{"id":"https://openalex.org/W4376643124","doi":"https://doi.org/10.1080/19420862.2023.2209920","title":"Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis","display_name":"Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis","publication_year":2023,"publication_date":"2023-05-15","ids":{"openalex":"https://openalex.org/W4376643124","doi":"https://doi.org/10.1080/19420862.2023.2209920","pmid":"https://pubmed.ncbi.nlm.nih.gov/37184136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10187109"},"language":"en","primary_location":{"id":"doi:10.1080/19420862.2023.2209920","doi":"https://doi.org/10.1080/19420862.2023.2209920","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19420862.2023.2209920","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2209920?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2209920?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068388745","display_name":"Susanne Klint","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Susanne Klint","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061643714","display_name":"Joachim Feldwisch","orcid":"https://orcid.org/0009-0000-2043-2482","observed_orcids":["https://orcid.org/0009-0000-2043-2482"]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Joachim Feldwisch","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071730738","display_name":"Lindvi Gudmundsdotter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lindvi Gudmundsdotter","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080630870","display_name":"Karin Dillner Bergstedt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Karin Dillner Bergstedt","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013820419","display_name":"Elin Gunneriusson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Elin Gunneriusson","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053442577","display_name":"Ingmarie H\u00f6id\u00e9n\u2010Guthenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ingmarie H\u00f6id\u00e9n Guthenberg","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071231493","display_name":"Anders Wennborg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anders Wennborg","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040856063","display_name":"Andrew C. Nyborg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew C. Nyborg","raw_affiliation_strings":["ACELYRIN","ACELYRIN, Agoura Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACELYRIN","institution_ids":[]},{"raw_affiliation_string":"ACELYRIN, Agoura Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016828717","display_name":"Amol P. Kamboj","orcid":"https://orcid.org/0000-0003-3611-7326","observed_orcids":["https://orcid.org/0000-0003-3611-7326"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amol P. Kamboj","raw_affiliation_strings":["ACELYRIN","ACELYRIN, Agoura Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACELYRIN","institution_ids":[]},{"raw_affiliation_string":"ACELYRIN, Agoura Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069421572","display_name":"Paul Michael J Peloso","orcid":"https://orcid.org/0000-0001-6979-306X","observed_orcids":["https://orcid.org/0000-0001-6979-306X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul M. Peloso","raw_affiliation_strings":["ACELYRIN","ACELYRIN, Agoura Hills, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ACELYRIN","institution_ids":[]},{"raw_affiliation_string":"ACELYRIN, Agoura Hills, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091955122","display_name":"David Bejker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"David Bejker","raw_affiliation_strings":["Affibody AB","Affibody AB, Solna, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033302171","display_name":"Fredrik Y. Frejd","orcid":"https://orcid.org/0000-0002-6421-4142","observed_orcids":["https://orcid.org/0000-0002-6421-4142"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I4210166806","display_name":"Affibody (Sweden)","ror":"https://ror.org/05w9s5139","country_code":"SE","type":"company","lineage":["https://openalex.org/I4210166806"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Fredrik Y. Frejd","raw_affiliation_strings":["Affibody AB","Uppsala University","Affibody AB, Solna, Sweden","Department of Immunology, Genetics and Pathology, IGP, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affibody AB","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Uppsala University","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Affibody AB, Solna, Sweden","institution_ids":["https://openalex.org/I4210166806"]},{"raw_affiliation_string":"Department of Immunology, Genetics and Pathology, IGP, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033302171"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I4210166806"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":6.4349,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97814668,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"2209920","last_page":"2209920"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-psoriasis","display_name":"plaque psoriasis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/psoriatic-arthritis","display_name":"psoriatic arthritis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/albumin-binding-domain","display_name":"albumin-binding domain","score":0.9419999718666077},{"id":"https://openalex.org/keywords/first-in-human-safety","display_name":"first-in-human safety","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.996999979019165},{"id":"https://openalex.org/keywords/uveitis","display_name":"uveitis","score":0.7360000014305115},{"id":"https://openalex.org/keywords/hidradenitis-suppurativa","display_name":"hidradenitis suppurativa","score":0.921999990940094},{"id":"https://openalex.org/keywords/axial-spondyloarthritis","display_name":"axial spondyloarthritis","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2780564577","wikidata":"https://www.wikidata.org/wiki/Q179945","display_name":"Psoriasis","level":2,"score":0.8969478607177734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8265911340713501},{"id":"https://openalex.org/C2777011040","wikidata":"https://www.wikidata.org/wiki/Q390643","display_name":"Psoriasis Area and Severity Index","level":3,"score":0.7279888391494751},{"id":"https://openalex.org/C2776260265","wikidata":"https://www.wikidata.org/wiki/Q511097","display_name":"Psoriatic arthritis","level":3,"score":0.6323138475418091},{"id":"https://openalex.org/C156730664","wikidata":"https://www.wikidata.org/wiki/Q23308590","display_name":"Interleukin 23","level":4,"score":0.5557364225387573},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.5407495498657227},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4605599343776703},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.4594375491142273},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.442289263010025},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3973979353904724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3972652554512024},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.3942793011665344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3595903515815735},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.31078895926475525},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015535","descriptor_name":"Arthritis, Psoriatic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017497","descriptor_name":"Hidradenitis Suppurativa","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1080/19420862.2023.2209920","doi":"https://doi.org/10.1080/19420862.2023.2209920","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19420862.2023.2209920","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2209920?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10187109","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10187109","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10187109/pdf/KMAB_15_2209920.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"},{"id":"pmid:37184136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37184136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Journal Article"},{"id":"pmh:oai:DiVA.org:uu-503201","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-503201","pdf_url":"https://uu.diva-portal.org/smash/get/diva2:1764718/FULLTEXT01","source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:c8401aa19f3c478fa57e57df7df533f1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c8401aa19f3c478fa57e57df7df533f1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mAbs, Vol 15, Iss 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/19420862.2023.2209920","doi":"https://doi.org/10.1080/19420862.2023.2209920","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19420862.2023.2209920","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19420862.2023.2209920?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376643124.pdf","grobid_xml":"https://content.openalex.org/works/W4376643124.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1511865798","https://openalex.org/W1566111314","https://openalex.org/W1605132184","https://openalex.org/W1737140009","https://openalex.org/W1963903021","https://openalex.org/W1971708477","https://openalex.org/W1989580374","https://openalex.org/W2009590651","https://openalex.org/W2032299291","https://openalex.org/W2035758624","https://openalex.org/W2052456089","https://openalex.org/W2068419991","https://openalex.org/W2077787026","https://openalex.org/W2079379157","https://openalex.org/W2080705760","https://openalex.org/W2086504443","https://openalex.org/W2124257367","https://openalex.org/W2152113638","https://openalex.org/W2160965670","https://openalex.org/W2162841866","https://openalex.org/W2285875128","https://openalex.org/W2339525054","https://openalex.org/W2412722422","https://openalex.org/W2490125347","https://openalex.org/W2564885013","https://openalex.org/W2602095186","https://openalex.org/W2613618878","https://openalex.org/W2619323349","https://openalex.org/W2765893416","https://openalex.org/W2794845062","https://openalex.org/W2801696506","https://openalex.org/W2810325094","https://openalex.org/W2883191655","https://openalex.org/W2967437723","https://openalex.org/W2972819009","https://openalex.org/W2989977128","https://openalex.org/W3002825154","https://openalex.org/W3004602546","https://openalex.org/W3019891848","https://openalex.org/W3045278545","https://openalex.org/W3081361112","https://openalex.org/W3100055007","https://openalex.org/W3112014074","https://openalex.org/W3128034858","https://openalex.org/W3154471392","https://openalex.org/W3156084043","https://openalex.org/W3176834192","https://openalex.org/W3194448077","https://openalex.org/W3195797661","https://openalex.org/W3199385513","https://openalex.org/W4280502063","https://openalex.org/W4308510052","https://openalex.org/W4386623580","https://openalex.org/W6715635055"],"related_works":["https://openalex.org/W4386623580","https://openalex.org/W4401104247","https://openalex.org/W4383980382","https://openalex.org/W1980801789","https://openalex.org/W4300190056","https://openalex.org/W1934536765","https://openalex.org/W2195057011","https://openalex.org/W2296439405","https://openalex.org/W4399482871","https://openalex.org/W1934863457"],"abstract_inverted_index":{"Psoriasis,":[0],"an":[1,42],"immune-mediated":[2],"inflammatory":[3],"disease,":[4],"affects":[5],"nearly":[6],"125":[7],"million":[8],"people":[9],"globally.":[10],"The":[11,224],"interleukin":[12],"(IL)-17A":[13],"homodimer":[14],"is":[15],"a":[16,68,93,217],"key":[17],"driver":[18],"of":[19,85,142],"psoriasis":[20,166,194],"and":[21,32,48,66,105,115,121,139,147,155,159,184,246],"other":[22],"autoimmune":[23],"diseases,":[24],"including":[25],"psoriatic":[26,222,240],"arthritis,":[27,241],"axial":[28,242],"spondyloarthritis,":[29,243],"hidradenitis":[30,244],"suppurativa,":[31,245],"uveitis.":[33,247],"Treatment":[34],"with":[35,118,165,175,186,220],"monoclonal":[36],"antibodies":[37],"(mAbs)":[38],"against":[39],"IL\u221217A":[40],"provides":[41],"improvement":[43],"in":[44,113,116,181,192,202,210,216],"the":[45,59,83,136,230],"Psoriasis":[46],"Area":[47],"Severity":[49],"Index":[50],"compared":[51],"to":[52,64,124,134,152,163,232],"conventional":[53],"systemic":[54],"agents.":[55],"In":[56],"this":[57],"study,":[58],"Affibody\u24c7":[60],"technology":[61],"was":[62,132,172,190,213],"used":[63],"identify":[65],"optimize":[67],"novel,":[69],"small,":[70],"biological":[71],"molecule":[72],"comprising":[73,100],"three":[74],"triple":[75],"helical":[76],"affinity":[77],"domains,":[78],"izokibep":[79,228],"(previously":[80],"ABY-035),":[81],"for":[82],"inhibition":[84],"IL-17A":[86,112],"signaling.":[87],"Preclinical":[88],"studies":[89],"show":[90],"that":[91,227],"izokibep,":[92,143],"small":[94],"18.6":[95],"kDa":[96],"IL-17":[97],"ligand":[98],"trap":[99],"two":[101],"IL-17A-specific":[102],"Affibody":[103],"domains":[104],"one":[106,197],"albumin-binding":[107],"domain,":[108],"selectively":[109],"inhibits":[110],"human":[111],"vitro":[114],"vivo":[117],"superior":[119],"potency":[120],"efficacy":[122,141,189],"relative":[123],"anti-IL-17A":[125],"mAbs.":[126],"A":[127,207],"Phase":[128],"1":[129],"first-in-human":[130],"study":[131,225],"conducted":[133],"establish":[135],"safety,":[137],"pharmacokinetics,":[138],"preliminary":[140],"when":[144],"administered":[145],"intravenously":[146],"subcutaneously":[148],"as":[149,156,238],"single":[150,157,218],"doses":[151,162],"healthy":[153,182],"subjects,":[154],"intravenous":[158],"multiple":[160,205],"subcutaneous":[161],"patients":[164,185,195,203],"(NCT02690142;":[167],"EudraCT":[168],"No:":[169],"2015\u2013004531\u201313).":[170],"Izokibep":[171],"well":[173],"tolerated":[174],"no":[176],"meaningful":[177],"safety":[178],"concerns":[179],"identified":[180],"volunteers":[183],"psoriasis.":[187],"Rapid":[188],"seen":[191],"all":[193],"after":[196],"dose":[198],"which":[199],"further":[200],"improved":[201],"receiving":[204],"doses.":[206],"therapeutic":[208],"decrease":[209],"joint":[211],"pain":[212],"also":[214],"observed":[215],"patient":[219],"concurrent":[221],"arthritis.":[223],"suggests":[226],"has":[229],"potential":[231],"safely":[233],"treat":[234],"IL17A-associated":[235],"diseases":[236],"such":[237],"psoriasis,":[239]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-17T00:00:00"}