{"id":"https://openalex.org/W4376470872","doi":"https://doi.org/10.3947/ic.2022.0176","title":"A Korean Post-Marketing Study of Abacavir/Dolutegravir/Lamivudine in Patients with HIV-1","display_name":"A Korean Post-Marketing Study of Abacavir/Dolutegravir/Lamivudine in Patients with HIV-1","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4376470872","doi":"https://doi.org/10.3947/ic.2022.0176","pmid":"https://pubmed.ncbi.nlm.nih.gov/37272234","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10551717"},"language":"en","primary_location":{"id":"doi:10.3947/ic.2022.0176","doi":"https://doi.org/10.3947/ic.2022.0176","is_oa":true,"landing_page_url":"https://doi.org/10.3947/ic.2022.0176","pdf_url":"http://icjournal.org/Synapse/Data/PDFData/0086IC/ic-55-337.pdf","source":{"id":"https://openalex.org/S206203058","display_name":"Infection and Chemotherapy","issn_l":"1598-8112","issn":["1598-8112","2092-6448","2093-2340"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319421","host_organization_name":"Jin Publishing & Printing Co.","host_organization_lineage":["https://openalex.org/P4310319421"],"host_organization_lineage_names":["Jin Publishing & Printing Co."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection &amp; Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://icjournal.org/Synapse/Data/PDFData/0086IC/ic-55-337.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101543676","display_name":"S.T. Shin","orcid":"https://orcid.org/0000-0003-3122-8879","observed_orcids":["https://orcid.org/0000-0003-3122-8879"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sang-Kyu Shin","raw_affiliation_strings":["GlaxoSmithKline Korea, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3122-8879","affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Korea, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017186394","display_name":"Jung-Eun Cho","orcid":"https://orcid.org/0000-0002-3639-9004","observed_orcids":["https://orcid.org/0000-0002-3639-9004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung-Eun Cho","raw_affiliation_strings":["GlaxoSmithKline Korea, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-3639-9004","affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Korea, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060745432","display_name":"Eun\u2010Bin Lee","orcid":"https://orcid.org/0000-0002-9028-7396","observed_orcids":["https://orcid.org/0000-0002-9028-7396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eun-Bin Lee","raw_affiliation_strings":["GlaxoSmithKline Korea, Seoul, Korea"],"raw_orcid":"https://orcid.org/0000-0002-9028-7396","affiliations":[{"raw_affiliation_string":"GlaxoSmithKline Korea, Seoul, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100689633","display_name":"Kim Ys","orcid":"https://orcid.org/0000-0003-1142-5488","observed_orcids":["https://orcid.org/0000-0003-1142-5488"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeon-Sook Kim","raw_affiliation_strings":["Division of Infectious Diseases, Chungnam National University School of Medicine, Daejeon, Korea"],"raw_orcid":"https://orcid.org/0000-0003-1142-5488","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Chungnam National University School of Medicine, Daejeon, Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012131421","display_name":"Sook\u2010In Jung","orcid":"https://orcid.org/0000-0002-1577-678X","observed_orcids":["https://orcid.org/0000-0002-1577-678X"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sook-In Jung","raw_affiliation_strings":["Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea"],"raw_orcid":"https://orcid.org/0000-0002-1577-678X","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea","institution_ids":["https://openalex.org/I111277659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101543676"],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.4117,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57704513,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"55","issue":"3","first_page":"337","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8899999856948853},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.8939999938011169},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.902999997138977},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8069999814033508},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.722000002861023},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/antiretroviral-drug-interactions","display_name":"antiretroviral drug interactions","score":0.6169999837875366},{"id":"https://openalex.org/keywords/concomitant-medications","display_name":"concomitant medications","score":0.5929999947547913},{"id":"https://openalex.org/keywords/genital-warts","display_name":"genital warts","score":0.746999979019165},{"id":"https://openalex.org/keywords/nasopharyngitis","display_name":"nasopharyngitis","score":0.722000002861023},{"id":"https://openalex.org/keywords/treatment-naive-and-treatment-experienced-patients","display_name":"treatment-naive and treatment-experienced patients","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2779502633","wikidata":"https://www.wikidata.org/wiki/Q937224","display_name":"Dolutegravir","level":5,"score":0.9739187955856323},{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.9560470581054688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9191519021987915},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.8766467571258545},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.648192822933197},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4712793231010437},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.4519564211368561},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.35438287258148193},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3070000410079956},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.26006656885147095},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.25729772448539734},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.15540340542793274},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.12764421105384827},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.08851298689842224}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3947/ic.2022.0176","doi":"https://doi.org/10.3947/ic.2022.0176","is_oa":true,"landing_page_url":"https://doi.org/10.3947/ic.2022.0176","pdf_url":"http://icjournal.org/Synapse/Data/PDFData/0086IC/ic-55-337.pdf","source":{"id":"https://openalex.org/S206203058","display_name":"Infection and Chemotherapy","issn_l":"1598-8112","issn":["1598-8112","2092-6448","2093-2340"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319421","host_organization_name":"Jin Publishing & Printing Co.","host_organization_lineage":["https://openalex.org/P4310319421"],"host_organization_lineage_names":["Jin Publishing & Printing Co."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection &amp; Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10551717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10551717","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10551717/pdf/ic-55-337.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Chemother","raw_type":"Text"},{"id":"pmid:37272234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37272234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection & chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3947/ic.2022.0176","doi":"https://doi.org/10.3947/ic.2022.0176","is_oa":true,"landing_page_url":"https://doi.org/10.3947/ic.2022.0176","pdf_url":"http://icjournal.org/Synapse/Data/PDFData/0086IC/ic-55-337.pdf","source":{"id":"https://openalex.org/S206203058","display_name":"Infection and Chemotherapy","issn_l":"1598-8112","issn":["1598-8112","2092-6448","2093-2340"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","kci-registered","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319421","host_organization_name":"Jin Publishing & Printing Co.","host_organization_lineage":["https://openalex.org/P4310319421"],"host_organization_lineage_names":["Jin Publishing & Printing Co."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infection &amp; Chemotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1477936221","display_name":"Utilising snake endogenous toxin inhibitors for the development of improved antivenom treatments","funder_award_id":"204731","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376470872.pdf","grobid_xml":"https://content.openalex.org/works/W4376470872.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2044130695","https://openalex.org/W2088742114","https://openalex.org/W2153375988","https://openalex.org/W2605932783","https://openalex.org/W4210486996","https://openalex.org/W4254160322"],"related_works":["https://openalex.org/W4313156096","https://openalex.org/W2754643281","https://openalex.org/W4392205211","https://openalex.org/W2956155508","https://openalex.org/W1993298127","https://openalex.org/W3179805972","https://openalex.org/W2094241860","https://openalex.org/W7143456851","https://openalex.org/W2508394693","https://openalex.org/W28488281"],"abstract_inverted_index":{"BACKGROUND:":[0],"Abacavir/dolutegravir/lamivudine":[1,266],"has":[2],"been":[3],"indicated":[4],"in":[5,19,35,39,42,143,188,193,258,310],"Korea":[6,144],"since":[7],"2015":[8,146],"for":[9,153,159,263],"treatment":[10,101],"of":[11,33,106,121,246,271,281,292],"human":[12],"immunodeficiency":[13],"virus":[14],"type":[15],"1":[16],"(HIV-1)":[17],"infection":[18,61],"combination.":[20],"This":[21,47],"regulatory":[22],"post-marketing":[23,49],"surveillance":[24,50],"(PMS)":[25],"study":[26,295],"evaluated":[27],"the":[28,119,154,196,212,227],"real-life":[29,111],"safety":[30,105,155],"and":[31,71,87,91,110,118,157,174,220,241,279,308],"effectiveness":[32,112,160],"abacavir/dolutegravir/lamivudine":[34,63,107,139,252,298],"patients":[36,55,73,122,136,259,272,282,311],"with":[37,59,123,138,195,312],"HIV-1":[38,60,125,269,275,313],"clinical":[40,82],"practice":[41],"Korea.":[43],"MATERIALS":[44],"AND":[45],"METHODS:":[46],"open-label":[48],"examined":[51],"data":[52],"from":[53,95],"consecutive":[54],"(aged":[56],"\u226512":[57],"years)":[58],"receiving":[62,251,260],"according":[64,113],"to":[65,114,254],"locally":[66],"approved":[67],"prescribing":[68],"information;":[69],"treatment-na\u00efve":[70],"treatment-experienced":[72],"were":[74,93,151,163,190,215,230],"permitted.":[75],"Data":[76],"regarding":[77],"patient":[78,96],"demographics,":[79],"medical":[80],"history,":[81],"characteristics,":[83],"medications":[84,262],"(HIV-1":[85],"related":[86],"concomitant),":[88],"resource":[89],"utilization":[90],"comorbidities":[92],"extracted":[94],"records":[97],"over":[98],"a":[99],"1-year":[100],"period.":[102],"Outcomes":[103],"included":[104],"(primary":[108],"endpoint)":[109],"physician's":[115],"global":[116],"assessment":[117],"proportion":[120],"plasma":[124,274],"RNA":[126,276],"count":[127],"<50":[128,277],"copies/mL":[129],"at":[130,140],"48":[131],"weeks.":[132],"RESULTS:":[133],"Of":[134,206,223,234],"663":[135],"treated":[137],"27":[141],"centers":[142],"(June":[145],"-":[147],"June":[148],"2021),":[149],"656":[150,187],"eligible":[152],"analyses":[156],"484":[158],"analyses.":[161],"Patients":[162],"mostly":[164,191],"male":[165],"(94.8%)":[166],"mean":[167,175],"age":[168],"was":[169,177,239,305],"42.2":[170],"\u00b1":[171,179],"14.0":[172],"years":[173],"weight":[176],"68.1":[178],"11.0":[180],"kg.":[181],"Adverse":[182],"events":[183],"(AEs,":[184],"n":[185],"=":[186],"total)":[189],"mild":[192],"severity,":[194],"most":[197,213,228],"common":[198],"being":[199],"nasopharyngitis":[200],"(7.9%),":[201],"retching":[202,216],"(7.5%),":[203],"headache":[204,218],"(4.9%).":[205],"121":[207],"adverse":[208],"drug":[209],"reactions":[210],"(ADRs),":[211],"frequent":[214,229],"(4.4%),":[217],"(1.8%)":[219],"dizziness":[221],"(1.7%).":[222],"55":[224],"serious":[225,236],"AEs,":[226],"anogenital":[231],"warts":[232],"(1.1%).":[233],"2":[235],"ADRs,":[237],"nothing":[238],"unexpected,":[240],"both":[242],"resolved.":[243],"The":[244],"risk":[245],"experiencing":[247],"an":[248],"AE":[249],"while":[250],"appeared":[253],"be":[255],"especially":[256],"increased":[257],"concomitant":[261],"other":[264],"conditions.":[265],"effectively":[267],"suppressed":[268],"(96.1%":[270],"had":[273],"copies/mL),":[278],"99.0%":[280],"showed":[283,296],"symptom":[284],"improvement":[285],"based":[286],"on":[287],"physician":[288],"assessment.":[289],"CONCLUSION:":[290],"Results":[291],"this":[293],"PMS":[294],"that":[297],"administered":[299],"as":[300],"highly":[301],"active":[302],"antiretroviral":[303],"therapy":[304],"well":[306],"tolerated":[307],"effective":[309],"infection.":[314]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-05-14T00:00:00"}