{"id":"https://openalex.org/W4376107641","doi":"https://doi.org/10.21203/rs.3.rs-2833478/v1","title":"An approach of scoring early host immune response from oro-nasopharyngeal swabs predicts covid-19 outcome providing possibility of early therapeutic intervention","display_name":"An approach of scoring early host immune response from oro-nasopharyngeal swabs predicts covid-19 outcome providing possibility of early therapeutic intervention","publication_year":2023,"publication_date":"2023-05-10","ids":{"openalex":"https://openalex.org/W4376107641","doi":"https://doi.org/10.21203/rs.3.rs-2833478/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-2833478/v1","doi":"https://doi.org/10.21203/rs.3.rs-2833478/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2833478/v1","pdf_url":"https://www.researchsquare.com/article/rs-2833478/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-2833478/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040654673","display_name":"Jagannath Pal","orcid":"https://orcid.org/0000-0002-7110-4048","observed_orcids":["https://orcid.org/0000-0002-7110-4048"]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jagannath Pal","raw_affiliation_strings":["PT. J.N.M.MEDICAL COLLEGE","Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;"],"raw_orcid":"https://orcid.org/0000-0002-7110-4048","affiliations":[{"raw_affiliation_string":"PT. J.N.M.MEDICAL COLLEGE","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021994557","display_name":"Yogita Rajput","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogita Rajput","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080437903","display_name":"Arvind Neral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arvind Neral","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Department of Microbiology, Pt.J.N.M. Medical College Raipur, C.G;","Department of Pathology, Pt.J.N.M. Medical College Raipur, C.G;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Microbiology, Pt.J.N.M. Medical College Raipur, C.G;","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Pathology, Pt.J.N.M. Medical College Raipur, C.G;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019514227","display_name":"Nikita Sherwani","orcid":"https://orcid.org/0009-0006-3557-4348","observed_orcids":["https://orcid.org/0009-0006-3557-4348"]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nikita Sherwani","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Department of Microbiology, Pt.J.N.M. Medical College Raipur, C.G;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Microbiology, Pt.J.N.M. Medical College Raipur, C.G;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024682075","display_name":"Vijaylakshmi Jain","orcid":"https://orcid.org/0000-0003-4616-9082","observed_orcids":["https://orcid.org/0000-0003-4616-9082"]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijaylakshmi Jain","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Department of Microbiology, Pt.J.N.M. Medical College Raipur, C.G;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Microbiology, Pt.J.N.M. Medical College Raipur, C.G;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019083474","display_name":"Malti Sahu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Malti Sahu","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091917750","display_name":"Fulsay Paikra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Fulsay Paikra","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Multidisciplinary Research Units (MRU) Pt. J.N.M. Medical College Raipur, C.G.;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091917751","display_name":"Heeramani Lodhi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Heeramani Lodhi","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Department of Anaesthesia and pain management, Pt.J.N.M. Medical College Raipur, C.G;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Anaesthesia and pain management, Pt.J.N.M. Medical College Raipur, C.G;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104245641","display_name":"Ravindra Kumar Panda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravindra Panda","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Department of Respiratory Medicine, Pt. J.N.M. Medical College Raipur, C.G.;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of Respiratory Medicine, Pt. J.N.M. Medical College Raipur, C.G.;","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112745407","display_name":"Vinit K. Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vinit Jain","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Superintendent, Dr. BRAM Hospital Raipur, C.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Superintendent, Dr. BRAM Hospital Raipur, C.G","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005740453","display_name":"Omprakash Sundrani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Omprakash sundrani","raw_affiliation_strings":["Pt.J.N.M. Medical College Raipur","Department of critical care medicine, Pt.J.N.M. Medical College Raipur, C.G"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pt.J.N.M. Medical College Raipur","institution_ids":["https://openalex.org/I2799791569"]},{"raw_affiliation_string":"Department of critical care medicine, Pt.J.N.M. Medical College Raipur, C.G","institution_ids":["https://openalex.org/I2799791569"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063099799","display_name":"Masood A. Shammas","orcid":"https://orcid.org/0000-0002-8932-6829","observed_orcids":["https://orcid.org/0000-0002-8932-6829"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2799791569","display_name":"Pt. Jawahar Lal Nehru Memorial Medical College","ror":"https://ror.org/04h4g6162","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799791569"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["IN","US"],"is_corresponding":false,"raw_author_name":"MASOOD shammas","raw_affiliation_strings":["Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute and VA Health Care System, Boston, MA","Multi-Disciplinary Research Unit (MRU ) Pt. J.N. M. Medical College Raipur , Chhattisgarh , 492001 INDIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Harvard (Dana Farber) Cancer Institute and VA Health Care System, Boston, MA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801671727","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Multi-Disciplinary Research Unit (MRU ) Pt. J.N. M. Medical College Raipur , Chhattisgarh , 492001 INDIA","institution_ids":["https://openalex.org/I2799791569"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040654673"],"corresponding_institution_ids":["https://openalex.org/I2799791569"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/host-immune-response","display_name":"host immune response","score":0.7450000047683716},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.8040000200271606},{"id":"https://openalex.org/keywords/interferon-response-genes","display_name":"interferon response genes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.9779999852180481},{"id":"https://openalex.org/keywords/severity-scores","display_name":"severity scoring","score":0.7860000133514404},{"id":"https://openalex.org/keywords/early-risk-stratification","display_name":"early risk stratification","score":0.5889999866485596},{"id":"https://openalex.org/keywords/dysregulated-inflammation","display_name":"dysregulated inflammation","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.6507434248924255},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6426210403442383},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.549781322479248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4963722825050354},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.4955695867538452},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.48322877287864685},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4670281410217285},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37806010246276855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34745192527770996},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32634860277175903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2677464485168457},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1569068431854248},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.06693142652511597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0604935884475708},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-2833478/v1","doi":"https://doi.org/10.21203/rs.3.rs-2833478/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2833478/v1","pdf_url":"https://www.researchsquare.com/article/rs-2833478/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-2833478/v1","doi":"https://doi.org/10.21203/rs.3.rs-2833478/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-2833478/v1","pdf_url":"https://www.researchsquare.com/article/rs-2833478/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324333","display_name":"Ministry of Health and Family Welfare","ror":"https://ror.org/04pqetg36"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4376107641.pdf","grobid_xml":"https://content.openalex.org/works/W4376107641.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1809966404","https://openalex.org/W1896432851","https://openalex.org/W1982854219","https://openalex.org/W1998387067","https://openalex.org/W1999023229","https://openalex.org/W2009422122","https://openalex.org/W2010789559","https://openalex.org/W2020617877","https://openalex.org/W2036500213","https://openalex.org/W2087668602","https://openalex.org/W2106684817","https://openalex.org/W2133402546","https://openalex.org/W2158345511","https://openalex.org/W2161074777","https://openalex.org/W2165528446","https://openalex.org/W2301132816","https://openalex.org/W2324009466","https://openalex.org/W2610932550","https://openalex.org/W2766441809","https://openalex.org/W2890296042","https://openalex.org/W2938019550","https://openalex.org/W2939946042","https://openalex.org/W2944544314","https://openalex.org/W2950891099","https://openalex.org/W3001118548","https://openalex.org/W3009314935","https://openalex.org/W3011224398","https://openalex.org/W3012422150","https://openalex.org/W3018517500","https://openalex.org/W3042494210","https://openalex.org/W3047168254","https://openalex.org/W3091873439","https://openalex.org/W3091975903","https://openalex.org/W3096333330","https://openalex.org/W3111912998","https://openalex.org/W3113930329","https://openalex.org/W3123967880","https://openalex.org/W3126238650","https://openalex.org/W3130823823","https://openalex.org/W3182774911","https://openalex.org/W3185213122","https://openalex.org/W3190429150","https://openalex.org/W3195703650","https://openalex.org/W3209911111","https://openalex.org/W4220933055","https://openalex.org/W4225541672","https://openalex.org/W4226084477","https://openalex.org/W4229044835","https://openalex.org/W4309008712","https://openalex.org/W6650067898","https://openalex.org/W6762181639"],"related_works":["https://openalex.org/W4401814391","https://openalex.org/W3082763671","https://openalex.org/W3126904753","https://openalex.org/W4379231858","https://openalex.org/W4200542916","https://openalex.org/W4308008374","https://openalex.org/W4313648243","https://openalex.org/W4319027632","https://openalex.org/W2038923568","https://openalex.org/W4306174581"],"abstract_inverted_index":{"Abstract":[0],"Unpredictable":[1],"fatal":[2],"outcome":[3],"of":[4,13,23,52,55,76,100,103,118,124,130,156,168,178,185],"COVID-19":[5,77,113,158],"is":[6],"attributed":[7],"to":[8,17,38,135],"dysregulated":[9],"inflammation.":[10],"The":[11,148],"purpose":[12],"this":[14],"study":[15],"was":[16,142],"develop":[18],"biomarkers":[19],"for":[20,171],"early":[21,84,179],"detection":[22],"host":[24],"immune":[25],"impairment":[26],"which":[27],"may":[28],"in":[29,49,68,152],"turn":[30],"identify":[31,107],"high":[32,53,108],"risk":[33,109],"patients.":[34,186],"We":[35,87],"used":[36],"RT-PCR":[37],"evaluate":[39],"if":[40],"impaired":[41,62],"anti-inflammatory":[42],"response":[43,59,93],"(as":[44],"defined":[45],"by":[46],"undetectable":[47],"IL-10":[48],"the":[50,140,153,157,169],"presence":[51],"expression":[54],"a":[56,90,116],"representative":[57],"interferon":[58],"gene)":[60],"and/or":[61],"adaptive":[63],"T":[64,91],"cell":[65,92],"response,":[66],"assessed":[67],"leftover":[69],"RNA":[70],"samples":[71,160],"extracted":[72],"from":[73],"oro-nasopharyngeal":[74],"swab":[75],"patients":[78,114,132],"at":[79],"diagnosis,":[80],"could":[81],"serve":[82],"as":[83],"prognostic":[85],"marker/s.":[86],"demonstrate":[88],"that":[89],"based":[94],"\u2018severity":[95],"score\u2019":[96],"comprising":[97],"rational":[98,183],"combination":[99],"Ct":[101],"values":[102],"target":[104],"genes":[105],"can":[106,161],"noncomorbid":[110],"potentially":[111],"critical":[112],"with":[115],"sensitivity":[117,134],"91%":[119],"(95%":[120,126,137,145],"CI:58.7-99.8)":[121],"and":[122,165,182],"specificity":[123,141],"92.6%":[125],"CI:75.7-99).":[127],"Although":[128],"inclusion":[129],"co-morbid":[131],"reduced":[133],"77%":[136],"CI:":[138,146],"54.6-92.2),":[139],"still":[143],"94%":[144],"79.8-99.3).":[147],"work":[149],"flow":[150],"developed":[151],"same":[154],"pipeline":[155],"diagnostic":[159],"also":[162],"reduce":[163],"expenditure":[164],"reporting":[166],"time":[167],"test":[170],"an":[172],"earliest":[173],"clinical":[174],"decision":[175],"ensuring":[176],"possibility":[177],"prophylactic":[180],"treatment":[181],"management":[184]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-12T00:00:00"}