{"id":"https://openalex.org/W4377019649","doi":"https://doi.org/10.1183/23120541.00021-2023","title":"Pulmonary exacerbations in insured patients with bronchiectasis over 2 years","display_name":"Pulmonary exacerbations in insured patients with bronchiectasis over 2 years","publication_year":2023,"publication_date":"2023-05-18","ids":{"openalex":"https://openalex.org/W4377019649","doi":"https://doi.org/10.1183/23120541.00021-2023","pmid":"https://pubmed.ncbi.nlm.nih.gov/37404848","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10316032"},"language":"en","primary_location":{"id":"doi:10.1183/23120541.00021-2023","doi":"https://doi.org/10.1183/23120541.00021-2023","is_oa":true,"landing_page_url":"https://doi.org/10.1183/23120541.00021-2023","pdf_url":"https://openres.ersjournals.com/content/erjor/early/2023/04/20/23120541.00021-2023.full.pdf","source":{"id":"https://openalex.org/S2738738902","display_name":"ERJ Open Research","issn_l":"2312-0541","issn":["2312-0541"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ERJ Open Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://openres.ersjournals.com/content/erjor/early/2023/04/20/23120541.00021-2023.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005915390","display_name":"Patrick A. Flume","orcid":"https://orcid.org/0000-0002-1560-6879","observed_orcids":["https://orcid.org/0000-0002-1560-6879"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick A. Flume","raw_affiliation_strings":["Medical University of South Carolina, Charleston, SC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Charleston, SC, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016971498","display_name":"Joseph Feliciano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112105","display_name":"Insmed (United States)","ror":"https://ror.org/0203rjz92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Feliciano","raw_affiliation_strings":["Insmed Incorporated, Bridgewater, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insmed Incorporated, Bridgewater, NJ, USA","institution_ids":["https://openalex.org/I4210112105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108944102","display_name":"Matthew Lucci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Lucci","raw_affiliation_strings":["Panalgo, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Panalgo, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033447711","display_name":"Jasmanda Wu","orcid":"https://orcid.org/0000-0001-9346-7715","observed_orcids":["https://orcid.org/0000-0001-9346-7715","https://orcid.org/0000-0002-6083-888X"]},"institutions":[{"id":"https://openalex.org/I4210112105","display_name":"Insmed (United States)","ror":"https://ror.org/0203rjz92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmanda Wu","raw_affiliation_strings":["Insmed Incorporated, Bridgewater, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insmed Incorporated, Bridgewater, NJ, USA","institution_ids":["https://openalex.org/I4210112105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043657968","display_name":"Sebastian Fucile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112105","display_name":"Insmed (United States)","ror":"https://ror.org/0203rjz92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Fucile","raw_affiliation_strings":["Insmed Incorporated, Bridgewater, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insmed Incorporated, Bridgewater, NJ, USA","institution_ids":["https://openalex.org/I4210112105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112440757","display_name":"Mariam Hassan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112105","display_name":"Insmed (United States)","ror":"https://ror.org/0203rjz92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariam Hassan","raw_affiliation_strings":["Insmed Incorporated, Bridgewater, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insmed Incorporated, Bridgewater, NJ, USA","institution_ids":["https://openalex.org/I4210112105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003337457","display_name":"Anjan Kumar Chatterjee","orcid":"https://orcid.org/0000-0002-9092-8560","observed_orcids":["https://orcid.org/0000-0002-9092-8560"]},"institutions":[{"id":"https://openalex.org/I4210112105","display_name":"Insmed (United States)","ror":"https://ror.org/0203rjz92","country_code":"US","type":"company","lineage":["https://openalex.org/I4210112105"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anjan Chatterjee","raw_affiliation_strings":["Insmed Incorporated, Bridgewater, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Insmed Incorporated, Bridgewater, NJ, USA","institution_ids":["https://openalex.org/I4210112105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005915390"],"corresponding_institution_ids":["https://openalex.org/I153297377"],"apc_list":{"value":750,"currency":"EUR","value_usd":808},"apc_paid":{"value":750,"currency":"EUR","value_usd":808},"fwci":2.2011,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.88631454,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"00021","last_page":"2023"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bronchiectasis","display_name":"bronchiectasis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pulmonary-exacerbations","display_name":"pulmonary exacerbations","score":0.9959999918937683},{"id":"https://openalex.org/keywords/exacerbation-rate","display_name":"exacerbation frequency","score":0.7440000176429749},{"id":"https://openalex.org/keywords/all-cause-hospitalization","display_name":"all-cause hospitalization","score":0.949999988079071},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9950000047683716},{"id":"https://openalex.org/keywords/insured-patients","display_name":"insured patients","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9675480127334595},{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.9565051794052124},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5958855152130127},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.554797887802124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5437991619110107},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.5343723893165588},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.49303123354911804},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4185985028743744},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.16648700833320618},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1183/23120541.00021-2023","doi":"https://doi.org/10.1183/23120541.00021-2023","is_oa":true,"landing_page_url":"https://doi.org/10.1183/23120541.00021-2023","pdf_url":"https://openres.ersjournals.com/content/erjor/early/2023/04/20/23120541.00021-2023.full.pdf","source":{"id":"https://openalex.org/S2738738902","display_name":"ERJ Open Research","issn_l":"2312-0541","issn":["2312-0541"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ERJ Open Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10316032","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10316032","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10316032/pdf/00021-2023.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ERJ Open Res","raw_type":"Text"},{"id":"pmid:37404848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37404848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ERJ open research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:af1fca1ef7714fee86a572b4cc632260","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/af1fca1ef7714fee86a572b4cc632260","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ERJ Open Research, Vol 9, Iss 4 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1183/23120541.00021-2023","doi":"https://doi.org/10.1183/23120541.00021-2023","is_oa":true,"landing_page_url":"https://doi.org/10.1183/23120541.00021-2023","pdf_url":"https://openres.ersjournals.com/content/erjor/early/2023/04/20/23120541.00021-2023.full.pdf","source":{"id":"https://openalex.org/S2738738902","display_name":"ERJ Open Research","issn_l":"2312-0541","issn":["2312-0541"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ERJ Open Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319810","display_name":"Insmed","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377019649.pdf","grobid_xml":"https://content.openalex.org/works/W4377019649.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1992873661","https://openalex.org/W2000416421","https://openalex.org/W2037529199","https://openalex.org/W2048089913","https://openalex.org/W2095331944","https://openalex.org/W2112103097","https://openalex.org/W2131402575","https://openalex.org/W2195693652","https://openalex.org/W2338883347","https://openalex.org/W2404048760","https://openalex.org/W2605886686","https://openalex.org/W2620070352","https://openalex.org/W2752498201","https://openalex.org/W2760102695","https://openalex.org/W2791659379","https://openalex.org/W2883063895","https://openalex.org/W2884964051","https://openalex.org/W2891610856","https://openalex.org/W2919654984","https://openalex.org/W2974346712","https://openalex.org/W2990320915","https://openalex.org/W4210754331","https://openalex.org/W4211256602","https://openalex.org/W4214942997","https://openalex.org/W4220937947"],"related_works":["https://openalex.org/W7165909623","https://openalex.org/W2313800746","https://openalex.org/W4399392786","https://openalex.org/W4312775280","https://openalex.org/W4410268548","https://openalex.org/W4396767906","https://openalex.org/W4416637318","https://openalex.org/W2906597039","https://openalex.org/W4414622753","https://openalex.org/W4312850621"],"abstract_inverted_index":{"Background":[0],"Patients":[1,61,86],"with":[2,62,87,103,118,146,169,225,239],"bronchiectasis":[3,47,75,119,226],"experience":[4],"persistent":[5],"symptoms":[6],"and":[7,18,79,130,179,190],"frequent":[8],"pulmonary":[9],"exacerbations;":[10],"this":[11],"study":[12,27],"investigated":[13],"the":[14,73,108,177,209,229],"frequency":[15],"of":[16,65,82,172,198,212,231,237],"exacerbations":[17,106,134,139,162,175,222,233],"all-cause":[19,202],"hospitalisation.":[20],"Methods":[21],"This":[22],"longitudinal,":[23],"retrospective,":[24],"claims":[25],"database":[26],"(IBM\u00ae":[28],"MarketScan\u00ae)":[29],"identified":[30,45,99],"patients":[31,117,199,224],"aged":[32,127],"\u226518":[33],"years":[34,129,142,236],"from":[35,206],"1":[36],"July":[37],"2015":[38],"through":[39],"30":[40],"September":[41],"2018.":[42],"Exacerbations":[43],"were":[44,84,92,120,123,126,166],"by":[46,55],"inpatient":[48],"claim":[49],"or":[50],"a":[51],"healthcare":[52],"interaction,":[53],"followed":[54],"antibiotic":[56],"prescription":[57],"within":[58],"7":[59],"days.":[60],"\u226536":[63],"months":[64,71,81],"continuous":[66],"health":[67],"plan":[68],"enrolment":[69],"(12":[70],"preceding":[72],"first":[74,178,210],"claim,i.e.,":[76],"baseline":[77,91,100,165],"period":[78],"\u226524":[80],"follow-up)":[83],"included.":[85],"cystic":[88],"fibrosis":[89],"at":[90,135,164],"excluded.":[93],"A":[94],"multivariable":[95],"logistic":[96],"regression":[97],"model":[98],"factors":[101],"associated":[102,145,168],"having":[104],"\u22652":[105,133,138,174],"over":[107,216,234,243],"2-year":[109],"follow-up":[110,182,213],"period.":[111],"Results":[112],"In":[113],"total,":[114],"14":[115],"798":[116],"identified;":[121],"64.5%":[122],"female,":[124],"82.7%":[125],"\u226555":[128],"42.7%":[131],"had":[132],"baseline.":[136],"Having":[137],"after":[140],"2":[141,217,235],"was":[143],"positively":[144],"chronic":[147],"macrolide":[148],"use,":[149,153],"long-acting":[150],"\u03b22":[151],"agonist":[152],"gastro-oesophageal":[154],"reflux":[155],"disease,":[156],"heart":[157],"failure":[158],"andPseudomonas":[159],"aeruginosa.":[160],"Frequent":[161,221],"(\u22652)":[163],"significantly":[167],"greater":[170],"likelihood":[171,230],"experiencing":[173,200],"during":[176],"second":[180],"year's":[181],"(unadjusted":[183],"odds":[184],"ratios":[185],"3.35":[186],"(95%":[187,192],"CI":[188,193],"3.1\u20133.6)":[189],"2.96":[191],"2.8\u20133.2),":[194],"respectively).":[195],"The":[196],"proportion":[197],"\u22651":[201],"hospitalisation":[203,241],"cumulatively":[204],"increased":[205,240],"41.0%":[207],"in":[208,223],"year":[211],"to":[214],"51.1%":[215],"years'":[218],"follow-up.":[219],"Conclusion":[220],"may":[227],"increase":[228],"future":[232],"follow-up,":[238],"rates":[242],"time.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-05-19T00:00:00"}
