{"id":"https://openalex.org/W4377019461","doi":"https://doi.org/10.1093/eurheartjsupp/suad111.012","title":"C12 DAPAGLIFLOZIN INCREASES PAMPK AND REDUCES MYOCARDIAL AND RENAL NF\u2013KB EXPRESSION IN PRECLINICAL MODELS OF SHORT\u2013TERM DOXORUBICIN CARDIOTOXICITY THROUGH MYD\u2013188 AND NLRP3 PATHWAYS","display_name":"C12 DAPAGLIFLOZIN INCREASES PAMPK AND REDUCES MYOCARDIAL AND RENAL NF\u2013KB EXPRESSION IN PRECLINICAL MODELS OF SHORT\u2013TERM DOXORUBICIN CARDIOTOXICITY THROUGH MYD\u2013188 AND NLRP3 PATHWAYS","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4377019461","doi":"https://doi.org/10.1093/eurheartjsupp/suad111.012"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartjsupp/suad111.012","doi":"https://doi.org/10.1093/eurheartjsupp/suad111.012","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartjsupp/suad111.012","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D5/50379253/suad111.012.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D5/50379253/suad111.012.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069310507","display_name":"Vincenzo Quagliariello","orcid":"https://orcid.org/0000-0002-4557-5401","observed_orcids":["https://orcid.org/0000-0002-4557-5401"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V Quagliariello","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066774199","display_name":"Andrea Paccone","orcid":"https://orcid.org/0000-0002-7945-0455","observed_orcids":["https://orcid.org/0000-0002-7945-0455"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Paccone","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083264214","display_name":"Martina Iovine","orcid":"https://orcid.org/0000-0001-5871-4098","observed_orcids":["https://orcid.org/0000-0001-5871-4098"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Iovine","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023256497","display_name":"Giuseppe Palma","orcid":"https://orcid.org/0000-0003-4385-5896","observed_orcids":["https://orcid.org/0000-0003-4385-5896"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G Palma","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023165471","display_name":"Antonio Luciano","orcid":"https://orcid.org/0000-0003-0183-6574","observed_orcids":["https://orcid.org/0000-0003-0183-6574"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Luciano","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Barbieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Barbieri","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090544235","display_name":"Francesca Bruzzese","orcid":"https://orcid.org/0000-0001-7741-9086","observed_orcids":["https://orcid.org/0000-0001-7741-9086"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Bruzzese","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045173249","display_name":"Carlo Maurea","orcid":"https://orcid.org/0000-0001-9634-1640","observed_orcids":["https://orcid.org/0000-0001-9634-1640"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Maurea","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F Zito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F Zito","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036389835","display_name":"Rosalaura Sabetta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Sabetta","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103281697","display_name":"Marco Montella","orcid":"https://orcid.org/0000-0002-8588-7653","observed_orcids":["https://orcid.org/0000-0002-8588-7653"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Montella","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067376970","display_name":"Renato Franco","orcid":"https://orcid.org/0000-0002-8340-3184","observed_orcids":["https://orcid.org/0000-0002-8340-3184","https://orcid.org/0000-0002-6424-7841"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R Franco","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075134017","display_name":"Nicola Maurea","orcid":"https://orcid.org/0000-0003-3704-0092","observed_orcids":["https://orcid.org/0000-0003-3704-0092"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]},{"id":"https://openalex.org/I4210141868","display_name":"Istituto Nazionale Tumori IRCCS \"Fondazione G. Pascale\"","ror":"https://ror.org/0506y2b23","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210141868","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N Maurea","raw_affiliation_strings":["Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori\u2013IRCCS\u2013Fondazione G. Pascale , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I4210141868"]},{"raw_affiliation_string":"Universit\u00e0 Salerno , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]},{"raw_affiliation_string":"Universit\u00e0 Vanvitelli di Napoli , Napoli; , Salerno; , Napoli; , Napoli","institution_ids":["https://openalex.org/I197809005"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"Supplement_D","first_page":"D5","last_page":"D5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.9070000052452087},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9670000076293945},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.4950000047683716},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8560000061988831},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.972000002861023},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.9879999756813049},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.515999972820282},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":0.902999997138977},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.8180000185966492},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7059999704360962},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.6579999923706055},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.43299999833106995},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.5070000290870667},{"id":"https://openalex.org/keywords/cardiorenal-protection","display_name":"cardiorenal protection","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8145046234130859},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8028864860534668},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.6227593421936035},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.5261247158050537},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4715198278427124},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4575381278991699},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.45144978165626526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43203577399253845},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37152600288391113},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3701469302177429},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.27732083201408386},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.1708798110485077},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.13236892223358154}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/eurheartjsupp/suad111.012","doi":"https://doi.org/10.1093/eurheartjsupp/suad111.012","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartjsupp/suad111.012","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D5/50379253/suad111.012.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/eurheartjsupp/suad111.012","doi":"https://doi.org/10.1093/eurheartjsupp/suad111.012","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartjsupp/suad111.012","pdf_url":"https://academic.oup.com/eurheartjsupp/article-pdf/25/Supplement_D/D5/50379253/suad111.012.pdf","source":{"id":"https://openalex.org/S81127","display_name":"European Heart Journal Supplements","issn_l":"1520-765X","issn":["1520-765X","1554-2815"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal Supplements","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377019461.pdf","grobid_xml":"https://content.openalex.org/works/W4377019461.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389957328","https://openalex.org/W4381114367","https://openalex.org/W4388600908","https://openalex.org/W4380793504","https://openalex.org/W4311738728","https://openalex.org/W6913081924","https://openalex.org/W4406956213","https://openalex.org/W4399345758","https://openalex.org/W4387812096","https://openalex.org/W4283778764"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Doxorubicin\u2013mediated":[2],"adverse":[3],"cardiovascular":[4],"events":[5],"are":[6,55],"among":[7],"the":[8,165,169,249,339,342],"leading":[9],"causes":[10],"of":[11,30,125,171,179,186,207,225,237,338,344,348],"morbidity":[12],"and":[13,42,54,112,132,136,151,157,167,173,190,212,240,258,274,326,333],"mortality":[14],"in":[15,33,72,192,197,230,245,260,272,277,286,290,303,308,330,346,353],"breast":[16],"cancer":[17,354],"patients.":[18,355],"Sodium\u2013glucose":[19],"cotransporter":[20],"2":[21,37],"(SGLT2)":[22],"inhibitors":[23],"have":[24],"recently":[25],"been":[26],"shown":[27],"to":[28,105,201,233,322],"be":[29],"therapeutic":[31],"value":[32],"patients":[34],"with":[35,45,88,181,219],"type":[36],"diabetes,":[38],"chronic":[39],"kidney":[40],"disease,":[41],"heart":[43,331],"failure":[44,332],"reduced":[46,184,216,255],"ejection":[47],"fraction":[48],"(HFrEF),":[49],"conditions":[50],"that":[51,61],"commonly":[52],"coexist":[53],"interrelated":[56],"pathophysiologically.":[57],"Purpose:":[58],"We":[59],"hypothesized":[60],"Dapagliflozin":[62],"(an":[63],"SGLT2i),":[64],"administered":[65],"during":[66],"doxorubicin,":[67],"could":[68],"improve":[69,323],"cardiac":[70,193,324],"function":[71,325],"preclinical":[73,317],"models":[74],"Methods":[75],"Female":[76],"C57Bl/6":[77],"mice":[78,203],"were":[79,115,153,214,242,254],"untreated":[80],"(Sham,":[81],"n=6)":[82,101],"or":[83,102],"treated":[84],"for":[85],"10":[86,177],"days":[87,178],"doxorubicin":[89,103],"i.p":[90],"at":[91,97],"2.17":[92],"mg/kg":[93,99],"(DOXO,":[94],"n=6),":[95],"DAPA":[96,106,162,220,319,345],"12":[98],"(DAPA,":[100],"combined":[104],"(DOXO\u2013DAPA,":[107],"n=6).":[108],"Ejection":[109],"fraction,":[110],"radial":[111,172],"longitudinal":[113,174,296],"strain":[114,175,282,297],"analyzed":[116],"through":[117,155],"transthoracic":[118],"echocardiography":[119],"(Vevo":[120],"2100).":[121],"Cardiac":[122,205],"tissue":[123,276],"expression":[124,185,206,253,271],"NLRP3":[126],"inflammasome,":[127],"Myd88,":[128],"DAMPs":[129,189],"(galectine":[130],"3":[131],"calgranulinS100),":[133],"pAMPK,":[134],"NF\u2013kB,":[135],"13":[137],"chemokines":[138],"(IL\u20131\u03b1,":[139],"IL\u20131\u03b2,":[140,208],"IL\u20132,":[141],"IL\u20134,":[142],"IL\u20136,":[143,209],"IL\u201310,":[144],"IL\u201312,":[145],"IL17\u2013\u03b1,":[146],"IL\u201318,":[147],"IFN\u2013\u03b3,":[148],"TNF\u2013\u03b1,":[149,210],"G\u2013CSF,":[150],"GM\u2013CSF)":[152],"quantified":[154],"ELISA":[156],"western":[158],"blot":[159],"methods.":[160],"Results":[161],"improved":[163],"significantly":[164,215],"EF":[166],"prevented":[168],"reduction":[170,269],"after":[176,217],"treatment":[180,218],"doxorubicin.":[182],"A":[183],"NLRP3,":[187],"MyD88,":[188],"NF\u2013kB":[191,270],"tissues":[194],"was":[195,227],"seen":[196],"DOXO\u2013DAPA":[198,278],"group":[199,262],"compared":[200,232],"DOXO":[202,234,246,264,291,309],"(p<0.001).":[204],"G\u2013CSF":[211],"GM\u2013CSF":[213],"indicating":[221],"anti\u2013inflammatory":[222],"properties.":[223],"Expression":[224],"pAMPK":[226],"strongly":[228,243],"enhanced":[229,244],"DAPA\u2013DOXO":[231,261,287,304],"group.":[235],"Levels":[236],"Calgranulin":[238],"S100":[239],"galectine\u20133":[241],"group;":[247],"on":[248],"other":[250],"hand":[251],"their":[252],"by":[256,351],"47.7":[257],"52.3%":[259],"vs":[263,279,288,305],"(p<0.005).":[265],"Hystology":[266],"evaluation":[267],"indicate":[268],"myocardial":[273],"renal":[275],"DOXO.":[280],"Radial":[281],"(RS)":[283],"is":[284,299,320],"38.8%":[285],"14.1%":[289],"groups":[292,310],"(P":[293,311],"<":[294,312],"0.05);":[295],"(LS)":[298],"\u2013":[300,306],"23.4":[301],"%":[302],"10.5%":[307],"0.001)":[313],"Conclusion":[314],"In":[315],"this":[316],"study,":[318],"able":[321],"reduce":[327],"biomarkers":[328],"involved":[329],"fibrosis.":[334],"The":[335],"overall":[336],"picture":[337],"study":[340],"pushes":[341],"use":[343],"prevention":[347],"cardiomyopathies":[349],"induced":[350],"anthracyclines":[352]},"counts_by_year":[{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-05-19T00:00:00"}