{"id":"https://openalex.org/W4376129558","doi":"https://doi.org/10.1055/a-2091-8062","title":"Exploring Chemical Modifications of Aromatic Amino Acid Residues in Peptides","display_name":"Exploring Chemical Modifications of Aromatic Amino Acid Residues in Peptides","publication_year":2023,"publication_date":"2023-05-11","ids":{"openalex":"https://openalex.org/W4376129558","doi":"https://doi.org/10.1055/a-2091-8062"},"language":"en","primary_location":{"id":"doi:10.1055/a-2091-8062","doi":"https://doi.org/10.1055/a-2091-8062","is_oa":false,"landing_page_url":"https://doi.org/10.1055/a-2091-8062","pdf_url":null,"source":{"id":"https://openalex.org/S197964166","display_name":"Synthesis","issn_l":"0039-7881","issn":["0039-7881","1437-210X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077313499","display_name":"Bishwajit Paul","orcid":"https://orcid.org/0000-0003-2095-8315","observed_orcids":["https://orcid.org/0000-0003-2095-8315"]},"institutions":[{"id":"https://openalex.org/I53465836","display_name":"Bangalore University","ror":"https://ror.org/050j2vm64","country_code":"IN","type":"education","lineage":["https://openalex.org/I53465836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Bishwajit Paul","raw_affiliation_strings":["Department of Chemistry, Bangalore University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bangalore University","institution_ids":["https://openalex.org/I53465836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010638869","display_name":"Modhu Sudan Maji","orcid":"https://orcid.org/0000-0001-9647-2683","observed_orcids":["https://orcid.org/0000-0001-9647-2683"]},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Modhu Sudan Maji","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology Kharagpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Kharagpur","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104115246","display_name":"Susanta Bhunia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Susanta Bhunia","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology Kharagpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Kharagpur","institution_ids":["https://openalex.org/I145894827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055968178","display_name":"Manasa Purushotham","orcid":"https://orcid.org/0000-0002-9855-2510","observed_orcids":["https://orcid.org/0000-0002-9855-2510"]},"institutions":[{"id":"https://openalex.org/I53465836","display_name":"Bangalore University","ror":"https://ror.org/050j2vm64","country_code":"IN","type":"education","lineage":["https://openalex.org/I53465836"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manasa Purushotham","raw_affiliation_strings":["Department of Chemistry, Bangalore University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Bangalore University","institution_ids":["https://openalex.org/I53465836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077981471","display_name":"Ganesh Karan","orcid":"https://orcid.org/0000-0002-3389-4149","observed_orcids":["https://orcid.org/0000-0002-3389-4149"]},"institutions":[{"id":"https://openalex.org/I145894827","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511","country_code":"IN","type":"education","lineage":["https://openalex.org/I145894827"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ganesh Karan","raw_affiliation_strings":["Department of Chemistry, Indian Institute of Technology Kharagpur"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Indian Institute of Technology Kharagpur","institution_ids":["https://openalex.org/I145894827"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6543,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81578128,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"55","issue":"22","first_page":"3701","last_page":"3724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12189","display_name":"Sulfur-Based Synthesis Techniques","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aromatic-amino-acids","display_name":"aromatic amino acids","score":0.875},{"id":"https://openalex.org/keywords/tryptophan-modification","display_name":"tryptophan modification","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tyrosine-modification","display_name":"tyrosine modification","score":1.0},{"id":"https://openalex.org/keywords/histidine-modification","display_name":"histidine modification","score":1.0},{"id":"https://openalex.org/keywords/reactive-groups","display_name":"reactive functional groups","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8931474685668945},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.7097182869911194},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6693850755691528},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.6160027980804443},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.6151492595672607},{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.6078345775604248},{"id":"https://openalex.org/C184133267","wikidata":"https://www.wikidata.org/wiki/Q5090480","display_name":"Chemical modification","level":2,"score":0.6004528999328613},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.5809386372566223},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.48324570059776306},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4617675840854645},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.45406362414360046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39366477727890015},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10989069938659668}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/a-2091-8062","doi":"https://doi.org/10.1055/a-2091-8062","is_oa":false,"landing_page_url":"https://doi.org/10.1055/a-2091-8062","pdf_url":null,"source":{"id":"https://openalex.org/S197964166","display_name":"Synthesis","issn_l":"0039-7881","issn":["0039-7881","1437-210X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthesis","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4784301364","display_name":null,"funder_award_id":"02(0433)/21/EMR-II","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"},{"id":"https://openalex.org/G693787186","display_name":null,"funder_award_id":"U.O DEV:D2a:BU-RP:2020-21","funder_id":"https://openalex.org/F4320324718","funder_display_name":"Bangalore University"}],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320324718","display_name":"Bangalore University","ror":"https://ror.org/050j2vm64"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":167,"referenced_works":["https://openalex.org/W1891141673","https://openalex.org/W1897236478","https://openalex.org/W1951491916","https://openalex.org/W1968652549","https://openalex.org/W1970821340","https://openalex.org/W1977949559","https://openalex.org/W1978513278","https://openalex.org/W1979806758","https://openalex.org/W1980491680","https://openalex.org/W1983401069","https://openalex.org/W1984670735","https://openalex.org/W1987480785","https://openalex.org/W1991437860","https://openalex.org/W1991663757","https://openalex.org/W1998331753","https://openalex.org/W2005293003","https://openalex.org/W2017684792","https://openalex.org/W2019275772","https://openalex.org/W2022939277","https://openalex.org/W2024109662","https://openalex.org/W2025120281","https://openalex.org/W2026395206","https://openalex.org/W2033043158","https://openalex.org/W2036161550","https://openalex.org/W2036997190","https://openalex.org/W2037872925","https://openalex.org/W2049644443","https://openalex.org/W2051710717","https://openalex.org/W2051873436","https://openalex.org/W2059885411","https://openalex.org/W2061973968","https://openalex.org/W2062499814","https://openalex.org/W2070783701","https://openalex.org/W2074531382","https://openalex.org/W2076781982","https://openalex.org/W2080854581","https://openalex.org/W2081465761","https://openalex.org/W2082215511","https://openalex.org/W2083868047","https://openalex.org/W2094186244","https://openalex.org/W2095907202","https://openalex.org/W2096262475","https://openalex.org/W2104254197","https://openalex.org/W2111038935","https://openalex.org/W2112501431","https://openalex.org/W2116087305","https://openalex.org/W2117358993","https://openalex.org/W2130038789","https://openalex.org/W2130477131","https://openalex.org/W2140877603","https://openalex.org/W2143963251","https://openalex.org/W2145662716","https://openalex.org/W2147124183","https://openalex.org/W2151468502","https://openalex.org/W2151709132","https://openalex.org/W2157873278","https://openalex.org/W2165286214","https://openalex.org/W2166118452","https://openalex.org/W2183586952","https://openalex.org/W2263462535","https://openalex.org/W2296564964","https://openalex.org/W2315282308","https://openalex.org/W2340625992","https://openalex.org/W2415206900","https://openalex.org/W2483119056","https://openalex.org/W2499159979","https://openalex.org/W2563087775","https://openalex.org/W2569012662","https://openalex.org/W2573219864","https://openalex.org/W2587649655","https://openalex.org/W2588017577","https://openalex.org/W2599574708","https://openalex.org/W2606011273","https://openalex.org/W2620484504","https://openalex.org/W2729329687","https://openalex.org/W2734489468","https://openalex.org/W2734540261","https://openalex.org/W2743271282","https://openalex.org/W2751693376","https://openalex.org/W2760438221","https://openalex.org/W2782049488","https://openalex.org/W2792055302","https://openalex.org/W2797413358","https://openalex.org/W2800021240","https://openalex.org/W2805942784","https://openalex.org/W2889102387","https://openalex.org/W2892082086","https://openalex.org/W2896706920","https://openalex.org/W2898385186","https://openalex.org/W2900259138","https://openalex.org/W2900761477","https://openalex.org/W2903360300","https://openalex.org/W2903718537","https://openalex.org/W2904581264","https://openalex.org/W2905133746","https://openalex.org/W2909923039","https://openalex.org/W2917912064","https://openalex.org/W2933400210","https://openalex.org/W2936465412","https://openalex.org/W2937463599","https://openalex.org/W2947590831","https://openalex.org/W2953135775","https://openalex.org/W2953319253","https://openalex.org/W2953544335","https://openalex.org/W2965302796","https://openalex.org/W2966318192","https://openalex.org/W2966408407","https://openalex.org/W2967638355","https://openalex.org/W2974048519","https://openalex.org/W2974656040","https://openalex.org/W2980369267","https://openalex.org/W2981882471","https://openalex.org/W2982893348","https://openalex.org/W2989719215","https://openalex.org/W2995332512","https://openalex.org/W2999705394","https://openalex.org/W3000185218","https://openalex.org/W3004597174","https://openalex.org/W3006586141","https://openalex.org/W3007582551","https://openalex.org/W3012846342","https://openalex.org/W3033054887","https://openalex.org/W3033139899","https://openalex.org/W3033689390","https://openalex.org/W3042135147","https://openalex.org/W3044661214","https://openalex.org/W3051338520","https://openalex.org/W3080834294","https://openalex.org/W3092346714","https://openalex.org/W3102348117","https://openalex.org/W3112022342","https://openalex.org/W3121781792","https://openalex.org/W3122676976","https://openalex.org/W3127297964","https://openalex.org/W3131508861","https://openalex.org/W3131574196","https://openalex.org/W3140320871","https://openalex.org/W3152968237","https://openalex.org/W3160077339","https://openalex.org/W3161581565","https://openalex.org/W3164234047","https://openalex.org/W3164610987","https://openalex.org/W3167288305","https://openalex.org/W3169481919","https://openalex.org/W3173047594","https://openalex.org/W3180015469","https://openalex.org/W3189068932","https://openalex.org/W3193047361","https://openalex.org/W3196665184","https://openalex.org/W3197895391","https://openalex.org/W3211840303","https://openalex.org/W3212100660","https://openalex.org/W4210468496","https://openalex.org/W4214559228","https://openalex.org/W4220929724","https://openalex.org/W4221057840","https://openalex.org/W4229005201","https://openalex.org/W4254689880","https://openalex.org/W4281286064","https://openalex.org/W4283803052","https://openalex.org/W4285293171","https://openalex.org/W4310112277","https://openalex.org/W4311820931","https://openalex.org/W4312114046","https://openalex.org/W4313276131","https://openalex.org/W4313313124","https://openalex.org/W4313421570"],"related_works":["https://openalex.org/W3087417897","https://openalex.org/W4388277599","https://openalex.org/W2345717958","https://openalex.org/W2952451636","https://openalex.org/W4389580005","https://openalex.org/W4399279529","https://openalex.org/W3135236241","https://openalex.org/W2155393139","https://openalex.org/W4318466140","https://openalex.org/W2805653753"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"chemical":[2,49,123],"diversification":[3],"of":[4,11,31,51,58,71,77,96,118],"biomolecules":[5],"set":[6],"forth":[7],"a":[8,105],"significant":[9,42],"area":[10],"research":[12],"that":[13],"constitutes":[14],"an":[15],"important":[16],"intersection":[17],"between":[18],"chemistry":[19],"and":[20,24,33,66,81,124,143],"biology.":[21],"Amino":[22],"acids":[23,101],"peptides":[25],"are":[26],"the":[27,48,56,69,72,93,109,116,122],"fundamental":[28],"building":[29],"blocks":[30],"proteins":[32],"play":[34],"essential":[35],"roles":[36],"in":[37,102,121],"all":[38],"living":[39],"organisms.":[40],"While":[41],"efforts":[43],"have":[44,113],"been":[45,84],"geared":[46],"toward":[47],"modification":[50],"amino":[52,74,100],"acid":[53,75],"residues,":[54],"particularly":[55],"functionalization":[57,95],"reactive":[59],"functional":[60],"groups":[61],"such":[62],"as":[63],"lysine":[64],"NH2":[65],"cysteine":[67],"SH,":[68],"exploration":[70],"aromatic":[73,99],"residues":[76],"tryptophan,":[78],"tyrosine,":[79],"phenylalanine,":[80],"histidine":[82],"has":[83],"relatively":[85],"limited.":[86],"Therefore,":[87],"this":[88],"review":[89],"highlights":[90],"strategies":[91],"for":[92],"side-chain":[94],"these":[97,119],"four":[98],"peptides,":[103],"with":[104],"focus":[106],"on":[107],"elucidating":[108],"underlying":[110],"mechanisms.":[111],"We":[112],"also":[114],"illustrated":[115],"use":[117],"modifications":[120],"biological":[125],"realm.":[126],"1":[127],"Introduction":[128],"2":[129],"Tryptophan":[130],"Modifications":[131,134,137,140],"3":[132],"Tyrosine":[133],"4":[135],"Phenylalanine":[136],"5":[138],"Histidine":[139],"6":[141],"Perspectives":[142],"Future":[144],"Outlook":[145]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2023-05-12T00:00:00"}