{"id":"https://openalex.org/W43768929","doi":null,"title":"The role of mitochondria and proteasomes in T cell apoptosis","display_name":"The role of mitochondria and proteasomes in T cell apoptosis","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W43768929","mag":"43768929"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.umass.edu:dissertations-3096","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.umass.edu/dissertations/AAI9909168","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations Available from Proquest","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.umass.edu/dissertations/AAI9909168","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060906575","display_name":"Lisa M. Grimm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa Grimm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060906575"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-apoptosis","display_name":"T cell apoptosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.9829999804496765},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9580000042915344},{"id":"https://openalex.org/keywords/thymocytes","display_name":"thymocytes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/negative-selection","display_name":"negative selection","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mitochondrial-genome","display_name":"mitochondrial genome","score":0.5590000152587891},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9049999713897705},{"id":"https://openalex.org/keywords/proteasome-inhibitors","display_name":"proteasome inhibitors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.9950000047683716},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6872178912162781},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6830134987831116},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.675129234790802},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5870243906974792},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4774347245693207},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4482543170452118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41432321071624756},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37183114886283875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22506311535835266}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.umass.edu:dissertations-3096","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.umass.edu/dissertations/AAI9909168","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations Available from Proquest","raw_type":"text"},{"id":"mag:43768929","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=3096&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.umass.edu:dissertations-3096","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.umass.edu/dissertations/AAI9909168","pdf_url":null,"source":{"id":"https://openalex.org/S4306402057","display_name":"Scholarworks (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations Available from Proquest","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1553062142","https://openalex.org/W2288451278","https://openalex.org/W1593628997","https://openalex.org/W2030369269","https://openalex.org/W2226304864","https://openalex.org/W1519096021","https://openalex.org/W2062701828","https://openalex.org/W2482893534","https://openalex.org/W1765198312","https://openalex.org/W3133580271"],"abstract_inverted_index":{"Apoptosis":[0,178],"is":[1,9,24,226,261],"a":[2,56,72,209,296],"type":[3],"of":[4,16,50,82,103,116,124,131,144,170,174,193,202,232,266,281,310],"programmed":[5],"cell":[6,64,111],"death":[7,244],"that":[8,80,164,258,276],"essential":[10],"for":[11,39,58,211,263,299],"the":[12,35,51,77,83,109,114,117,129,132,141,168,171,191,212,224,264,277,300,314,321],"development":[13],"and":[14,60,88,126,128,146,149,183,196,290,327],"maintenance":[15],"tissue":[17],"homeostasis":[18],"in":[19,26,62,67,76,92,108,155,176,215,228,270,302,317,329],"multicellular":[20],"organisms.":[21],"Because":[22],"apoptosis":[23,303,328],"important":[25],"many":[27,194,267,282],"biological":[28],"situations,":[29],"laboratories":[30,162],"are":[31,167],"working":[32],"to":[33,46,189,221],"delineate":[34],"signaling":[36,52],"pathways":[37,53,269],"responsible":[38],"this":[40,98,184,203,318],"process.":[41],"This":[42],"thesis":[43,99,204,319],"work":[44,205,315],"attempts":[45],"identify":[47],"new":[48],"components":[49],"by":[54,122,137,246],"examining":[55],"role":[57,210,298],"mitochondria":[59,68,175],"proteasomes":[61,326],"T":[63,110],"apoptosis.":[65,177,216,230],"Interest":[66],"was":[69],"initiated":[70],"when":[71],"library":[73],"screen":[74],"performed":[75],"laboratory":[78],"revealed":[79],"portions":[81],"mitochondrial":[84,104,118,133,150,291],"genome,":[85],"called":[86],"apt-1":[87],"apt-3,":[89],"were":[90,106,219],"downregulated":[91],"thymocytes":[93,233],"during":[94],"negative":[95],"selection.":[96],"In":[97],"work,":[100],"two":[101],"aspects":[102],"function":[105],"examined":[107],"hybridoma,":[112],"DO11.10:":[113],"integrity":[115,130],"genome":[119],"as":[120,135],"assessed":[121,136],"levels":[123,143],"apt-l":[125,145],"apt-3":[127,147],"membrane":[134,138],"potential.":[139],"Both":[140],"steady-state":[142],"RNA":[148],"transmembrane":[151,292],"potential":[152,293],"declined":[153],"rapidly":[154],"apoptotic":[156,268,283],"cells.":[157],"Recent":[158],"studies":[159,273],"from":[160],"other":[161],"indicate":[163,275],"these":[165],"changes":[166],"result":[169],"active":[172],"participation":[173],"relies":[179],"heavily":[180],"on":[181,207],"proteolysis,":[182],"dependence":[185],"has":[186],"encouraged":[187],"investigators":[188],"analyze":[190],"significance":[192],"proteases":[195],"proteolytic":[197,312],"pathways.":[198],"The":[199],"second":[200],"part":[201],"focused":[206],"describing":[208],"ubiquitin-proteasome":[213],"pathway":[214],"Proteasome":[217],"inhibitors":[218],"used":[220],"determine":[222],"whether":[223],"proteasome":[225,259,278,301],"required":[227],"thymocyte":[229],"Treatment":[231],"with":[234],"acetyl-leu-leu-methioninal":[235],"(LLM),":[236],"acetyl-leu-leu-norleucinal":[237],"(LLnL),":[238],"carbobenzoxyl-leu-leu-leucinal":[239],"(MG132),":[240],"or":[241,250],"lactacystin":[242],"inhibited":[243],"induced":[245],"dexamethasone,":[247],"ionizing":[248],"radiation,":[249],"phorbol":[251],"12-myristate":[252],"13-acetate":[253],"(PMA).":[254],"These":[255],"results":[256],"suggest":[257],"activity":[260],"necessary":[262],"progression":[265],"thymocytes.":[271],"Inhibitor":[272],"also":[274],"functions":[279],"upstream":[280],"events,":[284],"including:":[285],"PARP":[286],"cleavage,":[287],"caspase-3":[288],"activation,":[289],"depolarization.":[294],"Although":[295],"precise":[297],"cannot":[304],"be":[305],"assigned":[306],"without":[307],"an":[308],"identification":[309],"its":[311],"targets,":[313],"described":[316],"provides":[320],"first":[322],"definitive":[323],"link":[324],"between":[325],"mammalian":[330],"systems.":[331]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2016-06-24T00:00:00"}