{"id":"https://openalex.org/W4376113406","doi":"https://doi.org/10.1158/2159-8290.c.6637747","title":"Data from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax","display_name":"Data from Combinatorial BCL2 Family Expression in Acute Myeloid Leukemia Stem Cells Predicts Clinical Response to Azacitidine/Venetoclax","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W4376113406","doi":"https://doi.org/10.1158/2159-8290.c.6637747"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.6637747","doi":"https://doi.org/10.1158/2159-8290.c.6637747","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6637747","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.c.6637747","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056060551","display_name":"Alexander Waclawiczek","orcid":"https://orcid.org/0000-0002-8749-6736","observed_orcids":["https://orcid.org/0000-0002-8749-6736"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Waclawiczek","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8749-6736","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037129838","display_name":"Aino\u2010Maija Lepp\u00e4","orcid":"https://orcid.org/0000-0003-0849-1759","observed_orcids":["https://orcid.org/0000-0003-0849-1759"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aino-Maija Lepp\u00e4","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0849-1759","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039581367","display_name":"Simon Renders","orcid":"https://orcid.org/0000-0001-7883-2956","observed_orcids":["https://orcid.org/0000-0001-7883-2956"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Renders","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7883-2956","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039781031","display_name":"Karolin Stumpf","orcid":"https://orcid.org/0000-0002-8930-7265","observed_orcids":["https://orcid.org/0000-0002-8930-7265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karolin Stumpf","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8930-7265","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077898802","display_name":"Cecilia Reyneri","orcid":"https://orcid.org/0000-0002-9950-5468","observed_orcids":["https://orcid.org/0000-0002-9950-5468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Reyneri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9950-5468","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039312879","display_name":"Barbara Betz","orcid":"https://orcid.org/0000-0002-2767-5062","observed_orcids":["https://orcid.org/0000-0002-2767-5062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Betz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2767-5062","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018380807","display_name":"Maike Janssen","orcid":"https://orcid.org/0000-0001-9899-1022","observed_orcids":["https://orcid.org/0000-0001-9899-1022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maike Janssen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9899-1022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073258894","display_name":"Rabia Shahswar","orcid":"https://orcid.org/0000-0001-6266-6316","observed_orcids":["https://orcid.org/0000-0001-6266-6316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rabia Shahswar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6266-6316","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012482394","display_name":"Elisa Donato","orcid":"https://orcid.org/0000-0003-3541-9170","observed_orcids":["https://orcid.org/0000-0003-3541-9170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisa Donato","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3541-9170","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062422556","display_name":"Darja Karpova","orcid":"https://orcid.org/0000-0003-0695-1854","observed_orcids":["https://orcid.org/0000-0003-0695-1854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darja Karpova","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0695-1854","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043668590","display_name":"Vera Thiel","orcid":"https://orcid.org/0000-0003-1245-0175","observed_orcids":["https://orcid.org/0000-0003-1245-0175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vera Thiel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1245-0175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087384301","display_name":"Julia Marie Unglaub","orcid":"https://orcid.org/0000-0002-3577-5493","observed_orcids":["https://orcid.org/0000-0002-3577-5493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia M. Unglaub","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3577-5493","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053591758","display_name":"Susanna Grabowski","orcid":"https://orcid.org/0000-0003-1544-482X","observed_orcids":["https://orcid.org/0000-0003-1544-482X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susanna Grabowski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1544-482X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013161320","display_name":"Stefanie Gryzik","orcid":"https://orcid.org/0000-0001-5871-539X","observed_orcids":["https://orcid.org/0000-0001-5871-539X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefanie Gryzik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5871-539X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088988110","display_name":"Lisa Vierbaum","orcid":"https://orcid.org/0000-0003-3661-6512","observed_orcids":["https://orcid.org/0000-0003-3661-6512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Vierbaum","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3661-6512","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053949970","display_name":"Richard F. Schlenk","orcid":"https://orcid.org/0000-0003-2215-2059","observed_orcids":["https://orcid.org/0000-0003-2215-2059","https://orcid.org/0000-0002-5298-3120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard F. Schlenk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2215-2059","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026359397","display_name":"Christoph R\u00f6llig","orcid":"https://orcid.org/0000-0002-3791-0548","observed_orcids":["https://orcid.org/0000-0002-3791-0548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph R\u00f6llig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3791-0548","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084645599","display_name":"Michael Hundemer","orcid":"https://orcid.org/0000-0002-5596-2405","observed_orcids":["https://orcid.org/0000-0002-5596-2405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hundemer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5596-2405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009753849","display_name":"Caroline Pabst","orcid":"https://orcid.org/0000-0001-9716-5909","observed_orcids":["https://orcid.org/0000-0001-9716-5909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Pabst","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9716-5909","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053578678","display_name":"Michael Heuser","orcid":"https://orcid.org/0000-0001-5318-9044","observed_orcids":["https://orcid.org/0000-0001-5318-9044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Heuser","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5318-9044","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080023449","display_name":"Simon Raffel","orcid":"https://orcid.org/0000-0003-4671-1097","observed_orcids":["https://orcid.org/0000-0003-4671-1097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Raffel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4671-1097","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028388949","display_name":"Carsten M\u00fcller\u2010Tidow","orcid":"https://orcid.org/0000-0002-7166-5232","observed_orcids":["https://orcid.org/0000-0002-7166-5232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carsten M\u00fcller-Tidow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7166-5232","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089981698","display_name":"Tim Sauer","orcid":"https://orcid.org/0000-0001-5412-324X","observed_orcids":["https://orcid.org/0000-0001-5412-324X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Sauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5412-324X","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081577791","display_name":"Andreas Trumpp","orcid":"https://orcid.org/0000-0002-6212-3466","observed_orcids":["https://orcid.org/0000-0002-6212-3466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Trumpp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6212-3466","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/venetoclax","display_name":"venetoclax","score":0.8659999966621399},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":1.0},{"id":"https://openalex.org/keywords/leukemia-stem-cells","display_name":"leukemia stem cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bcl-2-family-proteins","display_name":"Bcl-2 family proteins","score":0.8790000081062317},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mcl-1","display_name":"Mcl-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5609999895095825},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.7369999885559082},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.6729999780654907},{"id":"https://openalex.org/keywords/monocyte-differentiation","display_name":"monocyte differentiation","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.9615522623062134},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.7786723375320435},{"id":"https://openalex.org/C9583187","wikidata":"https://www.wikidata.org/wiki/Q7919510","display_name":"Ven","level":2,"score":0.5915743708610535},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5571176409721375},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5569997429847717},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5202099680900574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4919314384460449},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.45283105969429016},{"id":"https://openalex.org/C2779176958","wikidata":"https://www.wikidata.org/wiki/Q18028939","display_name":"MCL1","level":4,"score":0.4280344843864441},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.41316425800323486},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.41114550828933716},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4010288119316101},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3884598910808563},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38697633147239685},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36829477548599243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2181059718132019},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.10797473788261414},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.10214462876319885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2159-8290.c.6637747","doi":"https://doi.org/10.1158/2159-8290.c.6637747","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6637747","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.c.6637747.v1","doi":"https://doi.org/10.1158/2159-8290.c.6637747.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6637747.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.c.6637747.v2","doi":"https://doi.org/10.1158/2159-8290.c.6637747.v2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2159-8290.c.6637747.v2","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.6637747","doi":"https://doi.org/10.1158/2159-8290.c.6637747","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6637747","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4323652032","https://openalex.org/W4385667536","https://openalex.org/W7126176047","https://openalex.org/W4417009076","https://openalex.org/W4386024128"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"BCL2":[2,141],"inhibitor":[3],"venetoclax":[4],"(VEN)":[5],"in":[6,62,115,144,196,214],"combination":[7],"with":[8,122,132,173],"azacitidine":[9],"(5-AZA)":[10],"is":[11,21,181,212],"currently":[12],"transforming":[13],"acute":[14],"myeloid":[15],"leukemia":[16],"(AML)":[17],"therapy.":[18],"However,":[19,175],"there":[20],"a":[22,95,123,147,199],"lack":[23,185],"of":[24,45,75,84,99,107,110,127,140,150,177,186],"clinically":[25,60,187],"relevant":[26],"biomarkers":[27],"that":[28],"predict":[29,203],"response":[30,121,158,178,205],"to":[31,42,159,168,179,202],"5-AZA/VEN.":[32,160],"Here,":[33,190],"we":[34,191],"integrated":[35],"transcriptomic,":[36],"proteomic,":[37],"functional,":[38],"and":[39,93,113,152,206],"clinical":[40,208],"data":[41],"identify":[43],"predictors":[44],"5-AZA/VEN":[46,76],"response.":[47],"Although":[48],"cultured":[49],"monocytic":[50,56],"AML":[51],"cells":[52,70],"displayed":[53,87],"upfront":[54],"resistance,":[55],"differentiation":[57],"was":[58],"not":[59],"predictive":[61,125],"our":[63],"patient":[64,157],"cohort.":[65],"We":[66,91],"identified":[67],"leukemic":[68],"stem":[69],"(LSC)":[71],"as":[72,198],"primary":[73],"targets":[74],"whose":[77],"elimination":[78],"determined":[79],"the":[80,105,184,215],"therapy":[81],"outcome.":[82],"LSCs":[83,197],"5-AZA/VEN-refractory":[85],"patients":[86,172],"perturbed":[88],"apoptotic":[89],"dependencies.":[90],"developed":[92],"validated":[94],"flow":[96],"cytometry-based":[97],"\u201cMediators":[98],"apoptosis":[100],"combinatorial":[101,138],"score\u201d":[102],"(MAC-Score)":[103],"linking":[104],"ratio":[106],"protein":[108],"expression":[109],"BCL2,":[111],"BCL-xL,":[112],"MCL1":[114],"LSCs.":[116],"MAC":[117,153,194],"scoring":[118,154,195],"predicts":[119,156],"initial":[120],"positive":[124],"value":[126],"more":[128],"than":[129],"97%":[130],"associated":[131],"increased":[133],"event-free":[134],"survival.":[135],"In":[136,216],"summary,":[137],"levels":[139],"family":[142],"members":[143],"AML-LSCs":[145],"are":[146],"key":[148],"denominator":[149],"response,":[151],"reliably":[155],"Significance:":[161],"Venetoclax/azacitidine":[162],"treatment":[163,180,204],"has":[164],"become":[165],"an":[166],"alternative":[167],"standard":[169],"chemotherapy":[170],"for":[171],"AML.":[174],"prediction":[176],"hampered":[182],"by":[183],"useful":[188],"biomarkers.":[189],"present":[192],"easy-to-implement":[193],"novel":[200],"strategy":[201],"facilitate":[207],"decision-making.":[209],"This":[210,217],"article":[211],"highlighted":[213],"Issue":[218],"feature,":[219],"p.":[220],"1275":[221]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-12T00:00:00"}
