{"id":"https://openalex.org/W4377020424","doi":"https://doi.org/10.1124/jpet.122.147510","title":"Structure-activity relationship of G protein-coupled receptor kinase 5 (GRK5) and its mutants","display_name":"Structure-activity relationship of G protein-coupled receptor kinase 5 (GRK5) and its mutants","publication_year":2023,"publication_date":"2023-05-18","ids":{"openalex":"https://openalex.org/W4377020424","doi":"https://doi.org/10.1124/jpet.122.147510"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.122.147510","doi":"https://doi.org/10.1124/jpet.122.147510","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.122.147510","pdf_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/326.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/326.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Priyanka Naik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Naik","raw_affiliation_strings":["Purdue University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue University","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043435719","display_name":"Qiuyan Chen","orcid":"https://orcid.org/0000-0002-6263-6843","observed_orcids":["https://orcid.org/0000-0002-6263-6843","https://orcid.org/0000-0001-9637-4995"]},"institutions":[{"id":"https://openalex.org/I592451","display_name":"Indiana University","ror":"https://ror.org/01kg8sb98","country_code":"US","type":"education","lineage":["https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiuyan Chen","raw_affiliation_strings":["Indiana University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University","institution_ids":["https://openalex.org/I592451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037144273","display_name":"John J. G. Tesmer","orcid":"https://orcid.org/0000-0003-1125-3727","observed_orcids":["https://orcid.org/0000-0003-1125-3727"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John JG. Tesmer","raw_affiliation_strings":["Purdue University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purdue University","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04934554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"385","issue":null,"first_page":"326","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grk5","display_name":"GRK5","score":0.9660000205039978},{"id":"https://openalex.org/keywords/rhodopsin","display_name":"rhodopsin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8870000243186951},{"id":"https://openalex.org/keywords/kinase-mutants","display_name":"kinase mutants","score":0.7009999752044678},{"id":"https://openalex.org/keywords/c-terminal-deletion","display_name":"C-terminal deletion","score":0.699999988079071},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.7950000166893005},{"id":"https://openalex.org/keywords/phosphatidylinositol-4-5-bisphosphate","display_name":"phosphatidylinositol 4,5-bisphosphate","score":0.6150000095367432},{"id":"https://openalex.org/keywords/kinase-inhibition","display_name":"kinase inhibition","score":0.7210000157356262},{"id":"https://openalex.org/keywords/gpcr-desensitization","display_name":"GPCR desensitization","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.519244909286499},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.44610846042633057},{"id":"https://openalex.org/C33235085","wikidata":"https://www.wikidata.org/wiki/Q4355943","display_name":"G protein-coupled receptor kinase","level":4,"score":0.4210633337497711},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4014061689376831},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3444145917892456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31275567412376404},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.24755853414535522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22356492280960083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17594602704048157},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09294551610946655}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1124/jpet.122.147510","doi":"https://doi.org/10.1124/jpet.122.147510","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.122.147510","pdf_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/326.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1124/jpet.122.147510","doi":"https://doi.org/10.1124/jpet.122.147510","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.122.147510","pdf_url":"https://jpet.aspetjournals.org/content/jpet/385/S3/326.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377020424.pdf","grobid_xml":"https://content.openalex.org/works/W4377020424.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171688146","https://openalex.org/W3168335218","https://openalex.org/W2615145336","https://openalex.org/W1848367707","https://openalex.org/W2094999165","https://openalex.org/W1754416593","https://openalex.org/W3181632501","https://openalex.org/W4396849833","https://openalex.org/W1985580256","https://openalex.org/W2008717144"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-05-19T00:00:00"}
