{"id":"https://openalex.org/W4377029403","doi":"https://doi.org/10.1124/jpet.122.538430","title":"SERCA Inhibition by Drugs - A Potential Therapeutic Strategy in Ischemia","display_name":"SERCA Inhibition by Drugs - A Potential Therapeutic Strategy in Ischemia","publication_year":2023,"publication_date":"2023-05-18","ids":{"openalex":"https://openalex.org/W4377029403","doi":"https://doi.org/10.1124/jpet.122.538430"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.122.538430","doi":"https://doi.org/10.1124/jpet.122.538430","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.122.538430","pdf_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/302.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/302.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084850297","display_name":"Jesika B. Colomer-Saucedo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesika Colomer-Saucedo","raw_affiliation_strings":["Southern Illinois Univ School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Southern Illinois Univ School of Medicine","institution_ids":["https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012861950","display_name":"Yuanzhao L. Darcy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanzhao L. Darcy","raw_affiliation_strings":["SIU School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIU School of Medicine","institution_ids":["https://openalex.org/I110378019","https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019577421","display_name":"Valeria A. Copello","orcid":"https://orcid.org/0000-0002-7035-4467","observed_orcids":["https://orcid.org/0000-0002-7035-4467"]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria A. Copello","raw_affiliation_strings":["SIU School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIU School of Medicine","institution_ids":["https://openalex.org/I110378019","https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041953211","display_name":"Paula D\u00edaz\u2010Sylvester","orcid":"https://orcid.org/0000-0002-1531-1958","observed_orcids":["https://orcid.org/0000-0002-1531-1958"]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Diaz-Sylvester","raw_affiliation_strings":["SIU School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIU School of Medicine","institution_ids":["https://openalex.org/I110378019","https://openalex.org/I196729704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051096454","display_name":"Melanie M. Loulousis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Loulousis","raw_affiliation_strings":["SIU School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIU School of Medicine","institution_ids":["https://openalex.org/I110378019","https://openalex.org/I196729704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070339203","display_name":"Julio A. Copello","orcid":"https://orcid.org/0000-0002-2388-7164","observed_orcids":["https://orcid.org/0000-0002-2388-7164"]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio A. Copello","raw_affiliation_strings":["SIU School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SIU School of Medicine","institution_ids":["https://openalex.org/I110378019","https://openalex.org/I196729704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09114273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"385","issue":null,"first_page":"302","last_page":"302"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serca-inhibition","display_name":"SERCA inhibition","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-calcium-atpase","display_name":"sarcoplasmic reticulum calcium ATPase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cgp-37157","display_name":"CGP-37157","score":0.9369999766349792},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.7770000100135803},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8309999704360962},{"id":"https://openalex.org/keywords/calcium-overload","display_name":"calcium overload","score":0.5929999947547913},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.4830000102519989},{"id":"https://openalex.org/keywords/acidosis","display_name":"acidosis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.6069999933242798},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cyclopiazonic-acid","display_name":"cyclopiazonic acid","score":0.8830000162124634}],"concepts":[{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4653151035308838},{"id":"https://openalex.org/C2781414619","wikidata":"https://www.wikidata.org/wiki/Q24785512","display_name":"SERCA","level":4,"score":0.46463683247566223},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4561852514743805},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.39693284034729004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30336689949035645},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3000134825706482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27002769708633423},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08847832679748535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1124/jpet.122.538430","doi":"https://doi.org/10.1124/jpet.122.538430","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.122.538430","pdf_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/302.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1124/jpet.122.538430","doi":"https://doi.org/10.1124/jpet.122.538430","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.122.538430","pdf_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/302.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377029403.pdf","grobid_xml":"https://content.openalex.org/works/W4377029403.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2794405775","https://openalex.org/W4389027735","https://openalex.org/W2518493563","https://openalex.org/W2274768510","https://openalex.org/W1984948704","https://openalex.org/W2021170235","https://openalex.org/W2109646227","https://openalex.org/W4388600235","https://openalex.org/W2006659398","https://openalex.org/W2061830768"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-05-19T00:00:00"}
