{"id":"https://openalex.org/W4376959508","doi":"https://doi.org/10.3389/fonc.2023.1151879","title":"Prognostic impact of the loss of E-cadherin and de novo expression of N-cadherin at the invasive front of primary and recurrent oral squamous cell carcinoma","display_name":"Prognostic impact of the loss of E-cadherin and de novo expression of N-cadherin at the invasive front of primary and recurrent oral squamous cell carcinoma","publication_year":2023,"publication_date":"2023-05-17","ids":{"openalex":"https://openalex.org/W4376959508","doi":"https://doi.org/10.3389/fonc.2023.1151879","pmid":"https://pubmed.ncbi.nlm.nih.gov/37265789","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10231494"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2023.1151879","doi":"https://doi.org/10.3389/fonc.2023.1151879","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1151879","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1151879/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1151879/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034062838","display_name":"Samer George Hakim","orcid":"https://orcid.org/0000-0003-2652-5553","observed_orcids":["https://orcid.org/0000-0003-2652-5553"]},"institutions":[{"id":"https://openalex.org/I4210101162","display_name":"Helios Hospital Schwerin","ror":"https://ror.org/018gc9r78","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210101162","https://openalex.org/I4210138940"]},{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Samer George Hakim","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","Department of Oral and Maxillofacial Surgery, Helios Medical Center, Schwerin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]},{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Helios Medical Center, Schwerin, Germany","institution_ids":["https://openalex.org/I4210101162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091967907","display_name":"Clara Taubitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Clara Taubitz","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110976913","display_name":"Steffen Hoppe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Hoppe","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062607071","display_name":"Daniel Steller","orcid":"https://orcid.org/0000-0001-9145-9308","observed_orcids":["https://orcid.org/0000-0001-9145-9308"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Steller","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057206849","display_name":"Dirk Rades","orcid":"https://orcid.org/0009-0008-2046-4968","observed_orcids":["https://orcid.org/0009-0008-2046-4968","https://orcid.org/0000-0002-3221-7541"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Rades","raw_affiliation_strings":["Department of Radiation Oncology, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085790556","display_name":"Julika Ribbat\u2010Idel","orcid":"https://orcid.org/0000-0003-1262-6572","observed_orcids":["https://orcid.org/0000-0003-1262-6572"]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julika Ribbat-Idel","raw_affiliation_strings":["Institute of Pathology, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105767766","display_name":"Ubai Alsharif","orcid":"https://orcid.org/0000-0002-4024-3950","observed_orcids":["https://orcid.org/0000-0002-4024-3950"]},"institutions":[{"id":"https://openalex.org/I155976169","display_name":"Witten/Herdecke University","ror":"https://ror.org/00yq55g44","country_code":"DE","type":"education","lineage":["https://openalex.org/I155976169"]},{"id":"https://openalex.org/I4210127529","display_name":"Klinikum Dortmund","ror":"https://ror.org/037pq2a43","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210127529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ubai Alsharif","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Dortmund General Hospital, Dortmund, and Faculty of Health, Witten/Herdecke University, Witten, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Dortmund General Hospital, Dortmund, and Faculty of Health, Witten/Herdecke University, Witten, Germany","institution_ids":["https://openalex.org/I155976169","https://openalex.org/I4210127529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031722316","display_name":"Mohamed Falougy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mohamed Falougy","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Head and Neck Cancer Center, University Hospital Schleswig-Holstein, L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I4210112713"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5034062838"],"corresponding_institution_ids":["https://openalex.org/I4210101162","https://openalex.org/I4210112713"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":2.2785,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89990001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1151879","last_page":"1151879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6782000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.6782000064849854,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.3068999946117401,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cadherin-loss","display_name":"E-cadherin loss","score":0.8579999804496765},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oral-squamous-cell-carcinoma","display_name":"oral squamous cell carcinoma","score":0.9639999866485596},{"id":"https://openalex.org/keywords/oral-cancer-recurrence","display_name":"recurrent oral cancer","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tumor-invasion-front","display_name":"tumor invasion front","score":0.8209999799728394},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.843999981880188},{"id":"https://openalex.org/keywords/postrecurrence-survival","display_name":"survival after recurrence","score":0.9120000004768372},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6729999780654907},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.8223745822906494},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.604205310344696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5785958170890808},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5770769119262695},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.562886655330658},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5449104309082031},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.502190113067627},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4682990610599518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4488969147205353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3574426770210266},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3273988366127014},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29487505555152893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2519882023334503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2023.1151879","doi":"https://doi.org/10.3389/fonc.2023.1151879","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1151879","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1151879/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10231494","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10231494","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10231494/pdf/fonc-13-1151879.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:37265789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37265789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e6b5ba45d8544f709d2198b76bec8e85","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6b5ba45d8544f709d2198b76bec8e85","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2023.1151879","doi":"https://doi.org/10.3389/fonc.2023.1151879","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1151879","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1151879/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376959508.pdf","grobid_xml":"https://content.openalex.org/works/W4376959508.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1558642436","https://openalex.org/W1968412266","https://openalex.org/W1969511542","https://openalex.org/W1971872239","https://openalex.org/W1989481111","https://openalex.org/W1989874614","https://openalex.org/W1989900857","https://openalex.org/W2000445173","https://openalex.org/W2014128353","https://openalex.org/W2023778490","https://openalex.org/W2033871653","https://openalex.org/W2041186264","https://openalex.org/W2047992261","https://openalex.org/W2048994014","https://openalex.org/W2051996704","https://openalex.org/W2077462602","https://openalex.org/W2081757927","https://openalex.org/W2108369647","https://openalex.org/W2115124950","https://openalex.org/W2118595054","https://openalex.org/W2121126525","https://openalex.org/W2132601370","https://openalex.org/W2154589460","https://openalex.org/W2160356573","https://openalex.org/W2441084609","https://openalex.org/W2515168102","https://openalex.org/W2519796843","https://openalex.org/W2563613918","https://openalex.org/W2567510695","https://openalex.org/W2741450739","https://openalex.org/W2766078810","https://openalex.org/W2775351798","https://openalex.org/W2783337717","https://openalex.org/W2807701194","https://openalex.org/W2889350033","https://openalex.org/W2897490162","https://openalex.org/W2956041543","https://openalex.org/W2968917632","https://openalex.org/W2974147039","https://openalex.org/W2977678095","https://openalex.org/W3021872426","https://openalex.org/W3096286467","https://openalex.org/W3106277352","https://openalex.org/W3107149761","https://openalex.org/W3120671844","https://openalex.org/W3124904365","https://openalex.org/W3130826446","https://openalex.org/W3143258920","https://openalex.org/W3159164887","https://openalex.org/W3200131421","https://openalex.org/W4200456285","https://openalex.org/W4211233744","https://openalex.org/W4319082411"],"related_works":["https://openalex.org/W2766078810","https://openalex.org/W2132601370","https://openalex.org/W2115124950","https://openalex.org/W4378800864","https://openalex.org/W2412640007","https://openalex.org/W2969945219","https://openalex.org/W2060942298","https://openalex.org/W2297949456","https://openalex.org/W2571789291","https://openalex.org/W1969511542"],"abstract_inverted_index":{"The":[0,66,217,272],"epithelial-mesenchymal":[1],"transition":[2,32],"(EMT)":[3],"is":[4,43,69,99,279],"a":[5,18,31,37,70,169,238],"biological":[6],"mechanism":[7],"in":[8,14,21,78,88,233,277],"multiple":[9],"pathophysiological":[10],"diseases.":[11],"Related":[12],"alterations":[13],"cadherin":[15,67,86,142],"expression":[16,139,176,193,208,232,276],"play":[17],"crucial":[19],"role":[20],"carcinogenesis,":[22],"progression,":[23],"angiogenesis,":[24],"and":[25,57,63,74,91,110,133,162,177,181,187,209,213,228,287,294],"immune":[26],"response.":[27],"EMT":[28,73],"cells":[29],"exhibit":[30],"from":[33,159,251],"an":[34,59,100,243,280],"epithelial":[35],"to":[36,241,254,291],"mesenchymal":[38],"phenotype":[39],"(cadherin-switch).":[40],"This":[41],"process":[42],"characterized":[44],"by":[45,124],"the":[46,85,89,104,107,113,126,130,135,145,155,234,257,262,269,296],"de":[47,206,230],"novo":[48,207,231],"development":[49],"of":[50,72,103,117,129,140,174,237,261,264,274],"N-cadherin":[51],"(N-CAD),":[52],"which":[53],"replaces":[54],"E-cadherin":[55],"(E-CAD)":[56],"signifies":[58],"increased":[60],"migratory":[61],"capacity":[62],"malignant":[64],"transformation.":[65],"switch":[68,87],"hallmark":[71,246],"has":[75],"been":[76],"studied":[77],"various":[79],"cancer":[80],"entities.":[81],"We":[82],"predicted":[83],"that":[84,222,247],"primary":[90,161,252,270],"recurrent":[92],"oral":[93,179,211],"squamous":[94],"cell":[95],"carcinoma":[96],"(re-OSCC)":[97],"tissues":[98],"inherent":[101,244],"characteristic":[102],"tumor,":[105,259],"affects":[106],"biologic":[108],"behavior,":[109],"further":[111],"reflects":[112],"post-recurrence":[114,127,215],"survival":[115,128],"outcome":[116,121],"these":[118],"patients.":[119],"Survival":[120],"was":[122,168,199],"analyzed":[123],"calculating":[125],"high-risk":[131],"group":[132],"correlating":[134],"standardized":[136],"h-score-based":[137],"IHC":[138],"both":[141,160,178],"types":[143],"with":[144,150],"clinical":[146],"follow-up.":[147],"94":[148],"patients":[149],"re-OSCC":[151,278],"were":[152,165],"observed":[153],"within":[154,256],"cohort.":[156],"Tissue":[157],"samples":[158],"recurring":[163],"tumors":[164],"collected.":[166],"There":[167,198],"significant":[170,202],"association":[171],"between":[172,204],"loss":[173,194,227,273],"E-CAD":[175,226,275],"cancer-specific":[180,212],"overall":[182],"survival,":[183,286],"(HR=2.72,":[184],"CI:1.50-4.95,":[185],"p=0.001)":[186],"(HR=3.84,":[188],"CI:1.93-7.63,":[189],"p=0.001),":[190],"respectively,":[191],"for":[192,268,284],"higher":[195],"than":[196],"60%.":[197],"no":[200],"statistically":[201],"correlation":[203],"N-CAD":[205,229],"Overall,":[210],"disease-free":[214],"survival.":[216],"current":[218],"study":[219],"clearly":[220],"shows":[221],"cadherin-switch,":[223],"identified":[224],"as":[225],"invasion":[235],"front":[236],"re-OSCC,":[239],"appears":[240],"be":[242,289],"histological":[245],"does":[248],"not":[249],"change":[250],"manifestation":[253],"recurrence":[255],"same":[258],"regardless":[260],"form":[263],"adjuvant":[265],"therapy":[266,293],"used":[267,290],"tumor.":[271],"independent":[281],"risk":[282],"factor":[283],"poor":[285],"may":[288],"stratify":[292],"de/escalate":[295],"multimodal":[297],"treatment.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-05-18T00:00:00"}