{"id":"https://openalex.org/W4375950802","doi":"https://doi.org/10.3389/fimmu.2023.1186916","title":"African swine fever virus QP383R dampens type I interferon production by promoting cGAS palmitoylation","display_name":"African swine fever virus QP383R dampens type I interferon production by promoting cGAS palmitoylation","publication_year":2023,"publication_date":"2023-05-09","ids":{"openalex":"https://openalex.org/W4375950802","doi":"https://doi.org/10.3389/fimmu.2023.1186916","pmid":"https://pubmed.ncbi.nlm.nih.gov/37228597","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10203406"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1186916","doi":"https://doi.org/10.3389/fimmu.2023.1186916","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1186916","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2023.1186916","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Siyuan Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyuan Hao","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102993756","display_name":"Xiaojie Zheng","orcid":"https://orcid.org/0009-0006-2107-5759","observed_orcids":["https://orcid.org/0009-0006-2107-5759"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojie Zheng","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079450919","display_name":"Yingqi Zhu","orcid":"https://orcid.org/0000-0001-5777-4662","observed_orcids":["https://orcid.org/0000-0001-5777-4662"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingqi Zhu","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389452","display_name":"Yao Yao","orcid":"https://orcid.org/0000-0003-2956-5649","observed_orcids":["https://orcid.org/0000-0003-2956-5649"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Yao","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610997","display_name":"Sihan Li","orcid":"https://orcid.org/0009-0001-5740-4052","observed_orcids":["https://orcid.org/0009-0001-5740-4052"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sihan Li","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004079337","display_name":"Yangyang Xu","orcid":"https://orcid.org/0000-0001-7173-7761","observed_orcids":["https://orcid.org/0000-0001-7173-7761"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Xu","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064455149","display_name":"Wen-hai Feng","orcid":"https://orcid.org/0000-0001-8151-6698","observed_orcids":["https://orcid.org/0000-0001-8151-6698"]},"institutions":[{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen-hai Feng","raw_affiliation_strings":["Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Frontiers Science Center for Molecular Design Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]},{"raw_affiliation_string":"State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China","institution_ids":["https://openalex.org/I52158045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064455149"],"corresponding_institution_ids":["https://openalex.org/I52158045"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":3.0149,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92504634,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":null,"first_page":"1186916","last_page":"1186916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/african-swine-fever-virus","display_name":"African swine fever virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cgas","display_name":"cGAS","score":0.9570000171661377},{"id":"https://openalex.org/keywords/protein-palmitoylation","display_name":"palmitoylation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.777999997138977},{"id":"https://openalex.org/keywords/cgamp","display_name":"cGAMP","score":0.8579999804496765},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.8519999980926514},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7838715314865112},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.7481020092964172},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6594756245613098},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.588632345199585},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5595330595970154},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.5148276686668396},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5092242956161499},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5007362365722656},{"id":"https://openalex.org/C2780209191","wikidata":"https://www.wikidata.org/wiki/Q14914339","display_name":"IRF3","level":4,"score":0.4911629855632782},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47461190819740295},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.4678668975830078},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.43675553798675537},{"id":"https://openalex.org/C2779758228","wikidata":"https://www.wikidata.org/wiki/Q858790","display_name":"DNA virus","level":4,"score":0.4246981143951416},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41650712490081787},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.31017380952835083},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23948445916175842},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23496761918067932},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.15671253204345703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08199620246887207},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000358","descriptor_name":"African Swine Fever Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054878","descriptor_name":"Lipoylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2023.1186916","doi":"https://doi.org/10.3389/fimmu.2023.1186916","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1186916","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10203406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10203406","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10203406/pdf/fimmu-14-1186916.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:37228597","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37228597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9900af2b83e040c9a3bdd00be0abb681","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9900af2b83e040c9a3bdd00be0abb681","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1186916","doi":"https://doi.org/10.3389/fimmu.2023.1186916","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1186916","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1258178360","display_name":null,"funder_award_id":"32172869","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4375950802.pdf","grobid_xml":"https://content.openalex.org/works/W4375950802.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1776390480","https://openalex.org/W1968178474","https://openalex.org/W1994942139","https://openalex.org/W1995744610","https://openalex.org/W2000177767","https://openalex.org/W2021848296","https://openalex.org/W2073737981","https://openalex.org/W2083860129","https://openalex.org/W2084880831","https://openalex.org/W2099610218","https://openalex.org/W2100867908","https://openalex.org/W2107423735","https://openalex.org/W2112078441","https://openalex.org/W2114085082","https://openalex.org/W2114216755","https://openalex.org/W2119864130","https://openalex.org/W2134644569","https://openalex.org/W2154171253","https://openalex.org/W2260285999","https://openalex.org/W2264201737","https://openalex.org/W2398563931","https://openalex.org/W2434618603","https://openalex.org/W2517088279","https://openalex.org/W2535906742","https://openalex.org/W2540080277","https://openalex.org/W2551567032","https://openalex.org/W2566571644","https://openalex.org/W2575503691","https://openalex.org/W2580172796","https://openalex.org/W2613902351","https://openalex.org/W2626567256","https://openalex.org/W2750227535","https://openalex.org/W2754087313","https://openalex.org/W2761880361","https://openalex.org/W2773182043","https://openalex.org/W2778279659","https://openalex.org/W2788541983","https://openalex.org/W2789695849","https://openalex.org/W2799828802","https://openalex.org/W2809259575","https://openalex.org/W2885484032","https://openalex.org/W2892190669","https://openalex.org/W2897106424","https://openalex.org/W2919704769","https://openalex.org/W2919896467","https://openalex.org/W2930648875","https://openalex.org/W2946147773","https://openalex.org/W2948096480","https://openalex.org/W2973949370","https://openalex.org/W2986334759","https://openalex.org/W2999006774","https://openalex.org/W3009223043","https://openalex.org/W3022260869","https://openalex.org/W3024191006","https://openalex.org/W3024846245","https://openalex.org/W3038620702","https://openalex.org/W3069213303","https://openalex.org/W3092534807","https://openalex.org/W3114062751","https://openalex.org/W3130305184","https://openalex.org/W3158635115","https://openalex.org/W3204303843","https://openalex.org/W3209428035","https://openalex.org/W3213411744","https://openalex.org/W4221020608","https://openalex.org/W4223446228","https://openalex.org/W4224212785","https://openalex.org/W4286493276","https://openalex.org/W4307291521","https://openalex.org/W4309124647","https://openalex.org/W4311484399"],"related_works":["https://openalex.org/W4404066766","https://openalex.org/W4285603270","https://openalex.org/W4402529668","https://openalex.org/W7151454687","https://openalex.org/W4295754330","https://openalex.org/W4224219689","https://openalex.org/W4207004196","https://openalex.org/W4388014250","https://openalex.org/W4286493276","https://openalex.org/W3209566925"],"abstract_inverted_index":{"Cyclic":[0],"GMP-AMP":[1,10],"synthase":[2],"(cGAS)":[3],"recognizes":[4],"viral":[5,158],"DNA":[6,102],"and":[7,19,70,78,92,104,112],"synthesizes":[8],"cyclic":[9],"(cGAMP),":[11],"which":[12],"activates":[13],"stimulator":[14],"of":[15,52,59,76,125],"interferon":[16],"genes":[17],"(STING/MITA)":[18],"downstream":[20,79],"mediators":[21],"to":[22,39,144,160],"elicit":[23],"an":[24,50,156],"innate":[25,141,163],"immune":[26,37,142,164],"response.":[27],"African":[28],"swine":[29],"fever":[30],"virus":[31],"(ASFV)":[32],"proteins":[33],"can":[34,138],"antagonize":[35,139],"host":[36,140],"responses":[38],"promote":[40],"its":[41],"infection.":[42],"Here,":[43],"we":[44,55,84,97,134],"identified":[45],"ASFV":[46,145],"protein":[47],"QP383R":[48,60,87,100,126,137],"as":[49],"inhibitor":[51],"cGAS.":[53],"Specifically,":[54],"found":[56],"that":[57,86,99,122,136],"overexpression":[58],"suppressed":[61,101],"type":[62],"I":[63],"interferons":[64],"(IFNs)":[65],"activation":[66],"stimulated":[67],"by":[68,146],"dsDNA":[69],"cGAS/STING,":[71],"resulting":[72],"in":[73,152],"decreased":[74],"transcription":[75],"IFN\u03b2":[77,128],"proinflammatory":[80],"cytokines.":[81],"In":[82],"addition,":[83],"showed":[85],"interacted":[88],"directly":[89],"with":[90],"cGAS":[91,94,105,109,151],"promoted":[93],"palmitoylation.":[95],"Moreover,":[96],"demonstrated":[98],"binding":[103],"dimerization,":[106],"thus":[107],"inhibiting":[108],"enzymatic":[110],"functions":[111],"reducing":[113],"cGAMP":[114],"production.":[115,129],"Finally,":[116],"the":[117,123,148],"truncation":[118],"mutation":[119],"analysis":[120],"indicated":[121],"284-383aa":[124],"inhibited":[127],"Considering":[130],"these":[131],"results":[132],"collectively,":[133],"conclude":[135],"response":[143],"targeting":[147],"core":[149],"component":[150],"cGAS-STING":[153],"signaling":[154],"pathways,":[155],"important":[157],"strategy":[159],"evade":[161],"this":[162],"sensor.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-05-10T00:00:00"}