W4386376695"],"abstract_inverted_index":{"Environmental":[0],"chemical":[1],"(EC)":[2],"exposure":[3,27,121,135],"may":[4],"be":[5,114],"impacting":[6,146],"male":[7,33],"reproductive":[8],"health.":[9],"The":[10],"translationally":[11],"relevant":[12],"biosolids":[13],"treated":[14],"pasture":[15],"(BTP)":[16],"sheep":[17],"model":[18],"was":[19],"used":[20],"to":[21,40,118,122,136],"investigate":[22],"gestational":[23,119,134],"low-level":[24,137],"EC":[25,120],"mixture":[26],"on":[28],"the":[29,90,124],"testes":[30,106],"of":[31,56,76,110,139],"F1":[32],"offspring.":[34],"Adult":[35],"rams":[36],"from":[37,62,133],"ewes":[38],"exposed":[39,92],"BTP":[41,73,91],"1":[42],"month":[43],"before":[44],"and":[45,54,71,81,83,108,148],"throughout":[46],"pregnancy":[47],"had":[48],"more":[49],"seminiferous":[50],"tubules":[51],"with":[52,94],"degeneration":[53],"depletion":[55],"elongating":[57],"spermatids,":[58],"indicating":[59],"possible":[60],"\"recovery\"":[61],"previously":[63],"reported":[64],"testicular":[65,131],"dysgenesis":[66],"syndrome-like":[67],"phenotype":[68],"in":[69,89,98],"neonatal":[70],"pre-pubertal":[72],"lambs.":[74],"Expression":[75],"transcription":[77],"factors":[78],"CREB1":[79],"(neonatal)":[80],"BCL11A":[82],"FOXP2":[84],"(pre-pubertal)":[85],"were":[86],"significantly":[87],"higher":[88],"testes,":[93],"no":[95],"changes":[96],"seen":[97],"adults.":[99],"Increased":[100],"CREB1,":[101],"which":[102],"is":[103],"crucial":[104],"for":[105],"development":[107],"regulation":[109],"steroidogenic":[111],"enzymes,":[112],"could":[113],"an":[115],"adaptive":[116],"response":[117],"facilitate":[123],"phenotypic":[125],"recovery.":[126],"Overall,":[127],"this":[128],"demonstrates":[129],"that":[130],"effects":[132],"mixtures":[138],"ECs":[140],"can":[141],"last":[142],"into":[143],"adulthood,":[144],"potentially":[145],"fertility":[147],"fecundity.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-05-19T00:00:00"}
