{"id":"https://openalex.org/W4377029569","doi":"https://doi.org/10.1128/jvi.00214-23","title":"Experimental Support for Human Papillomavirus Genome Amplification Early after Infectious Delivery","display_name":"Experimental Support for Human Papillomavirus Genome Amplification Early after Infectious Delivery","publication_year":2023,"publication_date":"2023-05-18","ids":{"openalex":"https://openalex.org/W4377029569","doi":"https://doi.org/10.1128/jvi.00214-23","pmid":"https://pubmed.ncbi.nlm.nih.gov/37223953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10308938"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00214-23","doi":"https://doi.org/10.1128/jvi.00214-23","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00214-23","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/25/2022.06.24.497572.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032738079","display_name":"Katarzyna Zwoli\u0144ska","orcid":"https://orcid.org/0000-0002-5872-7806","observed_orcids":["https://orcid.org/0000-0002-5872-7806"]},"institutions":[{"id":"https://openalex.org/I4405271557","display_name":"Feist-Weiller Cancer Center","ror":"https://ror.org/02mjksd55","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271557"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katarzyna Zwolinska","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA","institution_ids":["https://openalex.org/I4405271557","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009104889","display_name":"Malgorzata Bienkowska\u2010Haba","orcid":"https://orcid.org/0000-0002-9669-1875","observed_orcids":["https://orcid.org/0000-0002-9669-1875"]},"institutions":[{"id":"https://openalex.org/I4405271557","display_name":"Feist-Weiller Cancer Center","ror":"https://ror.org/02mjksd55","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271557"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malgorzata Bienkowska-Haba","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA","institution_ids":["https://openalex.org/I4405271557","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084169367","display_name":"Rona S. Scott","orcid":"https://orcid.org/0000-0003-3840-9189","observed_orcids":["https://orcid.org/0000-0003-3840-9189"]},"institutions":[{"id":"https://openalex.org/I4405271557","display_name":"Feist-Weiller Cancer Center","ror":"https://ror.org/02mjksd55","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271557"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rona S. Scott","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA"],"raw_orcid":"https://orcid.org/0000-0003-3840-9189","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA","institution_ids":["https://openalex.org/I4405271557","https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040739191","display_name":"Timothy R. Keiffer","orcid":"https://orcid.org/0000-0001-7104-6338","observed_orcids":["https://orcid.org/0000-0001-7104-6338"]},"institutions":[{"id":"https://openalex.org/I4405271557","display_name":"Feist-Weiller Cancer Center","ror":"https://ror.org/02mjksd55","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271557"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Keiffer","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA","institution_ids":["https://openalex.org/I4405271557","https://openalex.org/I81020160"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019740278","display_name":"Martin J. Sapp","orcid":"https://orcid.org/0000-0003-3916-8890","observed_orcids":["https://orcid.org/0000-0003-3916-8890"]},"institutions":[{"id":"https://openalex.org/I4405271557","display_name":"Feist-Weiller Cancer Center","ror":"https://ror.org/02mjksd55","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405271557"]},{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin Sapp","raw_affiliation_strings":["Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA"],"raw_orcid":"https://orcid.org/0000-0003-3916-8890","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Feist Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA","institution_ids":["https://openalex.org/I4405271557","https://openalex.org/I81020160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019740278"],"corresponding_institution_ids":["https://openalex.org/I4405271557","https://openalex.org/I81020160"],"apc_list":null,"apc_paid":null,"fwci":1.9878,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.86385575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"97","issue":"6","first_page":"e0021423","last_page":"e0021423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9620000123977661},{"id":"https://openalex.org/keywords/hpv-16","display_name":"HPV16","score":0.9700000286102295},{"id":"https://openalex.org/keywords/viral-genome-amplification","display_name":"viral genome amplification","score":0.9070000052452087},{"id":"https://openalex.org/keywords/viral-life-cycle","display_name":"viral life cycle","score":0.5960000157356262},{"id":"https://openalex.org/keywords/e1","display_name":"E1","score":0.652999997138977},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9399999976158142},{"id":"https://openalex.org/keywords/genome-copy-number","display_name":"genome copy number","score":0.6480000019073486},{"id":"https://openalex.org/keywords/infection-model","display_name":"infection model","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9138308167457581},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7064323425292969},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.6318470239639282},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5483910441398621},{"id":"https://openalex.org/C2776270601","wikidata":"https://www.wikidata.org/wiki/Q9055203","display_name":"Papillomaviridae","level":4,"score":0.5032009482383728},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.4987297058105469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.42958781123161316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19742736220359802},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10560402274131775},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.08362135291099548},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000087002","descriptor_name":"Viral Transcription","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009856","descriptor_name":"Oncogene Proteins, Viral","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030361","descriptor_name":"Papillomavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D041681","descriptor_name":"NIH 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052162","descriptor_name":"Human papillomavirus 16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.00214-23","doi":"https://doi.org/10.1128/jvi.00214-23","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.00214-23","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"doi:10.1101/2022.06.24.497572","doi":"https://doi.org/10.1101/2022.06.24.497572","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.24.497572","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/25/2022.06.24.497572.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10308938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10308938","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10308938/pdf/jvi.00214-23.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:37223953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37223953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2022.06.24.497572","doi":"https://doi.org/10.1101/2022.06.24.497572","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.24.497572","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/25/2022.06.24.497572.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2584513424","display_name":"COBRE Center for Molecular and Tumor Virology","funder_award_id":"P30GM110703","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4542662515","display_name":"Epigenetic Effects of Epstein-Barr Virus Infection in Oral Squamous Cell Carcinoma","funder_award_id":"R01DE025565","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000860854","display_name":"Center for Applied Immunology and Pathological Processes","funder_award_id":"P20GM134974","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000894317","display_name":"Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency and reactivation","funder_award_id":"P01AI127335","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000896057","display_name":"Immediate early events of the HPV life cycle","funder_award_id":"R01CA211576","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310395","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377029569.pdf","grobid_xml":"https://content.openalex.org/works/W4377029569.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W196945419","https://openalex.org/W799575622","https://openalex.org/W1488402216","https://openalex.org/W1520282948","https://openalex.org/W1574443991","https://openalex.org/W1585322963","https://openalex.org/W1709407895","https://openalex.org/W1773758992","https://openalex.org/W1895091249","https://openalex.org/W1973457835","https://openalex.org/W1977109470","https://openalex.org/W1980593642","https://openalex.org/W1983380555","https://openalex.org/W1989247572","https://openalex.org/W1993946476","https://openalex.org/W1998710947","https://openalex.org/W2001202839","https://openalex.org/W2001662078","https://openalex.org/W2002911683","https://openalex.org/W2003053867","https://openalex.org/W2008381030","https://openalex.org/W2029942202","https://openalex.org/W2032572462","https://openalex.org/W2050847569","https://openalex.org/W2064296266","https://openalex.org/W2066806676","https://openalex.org/W2074168173","https://openalex.org/W2091713524","https://openalex.org/W2102795910","https://openalex.org/W2104459561","https://openalex.org/W2111344666","https://openalex.org/W2113271936","https://openalex.org/W2119814307","https://openalex.org/W2122351693","https://openalex.org/W2133312492","https://openalex.org/W2137480395","https://openalex.org/W2142006870","https://openalex.org/W2146757491","https://openalex.org/W2148904894","https://openalex.org/W2149157897","https://openalex.org/W2160281011","https://openalex.org/W2167364910","https://openalex.org/W2224222646","https://openalex.org/W2271834480","https://openalex.org/W2317295289","https://openalex.org/W2434803486","https://openalex.org/W2548218227","https://openalex.org/W2553614503","https://openalex.org/W2598072236","https://openalex.org/W2616964127","https://openalex.org/W2754135856","https://openalex.org/W2790279538","https://openalex.org/W2794336305","https://openalex.org/W2898087090","https://openalex.org/W2945410212","https://openalex.org/W2969930435","https://openalex.org/W2988307800","https://openalex.org/W2998889036","https://openalex.org/W3024116083","https://openalex.org/W3048047018","https://openalex.org/W3093219874","https://openalex.org/W3198437819","https://openalex.org/W4288039589","https://openalex.org/W4319333291","https://openalex.org/W4321493193"],"related_works":["https://openalex.org/W1989247572","https://openalex.org/W2146757491","https://openalex.org/W2001662078","https://openalex.org/W2595495729","https://openalex.org/W2029477848","https://openalex.org/W2794336305","https://openalex.org/W3048047018","https://openalex.org/W1574443991","https://openalex.org/W2076961431","https://openalex.org/W7096345747"],"abstract_inverted_index":{"ABSTRACT":[0],"Even":[1],"though":[2],"replication":[3,161,263],"and":[4,60,78,93,98,114,204,275,318],"transcription":[5,61,152,188],"of":[6,23,32,40,66,71,103,108,119,145,184,195,215,238,262,290,329,370,387,395],"human":[7],"papillomavirus":[8],"type":[9],"16":[10],"(HPV16)":[11],"has":[12,375],"been":[13,376],"intensively":[14],"studied,":[15],"little":[16],"is":[17,91,162,245,253,312,334,366],"known":[18],"about":[19],"immediate":[20],"early":[21,155,191,199,371,393],"events":[22,394],"the":[24,30,45,88,109,120,154,190,196,235,241,270,326,330,362,379,385,388,396],"viral":[25,41,67,110,126,159,242,310,331,337],"life":[26,243],"cycle":[27,244],"due":[28,286],"to":[29,56,69,112,124,209,227,246,287,335],"lack":[31,214,289],"an":[33,96,172,291,316],"efficient":[34,187],"infection":[35,48,170,292,298,389],"model":[36,49,299,390],"allowing":[37],"genetic":[38],"dissection":[39],"factors.":[42],"We":[43,341],"employed":[44],"recently":[46,296],"developed":[47],"(Bienkowska-Haba":[50,300],"et":[51,301],"al.":[52,302],"PLOS":[53,303],"Pathogen":[54,304],"2018)":[55],"investigate":[57],"genome":[58,68,90,111,127,142,160,210,228,248,273,311,338],"amplification":[59,268,281],"immediately":[62],"after":[63],"infectious":[64],"delivery":[65],"nuclei":[70],"primary":[72],"keratinocytes.":[73],"Using":[74,294],"EdU":[75],"pulse":[76],"labeling":[77],"highly":[79],"sensitive":[80],"fluorescence":[81],"in":[82,95,106,240,315,352,378],"situ":[83],"hybridization,":[84],"we":[85,306,323],"observed":[86],"that":[87,158,234,256,309,325,346,361],"HPV16":[89,173,279],"replicated":[92],"amplified":[94,314],"E1":[97,104,147,317],"E2":[99,178,185,319,363],"dependent":[100,320],"manner.":[101,321],"Knockout":[102],"resulted":[105],"failure":[107],"replicate":[113],"amplify.":[115],"In":[116,193],"contrast,":[117],"knockout":[118],"E8^E2":[121,137,197,217,222,239,333],"repressor":[122,218,332],"led":[123],"increased":[125],"copy":[128,134,211,229,249,339],"number":[129],"confirming":[130],"previous":[131],"reports.":[132],"Genome":[133],"control":[135,247,336],"by":[136],"was":[138,282],"confirmed":[139],"for":[140,165,177,186,368,391],"differentiation-induced":[141,276],"amplification.":[143,277],"Lack":[144],"functional":[146,216],"had":[148],"no":[149],"effect":[150],"on":[151],"from":[153,189],"promoter,":[156],"suggesting":[157],"not":[163,220,343],"required":[164,367],"p97":[166],"promoter":[167,351,372],"activity.":[168],"However,":[169,278],"with":[171],"mutant":[174],"virus":[175],"defective":[176],"transcriptional":[179],"function":[180,237,328,365],"revealed":[181],"a":[182,288,353],"requirement":[183],"promoter.":[192],"absence":[194],"protein,":[198],"transcript":[200,223],"levels":[201,224],"are":[202],"unaltered":[203],"even":[205],"decreased":[206],"when":[207,225],"normalized":[208,226],"number.":[212,230,250,340],"Surprisingly,":[213],"did":[219,342],"affect":[221],"These":[231],"data":[232,358],"suggest":[233,360],"main":[236,327],"IMPORTANCE":[251],"It":[252],"being":[254],"assumed":[255],"HPV":[257,397],"utilizes":[258],"three":[259],"different":[260],"modes":[261],"during":[264,269],"its":[265,349],"lifecycle:":[266],"initial":[267,280],"establishment":[271],"phase,":[272],"maintenance":[274],"never":[283],"formally":[284],"proven":[285],"model.":[293],"our":[295],"established":[297],"2018),":[305],"demonstrate":[307],"herein":[308],"indeed":[313],"Furthermore,":[322],"find":[324,344],"evidence":[345],"it":[347],"regulates":[348],"own":[350],"negative":[354],"feedback":[355],"loop.":[356],"Our":[357],"also":[359],"transactivator":[364],"stimulation":[369],"activity,":[373],"which":[374],"debated":[377],"literature.":[380],"Overall,":[381],"this":[382],"report":[383],"confirms":[384],"usefulness":[386],"studying":[392],"lifecycle":[398],"using":[399],"mutational":[400],"approaches.":[401]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-19T00:00:00"}