{"id":"https://openalex.org/W4375950437","doi":"https://doi.org/10.1177/15910199231169597","title":"The first endovascular rat glioma model for pre-clinical evaluation of intra-arterial therapeutics","display_name":"The first endovascular rat glioma model for pre-clinical evaluation of intra-arterial therapeutics","publication_year":2023,"publication_date":"2023-05-08","ids":{"openalex":"https://openalex.org/W4375950437","doi":"https://doi.org/10.1177/15910199231169597","pmid":"https://pubmed.ncbi.nlm.nih.gov/37157800","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12280536"},"language":"en","primary_location":{"id":"doi:10.1177/15910199231169597","doi":"https://doi.org/10.1177/15910199231169597","is_oa":false,"landing_page_url":"https://doi.org/10.1177/15910199231169597","pdf_url":null,"source":{"id":"https://openalex.org/S193127762","display_name":"Interventional Neuroradiology","issn_l":"1591-0199","issn":["1591-0199","2385-2011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interventional Neuroradiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12280536/pdf/10.1177_15910199231169597.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038102032","display_name":"Jaims Lim","orcid":"https://orcid.org/0000-0002-9847-3601","observed_orcids":["https://orcid.org/0000-0002-9847-3601"]},"institutions":[{"id":"https://openalex.org/I1325611130","display_name":"Kaleida Health","ror":"https://ror.org/02sb3pg33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaims Lim","raw_affiliation_strings":["Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-9847-3601","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1325611130"]},{"raw_affiliation_string":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003162837","display_name":"Ammad A. Baig","orcid":"https://orcid.org/0000-0002-8241-6864","observed_orcids":["https://orcid.org/0000-0002-8241-6864"]},"institutions":[{"id":"https://openalex.org/I1325611130","display_name":"Kaleida Health","ror":"https://ror.org/02sb3pg33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ammad A. Baig","raw_affiliation_strings":["Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1325611130"]},{"raw_affiliation_string":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075041038","display_name":"Brianna M. Donnelly","orcid":"https://orcid.org/0000-0002-4109-0589","observed_orcids":["https://orcid.org/0000-0002-4109-0589"]},"institutions":[{"id":"https://openalex.org/I1325611130","display_name":"Kaleida Health","ror":"https://ror.org/02sb3pg33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brianna M. Donnelly","raw_affiliation_strings":["Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4109-0589","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1325611130"]},{"raw_affiliation_string":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018943967","display_name":"Lee Daniel Chaves","orcid":"https://orcid.org/0000-0001-9922-5012","observed_orcids":["https://orcid.org/0000-0001-9922-5012"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee D. Chaves","raw_affiliation_strings":["Department of Medicine, University of Kansas Medical Center, Kansas City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Kansas Medical Center, Kansas City, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026892831","display_name":"Suyog U. Pol","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suyog U. Pol","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079924329","display_name":"Carmon Koenigsknecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carmon Koenigsknecht","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013871153","display_name":"Donald Pionessa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Pionessa","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021590251","display_name":"Bennett Reuben Levy","orcid":"https://orcid.org/0000-0002-9450-3113","observed_orcids":["https://orcid.org/0000-0002-9450-3113"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett R. Levy","raw_affiliation_strings":["George Washington University School of Medicine, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Washington University School of Medicine, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055467666","display_name":"Liza C. Gutierrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liza Gutierrez","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049607907","display_name":"Vincent M. Tutino","orcid":"https://orcid.org/0000-0002-1331-2551","observed_orcids":["https://orcid.org/0000-0002-1331-2551"]},"institutions":[{"id":"https://openalex.org/I4210149000","display_name":"Jacobs Institute","ror":"https://ror.org/04c00sd86","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210149000"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent M. Tutino","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","Jacobs Institute, Buffalo, NY, USA","Mechanical and Aerospace Engineering, University at Buffalo School of Engineering and Applied Sciences, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Jacobs Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I4210149000"]},{"raw_affiliation_string":"Mechanical and Aerospace Engineering, University at Buffalo School of Engineering and Applied Sciences, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028101627","display_name":"Elad I. Levy","orcid":"https://orcid.org/0000-0002-6208-3724","observed_orcids":["https://orcid.org/0000-0002-6208-3724"]},"institutions":[{"id":"https://openalex.org/I1325611130","display_name":"Kaleida Health","ror":"https://ror.org/02sb3pg33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130"]},{"id":"https://openalex.org/I4210149000","display_name":"Jacobs Institute","ror":"https://ror.org/04c00sd86","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210149000"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elad I. Levy","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","Jacobs Institute, Buffalo, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-6208-3724","affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1325611130"]},{"raw_affiliation_string":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Jacobs Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I4210149000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037816826","display_name":"Adnan Hussain Siddiqui","orcid":"https://orcid.org/0000-0002-9519-0059","observed_orcids":["https://orcid.org/0000-0002-9519-0059"]},"institutions":[{"id":"https://openalex.org/I1325611130","display_name":"Kaleida Health","ror":"https://ror.org/02sb3pg33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1325611130"]},{"id":"https://openalex.org/I4210149000","display_name":"Jacobs Institute","ror":"https://ror.org/04c00sd86","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210149000"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Adnan H. Siddiqui","raw_affiliation_strings":["Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","Jacobs Institute, Buffalo, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Neurosurgery, Gates Vascular Institute at Kaleida Health, Buffalo, NY, USA","institution_ids":["https://openalex.org/I1325611130"]},{"raw_affiliation_string":"Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Jacobs Institute, Buffalo, NY, USA","institution_ids":["https://openalex.org/I4210149000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5037816826"],"corresponding_institution_ids":["https://openalex.org/I1325611130","https://openalex.org/I4210149000","https://openalex.org/I63190737"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.69,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.66566265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"31","issue":"4","first_page":"447","last_page":"456"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/intra-arterial-chemotherapy","display_name":"intra-arterial chemotherapy","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rat-glioma-model","display_name":"rat glioma model","score":0.7850000262260437},{"id":"https://openalex.org/keywords/c6-glioma","display_name":"C6 glioma","score":0.8169999718666077},{"id":"https://openalex.org/keywords/femoral-artery-catheterization","display_name":"femoral artery catheterization","score":0.9179999828338623},{"id":"https://openalex.org/keywords/internal-carotid-artery","display_name":"internal carotid artery","score":0.8690000176429749},{"id":"https://openalex.org/keywords/blood-brain-barrier-disruption","display_name":"blood-brain barrier disruption","score":0.9290000200271606},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9490000009536743},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":1.0},{"id":"https://openalex.org/keywords/irinotecan","display_name":"irinotecan","score":1.0},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9462145566940308},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6352505087852478},{"id":"https://openalex.org/C2779723990","wikidata":"https://www.wikidata.org/wiki/Q707174","display_name":"Femoral artery","level":2,"score":0.6317982077598572},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.4695575535297394},{"id":"https://openalex.org/C2778333808","wikidata":"https://www.wikidata.org/wiki/Q515848","display_name":"Internal carotid artery","level":2,"score":0.46246689558029175},{"id":"https://openalex.org/C2780259306","wikidata":"https://www.wikidata.org/wiki/Q412197","display_name":"Irinotecan","level":4,"score":0.4114249050617218},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.33894434571266174},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33196136355400085},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.26415979862213135},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2490321695804596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2190580666065216},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17937281727790833},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007261","descriptor_name":"Infusions, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057510","descriptor_name":"Endovascular Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1177/15910199231169597","doi":"https://doi.org/10.1177/15910199231169597","is_oa":false,"landing_page_url":"https://doi.org/10.1177/15910199231169597","pdf_url":null,"source":{"id":"https://openalex.org/S193127762","display_name":"Interventional Neuroradiology","issn_l":"1591-0199","issn":["1591-0199","2385-2011"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interventional Neuroradiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11092353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12280536","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12280536/pdf/10.1177_15910199231169597.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12280536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12280536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interv Neuroradiol","raw_type":"Text"},{"id":"pmid:37157800","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37157800","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:11092353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12280536","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12280536/pdf/10.1177_15910199231169597.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7918204433","display_name":"University of Buffalo Clinical and Translational Science Institute","funder_award_id":"UL1TR001412","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332641","display_name":"University at Buffalo","ror":"https://ror.org/01y64my43"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4375950437.pdf","grobid_xml":"https://content.openalex.org/works/W4375950437.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1483235606","https://openalex.org/W1630761673","https://openalex.org/W1678477870","https://openalex.org/W1893609016","https://openalex.org/W1900715992","https://openalex.org/W1969311117","https://openalex.org/W1977256132","https://openalex.org/W1985156459","https://openalex.org/W1990289715","https://openalex.org/W2020217107","https://openalex.org/W2020486016","https://openalex.org/W2025191689","https://openalex.org/W2026616100","https://openalex.org/W2028901608","https://openalex.org/W2042345104","https://openalex.org/W2048925428","https://openalex.org/W2054093324","https://openalex.org/W2063788554","https://openalex.org/W2068485719","https://openalex.org/W2071576628","https://openalex.org/W2080408103","https://openalex.org/W2082458378","https://openalex.org/W2084479512","https://openalex.org/W2088055227","https://openalex.org/W2110958713","https://openalex.org/W2113805975","https://openalex.org/W2126085321","https://openalex.org/W2128610705","https://openalex.org/W2153480544","https://openalex.org/W2164557897","https://openalex.org/W2204996528","https://openalex.org/W2219075584","https://openalex.org/W2228507732","https://openalex.org/W2318537454","https://openalex.org/W2415641365","https://openalex.org/W2416511646","https://openalex.org/W2503823987","https://openalex.org/W2584466409","https://openalex.org/W2620761917","https://openalex.org/W2709394596","https://openalex.org/W2763108561","https://openalex.org/W2964021827","https://openalex.org/W2989370125","https://openalex.org/W2995689361","https://openalex.org/W3007718925","https://openalex.org/W3021103346","https://openalex.org/W3201796693","https://openalex.org/W3216043873","https://openalex.org/W6776205171"],"related_works":["https://openalex.org/W4392887367","https://openalex.org/W4401197095","https://openalex.org/W4327608154","https://openalex.org/W1893609016","https://openalex.org/W4386019058","https://openalex.org/W4408504419","https://openalex.org/W2435724074","https://openalex.org/W2575565425","https://openalex.org/W4413464522","https://openalex.org/W1900715992"],"abstract_inverted_index":{"BackgroundSeveral":[0],"translational":[1],"animal":[2,19,76],"models":[3],"have":[4],"been":[5],"described":[6],"assessing":[7],"intra-arterial":[8],"(IA)":[9],"treatments":[10],"for":[11,45,144,223,285,289],"malignant":[12],"gliomas.":[13],"We":[14,40],"describe":[15],"the":[16,52,75,107,134,173,224,265,277],"first":[17,266],"endovascular":[18,184,267],"model":[20,54,271],"that":[21,272],"allows":[22,273],"testing":[23],"of":[24,66,72,226,247,251,256,276,282,293],"IA":[25,49,237,258,268,283],"drug":[26],"delivery":[27,50],"as":[28],"a":[29,42,86],"first-line":[30],"treatment,":[31],"which":[32,69,103],"is":[33],"difficult":[34],"to":[35,106,118,178,236],"do":[36],"in":[37,51,74,133],"actual":[38],"patients.":[39],"report":[41],"unique":[43],"protocol":[44,188,230],"vascular":[46],"access":[47,185,290],"and":[48,64,147,181,186,231,253,280,291],"rat":[53,269],"that,":[55],"unlike":[56],"prior":[57],"reports,":[58],"does":[59],"not":[60],"require":[61],"direct":[62],"puncture":[63],"opening":[65],"proximal":[67,294],"cerebrovasculature":[68],"carries":[70],"risk":[71],"ischemia":[73],"brain":[77,121],"post-delivery.MethodsWistar":[78],"rats":[79,126,161,200,220,242],"underwent":[80,162],"left":[81,108,135,174],"femoral":[82,163,228],"artery":[83,111,164,177],"catherization":[84],"with":[85,97,129,166,194,204,207],"Balt":[87],"Magic":[88],"1.2F":[89],"catheter":[90],"or":[91,169],"Marathon":[92],"Flow":[93],"directed":[94],"1.5F":[95],"Microcatheter":[96],"an":[98],"Asahi":[99],"Chikai":[100],"0.008":[101],"micro-guidewire":[102],"was":[104,116,189,192,214],"navigated":[105],"internal":[109,175],"carotid":[110,176],"under":[112],"x-ray.":[113],"25%":[114],"mannitol":[115],"administered":[117],"test":[119,179],"blood":[120],"barrier":[122],"breakdown":[123],"(BBBB).":[124],"Additional":[125,160],"were":[127,142,155,201,221],"implanted":[128,203],"C6":[130,138,205],"glioma":[131,270],"cells":[132],"frontal":[136],"lobe.":[137],"Glioma-Implanted":[139],"Rats":[140],"(C6GRs)":[141],"monitored":[143],"overall":[145],"survival":[146,213],"tumor":[148],"growth.":[149],"Tumor":[150],"volumes":[151],"from":[152],"MRI":[153],"images":[154],"calculated":[156],"utilizing":[157],"3D":[158],"slicer.":[159],"catheterization":[165,229,275],"Bevacizumab,":[167],"carboplatin,":[168,252],"irinotecan":[170,257],"injected":[171],"into":[172],"feasibility":[180],"safety.ResultsA":[182],"successful":[183],"BBBB":[187,191,232],"established.":[190],"confirmed":[193,208],"positive":[195],"Evans":[196],"blue":[197],"staining.":[198],"10":[199,245],"successfully":[202],"gliomas":[206,286],"growths":[209],"on":[210],"MRI.":[211],"Overall":[212],"19.75":[215],"\u00b1":[216],"2.21":[217],"days.":[218],"5":[219],"utilized":[222],"development":[225],"our":[227],"testing.":[233],"With":[234],"regards":[235],"chemotherapy":[238],"dosage":[239],"testing,":[240],"control":[241],"tolerated":[243],"targeted":[244],"mg/kg":[246,250,255],"bevascizumab,":[248],"2.4":[249],"15":[254],"ICA":[259],"injections":[260],"without":[261,287],"any":[262],"complications.ConclusionsWe":[263],"present":[264],"selective":[274],"intracranial":[278],"vasculature":[279],"assessment":[281],"therapies":[284],"need":[288],"sacrifice":[292],"cerebrovasculature.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-05-10T00:00:00"}